Details for: HCN2

Gene ID: 610

Symbol: HCN2

Ensembl ID: ENSG00000099822

Description: hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.29
    Marker Score: 13350
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.2
    Marker Score: 4876
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.18
    Marker Score: 2835
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.12
    Marker Score: 1736
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.06
    Marker Score: 2700
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.05
    Marker Score: 439
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.04
    Marker Score: 38391
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15349
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.98
    Marker Score: 2030
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.9
    Marker Score: 3716
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.84
    Marker Score: 7242
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.83
    Marker Score: 51116
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.82
    Marker Score: 224
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.8
    Marker Score: 7589
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.79
    Marker Score: 7414
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.71
    Marker Score: 27138
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.67
    Marker Score: 2604
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1262
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1352
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.65
    Marker Score: 9741.5
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.65
    Marker Score: 340
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.64
    Marker Score: 738
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.61
    Marker Score: 12202
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.61
    Marker Score: 4679
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.61
    Marker Score: 602
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 230
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 324
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.49
    Marker Score: 222
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.49
    Marker Score: 808
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 244
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 153
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.3
    Marker Score: 508
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.3
    Marker Score: 156
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.29
    Marker Score: 683
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.29
    Marker Score: 498
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.26
    Marker Score: 65
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.26
    Marker Score: 1741
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.25
    Marker Score: 249
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.25
    Marker Score: 1056
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.25
    Marker Score: 132
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.24
    Marker Score: 685
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.23
    Marker Score: 7630
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.22
    Marker Score: 95
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.19
    Marker Score: 390
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.17
    Marker Score: 212
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.17
    Marker Score: 790
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.17
    Marker Score: 109
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.16
    Marker Score: 82
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 124
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.14
    Marker Score: 260
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.14
    Marker Score: 107
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.14
    Marker Score: 173
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.14
    Marker Score: 90
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 47
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.13
    Marker Score: 144
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.12
    Marker Score: 113.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.12
    Marker Score: 140
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.12
    Marker Score: 26
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.11
    Marker Score: 110
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.11
    Marker Score: 45
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.11
    Marker Score: 45
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.11
    Marker Score: 22
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.11
    Marker Score: 21
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.1
    Marker Score: 106
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1
    Marker Score: 48.5
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.1
    Marker Score: 516
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1
    Marker Score: 1687
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.09
    Marker Score: 134

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - The HCN2 gene is located on chromosome 19p13.3. - It is a large gene encoding a protein of 1,243 amino acids. - It is expressed in a variety of cell types, including immune cells, neurons, and epithelial cells. **Pathways and functions:** - HCN2 is a key regulator of cell signaling in the central nervous system. - It is expressed in neurons and glial cells, where it is involved in synaptic plasticity, learning and memory, and pain sensation. - HCN2 also plays a role in immune responses, where it is expressed in immune cells and is involved in the regulation of inflammation and immune cell communication. **Clinical significance:** - Mutations in the HCN2 gene have been linked to a number of neurological and psychiatric disorders, including schizophrenia, autism, and epilepsy. - These mutations can lead to changes in the activity of HCN2 channels, which can disrupt cellular signaling and neuronal function. - Therefore, targeting HCN2 signaling is a promising strategy for treating these disorders.

Genular Protein ID: 1933186398

Symbol: HCN2_HUMAN

Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

UniProtKB Accession Codes:

Q9UL51 O60742 O60743 O75267 Q9UBS2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 13 Ensembl 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10524219

Title: The human gene coding for HCN2, a pacemaker channel of the heart.

PubMed ID: 10524219

DOI: 10.1016/s0167-4781(99)00092-5

PubMed ID: 10228147

Title: Two pacemaker channels from human heart with profoundly different activation kinetics.

PubMed ID: 10228147

DOI: 10.1093/emboj/18.9.2323

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 9630217

Title: Identification of a gene encoding a hyperpolarization-activated 'pacemaker' channel of brain.

PubMed ID: 9630217

DOI: 10.1016/s0092-8674(00)81434-8

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22006928

Title: Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.

PubMed ID: 22006928

DOI: 10.1074/jbc.m111.297606

PubMed ID: 22131395

Title: Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.

PubMed ID: 22131395

DOI: 10.1523/jneurosci.3727-11.2011

PubMed ID: 24324597

Title: Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.

PubMed ID: 24324597

DOI: 10.1371/journal.pone.0080376

PubMed ID: 29064616

Title: Gain-of-function HCN2 variants in genetic epilepsy.

PubMed ID: 29064616

DOI: 10.1002/humu.23357

PubMed ID: 29463886

Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.

PubMed ID: 29463886

DOI: 10.1038/s41380-018-0020-x

Sequence Information:

  • Length: 889
  • Mass: 96950
  • Checksum: 4B263E0C06C2A47D
  • Sequence:
    • MDARGGGGRP GESPGATPAP GPPPPPPPAP PQQQPPPPPP PAPPPGPGPA PPQHPPRAEA 
LPPEAADEGG PRGRLRSRDS SCGRPGTPGA ASTAKGSPNG ECGRGEPQCS PAGPEGPARG 
PKVSFSCRGA ASGPAPGPGP AEEAGSEEAG PAGEPRGSQA SFMQRQFGAL LQPGVNKFSL 
RMFGSQKAVE REQERVKSAG AWIIHPYSDF RFYWDFTMLL FMVGNLIIIP VGITFFKDET 
TAPWIVFNVV SDTFFLMDLV LNFRTGIVIE DNTEIILDPE KIKKKYLRTW FVVDFVSSIP 
VDYIFLIVEK GIDSEVYKTA RALRIVRFTK ILSLLRLLRL SRLIRYIHQW EEIFHMTYDL 
ASAVMRICNL ISMMLLLCHW DGCLQFLVPM LQDFPRNCWV SINGMVNHSW SELYSFALFK 
AMSHMLCIGY GRQAPESMTD IWLTMLSMIV GATCYAMFIG HATALIQSLD SSRRQYQEKY 
KQVEQYMSFH KLPADFRQKI HDYYEHRYQG KMFDEDSILG ELNGPLREEI VNFNCRKLVA 
SMPLFANADP NFVTAMLTKL KFEVFQPGDY IIREGTIGKK MYFIQHGVVS VLTKGNKEMK 
LSDGSYFGEI CLLTRGRRTA SVRADTYCRL YSLSVDNFNE VLEEYPMMRR AFETVAIDRL 
DRIGKKNSIL LHKVQHDLNS GVFNNQENAI IQEIVKYDRE MVQQAELGQR VGLFPPPPPP 
PQVTSAIATL QQAAAMSFCP QVARPLVGPL ALGSPRLVRR PPPGPAPAAA SPGPPPPASP 
PGAPASPRAP RTSPYGGLPA APLAGPALPA RRLSRASRPL SASQPSLPHG APGPAASTRP 
ASSSTPRLGP TPAARAAAPS PDRRDSASPG AAGGLDPQDS ARSRLSSNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.