Cd274 | ENSMUSG00000016496 | NCBI 60533

Details for: Cd274

Gene ID: 60533

Symbol: Cd274

Ensembl ID: ENSMUSG00000016496

Description: CD274 antigen

Associated with

Adaptive immune system
(R-MMU-1280218)
Costimulation by the cd28 family
(R-MMU-388841)
Immune system
(R-MMU-168256)
Pd-1 signaling
(R-MMU-389948)
Actin cytoskeleton
(GO:0015629)
Adaptive immune response
(GO:0002250)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to lipopolysaccharide
(GO:0071222)
Early endosome membrane
(GO:0031901)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Membrane
(GO:0016020)
Negative regulation of activated t cell proliferation
(GO:0046007)
Negative regulation of cd4-positive, alpha-beta t cell proliferation
(GO:2000562)
Negative regulation of cd8-positive, alpha-beta t cell activation
(GO:2001186)
Negative regulation of interleukin-10 production
(GO:0032693)
Negative regulation of t cell proliferation
(GO:0042130)
Negative regulation of tumor necrosis factor superfamily cytokine production
(GO:1903556)
Negative regulation of type ii interferon production
(GO:0032689)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of activated cd8-positive, alpha-beta t cell apoptotic process
(GO:1905404)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tolerance induction to tumor cell
(GO:0002845)
Protein binding
(GO:0005515)
Recycling endosome membrane
(GO:0055038)
Response to cytokine
(GO:0034097)
Signal transduction
(GO:0007165)
T cell costimulation
(GO:0031295)
Transcription coactivator activity
(GO:0003713)
Trif-dependent toll-like receptor signaling pathway
(GO:0035666)

Other Information

Proteins

Programmed cell death 1 ligand 1

Genular Protein ID: 4159855214

Symbol: PD1L1_MOUSE

Name: Programmed cell death 1 ligand 1

UniProtKB Accession Codes:

Q9EP73

Database IDs:

Citations:

PubMed ID: 11015443

Title: Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation.

PubMed ID: 11015443

DOI: 10.1084/jem.192.7.1027

PubMed ID: 11238124

Title: B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function.

PubMed ID: 11238124

DOI: 10.1182/blood.v97.6.1809

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11224527

Title: PD-L2 is a second ligand for PD-1 and inhibits T cell activation.

PubMed ID: 11224527

DOI: 10.1038/85330

PubMed ID: 12218188

Title: Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.

PubMed ID: 12218188

DOI: 10.1073/pnas.192461099

PubMed ID: 12719480

Title: Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.

PubMed ID: 12719480

DOI: 10.1084/jem.20021752

PubMed ID: 27281199

Title: Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers.

PubMed ID: 27281199

DOI: 10.1038/nature18294

Sequence Information:

Length: 290
Mass: 32780
Checksum: AB7C46CF853EBB02
Sequence:

MRIFAGIIFT ACCHLLRAFT ITAPKDLYVV EYGSNVTMEC RFPVERELDL LALVVYWEKE 
DEQVIQFVAG EEDLKPQHSN FRGRASLPKD QLLKGNAALQ ITDVKLQDAG VYCCIISYGG 
ADYKRITLKV NAPYRKINQR ISVDPATSEH ELICQAEGYP EAEVIWTNSD HQPVSGKRSV 
TTSRTEGMLL NVTSSLRVNA TANDVFYCTF WRSQPGQNHT AELIIPELPA THPPQNRTHW 
VLLGSILLFL IVVSTVLLFL RKQVRMLDVE KCGVEDTSSK NRNDTQFEET

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd274

Associated with

Other Information

Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation. PubMed ID: 11015443

B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. PubMed ID: 11238124

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PD-L2 is a second ligand for PD-1 and inhibits T cell activation. PubMed ID: 11224527

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. PubMed ID: 12218188

Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. PubMed ID: 12719480

Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers. PubMed ID: 27281199