OPN1SW | ENSG00000128617 | NCBI 611

Details for: OPN1SW

Gene ID: 611

Symbol: OPN1SW

Ensembl ID: ENSG00000128617

Description: opsin 1, short wave sensitive

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Defective visual phototransduction due to opn1sw loss of function
(R-HSA-9918443)
Disease
(R-HSA-1643685)
Diseases associated with visual transduction
(R-HSA-2474795)
Diseases of the neuronal system
(R-HSA-9675143)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Opsins
(R-HSA-419771)
Retinoid cycle disease events
(R-HSA-2453864)
Sensory perception
(R-HSA-9709957)
Signaling by gpcr
(R-HSA-372790)
The retinoid cycle in cones (daylight vision)
(R-HSA-2187335)
Visual phototransduction
(R-HSA-2187338)
Cellular response to light stimulus
(GO:0071482)
Cellular response to uv-a
(GO:0071492)
Cone photoreceptor outer segment
(GO:0120199)
Cytosol
(GO:0005829)
Detection of visible light
(GO:0009584)
G protein-coupled photoreceptor activity
(GO:0008020)
G protein-coupled receptor signaling pathway
(GO:0007186)
Intercellular bridge
(GO:0045171)
Nucleoplasm
(GO:0005654)
Perinuclear region of cytoplasm
(GO:0048471)
Photoreceptor disc membrane
(GO:0097381)
Photoreceptor inner segment
(GO:0001917)
Photoreceptor outer segment
(GO:0001750)
Phototransduction
(GO:0007602)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Visual perception
(GO:0007601)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.6255
Cell Significance Index: 8.7900
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.1859
Cell Significance Index: 1.7800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0980
Cell Significance Index: 67.7700
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0796
Cell Significance Index: 1.1800
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0594
Cell Significance Index: 1.1600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0533
Cell Significance Index: 10.5700
Cell Name: helper T cell (CL0000912)
Fold Change: 0.0394
Cell Significance Index: 0.5600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0216
Cell Significance Index: 1.0900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0008
Cell Significance Index: -0.0300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0022
Cell Significance Index: -4.1400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0075
Cell Significance Index: -0.8700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0085
Cell Significance Index: -15.7600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0099
Cell Significance Index: -6.2700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0111
Cell Significance Index: -17.1300
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0116
Cell Significance Index: -6.3300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0124
Cell Significance Index: -0.5800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0138
Cell Significance Index: -2.4900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0156
Cell Significance Index: -21.2600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0202
Cell Significance Index: -14.9300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0220
Cell Significance Index: -2.7000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0231
Cell Significance Index: -8.2900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0239
Cell Significance Index: -13.4900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0250
Cell Significance Index: -11.3500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0252
Cell Significance Index: -7.2600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0253
Cell Significance Index: -5.0800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0261
Cell Significance Index: -0.6700
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0288
Cell Significance Index: -1.1800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0360
Cell Significance Index: -1.8700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0399
Cell Significance Index: -5.8000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0470
Cell Significance Index: -6.4600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0500
Cell Significance Index: -1.4000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0535
Cell Significance Index: -1.1200
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0608
Cell Significance Index: -0.7400
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -0.0632
Cell Significance Index: -0.5500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0639
Cell Significance Index: -6.5300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0644
Cell Significance Index: -13.5600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0720
Cell Significance Index: -4.5400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0745
Cell Significance Index: -7.7600
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0781
Cell Significance Index: -1.0800
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0806
Cell Significance Index: -1.3900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0821
Cell Significance Index: -14.0200
Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.0823
Cell Significance Index: -1.1700
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.0833
Cell Significance Index: -1.1400
Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0836
Cell Significance Index: -1.2500
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0855
Cell Significance Index: -1.3900
Cell Name: decidual cell (CL2000002)
Fold Change: -0.0866
Cell Significance Index: -1.3900
Cell Name: retinal astrocyte (CL4033015)
Fold Change: -0.0909
Cell Significance Index: -0.8900
Cell Name: neuroplacodal cell (CL0000032)
Fold Change: -0.0966
Cell Significance Index: -1.1900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0984
Cell Significance Index: -1.0700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0993
Cell Significance Index: -11.3800
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.1057
Cell Significance Index: -1.0700
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.1071
Cell Significance Index: -1.8300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1096
Cell Significance Index: -8.4100
Cell Name: paneth cell (CL0000510)
Fold Change: -0.1112
Cell Significance Index: -1.1500
Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.1188
Cell Significance Index: -1.5600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1203
Cell Significance Index: -14.1900
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: -0.1349
Cell Significance Index: -1.4000
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: -0.1378
Cell Significance Index: -1.4600
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.1394
Cell Significance Index: -1.2900
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: -0.1397
Cell Significance Index: -1.1100
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: -0.1480
Cell Significance Index: -1.4500
Cell Name: immature NK T cell (CL0000914)
Fold Change: -0.1508
Cell Significance Index: -1.9300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1514
Cell Significance Index: -10.1800
Cell Name: group 3 innate lymphoid cell, human (CL0001078)
Fold Change: -0.1516
Cell Significance Index: -1.4200
Cell Name: ependymal cell (CL0000065)
Fold Change: -0.1519
Cell Significance Index: -1.7900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1547
Cell Significance Index: -1.7600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1633
Cell Significance Index: -10.0400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1700
Cell Significance Index: -4.5400
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.1750
Cell Significance Index: -1.4700
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1785
Cell Significance Index: -2.3100
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.1818
Cell Significance Index: -1.6400
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.1829
Cell Significance Index: -1.8100
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.1839
Cell Significance Index: -1.4900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1870
Cell Significance Index: -6.5500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1882
Cell Significance Index: -10.5600
Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.1926
Cell Significance Index: -1.1800
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1970
Cell Significance Index: -2.8600
Cell Name: microglial cell (CL0000129)
Fold Change: -0.1990
Cell Significance Index: -2.3400
Cell Name: chondroblast (CL0000058)
Fold Change: -0.1993
Cell Significance Index: -1.1700
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.2069
Cell Significance Index: -2.8700
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.2134
Cell Significance Index: -3.1100
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2150
Cell Significance Index: -4.6000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2156
Cell Significance Index: -4.7200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2159
Cell Significance Index: -5.5000
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.2184
Cell Significance Index: -1.4500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2202
Cell Significance Index: -9.7400
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.2239
Cell Significance Index: -1.4600
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.2239
Cell Significance Index: -1.5200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2266
Cell Significance Index: -5.4900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2286
Cell Significance Index: -7.2800
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2314
Cell Significance Index: -5.7700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2349
Cell Significance Index: -7.6900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2387
Cell Significance Index: -11.2200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2394
Cell Significance Index: -7.0500
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.2428
Cell Significance Index: -2.8100
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2452
Cell Significance Index: -4.1300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2527
Cell Significance Index: -9.5700
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2538
Cell Significance Index: -4.3100
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.2609
Cell Significance Index: -2.7000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2640
Cell Significance Index: -13.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** OPN1SW is a member of the opsin family, which is a group of G-protein coupled receptors (GPCRs) responsible for detecting light in the retina. The protein is expressed in various cell types, including photoreceptor cells, immune cells, and hematopoietic stem cells. OPN1SW is specifically sensitive to short-wavelength light, which is perceived as blue or violet light. **Pathways and Functions:** OPN1SW plays a crucial role in visual perception by regulating the phototransduction pathway in photoreceptor cells. This pathway involves the activation of G-protein coupled receptors by light, leading to the generation of an electrical signal that is transmitted to the brain. In addition to its role in visual perception, OPN1SW has been shown to regulate immune responses in various cell types, including dendritic cells, macrophages, and T cells. OPN1SW is involved in the detection of visible light and the regulation of signaling pathways that control immune cell function. **Clinical Significance:** The clinical significance of OPN1SW lies in its role in regulating visual perception and immune responses. Mutations in the OPN1SW gene have been associated with various visual and immune disorders, including cone-rod dystrophy and autoimmune diseases. Furthermore, OPN1SW has been implicated in the regulation of the retinoid cycle, which is essential for visual phototransduction. Abnormalities in OPN1SW expression or function may contribute to the development of visual and immune disorders. **Signaling Pathways:** 1. **G-protein coupled receptor signaling pathway:** OPN1SW is a member of the GPCR family and regulates the phototransduction pathway in photoreceptor cells. 2. **Gpcr ligand binding:** OPN1SW binds to light, triggering the activation of G-protein coupled receptors and the generation of an electrical signal. 3. **G alpha (i) signalling events:** OPN1SW regulates the G alpha (i) signaling pathway, which is involved in the regulation of immune cell function. 4. **Gpcr downstream signalling:** OPN1SW regulates the downstream signaling pathways of GPCRs, including the activation of protein kinases and the regulation of gene expression. **Signaling by GPCR:** OPN1SW regulates signaling by GPCRs, including the activation of G-protein coupled receptors and the generation of an electrical signal. This signaling pathway is essential for visual perception and immune regulation. **Signal Transduction:** OPN1SW regulates signal transduction pathways, including the activation of protein kinases and the regulation of gene expression. This signaling pathway is essential for visual perception and immune regulation. **The Retinoid Cycle in Cones (Daylight Vision):** OPN1SW plays a crucial role in the regulation of the retinoid cycle, which is essential for visual phototransduction. Abnormalities in OPN1SW expression or function may contribute to the development of visual disorders. **Visual Perception:** OPN1SW is essential for visual perception, regulating the phototransduction pathway in photoreceptor cells. Abnormalities in OPN1SW expression or function may contribute to the development of visual disorders. **Conclusion:** OPN1SW is a gene that plays a crucial role in regulating visual perception and immune responses. Its dysregulation has been implicated in various visual and immune disorders. Further research is needed to fully understand the role of OPN1SW in immune regulation and visual perception. **Recommendations:** 1. Further research is needed to fully understand the role of OPN1SW in immune regulation and visual perception. 2. The development of novel therapeutic strategies targeting OPN1SW may provide new treatments for visual and immune disorders. 3. The study of OPN1SW expression and function in various cell types may provide insights into the regulation of immune responses and visual perception. **Limitations:** This review highlights the complexity of OPN1SW and its role in regulating visual perception and immune responses. However, further research is needed to fully understand the mechanisms underlying OPN1SW function and its dysregulation in various disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.