Details for: TNFRSF17

Gene ID: 608

Symbol: TNFRSF17

Ensembl ID: ENSG00000048462

Description: TNF receptor superfamily member 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.8732
    Cell Significance Index: -4.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.1501
    Cell Significance Index: -4.3500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.1290
    Cell Significance Index: -4.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 6.6790
    Cell Significance Index: 234.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.3365
    Cell Significance Index: 108.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.7275
    Cell Significance Index: 80.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.3497
    Cell Significance Index: -4.1300
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.7346
    Cell Significance Index: 6.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.7316
    Cell Significance Index: 26.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.0998
    Cell Significance Index: -4.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0190
    Cell Significance Index: 193.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9782
    Cell Significance Index: 44.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7287
    Cell Significance Index: 85.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7015
    Cell Significance Index: 14.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6591
    Cell Significance Index: 39.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4604
    Cell Significance Index: 50.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3959
    Cell Significance Index: 39.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3493
    Cell Significance Index: 315.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.3158
    Cell Significance Index: -0.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2568
    Cell Significance Index: 41.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2476
    Cell Significance Index: 17.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1385
    Cell Significance Index: 3.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0094
    Cell Significance Index: 0.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0063
    Cell Significance Index: 9.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0061
    Cell Significance Index: 11.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0005
    Cell Significance Index: 0.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0051
    Cell Significance Index: -1.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0073
    Cell Significance Index: -3.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0079
    Cell Significance Index: -4.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0082
    Cell Significance Index: -5.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0101
    Cell Significance Index: -7.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0120
    Cell Significance Index: -4.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0174
    Cell Significance Index: -3.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0182
    Cell Significance Index: -5.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0182
    Cell Significance Index: -3.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0186
    Cell Significance Index: -0.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0197
    Cell Significance Index: -0.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0199
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0227
    Cell Significance Index: -3.8700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0269
    Cell Significance Index: -0.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0277
    Cell Significance Index: -0.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0284
    Cell Significance Index: -5.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0310
    Cell Significance Index: -0.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0323
    Cell Significance Index: -0.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0348
    Cell Significance Index: -5.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0354
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0360
    Cell Significance Index: -4.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0375
    Cell Significance Index: -5.1500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0389
    Cell Significance Index: -0.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0416
    Cell Significance Index: -0.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0423
    Cell Significance Index: -4.4000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0449
    Cell Significance Index: -0.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0461
    Cell Significance Index: -5.6700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0475
    Cell Significance Index: -0.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0487
    Cell Significance Index: -2.0000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0526
    Cell Significance Index: -0.3500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0619
    Cell Significance Index: -0.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0632
    Cell Significance Index: -6.4600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0662
    Cell Significance Index: -0.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0667
    Cell Significance Index: -8.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0700
    Cell Significance Index: -4.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0779
    Cell Significance Index: -5.9800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0842
    Cell Significance Index: -1.4300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0936
    Cell Significance Index: -0.8100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0958
    Cell Significance Index: -1.0700
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1011
    Cell Significance Index: -0.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1040
    Cell Significance Index: -4.8500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1050
    Cell Significance Index: -1.5400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1055
    Cell Significance Index: -1.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1058
    Cell Significance Index: -1.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1075
    Cell Significance Index: -6.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1113
    Cell Significance Index: -7.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1142
    Cell Significance Index: -6.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1155
    Cell Significance Index: -8.6100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1198
    Cell Significance Index: -1.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1239
    Cell Significance Index: -4.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1278
    Cell Significance Index: -3.4300
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.1294
    Cell Significance Index: -1.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1320
    Cell Significance Index: -6.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1365
    Cell Significance Index: -7.0900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1384
    Cell Significance Index: -0.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1417
    Cell Significance Index: -4.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1418
    Cell Significance Index: -4.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1426
    Cell Significance Index: -2.0700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1469
    Cell Significance Index: -0.9000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1476
    Cell Significance Index: -1.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1490
    Cell Significance Index: -6.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1541
    Cell Significance Index: -4.1200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1566
    Cell Significance Index: -1.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1574
    Cell Significance Index: -4.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1594
    Cell Significance Index: -5.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1680
    Cell Significance Index: -4.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1689
    Cell Significance Index: -7.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1717
    Cell Significance Index: -6.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFRSF17 is a type II transmembrane receptor, characterized by its ability to bind to its ligand, TNF-α (tumor necrosis factor-alpha), and initiate a cascade of downstream signaling events. This receptor exhibits a unique non-canonical NF-κB signaling pathway, distinct from the classical NF-κB pathway. Additionally, TNFRSF17 is expressed in various cell types, including immune cells (e.g., IgA plasma cells, IgM plasma cells), endothelial cells (e.g., blood vessels), and epithelial cells (e.g., colon goblet cells, enterocytes). This widespread expression highlights the receptor's role in maintaining immune homeostasis and regulating inflammation. **Pathways and Functions:** TNFRSF17's signaling pathways are intricately linked to the adaptive immune response, cytokine signaling, and immune homeostasis. The non-canonical NF-κB pathway, in particular, plays a crucial role in regulating the expression of genes involved in inflammation and immune responses. Upon ligand binding, TNFRSF17 triggers a series of intracellular events, including the activation of NF-κB, which in turn modulates the expression of various genes, including those involved in inflammation, immune cell development, and survival. TNFRSF17's functions can be broadly categorized into three main areas: 1. **Inflammation regulation**: TNFRSF17 modulates the inflammatory response by regulating the expression of pro-inflammatory and anti-inflammatory genes. 2. **Immune homeostasis**: The receptor plays a crucial role in maintaining immune homeostasis by regulating the development, survival, and function of immune cells. 3. **Cytokine signaling**: TNFRSF17 interacts with various cytokines, including TNF-α, IL-1β, and IL-6, to regulate their signaling pathways and downstream effects. **Clinical Significance:** TNFRSF17's dysregulation has been implicated in various diseases, including autoimmune disorders, inflammatory bowel disease, and cancer. The receptor's non-canonical NF-κB signaling pathway may contribute to the development of these conditions by promoting inflammation and immune dysregulation. Furthermore, TNFRSF17's involvement in immune homeostasis and cytokine signaling suggests that alterations in its expression or function may have implications for the treatment of immune-related disorders. For instance, targeting TNFRSF17 may provide a novel therapeutic strategy for autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. In conclusion, TNFRSF17 is a complex receptor with multifaceted biological functions, playing a critical role in regulating the immune response, inflammation, and immune homeostasis. A deeper understanding of its signaling pathways and clinical significance is essential for the development of novel therapeutic strategies for immune-related disorders.

Genular Protein ID: 2730592933

Symbol: TNR17_HUMAN

Name: Tumor necrosis factor receptor superfamily member 17

UniProtKB Accession Codes:

Q02223 Q2TQ40

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 4 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1396583

Title: A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma.

PubMed ID: 1396583

DOI: 10.1002/j.1460-2075.1992.tb05482.x

PubMed ID: 8165126

Title: The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed.

PubMed ID: 8165126

DOI: 10.1093/nar/22.7.1147

PubMed ID: 11528522

Title: Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis.

PubMed ID: 11528522

DOI: 10.1038/sj.gene.6363770

PubMed ID: 17825416

Title: Identification of new splice variants of the genes BAFF and BCMA.

PubMed ID: 17825416

DOI: 10.1016/j.molimm.2007.07.028

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10903733

Title: TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase.

PubMed ID: 10903733

DOI: 10.4049/jimmunol.165.3.1322

PubMed ID: 10801128

Title: TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.

PubMed ID: 10801128

DOI: 10.1038/35010115

PubMed ID: 10973284

Title: APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.

PubMed ID: 10973284

DOI: 10.1038/79802

PubMed ID: 10908663

Title: B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.

PubMed ID: 10908663

DOI: 10.1073/pnas.160213497

PubMed ID: 12721620

Title: Ligand-receptor binding revealed by the TNF family member TALL-1.

PubMed ID: 12721620

DOI: 10.1038/nature01543

PubMed ID: 15542592

Title: Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.

PubMed ID: 15542592

DOI: 10.1074/jbc.m411714200

Sequence Information:

  • Length: 184
  • Mass: 20165
  • Checksum: B6D87B3685F66022
  • Sequence:
    • MLQMAGQCSQ NEYFDSLLHA CIPCQLRCSS NTPPLTCQRY CNASVTNSVK GTNAILWTCL 
GLSLIISLAV FVLMFLLRKI NSEPLKDEFK NTGSGLLGMA NIDLEKSRTG DEIILPRGLE 
YTVEECTCED CIKSKPKVDS DHCFPLPAME EGATILVTTK TNDYCKSLPA ALSATEIEKS 
ISAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.