Gene OPN1SW - ENSG00000128617 | NCBI Gene ID: 611

Details for: OPN1SW

Gene ID: 611

Symbol: OPN1SW

Ensembl ID: ENSG00000128617

Description: opsin 1, short wave sensitive

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Disease
(R-HSA-1643685)
Diseases associated with visual transduction
(R-HSA-2474795)
Diseases of the neuronal system
(R-HSA-9675143)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Opsins
(R-HSA-419771)
Retinoid cycle disease events
(R-HSA-2453864)
Sensory perception
(R-HSA-9709957)
Signaling by gpcr
(R-HSA-372790)
The retinoid cycle in cones (daylight vision)
(R-HSA-2187335)
Visual phototransduction
(R-HSA-2187338)
Cellular response to light stimulus
(GO:0071482)
Cellular response to uv-a
(GO:0071492)
Cone photoreceptor outer segment
(GO:0120199)
Cytosol
(GO:0005829)
Detection of visible light
(GO:0009584)
G protein-coupled photoreceptor activity
(GO:0008020)
G protein-coupled receptor signaling pathway
(GO:0007186)
Intercellular bridge
(GO:0045171)
Nucleoplasm
(GO:0005654)
Perinuclear region of cytoplasm
(GO:0048471)
Photoreceptor disc membrane
(GO:0097381)
Photoreceptor inner segment
(GO:0001917)
Photoreceptor outer segment
(GO:0001750)
Phototransduction
(GO:0007602)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Visual perception
(GO:0007601)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythrocyte (CL0000232)
Fold Change: 10.45
Marker Score: 5789
Cell Name: megakaryocyte (CL0000556)
Fold Change: 3.49
Marker Score: 1980
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 3.31
Marker Score: 1742.5
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.34
Marker Score: 2358
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.2
Marker Score: 1514
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.61
Marker Score: 672
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 871
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.34
Marker Score: 5191.5
Cell Name: precursor B cell (CL0000817)
Fold Change: 1.15
Marker Score: 757
Cell Name: goblet cell (CL0000160)
Fold Change: 1.14
Marker Score: 7561
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71826
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48050
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.98
Marker Score: 2487
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5352
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5287
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.84
Marker Score: 643
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: neutrophil (CL0000775)
Fold Change: 0.64
Marker Score: 387
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 471
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 475
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 277
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.45
Marker Score: 7075
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 372
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.35
Marker Score: 2097
Cell Name: S cone cell (CL0003050)
Fold Change: 0.31
Marker Score: 93
Cell Name: mast cell (CL0000097)
Fold Change: 0.27
Marker Score: 154
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.24
Marker Score: 446
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.21
Marker Score: 334
Cell Name: fibroblast (CL0000057)
Fold Change: 0.2
Marker Score: 189
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.19
Marker Score: 392
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.19
Marker Score: 100
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.16
Marker Score: 77
Cell Name: macrophage (CL0000235)
Fold Change: 0.16
Marker Score: 175
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.15
Marker Score: 75
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.15
Marker Score: 307
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.14
Marker Score: 129
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.14
Marker Score: 167
Cell Name: glial cell (CL0000125)
Fold Change: 0.12
Marker Score: 134
Cell Name: monocyte (CL0000576)
Fold Change: 0.11
Marker Score: 149
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.11
Marker Score: 25
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.11
Marker Score: 74
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.11
Marker Score: 73
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.1
Marker Score: 60
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.1
Marker Score: 25
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.1
Marker Score: 25
Cell Name: plasma cell (CL0000786)
Fold Change: 0.09
Marker Score: 99
Cell Name: B cell (CL0000236)
Fold Change: 0.09
Marker Score: 84
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.09
Marker Score: 367
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.08
Marker Score: 22
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.08
Marker Score: 25
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.08
Marker Score: 43
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.08
Marker Score: 24
Cell Name: pericyte (CL0000669)
Fold Change: 0.08
Marker Score: 47
Cell Name: club cell (CL0000158)
Fold Change: 0.08
Marker Score: 88
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.08
Marker Score: 38
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.07
Marker Score: 19
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.07
Marker Score: 21
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.07
Marker Score: 33
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.07
Marker Score: 20
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.07
Marker Score: 21
Cell Name: T cell (CL0000084)
Fold Change: 0.07
Marker Score: 125
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.07
Marker Score: 25
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.07
Marker Score: 69
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.07
Marker Score: 54
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.07
Marker Score: 104
Cell Name: progenitor cell (CL0011026)
Fold Change: 0.07
Marker Score: 449
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.07
Marker Score: 25
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.07
Marker Score: 22
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.07
Marker Score: 22
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.07
Marker Score: 24
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.07
Marker Score: 21
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.07
Marker Score: 21
Cell Name: podocyte (CL0000653)
Fold Change: 0.06
Marker Score: 24
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.06
Marker Score: 22
Cell Name: melanocyte (CL0000148)
Fold Change: 0.06
Marker Score: 26
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.06
Marker Score: 25
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.06
Marker Score: 18
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.06
Marker Score: 24
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.06
Marker Score: 18
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.06
Marker Score: 76
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.06
Marker Score: 20
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.05
Marker Score: 32
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.05
Marker Score: 25
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.05
Marker Score: 35
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.05
Marker Score: 22
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.05
Marker Score: 20
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.05
Marker Score: 23
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.05
Marker Score: 21
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.05
Marker Score: 64
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.05
Marker Score: 62
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.05
Marker Score: 25
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.05
Marker Score: 25
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.05
Marker Score: 96
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.05
Marker Score: 62

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Other Information

Description

**Key characteristics:** - The protein is a transmembrane protein with a molecular weight of approximately 140 kDa. - It is a member of the opsin family of G protein-coupled receptors (GPCRs). - It is expressed in the retina, where it is primarily found in cone cells. - It is also expressed in other cell types, including erythrocytes, megakaryocytes, and blood vessel endothelial cells. **Pathways and functions:** - OPN1SW is a key component of the visual transduction pathway in cones. - It is a ligand for G protein-coupled receptor (GPCR) opsin, which is expressed in rod and cone cells in the retina. - When opsin binds to its ligand, it triggers a cascade of intracellular events that ultimately lead to the activation of G proteins. - These G proteins then transmit signals to the cytosol, which ultimately modulates the activity of downstream target proteins involved in visual signal transduction. **Clinical significance:** - Mutations in the OPN1SW gene have been linked to several eye diseases, including retinoid cycle diseases and age-related macular degeneration (AMD). - These diseases are characterized by progressive damage to the retina and vision loss. - Genetic studies have identified variants in the OPN1SW gene that are associated with increased susceptibility to these diseases. - Understanding the role of OPN1SW in visual transduction has potential implications for the development of new therapeutic strategies for eye diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.