Details for: BCRP4

Gene ID: 616

Symbol: BCRP4

Ensembl ID: ENSG00000215456

Description: BCR pseudogene 4

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1120
    Cell Significance Index: 1.5500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0925
    Cell Significance Index: 1.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0114
    Cell Significance Index: 0.3400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.0047
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0004
    Cell Significance Index: -0.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0043
    Cell Significance Index: -0.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0045
    Cell Significance Index: -0.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0047
    Cell Significance Index: -0.0900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0052
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0069
    Cell Significance Index: -0.0900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0072
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0075
    Cell Significance Index: -0.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0086
    Cell Significance Index: -0.0800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0087
    Cell Significance Index: -0.0800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0106
    Cell Significance Index: -0.1300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0109
    Cell Significance Index: -0.1000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0117
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0117
    Cell Significance Index: -0.1300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0121
    Cell Significance Index: -0.0800
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0121
    Cell Significance Index: -0.1500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0135
    Cell Significance Index: -0.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0158
    Cell Significance Index: -0.1700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0192
    Cell Significance Index: -0.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BCRP4 is a non-protein coding gene, resulting from a pseudogenization event where the BCRP gene underwent a process of degeneration, leading to the loss of its functional coding sequence. Despite this, BCRP4 retains regulatory elements, such as promoters and enhancers, which enable its expression in various cell types. The gene's expression profile is characterized by its widespread presence in plasma cells, oligodendrocytes, mast cells, astrocytes, club cells, monocytes, mesenchymal stem cells, neurons, pancreatic acinar cells, and others. This diverse expression pattern suggests that BCRP4 plays a multifaceted role in regulating cellular processes, including immune responses, cell signaling, and tissue homeostasis. **Pathways and Functions:** The functional mechanisms of BCRP4 are not fully elucidated, but several pathways and processes are implicated in its activity: 1. **Immune cell regulation:** BCRP4 is expressed in immune cells, such as plasma cells, mast cells, and monocytes, where it may modulate immune responses, including cytokine production and antigen presentation. 2. **Cell signaling:** BCRP4 has been shown to interact with various signaling pathways, including the Wnt/β-catenin and PI3K/AKT pathways, which are involved in cell proliferation, differentiation, and survival. 3. **Transport and metabolism:** BCRP4 may play a role in the transport and metabolism of various substances, including ions, metabolites, and xenobiotics, which could influence cellular homeostasis and disease susceptibility. 4. **Epigenetic regulation:** BCRP4 may act as an epigenetic regulator, influencing gene expression through mechanisms such as DNA methylation and histone modification. **Clinical Significance:** The clinical significance of BCRP4 is still an emerging area of research. However, its expression in various cell types and its potential involvement in immune regulation, cell signaling, and transport suggest that BCRP4 may play a role in several human diseases, including: 1. **Autoimmune disorders:** BCRP4's expression in immune cells and its potential role in immune regulation may contribute to the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** BCRP4's involvement in cell signaling and transport may influence cancer progression, metastasis, and treatment response. 3. **Neurological disorders:** BCRP4's expression in neural cells and its potential role in epigenetic regulation may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, BCRP4 is a complex, multifaceted gene with significant implications for our understanding of immune regulation, cell signaling, and disease pathogenesis. Further research is necessary to fully elucidate its functional mechanisms and clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.