Details for: BCL9

Gene ID: 607

Symbol: BCL9

Ensembl ID: ENSG00000116128

Description: BCL9 transcription coactivator

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.3
    Marker Score: 30592.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169255
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.42
    Marker Score: 30251
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.39
    Marker Score: 3263
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.3
    Marker Score: 49372
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19352
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.19
    Marker Score: 9142
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.15
    Marker Score: 647
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.13
    Marker Score: 906
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.09
    Marker Score: 572
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.08
    Marker Score: 435
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.06
    Marker Score: 332
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.98
    Marker Score: 19564
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.94
    Marker Score: 8939
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9
    Marker Score: 1580
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1839
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5117
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1436
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.87
    Marker Score: 3345
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 498
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.83
    Marker Score: 397
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.82
    Marker Score: 12209
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.79
    Marker Score: 612
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.79
    Marker Score: 48673
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4739
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.76
    Marker Score: 1667
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.76
    Marker Score: 2801
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.74
    Marker Score: 239
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3053
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 664
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.73
    Marker Score: 16205
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.72
    Marker Score: 6181.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.71
    Marker Score: 414
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.71
    Marker Score: 274
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 339.5
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.7
    Marker Score: 6630
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.67
    Marker Score: 157
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.67
    Marker Score: 1635
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.65
    Marker Score: 322
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.62
    Marker Score: 653
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.61
    Marker Score: 255
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.59
    Marker Score: 396
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.59
    Marker Score: 2097
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.59
    Marker Score: 788
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.58
    Marker Score: 257
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.58
    Marker Score: 2420.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.58
    Marker Score: 2392
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.56
    Marker Score: 516.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.56
    Marker Score: 1081
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.55
    Marker Score: 637
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.55
    Marker Score: 1146
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 351
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.55
    Marker Score: 142
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.55
    Marker Score: 680
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.54
    Marker Score: 586
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.54
    Marker Score: 122
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.54
    Marker Score: 19878
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 221
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.52
    Marker Score: 303
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.52
    Marker Score: 1221
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.51
    Marker Score: 793
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.5
    Marker Score: 715
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.5
    Marker Score: 2944
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.49
    Marker Score: 610
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.49
    Marker Score: 2257
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.48
    Marker Score: 585
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.48
    Marker Score: 152
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.48
    Marker Score: 315
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.47
    Marker Score: 523
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.47
    Marker Score: 229
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.47
    Marker Score: 499
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.47
    Marker Score: 136
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.46
    Marker Score: 498
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.46
    Marker Score: 779.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.46
    Marker Score: 251
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.45
    Marker Score: 15607
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.45
    Marker Score: 122
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.45
    Marker Score: 141
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.44
    Marker Score: 259
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.44
    Marker Score: 1264
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.44
    Marker Score: 421
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 290
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.44
    Marker Score: 233
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.43
    Marker Score: 100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.43
    Marker Score: 4798.5

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Other Information

**Key characteristics:** * BCL9 is a protein that belongs to the BCL family of coactivators. * It is a key component of the beta-catenin-tcf complex, a signaling pathway involved in various cellular processes, including cell differentiation, proliferation, and survival. * BCL9 interacts with the beta-catenin protein, which is a key regulator of the Wnt signaling pathway. * It is also involved in the formation of the beta-catenin:tcf transactivating complex, a key step in cell differentiation and survival. * BCL9 negatively regulates the activity of the beta-catenin transactivating complex. **Pathways and functions:** * BCL9 is involved in the Beta-catenin-tcf complex, a key signaling pathway that regulates cell differentiation and proliferation. * It is also involved in the Canonical wnt signaling pathway, a crucial pathway for cell survival, proliferation, and differentiation. * BCL9 negatively regulates the activity of the beta-catenin transactivating complex, thereby inhibiting the activation of the Wnt signaling pathway. * It is involved in the Myoblast differentiation pathway, promoting the development of skeletal muscle cells from progenitor cells. * BCL9 is also involved in the Myotube differentiation pathway, promoting the development of skeletal muscle fibers from satellite cells. **Clinical significance:** * Mutations in BCL9 have been linked to various human diseases, including cancer, developmental disorders, and muscle diseases. * Targeting BCL9 has emerged as a potential therapeutic approach for cancer and other diseases that are characterized by abnormal cell growth. **Conclusion:** BCL9 is a key transcription coactivator that plays a critical role in various cellular processes, including cell differentiation, proliferation, and survival. Its dysregulation has been linked to numerous human diseases, highlighting its potential clinical significance in the development of novel therapeutic strategies.

Genular Protein ID: 3916718572

Symbol: BCL9_HUMAN

Name: B-cell CLL/lymphoma 9 protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9490669

Title: Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21.

PubMed ID: 9490669

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11955446

Title: Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.

PubMed ID: 11955446

DOI: 10.1016/s0092-8674(02)00679-7

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17052462

Title: Crystal structure of a beta-catenin/BCL9/Tcf4 complex.

PubMed ID: 17052462

DOI: 10.1016/j.molcel.2006.09.001

PubMed ID: 18498752

Title: Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.

PubMed ID: 18498752

DOI: 10.1016/j.molcel.2008.03.011

Sequence Information:

  • Length: 1426
  • Mass: 149290
  • Checksum: 51EF3D0DCA2103CB
  • Sequence:
  • MHSSNPKVRS SPSGNTQSSP KSKQEVMVRP PTVMSPSGNP QLDSKFSNQG KQGGSASQSQ 
    PSPCDSKSGG HTPKALPGPG GSMGLKNGAG NGAKGKGKRE RSISADSFDQ RDPGTPNDDS 
    DIKECNSADH IKSQDSQHTP HSMTPSNATA PRSSTPSHGQ TTATEPTPAQ KTPAKVVYVF 
    STEMANKAAE AVLKGQVETI VSFHIQNISN NKTERSTAPL NTQISALRND PKPLPQQPPA 
    PANQDQNSSQ NTRLQPTPPI PAPAPKPAAP PRPLDRESPG VENKLIPSVG SPASSTPLPP 
    DGTGPNSTPN NRAVTPVSQG SNSSSADPKA PPPPPVSSGE PPTLGENPDG LSQEQLEHRE 
    RSLQTLRDIQ RMLFPDEKEF TGAQSGGPQQ NPGVLDGPQK KPEGPIQAMM AQSQSLGKGP 
    GPRTDVGAPF GPQGHRDVPF SPDEMVPPSM NSQSGTIGPD HLDHMTPEQI AWLKLQQEFY 
    EEKRRKQEQV VVQQCSLQDM MVHQHGPRGV VRGPPPPYQM TPSEGWAPGG TEPFSDGINM 
    PHSLPPRGMA PHPNMPGSQM RLPGFAGMIN SEMEGPNVPN PASRPGLSGV SWPDDVPKIP 
    DGRNFPPGQG IFSGPGRGER FPNPQGLSEE MFQQQLAEKQ LGLPPGMAME GIRPSMEMNR 
    MIPGSQRHME PGNNPIFPRI PVEGPLSPSR GDFPKGIPPQ MGPGRELEFG MVPSGMKGDV 
    NLNVNMGSNS QMIPQKMREA GAGPEEMLKL RPGGSDMLPA QQKMVPLPFG EHPQQEYGMG 
    PRPFLPMSQG PGSNSGLRNL REPIGPDQRT NSRLSHMPPL PLNPSSNPTS LNTAPPVQRG 
    LGRKPLDISV AGSQVHSPGI NPLKSPTMHQ VQSPMLGSPS GNLKSPQTPS QLAGMLAGPA 
    AAASIKSPPV LGSAAASPVH LKSPSLPAPS PGWTSSPKPP LQSPGIPPNH KAPLTMASPA 
    MLGNVESGGP PPPTASQPAS VNIPGSLPSS TPYTMPPEPT LSQNPLSIMM SRMSKFAMPS 
    STPLYHDAIK TVASSDDDSP PARSPNLPSM NNMPGMGINT QNPRISGPNP VVPMPTLSPM 
    GMTQPLSHSN QMPSPNAVGP NIPPHGVPMG PGLMSHNPIM GHGSQEPPMV PQGRMGFPQG 
    FPPVQSPPQQ VPFPHNGPSG GQGSFPGGMG FPGEGPLGRP SNLPQSSADA ALCKPGGPGG 
    PDSFTVLGNS MPSVFTDPDL QEVIRPGATG IPEFDLSRII PSEKPSQTLQ YFPRGEVPGR 
    KQPQGPGPGF SHMQGMMGEQ APRMGLALPG MGGPGPVGTP DIPLGTAPSM PGHNPMRPPA 
    FLQQGMMGPH HRMMSPAQST MPGQPTLMSN PAAAVGMIPG KDRGPAGLYT HPGPVGSPGM 
    MMSMQGMMGP QQNIMIPPQM RPRGMAADVG MGGFSQGPGN PGNMMF

Genular Protein ID: 3692688952

Symbol: Q1JQ81_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1426
  • Mass: 149302
  • Checksum: E8F7AC81730A02C2
  • Sequence:
  • MHSSNPKVRS SPSGNTQSSP KSKQEVMVRP PTVMSPSGNP QLDSKFSNQG KQGGSASQSQ 
    PSPCDSKSGG HTPKALPGPG GSMGLKNGAG NGAKGKGKRE RSISADSFDQ RDPGTPNDDS 
    DIKECNSADH IKSQDSQHTP HSMTPSNATA PRSSTPSHGQ TTATEPTPAQ KTPAKVVYVF 
    STEMANKAAE AVLKGQVETI VSFHIQNISN NKTERSTAPL NTQISALRND PKPLPQQPPA 
    PANQDQNSSQ NTRLQPTPPI PAPAPKPAAP PRPLDRESPG VENKLIPSVG SPASSTPLPP 
    DGTGPNSTPN NRAVTPVSQG SNSSSADPKA PPPPPVSSGE PPTLGENPDG LSQEQLEHRE 
    RSLQTLRDIQ RMLFPDEKEF TGAQSGGPQQ NPGVLDGPQK KPEGPIQAMM AQSQSLGKGP 
    GPRTDVGAPF GPQGHRDVPF SPDEMVPPSM NSQSGTIGPD HLDHMTPEQI AWLKLQQEFY 
    EEKRRKQEQV VVQQCSLQDM MVHQHGPRGV VRGPPPPYQM TPSEGWAPGG TEPFSDGINM 
    PHSLPPRGMA PHPNMPGSQM RLPGFAGMIN SEMEGPNVPN PASRPGLSGV SWPDDVPKIP 
    DGRNFPPGQG IFSGPGRGER FPNPQGLSEE MFQQQLAEKQ LGLPPGMAME GIRPSMEMNR 
    MIPGSQRHME PGNNPIFPRI PVEGPLSPSR GDFPKGIPPQ MGPGRELEFG MVPSGMKGDV 
    NLNVNMGSNS QMIPQKMREA GAGPEEMLKL RPGGSDMLPA QQKMVPLPFG EHPQQEYGMG 
    PRPFLPMSQG PGSNSGLRNL REPIGPDQRT NSRLSHMPPL PLNPSSNPIS LNTAPPVQRG 
    LGRKPLDISV AGSQVHSPGI NPLKSPTMHQ VQSPMLGSPS GNLKSPQTPS QLAGMLAGPA 
    AAASIKSPPV LGSAAASPVH LKSPSLPAPS PGWTSSPKPP LQSPGIPPNH KAPLTMASPA 
    MLGNVESGGP PPPTASQPAS VNIPGSLPSS TPYTMPPEPT LSQNPLSIMM SRMSKFAMPS 
    STPLYHDAIK TVASSDDDSP PARSPNLPSM NNMPGMGINT QNPRISGPNP VVPMPTLSPM 
    GMTQPLSHSN QMPSPNAVGP NIPPHGVPMG PGLMSHNPIM GHGSQEPPMV PQGRMGFPQG 
    FPPVQSPPQQ VPFPHNGPSG GQGSFPGGMG FPGEGPLGRP SNLPQSSADA ALCKPGGPGG 
    PDSFTVLGNS MPSVFTDPDL QEVIRPGATG IPEFDLSRII PSEKPSQTLQ YFPRGEVPGR 
    KQPQGPGPGF SHMQGMMGEQ APRMGLALPG MGGPGPVGTP DIPLGTAPSM PGHNPMRPPA 
    FLQQGMMGPH HRMMSPAQST MPGQPTLMSN PAAAVGMIPG KDRGPAGLYT HPGPVGSPGM 
    MMSMQGMMGP QQNIMIPPQM RPRGMAADVG MGGFSQGPGN PGNMMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.