Details for: HCN2

Gene ID: 610

Symbol: HCN2

Ensembl ID: ENSG00000099822

Description: hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.6730
    Cell Significance Index: -8.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.9776
    Cell Significance Index: 14.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9134
    Cell Significance Index: 20.0000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.7459
    Cell Significance Index: 6.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5342
    Cell Significance Index: 107.1600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.4504
    Cell Significance Index: 5.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3764
    Cell Significance Index: 260.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3012
    Cell Significance Index: 108.0400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2906
    Cell Significance Index: 2.2400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2556
    Cell Significance Index: 3.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2380
    Cell Significance Index: 15.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2258
    Cell Significance Index: 6.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2246
    Cell Significance Index: 6.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1628
    Cell Significance Index: 7.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1614
    Cell Significance Index: 6.1100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1248
    Cell Significance Index: 1.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0830
    Cell Significance Index: 5.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0402
    Cell Significance Index: 2.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0268
    Cell Significance Index: 0.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0155
    Cell Significance Index: 3.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0072
    Cell Significance Index: 0.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0005
    Cell Significance Index: 0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -1.0000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0048
    Cell Significance Index: -2.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0091
    Cell Significance Index: -4.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0101
    Cell Significance Index: -6.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0104
    Cell Significance Index: -7.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0113
    Cell Significance Index: -7.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0126
    Cell Significance Index: -7.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0141
    Cell Significance Index: -10.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0172
    Cell Significance Index: -7.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0180
    Cell Significance Index: -2.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0212
    Cell Significance Index: -0.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0213
    Cell Significance Index: -0.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0227
    Cell Significance Index: -6.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0309
    Cell Significance Index: -1.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0363
    Cell Significance Index: -0.7800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0405
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0429
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0461
    Cell Significance Index: -9.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0496
    Cell Significance Index: -6.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0513
    Cell Significance Index: -7.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0518
    Cell Significance Index: -2.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0530
    Cell Significance Index: -6.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0561
    Cell Significance Index: -5.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0582
    Cell Significance Index: -6.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0592
    Cell Significance Index: -1.1700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0602
    Cell Significance Index: -1.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0639
    Cell Significance Index: -8.2600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0666
    Cell Significance Index: -0.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0670
    Cell Significance Index: -1.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0706
    Cell Significance Index: -2.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0726
    Cell Significance Index: -1.7400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0727
    Cell Significance Index: -0.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0740
    Cell Significance Index: -1.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0749
    Cell Significance Index: -8.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0812
    Cell Significance Index: -9.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0816
    Cell Significance Index: -2.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0925
    Cell Significance Index: -3.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0927
    Cell Significance Index: -9.6500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0956
    Cell Significance Index: -1.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0991
    Cell Significance Index: -7.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1046
    Cell Significance Index: -1.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1113
    Cell Significance Index: -8.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1117
    Cell Significance Index: -7.9000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1192
    Cell Significance Index: -1.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1213
    Cell Significance Index: -4.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1250
    Cell Significance Index: -8.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1278
    Cell Significance Index: -6.6400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1279
    Cell Significance Index: -2.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1343
    Cell Significance Index: -3.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1360
    Cell Significance Index: -7.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1383
    Cell Significance Index: -6.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1383
    Cell Significance Index: -6.4500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1466
    Cell Significance Index: -1.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1620
    Cell Significance Index: -7.0500
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1827
    Cell Significance Index: -2.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1841
    Cell Significance Index: -6.4700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1976
    Cell Significance Index: -2.7700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1978
    Cell Significance Index: -4.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2003
    Cell Significance Index: -5.7700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2005
    Cell Significance Index: -3.0000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2068
    Cell Significance Index: -6.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2103
    Cell Significance Index: -7.7200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2207
    Cell Significance Index: -2.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2227
    Cell Significance Index: -2.6600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2244
    Cell Significance Index: -2.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2274
    Cell Significance Index: -6.5200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2282
    Cell Significance Index: -2.9600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2322
    Cell Significance Index: -4.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2536
    Cell Significance Index: -3.4600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2667
    Cell Significance Index: -3.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2676
    Cell Significance Index: -6.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2780
    Cell Significance Index: -7.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2787
    Cell Significance Index: -6.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Hyperpolarization-activated properties**: HCN2 channels are activated by hyperpolarization, which means that they open in response to a decrease in membrane potential. This property is distinct from other voltage-gated channels, which are activated by depolarization. 2. **Cyclic nucleotide-gated**: HCN2 channels are regulated by cyclic nucleotides, such as cAMP and cGMP, which bind to specific receptors and activate the channel. 3. **Potassium and sodium conductance**: HCN2 channels exhibit both potassium and sodium conductance, allowing for the movement of these ions across the plasma membrane. 4. **Unique subunit composition**: HCN2 channels are composed of multiple subunits, which are essential for their function and regulation. **Pathways and Functions** 1. **Regulation of membrane potential**: HCN2 channels play a crucial role in regulating membrane potential in various cell types, including neurons and glial cells. By controlling the flow of potassium and sodium ions, HCN2 channels help to maintain the resting membrane potential and regulate neuronal excitability. 2. **Neuronal excitability**: HCN2 channels are involved in the regulation of neuronal excitability, particularly in the context of hyperpolarization-activated currents. These currents are essential for the generation of slow, hyperpolarizing currents in neurons, which can contribute to the regulation of neuronal activity. 3. **Cell-cell signaling**: HCN2 channels are involved in cell-cell signaling pathways, particularly in the context of cyclic nucleotide-mediated signaling. These channels can modulate the activity of other ion channels and receptors, influencing cellular responses to various stimuli. 4. **Regulation of membrane depolarization**: HCN2 channels can regulate membrane depolarization during cardiac muscle cell action potentials. By controlling the flow of potassium and sodium ions, HCN2 channels can modulate the timing and duration of action potentials. **Clinical Significance** 1. **Neurological disorders**: HCN2 channels have been implicated in various neurological disorders, including epilepsy, migraines, and Parkinson's disease. Mutations in the HCN2 gene have been associated with these conditions, highlighting the importance of HCN2 channels in maintaining normal neuronal function. 2. **Cardiac arrhythmias**: HCN2 channels have been implicated in the regulation of cardiac rhythm, particularly in the context of cardiac arrhythmias. Alterations in HCN2 channel function or expression can contribute to the development of arrhythmias. 3. **Cancer**: HCN2 channels have been implicated in cancer development and progression, particularly in the context of stem cell maintenance and tumor growth. 4. **Therapeutic targeting**: HCN2 channels have been identified as potential therapeutic targets for various conditions, including neurological disorders and cardiac arrhythmias. Small molecule modulators of HCN2 channels have been developed to modulate channel activity and treat these conditions. In conclusion, HCN2 channels are critical regulators of membrane potential in various cell types, and their dysregulation has been implicated in various physiological and pathological processes. Further research is needed to fully understand the role of HCN2 channels in maintaining normal function and to develop effective therapeutic strategies for the treatment of associated disorders.

Genular Protein ID: 1933186398

Symbol: HCN2_HUMAN

Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

UniProtKB Accession Codes:

Q9UL51 O60742 O60743 O75267 Q9UBS2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 13 Ensembl 1 EvolutionaryTrace 1 GO 21 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10524219

Title: The human gene coding for HCN2, a pacemaker channel of the heart.

PubMed ID: 10524219

DOI: 10.1016/s0167-4781(99)00092-5

PubMed ID: 10228147

Title: Two pacemaker channels from human heart with profoundly different activation kinetics.

PubMed ID: 10228147

DOI: 10.1093/emboj/18.9.2323

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 9630217

Title: Identification of a gene encoding a hyperpolarization-activated 'pacemaker' channel of brain.

PubMed ID: 9630217

DOI: 10.1016/s0092-8674(00)81434-8

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22006928

Title: Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.

PubMed ID: 22006928

DOI: 10.1074/jbc.m111.297606

PubMed ID: 25197093

Title: Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.

PubMed ID: 25197093

DOI: 10.1073/pnas.1410389111

PubMed ID: 26546007

Title: The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contain multiple S-palmitoylation sites.

PubMed ID: 26546007

DOI: 10.1007/s12576-015-0420-5

PubMed ID: 22131395

Title: Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.

PubMed ID: 22131395

DOI: 10.1523/jneurosci.3727-11.2011

PubMed ID: 24324597

Title: Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.

PubMed ID: 24324597

DOI: 10.1371/journal.pone.0080376

PubMed ID: 29064616

Title: Gain-of-function HCN2 variants in genetic epilepsy.

PubMed ID: 29064616

DOI: 10.1002/humu.23357

PubMed ID: 29463886

Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.

PubMed ID: 29463886

DOI: 10.1038/s41380-018-0020-x

Sequence Information:

  • Length: 889
  • Mass: 96950
  • Checksum: 4B263E0C06C2A47D
  • Sequence:
    • MDARGGGGRP GESPGATPAP GPPPPPPPAP PQQQPPPPPP PAPPPGPGPA PPQHPPRAEA 
LPPEAADEGG PRGRLRSRDS SCGRPGTPGA ASTAKGSPNG ECGRGEPQCS PAGPEGPARG 
PKVSFSCRGA ASGPAPGPGP AEEAGSEEAG PAGEPRGSQA SFMQRQFGAL LQPGVNKFSL 
RMFGSQKAVE REQERVKSAG AWIIHPYSDF RFYWDFTMLL FMVGNLIIIP VGITFFKDET 
TAPWIVFNVV SDTFFLMDLV LNFRTGIVIE DNTEIILDPE KIKKKYLRTW FVVDFVSSIP 
VDYIFLIVEK GIDSEVYKTA RALRIVRFTK ILSLLRLLRL SRLIRYIHQW EEIFHMTYDL 
ASAVMRICNL ISMMLLLCHW DGCLQFLVPM LQDFPRNCWV SINGMVNHSW SELYSFALFK 
AMSHMLCIGY GRQAPESMTD IWLTMLSMIV GATCYAMFIG HATALIQSLD SSRRQYQEKY 
KQVEQYMSFH KLPADFRQKI HDYYEHRYQG KMFDEDSILG ELNGPLREEI VNFNCRKLVA 
SMPLFANADP NFVTAMLTKL KFEVFQPGDY IIREGTIGKK MYFIQHGVVS VLTKGNKEMK 
LSDGSYFGEI CLLTRGRRTA SVRADTYCRL YSLSVDNFNE VLEEYPMMRR AFETVAIDRL 
DRIGKKNSIL LHKVQHDLNS GVFNNQENAI IQEIVKYDRE MVQQAELGQR VGLFPPPPPP 
PQVTSAIATL QQAAAMSFCP QVARPLVGPL ALGSPRLVRR PPPGPAPAAA SPGPPPPASP 
PGAPASPRAP RTSPYGGLPA APLAGPALPA RRLSRASRPL SASQPSLPHG APGPAASTRP 
ASSSTPRLGP TPAARAAAPS PDRRDSASPG AAGGLDPQDS ARSRLSSNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.