Details for: TNFRSF17

Gene ID: 608

Symbol: TNFRSF17

Ensembl ID: ENSG00000048462

Description: TNF receptor superfamily member 17

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.49
    Marker Score: 2976
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.28
    Marker Score: 2295
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.53
    Marker Score: 1832.5
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.5
    Marker Score: 522
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.43
    Marker Score: 1421
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.27
    Marker Score: 553
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.22
    Marker Score: 320
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.04
    Marker Score: 287
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251810
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.99
    Marker Score: 626
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.94
    Marker Score: 1253
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.93
    Marker Score: 2767
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5269
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 406
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.82
    Marker Score: 406
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.82
    Marker Score: 2239.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.78
    Marker Score: 867
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.74
    Marker Score: 710
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.7
    Marker Score: 184
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.62
    Marker Score: 377
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.56
    Marker Score: 143
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.52
    Marker Score: 495
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.39
    Marker Score: 4481
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.38
    Marker Score: 216
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.36
    Marker Score: 731
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.35
    Marker Score: 265
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 650
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.33
    Marker Score: 572
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.3
    Marker Score: 856
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.29
    Marker Score: 4604
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.29
    Marker Score: 101
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.29
    Marker Score: 271
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.29
    Marker Score: 256
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.28
    Marker Score: 394.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.26
    Marker Score: 275
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.24
    Marker Score: 58
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.24
    Marker Score: 184
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.23
    Marker Score: 478.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.21
    Marker Score: 49
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2
    Marker Score: 116
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.19
    Marker Score: 114
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.19
    Marker Score: 144
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.19
    Marker Score: 255
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.19
    Marker Score: 226
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 103
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.17
    Marker Score: 277
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.16
    Marker Score: 165
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.16
    Marker Score: 88
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.16
    Marker Score: 72
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.15
    Marker Score: 545
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.14
    Marker Score: 106
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.14
    Marker Score: 930
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.13
    Marker Score: 56
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.13
    Marker Score: 30
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.12
    Marker Score: 59
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.11
    Marker Score: 243
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.1
    Marker Score: 66
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 303
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.09
    Marker Score: 56
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.09
    Marker Score: 111
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 81

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Other Information

**Key characteristics:** * TNFRSF17 is a transmembrane protein that is expressed on the surface of immune cells, such as macrophages, dendritic cells, and lymphocytes. * It is a type I cytokine receptor, which means that it is a receptor for cytokines. * TNFRSF17 is a key regulator of the adaptive immune response. * It is involved in the regulation of inflammation, cell growth, and differentiation. **Pathways and functions:** * TNFRSF17 is a key regulator of the adaptive immune response. * It is involved in the activation of the adaptive immune response by binding to cytokines such as TNF-alpha and TNF-beta. * It also plays a role in the regulation of cell growth and differentiation. * TNFRSF17 is also involved in the regulation of inflammation. **Clinical significance:** * Mutations in TNFRSF17 have been linked to a number of human diseases, including cancer and autoimmune disorders. * TNFRSF17 is a promising target for the treatment of these diseases. * Inhibitors of TNFRSF17 have been shown to be effective in treating cancer and autoimmune disorders.

Genular Protein ID: 2730592933

Symbol: TNR17_HUMAN

Name: Tumor necrosis factor receptor superfamily member 17

UniProtKB Accession Codes:

Q02223 Q2TQ40

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 4 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1396583

Title: A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma.

PubMed ID: 1396583

DOI: 10.1002/j.1460-2075.1992.tb05482.x

PubMed ID: 8165126

Title: The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed.

PubMed ID: 8165126

DOI: 10.1093/nar/22.7.1147

PubMed ID: 11528522

Title: Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis.

PubMed ID: 11528522

DOI: 10.1038/sj.gene.6363770

PubMed ID: 17825416

Title: Identification of new splice variants of the genes BAFF and BCMA.

PubMed ID: 17825416

DOI: 10.1016/j.molimm.2007.07.028

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10903733

Title: TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase.

PubMed ID: 10903733

DOI: 10.4049/jimmunol.165.3.1322

PubMed ID: 10801128

Title: TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.

PubMed ID: 10801128

DOI: 10.1038/35010115

PubMed ID: 10973284

Title: APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.

PubMed ID: 10973284

DOI: 10.1038/79802

PubMed ID: 10908663

Title: B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.

PubMed ID: 10908663

DOI: 10.1073/pnas.160213497

PubMed ID: 12721620

Title: Ligand-receptor binding revealed by the TNF family member TALL-1.

PubMed ID: 12721620

DOI: 10.1038/nature01543

PubMed ID: 15542592

Title: Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.

PubMed ID: 15542592

DOI: 10.1074/jbc.m411714200

Sequence Information:

  • Length: 184
  • Mass: 20165
  • Checksum: B6D87B3685F66022
  • Sequence:
    • MLQMAGQCSQ NEYFDSLLHA CIPCQLRCSS NTPPLTCQRY CNASVTNSVK GTNAILWTCL 
GLSLIISLAV FVLMFLLRKI NSEPLKDEFK NTGSGLLGMA NIDLEKSRTG DEIILPRGLE 
YTVEECTCED CIKSKPKVDS DHCFPLPAME EGATILVTTK TNDYCKSLPA ALSATEIEKS 
ISAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.