PROK2 | ENSG00000163421 | NCBI 60675

Details for: PROK2

Gene ID: 60675

Symbol: PROK2

Ensembl ID: ENSG00000163421

Description: prokineticin 2

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Angiogenesis
(GO:0001525)
Chemotaxis
(GO:0006935)
Circadian rhythm
(GO:0007623)
Endothelial cell proliferation
(GO:0001935)
Extracellular region
(GO:0005576)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor signaling pathway
(GO:0007186)
Inflammatory response
(GO:0006954)
Negative regulation of apoptotic process
(GO:0043066)
Neuropeptide signaling pathway
(GO:0007218)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of smooth muscle contraction
(GO:0045987)
Protein binding
(GO:0005515)
Sensory perception of pain
(GO:0019233)
Spermatogenesis
(GO:0007283)

Other Information

Proteins

Prokineticin-2

Genular Protein ID: 2661517108

Symbol: PROK2_HUMAN

Name: Prokineticin-2

UniProtKB Accession Codes:

Q9HC23 Q53Z79 Q6ISR0

Database IDs:

Citations:

PubMed ID: 11259612

Title: Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle.

PubMed ID: 11259612

DOI: 10.1124/mol.59.4.692

PubMed ID: 15772293

Title: Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.

PubMed ID: 15772293

DOI: 10.1124/mol.105.011619

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10580115

Title: The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes.

PubMed ID: 10580115

DOI: 10.1016/s0014-5793(99)01473-8

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 17054399

Title: Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2.

PubMed ID: 17054399

DOI: 10.1371/journal.pgen.0020175

PubMed ID: 18559922

Title: Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum.

PubMed ID: 18559922

DOI: 10.1210/jc.2007-2654

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

PubMed ID: 25077900

Title: The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients.

PubMed ID: 25077900

DOI: 10.1210/jc.2014-2110

Sequence Information:

Length: 129
Mass: 14314
Checksum: 0487679E8700DA55
Sequence:

MRSLCCAPLL LLLLLPPLLL TPRAGDAAVI TGACDKDSQC GGGMCCAVSI WVKSIRICTP 
MGKLGDSCHP LTRKNNFGNG RQERRKRKRS KRKKEVPFFG RRMHHTCPCL PGLACLRTSF 
NRFICLAQK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PROK2

Associated with

Other Information

Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle. PubMed ID: 11259612

Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1. PubMed ID: 15772293

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes. PubMed ID: 10580115

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2. PubMed ID: 17054399

Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum. PubMed ID: 18559922

Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. PubMed ID: 23643382

The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients. PubMed ID: 25077900