HCN2 | ENSG00000099822 | NCBI 610

Details for: HCN2

Gene ID: 610

Symbol: HCN2

Ensembl ID: ENSG00000099822

Description: hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

Associated with

Hcn channels
(R-HSA-1296061)
Neuronal system
(R-HSA-112316)
Potassium channels
(R-HSA-1296071)
Axon
(GO:0030424)
Camp binding
(GO:0030552)
Cell-cell signaling
(GO:0007267)
Cellular response to camp
(GO:0071320)
Cellular response to cgmp
(GO:0071321)
Dendrite
(GO:0030425)
Hcn channel complex
(GO:0098855)
Identical protein binding
(GO:0042802)
Intracellular camp-activated cation channel activity
(GO:0005222)
Membrane depolarization during cardiac muscle cell action potential
(GO:0086012)
Plasma membrane
(GO:0005886)
Potassium ion import across plasma membrane
(GO:1990573)
Potassium ion transmembrane transport
(GO:0071805)
Protein binding
(GO:0005515)
Regulation of membrane depolarization
(GO:0003254)
Regulation of membrane potential
(GO:0042391)
Sodium ion import across plasma membrane
(GO:0098719)
Sodium ion transmembrane transport
(GO:0035725)
Voltage-gated potassium channel activity
(GO:0005249)
Voltage-gated potassium channel complex
(GO:0008076)
Voltage-gated sodium channel activity
(GO:0005248)

Other Information

Proteins

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Genular Protein ID: 1933186398

Symbol: HCN2_HUMAN

Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

UniProtKB Accession Codes:

Q9UL51 O60742 O60743 O75267 Q9UBS2

Database IDs:

Citations:

PubMed ID: 10524219

Title: The human gene coding for HCN2, a pacemaker channel of the heart.

PubMed ID: 10524219

DOI: 10.1016/s0167-4781(99)00092-5

PubMed ID: 10228147

Title: Two pacemaker channels from human heart with profoundly different activation kinetics.

PubMed ID: 10228147

DOI: 10.1093/emboj/18.9.2323

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 9630217

Title: Identification of a gene encoding a hyperpolarization-activated 'pacemaker' channel of brain.

PubMed ID: 9630217

DOI: 10.1016/s0092-8674(00)81434-8

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22006928

Title: Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.

PubMed ID: 22006928

DOI: 10.1074/jbc.m111.297606

PubMed ID: 22131395

Title: Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.

PubMed ID: 22131395

DOI: 10.1523/jneurosci.3727-11.2011

PubMed ID: 24324597

Title: Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.

PubMed ID: 24324597

DOI: 10.1371/journal.pone.0080376

PubMed ID: 29064616

Title: Gain-of-function HCN2 variants in genetic epilepsy.

PubMed ID: 29064616

DOI: 10.1002/humu.23357

PubMed ID: 29463886

Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.

PubMed ID: 29463886

DOI: 10.1038/s41380-018-0020-x

Sequence Information:

Length: 889
Mass: 96950
Checksum: 4B263E0C06C2A47D
Sequence:

MDARGGGGRP GESPGATPAP GPPPPPPPAP PQQQPPPPPP PAPPPGPGPA PPQHPPRAEA 
LPPEAADEGG PRGRLRSRDS SCGRPGTPGA ASTAKGSPNG ECGRGEPQCS PAGPEGPARG 
PKVSFSCRGA ASGPAPGPGP AEEAGSEEAG PAGEPRGSQA SFMQRQFGAL LQPGVNKFSL 
RMFGSQKAVE REQERVKSAG AWIIHPYSDF RFYWDFTMLL FMVGNLIIIP VGITFFKDET 
TAPWIVFNVV SDTFFLMDLV LNFRTGIVIE DNTEIILDPE KIKKKYLRTW FVVDFVSSIP 
VDYIFLIVEK GIDSEVYKTA RALRIVRFTK ILSLLRLLRL SRLIRYIHQW EEIFHMTYDL 
ASAVMRICNL ISMMLLLCHW DGCLQFLVPM LQDFPRNCWV SINGMVNHSW SELYSFALFK 
AMSHMLCIGY GRQAPESMTD IWLTMLSMIV GATCYAMFIG HATALIQSLD SSRRQYQEKY 
KQVEQYMSFH KLPADFRQKI HDYYEHRYQG KMFDEDSILG ELNGPLREEI VNFNCRKLVA 
SMPLFANADP NFVTAMLTKL KFEVFQPGDY IIREGTIGKK MYFIQHGVVS VLTKGNKEMK 
LSDGSYFGEI CLLTRGRRTA SVRADTYCRL YSLSVDNFNE VLEEYPMMRR AFETVAIDRL 
DRIGKKNSIL LHKVQHDLNS GVFNNQENAI IQEIVKYDRE MVQQAELGQR VGLFPPPPPP 
PQVTSAIATL QQAAAMSFCP QVARPLVGPL ALGSPRLVRR PPPGPAPAAA SPGPPPPASP 
PGAPASPRAP RTSPYGGLPA APLAGPALPA RRLSRASRPL SASQPSLPHG APGPAASTRP 
ASSSTPRLGP TPAARAAAPS PDRRDSASPG AAGGLDPQDS ARSRLSSNL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HCN2

Associated with

Other Information

The human gene coding for HCN2, a pacemaker channel of the heart. PubMed ID: 10524219

Two pacemaker channels from human heart with profoundly different activation kinetics. PubMed ID: 10228147

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Identification of a gene encoding a hyperpolarization-activated 'pacemaker' channel of brain. PubMed ID: 9630217

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. PubMed ID: 22006928

Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy. PubMed ID: 22131395

Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner. PubMed ID: 24324597

Gain-of-function HCN2 variants in genetic epilepsy. PubMed ID: 29064616

A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development. PubMed ID: 29463886