Details for: ELAC2

Gene ID: 60528

Symbol: ELAC2

Ensembl ID: ENSG00000006744

Description: elaC ribonuclease Z 2

Associated with

Other Information

Genular Protein ID: 3372274879

Symbol: RNZ2_HUMAN

Name: Zinc phosphodiesterase ELAC protein 2

UniProtKB Accession Codes:

Q9BQ52 B4DPL9 Q6IA94 Q9HAS8 Q9HAS9 Q9NVT1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 6 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11175785

Title: A candidate prostate cancer susceptibility gene at chromosome 17p.

PubMed ID: 11175785

DOI: 10.1038/84808

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12711671

Title: A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.

PubMed ID: 12711671

DOI: 10.1093/nar/gkg337

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21857155

Title: RNA processing in human mitochondria.

PubMed ID: 21857155

DOI: 10.4161/cc.10.17.17060

PubMed ID: 21593607

Title: Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs.

PubMed ID: 21593607

DOI: 10.4161/rna.8.4.15393

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24703694

Title: Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids.

PubMed ID: 24703694

DOI: 10.1016/j.cmet.2014.03.013

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10986046

Title: Association of HPC2/ELAC2 genotypes and prostate cancer.

PubMed ID: 10986046

DOI: 10.1086/303096

PubMed ID: 11507049

Title: ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer.

PubMed ID: 11507049

PubMed ID: 11522646

Title: Role of HPC2/ELAC2 in hereditary prostate cancer.

PubMed ID: 11522646

PubMed ID: 12522685

Title: Association of common missense changes in ELAC2 (HPC2) with prostate cancer in a Japanese case-control series.

PubMed ID: 12522685

DOI: 10.1007/s100380200099

PubMed ID: 12515253

Title: Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer.

PubMed ID: 12515253

DOI: 10.1086/344516

PubMed ID: 12949798

Title: Ser217Leu polymorphism of the HPC2/ELAC2 gene associated with prostatic cancer risk in Japanese men.

PubMed ID: 12949798

DOI: 10.1002/ijc.11347

PubMed ID: 12783937

Title: ELAC2/HPC2 polymorphisms, prostate-specific antigen levels, and prostate cancer.

PubMed ID: 12783937

DOI: 10.1093/jnci/95.11.818

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

PubMed ID: 23849775

Title: ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy.

PubMed ID: 23849775

DOI: 10.1016/j.ajhg.2013.06.006

Sequence Information:

  • Length: 826
  • Mass: 92219
  • Checksum: 4AE701C755EC7339
  • Sequence:
    • MWALCSLLRS AAGRTMSQGR TISQAPARRE RPRKDPLRHL RTREKRGPSG CSGGPNTVYL 
QVVAAGSRDS GAALYVFSEF NRYLFNCGEG VQRLMQEHKL KVARLDNIFL TRMHWSNVGG 
LSGMILTLKE TGLPKCVLSG PPQLEKYLEA IKIFSGPLKG IELAVRPHSA PEYEDETMTV 
YQIPIHSEQR RGKHQPWQSP ERPLSRLSPE RSSDSESNEN EPHLPHGVSQ RRGVRDSSLV 
VAFICKLHLK RGNFLVLKAK EMGLPVGTAA IAPIIAAVKD GKSITHEGRE ILAEELCTPP 
DPGAAFVVVE CPDESFIQPI CENATFQRYQ GKADAPVALV VHMAPASVLV DSRYQQWMER 
FGPDTQHLVL NENCASVHNL RSHKIQTQLN LIHPDIFPLL TSFRCKKEGP TLSVPMVQGE 
CLLKYQLRPR REWQRDAIIT CNPEEFIVEA LQLPNFQQSV QEYRRSAQDG PAPAEKRSQY 
PEIIFLGTGS AIPMKIRNVS ATLVNISPDT SLLLDCGEGT FGQLCRHYGD QVDRVLGTLA 
AVFVSHLHAD HHTGLPSILL QRERALASLG KPLHPLLVVA PNQLKAWLQQ YHNQCQEVLH 
HISMIPAKCL QEGAEISSPA VERLISSLLR TCDLEEFQTC LVRHCKHAFG CALVHTSGWK 
VVYSGDTMPC EALVRMGKDA TLLIHEATLE DGLEEEAVEK THSTTSQAIS VGMRMNAEFI 
MLNHFSQRYA KVPLFSPNFS EKVGVAFDHM KVCFGDFPTM PKLIPPLKAL FAGDIEEMEE 
RREKRELRQV RAALLSRELA GGLEDGEPQQ KRAHTEEPQA KKVRAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.