Details for: BCL7A

Gene ID: 605

Symbol: BCL7A

Ensembl ID: ENSG00000110987

Description: BAF chromatin remodeling complex subunit BCL7A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.44
    Marker Score: 24750
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.06
    Marker Score: 1013
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.01
    Marker Score: 8364
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.85
    Marker Score: 5491
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.78
    Marker Score: 4845
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.76
    Marker Score: 1734
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.65
    Marker Score: 1006
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.55
    Marker Score: 1028
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.51
    Marker Score: 3699.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.49
    Marker Score: 5526
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168384
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.46
    Marker Score: 373
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.43
    Marker Score: 1691
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.43
    Marker Score: 2982
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.39
    Marker Score: 3274
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.39
    Marker Score: 2357
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.37
    Marker Score: 5294.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.36
    Marker Score: 1525
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.36
    Marker Score: 11659
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.3
    Marker Score: 1350
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.26
    Marker Score: 2567
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.26
    Marker Score: 1328
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.25
    Marker Score: 1506
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.24
    Marker Score: 1251
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.24
    Marker Score: 2611
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.22
    Marker Score: 830
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.21
    Marker Score: 283
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.18
    Marker Score: 1256
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.17
    Marker Score: 1295
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.14
    Marker Score: 761.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.14
    Marker Score: 1074.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.14
    Marker Score: 17000
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.13
    Marker Score: 1150
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.12
    Marker Score: 4659
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.12
    Marker Score: 42628
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.12
    Marker Score: 704
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.12
    Marker Score: 68808
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.11
    Marker Score: 10443
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.11
    Marker Score: 539.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.08
    Marker Score: 10301
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.08
    Marker Score: 1134
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.05
    Marker Score: 38742
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251734
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.01
    Marker Score: 951
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.01
    Marker Score: 20023
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1
    Marker Score: 4103
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71755
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47980
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Marker Score: 4050.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.99
    Marker Score: 4591
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.99
    Marker Score: 5200
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.99
    Marker Score: 2071
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.97
    Marker Score: 1048
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.95
    Marker Score: 12713
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.94
    Marker Score: 1177
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.93
    Marker Score: 1002
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.93
    Marker Score: 1430
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.92
    Marker Score: 9459
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.91
    Marker Score: 967
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9
    Marker Score: 3467
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.89
    Marker Score: 664
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.88
    Marker Score: 514
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.88
    Marker Score: 521.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.88
    Marker Score: 295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4957
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.86
    Marker Score: 2296
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.86
    Marker Score: 197
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.85
    Marker Score: 302
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.84
    Marker Score: 572
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.84
    Marker Score: 724
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.83
    Marker Score: 7221
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.83
    Marker Score: 1002.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.81
    Marker Score: 456
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.81
    Marker Score: 2051
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.8
    Marker Score: 191
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.8
    Marker Score: 6132
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.79
    Marker Score: 709
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3229
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.77
    Marker Score: 265
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.76
    Marker Score: 982
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.74
    Marker Score: 684
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.74
    Marker Score: 408
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.74
    Marker Score: 234
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.73
    Marker Score: 387
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.73
    Marker Score: 692
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.72
    Marker Score: 763

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Other Information

**Key characteristics:** - BCL7A is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the BCL7A family of proteins. - BCL7A is involved in the regulation of cell differentiation, proliferation, and apoptosis. **Pathways and functions:** - BCL7A is a key component of the BAF complex, which is responsible for the remodeling of chromatin to facilitate gene expression. - The BAF complex is involved in the regulation of cell differentiation, proliferation, and apoptosis. - BCL7A is also involved in the regulation of the G1/S transition of the mitotic cell cycle. - It is a negative regulator of cell differentiation, proliferation, and apoptosis. **Clinical significance:** - Mutations in BCL7A have been linked to several human cancers, including acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and multiple myeloma. - BCL7A inhibitors are being investigated as potential therapeutic agents for cancer.

Genular Protein ID: 1312696442

Symbol: BCL7A_HUMAN

Name: B-cell CLL/lymphoma 7 protein family member A

UniProtKB Accession Codes:

Q4VC05 B4DJN6 B7ZB21 Q13843 Q14CT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 9 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 GO 14 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8605326

Title: Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon.

PubMed ID: 8605326

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

Sequence Information:

  • Length: 210
  • Mass: 22810
  • Checksum: 4AB4AC3B309ADDB8
  • Sequence:
    • MSGRSVRAET RSRAKDDIKR VMAAIEKVRK WEKKWVTVGD TSLRIYKWVP VTEPKVDDKN 
KNKKKGKDEK CGSEVTTPEN SSSPGMMDMH DDNSNQSSIA DASPIKQENS SNSSPAPEPN 
SAVPSDGTEA KVDEAQADGK EHPGAEDASD EQNSQSSMEH SMNSSEKVDR QPSGDSGLAA 
ETSAISQDLE GVPPSKKMKL EASQQNSEEM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.