Details for: BCR

Gene ID: 613

Symbol: BCR

Ensembl ID: ENSG00000186716

Description: BCR activator of RhoGEF and GTPase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.28
    Marker Score: 48706
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.79
    Marker Score: 67886
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.69
    Marker Score: 12974.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.69
    Marker Score: 2454
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.67
    Marker Score: 2083
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.66
    Marker Score: 6435
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.66
    Marker Score: 520
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.59
    Marker Score: 3752
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.55
    Marker Score: 16032
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.51
    Marker Score: 6252
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.5
    Marker Score: 55304
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.5
    Marker Score: 22357.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.47
    Marker Score: 879
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167864
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.46
    Marker Score: 2250
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.45
    Marker Score: 13798
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.42
    Marker Score: 87057
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.4
    Marker Score: 27829
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.35
    Marker Score: 889
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.31
    Marker Score: 378
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.3
    Marker Score: 729
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.29
    Marker Score: 3690
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.25
    Marker Score: 12692.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19450.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2473
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.18
    Marker Score: 10149
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.18
    Marker Score: 802
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.17
    Marker Score: 4754.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.17
    Marker Score: 701
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.14
    Marker Score: 666
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.13
    Marker Score: 874
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.13
    Marker Score: 240
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.12
    Marker Score: 651
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.1
    Marker Score: 1853
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.08
    Marker Score: 1100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.08
    Marker Score: 1165.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.05
    Marker Score: 910
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.03
    Marker Score: 1023.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.03
    Marker Score: 9670
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.02
    Marker Score: 3418
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.02
    Marker Score: 680
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.01
    Marker Score: 4674
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1
    Marker Score: 1134.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71733
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47957
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.99
    Marker Score: 1064
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.99
    Marker Score: 1326
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.98
    Marker Score: 236
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.98
    Marker Score: 2404
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.97
    Marker Score: 5857
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.97
    Marker Score: 1201
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.97
    Marker Score: 353
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.96
    Marker Score: 308
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.91
    Marker Score: 30878
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.91
    Marker Score: 478
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2713
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.9
    Marker Score: 2410
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.9
    Marker Score: 12057
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.9
    Marker Score: 1032
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.89
    Marker Score: 500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1444
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.87
    Marker Score: 770
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.87
    Marker Score: 413
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.86
    Marker Score: 331
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.86
    Marker Score: 6404
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4899
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.86
    Marker Score: 948
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1212.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.85
    Marker Score: 269
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.84
    Marker Score: 3630.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.83
    Marker Score: 2964
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.82
    Marker Score: 954
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.82
    Marker Score: 1425
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.81
    Marker Score: 206
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.8
    Marker Score: 717
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 606
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.79
    Marker Score: 217
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.79
    Marker Score: 12627
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.79
    Marker Score: 949
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.78
    Marker Score: 377
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.78
    Marker Score: 203
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.78
    Marker Score: 1650
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.77
    Marker Score: 324
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.77
    Marker Score: 6768
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.76
    Marker Score: 369
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.76
    Marker Score: 804
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.75
    Marker Score: 304
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.75
    Marker Score: 242
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.75
    Marker Score: 715
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.75
    Marker Score: 280
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.75
    Marker Score: 786
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.74
    Marker Score: 259.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.74
    Marker Score: 3097

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Other Information

**Key characteristics:** - BCR is a protein that is involved in the Cdc42 gtpase cycle, which is a signaling pathway that is involved in cell cycle regulation. - BCR is also involved in the disease, Diseases of signal transduction by growth factor receptors and second messengers, and the signaling by Rho GTPases pathway. **Pathways and functions:** - BCR activates RhoGEF, which is a guanosine triphosphate-dependent protein kinase that is involved in the cell cycle. - BCR also activates GTPase, which is a protein that is involved in signal transduction. - RhoGEF and GTPase are both involved in the activation of the cdc42 protein kinase, which is a central enzyme in the cell cycle. **Clinical significance:** - Mutations in the BCR gene have been linked to several diseases, including Alzheimer's disease, schizophrenia, and cancer. - BCR is a potential target for therapy in these diseases, as it is involved in the signaling pathways that are disrupted in these disorders.

Genular Protein ID: 3858177654

Symbol: BCR_HUMAN

Name: Renal carcinoma antigen NY-REN-26

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3285291

Title: bcr genes and transcripts.

PubMed ID: 3285291

PubMed ID: 7665185

Title: Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.

PubMed ID: 7665185

DOI: 10.1006/geno.1995.1008

PubMed ID: 3107980

Title: cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia.

PubMed ID: 3107980

DOI: 10.1002/j.1460-2075.1987.tb04727.x

PubMed ID: 3540951

Title: Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.

PubMed ID: 3540951

DOI: 10.1073/pnas.83.24.9768

PubMed ID: 2989703

Title: Structural organization of the bcr gene and its role in the Ph' translocation.

PubMed ID: 2989703

DOI: 10.1038/315758a0

PubMed ID: 2263470

Title: Unique organization of the human BCR gene promoter.

PubMed ID: 2263470

DOI: 10.1093/nar/18.23.7119

PubMed ID: 2825022

Title: A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia.

PubMed ID: 2825022

DOI: 10.1038/330386a0

PubMed ID: 2915904

Title: Alternative 5' end of the bcr-abl transcript in chronic myelogenous leukemia.

PubMed ID: 2915904

PubMed ID: 2407300

Title: Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript.

PubMed ID: 2407300

PubMed ID: 1900918

Title: Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines.

PubMed ID: 1900918

DOI: 10.1128/mcb.11.4.1854-1860.1991

PubMed ID: 1903516

Title: Bcr encodes a GTPase-activating protein for p21rac.

PubMed ID: 1903516

DOI: 10.1038/351400a0

PubMed ID: 1712671

Title: BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.

PubMed ID: 1712671

DOI: 10.1016/0092-8674(91)90148-r

PubMed ID: 1657398

Title: The BCR gene encodes a novel serine/threonine kinase activity within a single exon.

PubMed ID: 1657398

DOI: 10.1016/0092-8674(91)90521-y

PubMed ID: 7479768

Title: Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

PubMed ID: 7479768

DOI: 10.1073/pnas.92.22.10282

PubMed ID: 9407116

Title: The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.

PubMed ID: 9407116

DOI: 10.1074/jbc.272.52.33260

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15302586

Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.

PubMed ID: 15302586

DOI: 10.1016/j.yexcr.2004.05.010

PubMed ID: 15494376

Title: Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3.

PubMed ID: 15494376

DOI: 10.1242/jcs.01472

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17116687

Title: Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.

PubMed ID: 17116687

DOI: 10.1128/mcb.00756-06

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11780146

Title: Structure of the Bcr-Abl oncoprotein oligomerization domain.

PubMed ID: 11780146

DOI: 10.1038/nsb747

PubMed ID: 20962234

Title: Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

PubMed ID: 20962234

DOI: 10.1523/jneurosci.1711-10.2010

PubMed ID: 23940119

Title: The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.

PubMed ID: 23940119

DOI: 10.1083/jcb.201304133

PubMed ID: 25331951

Title: src homology 2 domain containing protein 5 (sh2d5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.

PubMed ID: 25331951

DOI: 10.1074/jbc.m114.615112

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1271
  • Mass: 142819
  • Checksum: 4BF66FA1E9D205FE
  • Sequence:
  • MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ 
    TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA PADGADPPPA EEPEARPDGE 
    GSPGKARPGT ARRPGAAASG ERDDRGPPAS VAALRSNFER IRKGHGQPGA DAEKPFYVNV 
    EFHHERGLVK VNDKEVSDRI SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC 
    GVDGDYEDAE LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ 
    STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS SRVSPSPTTY 
    RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS EATIVGVRKT GQIWPNDGEG 
    AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ DGLPYIDDSP SSSPHLSSKG RGSRDALVSG 
    ALESTKASEL DLEKGLEMRK WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS 
    QQIETIFFKV PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV 
    AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV TRSTLVLHDL 
    LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPRRQSMT VKKGEHRQLL KDSFMVELVE 
    GARKLRHVFL FTDLLLCTKL KKQSGGKTQQ YDCKWYIPLT DLSFQMVDEL EAVPNIPLVP 
    DEELDALKIK ISQIKNDIQR EKRANKGSKA TERLKKKLSE QESLLLLMSP SMAFRVHSRN 
    GKSYTFLISS DYERAEWREN IREQQKKCFR SFSLTSVELQ MLTNSCVKLQ TVHSIPLTIN 
    KEDDESPGLY GFLNVIVHSA TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY RDTAEPNWNE 
    EFEIELEGSQ TLRILCYEKC YNKTKIPKED GESTDRLMGK GQVQLDPQAL QDRDWQRTVI 
    AMNGIEVKLS VKFNSREFSL KRMPSRKQTG VFGVKIAVVT KRERSKVPYI VRQCVEEIER 
    RGMEEVGIYR VSGVATDIQA LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF 
    TDEFYPNFAE GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKEAVNKMSL 
    HNLATVFGPT LLRPSEKESK LPANPSQPIT MTDSWSLEVM SQVQVLLYFL QLEAIPAPDS 
    KRQSILFSTE V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.