Details for: BCR

Gene ID: 613

Symbol: BCR

Ensembl ID: ENSG00000186716

Description: BCR activator of RhoGEF and GTPase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 205.4708
    Cell Significance Index: -31.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 110.5883
    Cell Significance Index: -28.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.7527
    Cell Significance Index: -25.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.5359
    Cell Significance Index: -30.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.1277
    Cell Significance Index: -25.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.9782
    Cell Significance Index: -32.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4844
    Cell Significance Index: -30.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5365
    Cell Significance Index: -23.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1499
    Cell Significance Index: -32.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.0668
    Cell Significance Index: 91.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.9059
    Cell Significance Index: 72.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6443
    Cell Significance Index: 162.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3126
    Cell Significance Index: 263.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2677
    Cell Significance Index: 251.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1233
    Cell Significance Index: 402.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1065
    Cell Significance Index: 71.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8650
    Cell Significance Index: 58.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8645
    Cell Significance Index: 140.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8595
    Cell Significance Index: 105.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8258
    Cell Significance Index: 46.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7994
    Cell Significance Index: 22.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6154
    Cell Significance Index: 425.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6055
    Cell Significance Index: 36.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5976
    Cell Significance Index: 31.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3801
    Cell Significance Index: 26.2900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3720
    Cell Significance Index: 5.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3466
    Cell Significance Index: 7.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3393
    Cell Significance Index: 9.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3181
    Cell Significance Index: 173.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2997
    Cell Significance Index: 18.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2991
    Cell Significance Index: 6.4800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.2939
    Cell Significance Index: 4.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2900
    Cell Significance Index: 52.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2871
    Cell Significance Index: 22.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2586
    Cell Significance Index: 233.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2553
    Cell Significance Index: 6.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2012
    Cell Significance Index: 10.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1920
    Cell Significance Index: 5.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1881
    Cell Significance Index: 8.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1822
    Cell Significance Index: 8.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1440
    Cell Significance Index: 27.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1182
    Cell Significance Index: 5.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0620
    Cell Significance Index: 27.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0519
    Cell Significance Index: 95.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0503
    Cell Significance Index: 94.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0398
    Cell Significance Index: 5.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0333
    Cell Significance Index: 45.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0198
    Cell Significance Index: 0.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0175
    Cell Significance Index: 0.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0137
    Cell Significance Index: 21.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0058
    Cell Significance Index: 3.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0046
    Cell Significance Index: 2.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0079
    Cell Significance Index: -5.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0210
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0237
    Cell Significance Index: -3.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0305
    Cell Significance Index: -23.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0323
    Cell Significance Index: -4.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0358
    Cell Significance Index: -26.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0457
    Cell Significance Index: -7.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0499
    Cell Significance Index: -28.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0572
    Cell Significance Index: -35.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0947
    Cell Significance Index: -27.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1005
    Cell Significance Index: -11.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1094
    Cell Significance Index: -2.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1130
    Cell Significance Index: -2.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1240
    Cell Significance Index: -15.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1363
    Cell Significance Index: -16.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1445
    Cell Significance Index: -14.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1483
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1676
    Cell Significance Index: -35.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1873
    Cell Significance Index: -21.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2192
    Cell Significance Index: -22.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2368
    Cell Significance Index: -17.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2483
    Cell Significance Index: -5.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2855
    Cell Significance Index: -4.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3076
    Cell Significance Index: -19.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3082
    Cell Significance Index: -8.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3085
    Cell Significance Index: -24.4400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3110
    Cell Significance Index: -4.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3166
    Cell Significance Index: -22.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3200
    Cell Significance Index: -10.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3203
    Cell Significance Index: -4.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3596
    Cell Significance Index: -5.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4433
    Cell Significance Index: -27.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5048
    Cell Significance Index: -26.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5343
    Cell Significance Index: -13.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5591
    Cell Significance Index: -9.8800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5860
    Cell Significance Index: -8.8300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5946
    Cell Significance Index: -12.6200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5969
    Cell Significance Index: -10.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6303
    Cell Significance Index: -16.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6306
    Cell Significance Index: -12.6600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.6447
    Cell Significance Index: -5.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6719
    Cell Significance Index: -21.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6840
    Cell Significance Index: -23.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7073
    Cell Significance Index: -17.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7235
    Cell Significance Index: -26.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7266
    Cell Significance Index: -23.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7556
    Cell Significance Index: -26.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7834
    Cell Significance Index: -15.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin Cytoskeleton Organization:** BCR is a GTPase activator that regulates actin cytoskeleton organization, which is essential for cell migration, adhesion, and morphology. 2. **Signal Transduction:** BCR is involved in signal transduction pathways, including those mediated by Rho GTPases, which regulate various cellular processes, such as cell migration, adhesion, and morphology. 3. **Cellular Localization:** BCR is expressed in multiple cell types, including astrocytes, GABAergic cortical interneurons, endothelial cells, and renal cells. 4. **Protein Binding:** BCR interacts with various proteins, including RhoGEF, GTPase, and other signaling molecules, to regulate its activity. **Pathways and Functions:** 1. **Rho GTPase Cycle:** BCR activates Rho GTPases, which regulate actin cytoskeleton organization, cell migration, and adhesion. 2. **Cytosol and Actin Cytoskeleton Organization:** BCR regulates actin cytoskeleton organization in the cytosol, which is essential for cell migration, adhesion, and morphology. 3. **Cell Migration and Adhesion:** BCR regulates cell migration and adhesion by modulating the actin cytoskeleton organization and signaling pathways. 4. **Signal Transduction:** BCR is involved in signal transduction pathways, including those mediated by Rho GTPases, which regulate various cellular processes. **Clinical Significance:** 1. **Cancer:** Dysregulation of BCR has been implicated in various cancers, including renal carcinoma, where it acts as a tumor suppressor gene. 2. **Neurological Disorders:** BCR is involved in the regulation of neuronal morphology and signaling, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Diseases:** BCR regulates vascular permeability and cell migration, and its dysregulation has been implicated in cardiovascular diseases, such as atherosclerosis and hypertension. 4. **Inflammatory Response:** BCR regulates the inflammatory response by modulating the activity of Rho GTPases, which are involved in the regulation of inflammatory signaling pathways. In conclusion, the BCR gene is a critical regulator of actin cytoskeleton organization and signal transduction, and its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases. Further research is needed to fully understand the role of BCR in these diseases and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 3858177654

Symbol: BCR_HUMAN

Name: Renal carcinoma antigen NY-REN-26

UniProtKB Accession Codes:

P11274 P78501 Q12842 Q4LE80 Q6NZI3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 DrugCentral 1 EC 2 ELM 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 2 Rhea 8 SASBDB 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3285291

Title: bcr genes and transcripts.

PubMed ID: 3285291

PubMed ID: 7665185

Title: Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.

PubMed ID: 7665185

DOI: 10.1006/geno.1995.1008

PubMed ID: 3107980

Title: cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia.

PubMed ID: 3107980

DOI: 10.1002/j.1460-2075.1987.tb04727.x

PubMed ID: 3540951

Title: Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.

PubMed ID: 3540951

DOI: 10.1073/pnas.83.24.9768

PubMed ID: 2989703

Title: Structural organization of the bcr gene and its role in the Ph' translocation.

PubMed ID: 2989703

DOI: 10.1038/315758a0

PubMed ID: 2263470

Title: Unique organization of the human BCR gene promoter.

PubMed ID: 2263470

DOI: 10.1093/nar/18.23.7119

PubMed ID: 2825022

Title: A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia.

PubMed ID: 2825022

DOI: 10.1038/330386a0

PubMed ID: 2915904

Title: Alternative 5' end of the bcr-abl transcript in chronic myelogenous leukemia.

PubMed ID: 2915904

PubMed ID: 2407300

Title: Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript.

PubMed ID: 2407300

PubMed ID: 1900918

Title: Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines.

PubMed ID: 1900918

DOI: 10.1128/mcb.11.4.1854-1860.1991

PubMed ID: 1903516

Title: Bcr encodes a GTPase-activating protein for p21rac.

PubMed ID: 1903516

DOI: 10.1038/351400a0

PubMed ID: 1712671

Title: BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.

PubMed ID: 1712671

DOI: 10.1016/0092-8674(91)90148-r

PubMed ID: 1657398

Title: The BCR gene encodes a novel serine/threonine kinase activity within a single exon.

PubMed ID: 1657398

DOI: 10.1016/0092-8674(91)90521-y

PubMed ID: 7479768

Title: Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

PubMed ID: 7479768

DOI: 10.1073/pnas.92.22.10282

PubMed ID: 9407116

Title: The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.

PubMed ID: 9407116

DOI: 10.1074/jbc.272.52.33260

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15302586

Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.

PubMed ID: 15302586

DOI: 10.1016/j.yexcr.2004.05.010

PubMed ID: 15494376

Title: Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3.

PubMed ID: 15494376

DOI: 10.1242/jcs.01472

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17116687

Title: Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.

PubMed ID: 17116687

DOI: 10.1128/mcb.00756-06

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11780146

Title: Structure of the Bcr-Abl oncoprotein oligomerization domain.

PubMed ID: 11780146

DOI: 10.1038/nsb747

PubMed ID: 20962234

Title: Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

PubMed ID: 20962234

DOI: 10.1523/jneurosci.1711-10.2010

PubMed ID: 23940119

Title: The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.

PubMed ID: 23940119

DOI: 10.1083/jcb.201304133

PubMed ID: 25331951

Title: src homology 2 domain containing protein 5 (sh2d5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.

PubMed ID: 25331951

DOI: 10.1074/jbc.m114.615112

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1271
  • Mass: 142819
  • Checksum: 4BF66FA1E9D205FE
  • Sequence:
    • MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ 
TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA PADGADPPPA EEPEARPDGE 
GSPGKARPGT ARRPGAAASG ERDDRGPPAS VAALRSNFER IRKGHGQPGA DAEKPFYVNV 
EFHHERGLVK VNDKEVSDRI SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC 
GVDGDYEDAE LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ 
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS SRVSPSPTTY 
RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS EATIVGVRKT GQIWPNDGEG 
AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ DGLPYIDDSP SSSPHLSSKG RGSRDALVSG 
ALESTKASEL DLEKGLEMRK WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS 
QQIETIFFKV PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV 
AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV TRSTLVLHDL 
LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPRRQSMT VKKGEHRQLL KDSFMVELVE 
GARKLRHVFL FTDLLLCTKL KKQSGGKTQQ YDCKWYIPLT DLSFQMVDEL EAVPNIPLVP 
DEELDALKIK ISQIKNDIQR EKRANKGSKA TERLKKKLSE QESLLLLMSP SMAFRVHSRN 
GKSYTFLISS DYERAEWREN IREQQKKCFR SFSLTSVELQ MLTNSCVKLQ TVHSIPLTIN 
KEDDESPGLY GFLNVIVHSA TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY RDTAEPNWNE 
EFEIELEGSQ TLRILCYEKC YNKTKIPKED GESTDRLMGK GQVQLDPQAL QDRDWQRTVI 
AMNGIEVKLS VKFNSREFSL KRMPSRKQTG VFGVKIAVVT KRERSKVPYI VRQCVEEIER 
RGMEEVGIYR VSGVATDIQA LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF 
TDEFYPNFAE GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKEAVNKMSL 
HNLATVFGPT LLRPSEKESK LPANPSQPIT MTDSWSLEVM SQVQVLLYFL QLEAIPAPDS 
KRQSILFSTE V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.