Details for: BCL7A

Gene ID: 605

Symbol: BCL7A

Ensembl ID: ENSG00000110987

Description: BAF chromatin remodeling complex subunit BCL7A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.7022
    Cell Significance Index: -30.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.4487
    Cell Significance Index: -27.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.0111
    Cell Significance Index: -27.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.8978
    Cell Significance Index: -27.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.6697
    Cell Significance Index: -32.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6020
    Cell Significance Index: -31.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4591
    Cell Significance Index: -33.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.9796
    Cell Significance Index: 67.9400
  • Cell Name: centroblast (CL0009112)
    Fold Change: 4.8606
    Cell Significance Index: 11.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.7885
    Cell Significance Index: 103.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5107
    Cell Significance Index: 226.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0750
    Cell Significance Index: -6.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7543
    Cell Significance Index: 206.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5460
    Cell Significance Index: 81.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2587
    Cell Significance Index: 70.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.2403
    Cell Significance Index: 30.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0904
    Cell Significance Index: 37.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9656
    Cell Significance Index: 193.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9289
    Cell Significance Index: 838.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9061
    Cell Significance Index: 179.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.8663
    Cell Significance Index: 22.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8475
    Cell Significance Index: 59.9400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.8270
    Cell Significance Index: 1.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8149
    Cell Significance Index: 48.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7737
    Cell Significance Index: 84.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7031
    Cell Significance Index: 114.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6546
    Cell Significance Index: 80.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5810
    Cell Significance Index: 256.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5032
    Cell Significance Index: 90.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4880
    Cell Significance Index: 14.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4726
    Cell Significance Index: 24.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4600
    Cell Significance Index: 53.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4170
    Cell Significance Index: 149.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4095
    Cell Significance Index: 25.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3864
    Cell Significance Index: 29.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3386
    Cell Significance Index: 23.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3192
    Cell Significance Index: 174.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2469
    Cell Significance Index: 11.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1861
    Cell Significance Index: 128.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1654
    Cell Significance Index: 16.3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1534
    Cell Significance Index: 1.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1320
    Cell Significance Index: 3.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0657
    Cell Significance Index: 3.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0641
    Cell Significance Index: 1.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0515
    Cell Significance Index: 1.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0489
    Cell Significance Index: 9.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0247
    Cell Significance Index: 38.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0229
    Cell Significance Index: 0.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0226
    Cell Significance Index: 3.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0221
    Cell Significance Index: 3.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0218
    Cell Significance Index: 16.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0175
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0111
    Cell Significance Index: 20.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0098
    Cell Significance Index: 18.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0049
    Cell Significance Index: 0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0026
    Cell Significance Index: -3.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0237
    Cell Significance Index: -15.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0288
    Cell Significance Index: -13.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0303
    Cell Significance Index: -22.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0350
    Cell Significance Index: -25.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0397
    Cell Significance Index: -5.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0406
    Cell Significance Index: -5.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0562
    Cell Significance Index: -31.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0581
    Cell Significance Index: -36.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0737
    Cell Significance Index: -10.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0778
    Cell Significance Index: -5.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0885
    Cell Significance Index: -1.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0957
    Cell Significance Index: -27.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1078
    Cell Significance Index: -3.0900
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.1144
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1158
    Cell Significance Index: -13.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1251
    Cell Significance Index: -2.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1289
    Cell Significance Index: -5.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1386
    Cell Significance Index: -14.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1397
    Cell Significance Index: -3.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1566
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1673
    Cell Significance Index: -35.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1852
    Cell Significance Index: -11.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1922
    Cell Significance Index: -2.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2140
    Cell Significance Index: -4.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2155
    Cell Significance Index: -4.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2187
    Cell Significance Index: -8.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2410
    Cell Significance Index: -17.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2432
    Cell Significance Index: -6.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2654
    Cell Significance Index: -21.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2950
    Cell Significance Index: -30.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3504
    Cell Significance Index: -5.8700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3572
    Cell Significance Index: -2.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4048
    Cell Significance Index: -24.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4288
    Cell Significance Index: -10.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4353
    Cell Significance Index: -11.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4381
    Cell Significance Index: -11.7400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4460
    Cell Significance Index: -6.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4494
    Cell Significance Index: -23.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4502
    Cell Significance Index: -14.4200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4996
    Cell Significance Index: -3.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5009
    Cell Significance Index: -7.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5241
    Cell Significance Index: -17.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5480
    Cell Significance Index: -11.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5698
    Cell Significance Index: -16.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BCL7A is a member of the BCL7 gene family, which encodes a family of proteins involved in chromatin remodeling and transcription regulation. The BCL7A protein is a subunit of the BAF complex, which is composed of multiple subunits that interact to form a complex that can remodel chromatin structure. BCL7A has been shown to interact with other proteins, including transcription factors and histone-modifying enzymes, to regulate chromatin structure and gene expression. **Pathways and Functions:** BCL7A is involved in a wide range of cellular processes, including: 1. **Chromatin remodeling**: BCL7A is a key component of the BAF complex, which plays a crucial role in regulating chromatin structure and gene expression. 2. **Negative regulation of cell differentiation**: BCL7A has been shown to repress the expression of genes involved in cell differentiation, highlighting its role in maintaining the undifferentiated state of cells. 3. **Positive regulation of cell population proliferation**: BCL7A has been shown to promote the proliferation of cells, including immune cells. 4. **Negative regulation of DNA-templated transcription**: BCL7A has been shown to repress the expression of genes involved in DNA-templated transcription, highlighting its role in regulating gene expression. 5. **Positive regulation of double-strand break repair**: BCL7A has been shown to promote the repair of DNA double-strand breaks, highlighting its role in maintaining genome stability. **Clinical Significance:** BCL7A has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: BCL7A has been shown to play a critical role in the development and maturation of immune cells, highlighting its importance in immunodeficiency disorders. 2. **Cancer**: BCL7A has been implicated in the development and progression of various cancers, including lymphoma and leukemia. 3. **Neurological disorders**: BCL7A has been shown to be involved in the development and progression of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, BCL7A is a critical regulator of chromatin remodeling and immune cell development. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms by which BCL7A regulates gene expression and cellular processes. **References:** * [Insert references to relevant studies on BCL7A] Note: This article is a summary of the gene BCL7A and its functions, and is not intended to be a comprehensive review of the literature.

Genular Protein ID: 1312696442

Symbol: BCL7A_HUMAN

Name: B-cell CLL/lymphoma 7 protein family member A

UniProtKB Accession Codes:

Q4VC05 B4DJN6 B7ZB21 Q13843 Q14CT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 9 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 15 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8605326

Title: Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon.

PubMed ID: 8605326

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

Sequence Information:

  • Length: 210
  • Mass: 22810
  • Checksum: 4AB4AC3B309ADDB8
  • Sequence:
    • MSGRSVRAET RSRAKDDIKR VMAAIEKVRK WEKKWVTVGD TSLRIYKWVP VTEPKVDDKN 
KNKKKGKDEK CGSEVTTPEN SSSPGMMDMH DDNSNQSSIA DASPIKQENS SNSSPAPEPN 
SAVPSDGTEA KVDEAQADGK EHPGAEDASD EQNSQSSMEH SMNSSEKVDR QPSGDSGLAA 
ETSAISQDLE GVPPSKKMKL EASQQNSEEM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.