Details for: Unc5b

Gene ID: 60630

Symbol: Unc5b

Ensembl ID: ENSRNOG00000000567

Description: unc-5 netrin receptor B

Associated with

  • Anterior/posterior axon guidance
    (GO:0033564)
  • Apoptotic process
    (GO:0006915)
  • Axon guidance
    (GO:0007411)
  • Membrane raft
    (GO:0045121)
  • Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    (GO:2001240)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Netrin-activated signaling pathway
    (GO:0038007)
  • Netrin receptor activity
    (GO:0005042)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
    (GO:2001241)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Protein binding
    (GO:0005515)

Other Information

Genular Protein ID: 314877480

Symbol: UNC5B_RAT

Name: Netrin receptor UNC5B

UniProtKB Accession Codes:

O08722

Database IDs:

AGR 1 AlphaFoldDB 1 CDD 1 CTD 1 DIP 1 EMBL 1 EvolutionaryTrace 1 GO 10 Gene3D 4 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PaxDb 1 Pfam 5 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SwissPalm 1 UCSC 1 UniProtKB 4 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 9126742

Title: Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors.

PubMed ID: 9126742

DOI: 10.1038/386833a0

PubMed ID: 10399920

Title: A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion.

PubMed ID: 10399920

DOI: 10.1016/s0092-8674(00)80804-1

PubMed ID: 11387206

Title: Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.

PubMed ID: 11387206

DOI: 10.1093/emboj/20.11.2715

PubMed ID: 15729359

Title: The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase.

PubMed ID: 15729359

DOI: 10.1038/sj.emboj.7600584

PubMed ID: 18582460

Title: Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H.

PubMed ID: 18582460

DOI: 10.1016/j.yexcr.2008.06.001

PubMed ID: 19328064

Title: Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor.

PubMed ID: 19328064

DOI: 10.1016/j.molcel.2009.02.016

Sequence Information:

  • Length: 945
  • Mass: 103521
  • Checksum: 6E9C2A262E560B9B
  • Sequence:
    • MRARSGARGA LLLALLLCWD PTPSLAGIDS GGQALPDSFP SAPAEQLPHF LLEPEDAYIV 
KNKPVELHCR AFPATQIYFK CNGEWVSQKG HVTQESLDEA TGLRIREVQI EVSRQQVEEL 
FGLEDYWCQC VAWSSSGTTK SRRAYIRIAY LRKNFDQEPL AKEVPLDHEV LLQCRPPEGV 
PVAEVEWLKN EDVIDPAQDT NFLLTIDHNL IIRQARLSDT ANYTCVAKNI VAKRRSTTAT 
VIVYVNGGWS SWAEWSPCSN RCGRGWQKRT RTCTNPAPLN GGAFCEGQAC QKTACTTVCP 
VDGAWTEWSK WSACSTECAH WRSRECMAPP PQNGGRDCSG TLLDSKNCTD GLCVLNQRTL 
NDPKSRPLEP SGDVALYAGL VVAVFVVLAV LMAVGVIVYR RNCRDFDTDI TDSSAALTGG 
FHPVNFKTAR PSNPQLLHPS APPDLTASAG IYRGPVYALQ DSADKIPMTN SPLLDPLPSL 
KIKVYDSSTI GSGAGLADGA DLLGVLPPGT YPGDFSRDTH FLHLRSASLG SQHLLGLPRD 
PSSSVSGTFG CLGGRLTIPG TGVSLLVPNG AIPQGKFYDL YLRINKTEST LPLSEGSQTV 
LSPSVTCGPT GLLLCRPVVL TVPHCAEVIA GDWIFQLKTQ AHQGHWEEVV TLDEETLNTP 
CYCQLEAKSC HILLDQLGTY VFTGESYSRS AVKRLQLAIF APALCTSLEY SLRVYCLEDT 
PAALKEVLEL ERTLGGYLVE EPKTLLFKDS YHNLRLSLHD IPHAHWRSKL LAKYQEIPFY 
HVWNGSQKAL HCTFTLERHS LASTEFTCKV CVRQVEGEGQ IFQLHTTLAE TPAGSLDALC 
SAPGNAATTQ LGPYAFKIPL SIRQKICNSL DAPNSRGNDW RLLAQKLSMD RYLNYFATKA 
SPTGVILDLW EARQQDDGDL NSLASALEEM GKSEMLVAMT TDGDC

Genular Protein ID: 2928616165

Symbol: A0A8I6A411_RAT

Name: N/A

UniProtKB Accession Codes:

A0A8I6A411

Database IDs:

ARBA 10 CDD 1 CTD 1 Ensembl 2 GO 4 Gene3D 4 GeneTree 1 InterPro 14 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 7 Pfam 5 Proteomes 2 RGD 2 RefSeq 1 RuleBase 1 SMART 5 SUPFAM 3

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

  • Length: 935
  • Mass: 102368
  • Checksum: 302AA35FFEF09EA7
  • Sequence:
    • MRARSGARGA LLLLALLLCW DPTPSLAGID SGGQALPDSF PSAPAEQLPH FLLEPEDAYI 
VKNKPVELHC RAFPATQIYF KCNGEWVSQK GHVTQESLDE ATGLRIREVQ IEVSRQQVEE 
LFGLEDYWCQ CVAWSSSGTT KSRRAYIRIA YLRKNFDQEP LAKEVPLDHE VLLQCRPPEG 
VPVAEVEWLK NEDVIDPAQD TNFLLTIDHN LIIRQARLSD TANYTCVAKN IVAKRRSTTA 
TVIVYVNGGW SSWAEWSPCS NRCGRGWQKR TRTCTNPAPL NGGAFCEGQA FQKTACTTVC 
PVDGAWTEWS KWSACSTECA HWRSRECMAP PPQNGGRDCS GTLLDSKNCT DGLCVLTLEP 
SGDVALYAGL VVAVFVVLAV LMAVGVIVYR RNCRDFDTDI TDSSAALTGG FHPVNFKTAR 
PSNPQLLHPS APPDLTASAG IYRGPVYALQ DSADKIPMTN SPLLDPLPSL KIKVYDSSTI 
GSGAGLADGA DLLGVLPPGT YPGDFSRDTH FLHLRSASLG SQHLLGLPRD PSSSVSGTFG 
CLGGRLTIPG TGVSLLVPNG AIPQGKFYDL YLRINKTEST LPLSEGSQTV LSPSVTCGPT 
GLLLCRPVVL TVPHCAEVIA GDWIFQLKTQ AHQGHWEEVV TLDEETLNTP CYCQLEAKSC 
HILLDQLGTY VFTGESYSRS AVKRLQLAIF APALCTSLEY SLRVYCLEDT PAALKEVLEL 
ERTLGGYLVE EPKPLLFKDS YHNLRLSLHD IPHAHWRSKL LAKYQEIPFY HVWNGSQKAL 
HCTFTLERHS LASTEFTCKV CVRQVEGEGQ IFQLHTTLAE TPAGSLDALC SAPGNAATTQ 
LGPYAFKIPL SIRQKICNSL DAPNSRGNDW RLLAQKLSMD RYLNYFATKA SPTGVILDLW 
EARQQDDGDL NSLASALEEM GKSEMLVAMT TDGDC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.