SPCS3 | ENSG00000129128 | NCBI 60559

Details for: SPCS3

Gene ID: 60559

Symbol: SPCS3

Ensembl ID: ENSG00000129128

Description: signal peptidase complex subunit 3

Associated with

Disease
(R-HSA-1643685)
Incretin synthesis, secretion, and inactivation
(R-HSA-400508)
Infectious disease
(R-HSA-5663205)
Maturation of hrsv a proteins
(R-HSA-9828806)
Metabolism of proteins
(R-HSA-392499)
Peptide hormone metabolism
(R-HSA-2980736)
Respiratory syncytial virus (rsv) genome replication, transcription and translation
(R-HSA-9820965)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Synthesis, secretion, and deacylation of ghrelin
(R-HSA-422085)
Synthesis, secretion, and inactivation of glucagon-like peptide-1 (glp-1)
(R-HSA-381771)
Synthesis, secretion, and inactivation of glucose-dependent insulinotropic polypeptide (gip)
(R-HSA-400511)
Translation
(R-HSA-72766)
Viral infection pathways
(R-HSA-9824446)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Protein binding
(GO:0005515)
Protein targeting to er
(GO:0045047)
Proteolysis
(GO:0006508)
Signal peptidase complex
(GO:0005787)
Signal peptide processing
(GO:0006465)
Viral protein processing
(GO:0019082)

Other Information

Proteins

Signal peptidase complex subunit 3

Genular Protein ID: 2047781244

Symbol: SPCS3_HUMAN

Name: Signal peptidase complex subunit 3

UniProtKB Accession Codes:

P61009 P12280 Q9H0S7

Database IDs:

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27499293

Title: Inverting the topology of a transmembrane protein by regulating the translocation of the first transmembrane helix.

PubMed ID: 27499293

DOI: 10.1016/j.molcel.2016.06.032

PubMed ID: 27383988

Title: A CRISPR screen defines a signal peptide processing pathway required by flaviviruses.

PubMed ID: 27383988

DOI: 10.1038/nature18625

PubMed ID: 34388369

Title: Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.

PubMed ID: 34388369

DOI: 10.1016/j.molcel.2021.07.031

Sequence Information:

Length: 180
Mass: 20313
Checksum: 342AB8E0F3F6D71A
Sequence:

MNTVLSRANS LFAFSLSVMA ALTFGCFITT AFKDRSVPVR LHVSRIMLKN VEDFTGPRER 
SDLGFITFDI TADLENIFDW NVKQLFLYLS AEYSTKNNAL NQVVLWDKIV LRGDNPKLLL 
KDMKTKYFFF DDGNGLKGNR NVTLTLSWNV VPNAGILPLV TGSGHVSVPF PDTYEITKSY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SPCS3

Associated with

Other Information

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Inverting the topology of a transmembrane protein by regulating the translocation of the first transmembrane helix. PubMed ID: 27499293

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. PubMed ID: 27383988

Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. PubMed ID: 34388369