Details for: BDH1

Gene ID: 622

Symbol: BDH1

Ensembl ID: ENSG00000161267

Description: 3-hydroxybutyrate dehydrogenase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 123.6296
    Cell Significance Index: -19.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 77.0767
    Cell Significance Index: -19.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.3161
    Cell Significance Index: -20.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.9914
    Cell Significance Index: -23.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.0476
    Cell Significance Index: -20.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.8757
    Cell Significance Index: -22.0400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 10.6198
    Cell Significance Index: 13.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.5596
    Cell Significance Index: -22.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7044
    Cell Significance Index: -22.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 4.3615
    Cell Significance Index: 64.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.6850
    Cell Significance Index: 121.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9484
    Cell Significance Index: 390.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9265
    Cell Significance Index: 382.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8045
    Cell Significance Index: 51.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6037
    Cell Significance Index: 174.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3730
    Cell Significance Index: 60.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.3437
    Cell Significance Index: 22.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3377
    Cell Significance Index: 50.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1980
    Cell Significance Index: 429.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1510
    Cell Significance Index: 187.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1399
    Cell Significance Index: 17.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1000
    Cell Significance Index: 69.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0861
    Cell Significance Index: 56.4200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.9625
    Cell Significance Index: 2.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9064
    Cell Significance Index: 25.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8809
    Cell Significance Index: 22.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8349
    Cell Significance Index: 57.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6559
    Cell Significance Index: 30.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6471
    Cell Significance Index: 584.3100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6208
    Cell Significance Index: 7.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5647
    Cell Significance Index: 107.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5424
    Cell Significance Index: 7.4000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.5373
    Cell Significance Index: 5.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4730
    Cell Significance Index: 15.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4306
    Cell Significance Index: 3.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4158
    Cell Significance Index: 41.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3943
    Cell Significance Index: 71.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3903
    Cell Significance Index: 56.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3776
    Cell Significance Index: 13.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3465
    Cell Significance Index: 4.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3085
    Cell Significance Index: 6.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2643
    Cell Significance Index: 182.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2506
    Cell Significance Index: 19.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1836
    Cell Significance Index: 10.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1752
    Cell Significance Index: 95.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1342
    Cell Significance Index: 16.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1231
    Cell Significance Index: 2.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1125
    Cell Significance Index: 3.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0869
    Cell Significance Index: 1.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0826
    Cell Significance Index: 1.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0816
    Cell Significance Index: 36.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0658
    Cell Significance Index: 4.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0590
    Cell Significance Index: 111.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0578
    Cell Significance Index: 3.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0363
    Cell Significance Index: 23.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0221
    Cell Significance Index: 2.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0090
    Cell Significance Index: 13.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0061
    Cell Significance Index: 11.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0017
    Cell Significance Index: 1.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0122
    Cell Significance Index: -16.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0201
    Cell Significance Index: -15.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0239
    Cell Significance Index: -1.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0245
    Cell Significance Index: -1.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0304
    Cell Significance Index: -17.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0419
    Cell Significance Index: -0.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0422
    Cell Significance Index: -5.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0429
    Cell Significance Index: -5.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0433
    Cell Significance Index: -7.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0594
    Cell Significance Index: -17.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0750
    Cell Significance Index: -9.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0759
    Cell Significance Index: -8.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0857
    Cell Significance Index: -1.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0864
    Cell Significance Index: -6.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0944
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1087
    Cell Significance Index: -22.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1233
    Cell Significance Index: -12.6000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1243
    Cell Significance Index: -1.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1285
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1355
    Cell Significance Index: -15.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1466
    Cell Significance Index: -2.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1748
    Cell Significance Index: -3.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1862
    Cell Significance Index: -19.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2068
    Cell Significance Index: -4.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2142
    Cell Significance Index: -6.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2186
    Cell Significance Index: -13.4000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2211
    Cell Significance Index: -2.7900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2261
    Cell Significance Index: -9.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2268
    Cell Significance Index: -4.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2297
    Cell Significance Index: -18.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2323
    Cell Significance Index: -7.4000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2701
    Cell Significance Index: -4.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2767
    Cell Significance Index: -5.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2813
    Cell Significance Index: -9.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3103
    Cell Significance Index: -7.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3294
    Cell Significance Index: -11.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3586
    Cell Significance Index: -7.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3772
    Cell Significance Index: -19.6500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3985
    Cell Significance Index: -6.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The BDH1 gene is a single-codon gene that encodes a protein belonging to the short chain dehydrogenase/reductase family. The BDH1 protein is a mitochondrial matrix enzyme that catalyzes the conversion of 3-hydroxybutyrate to acetoacetate. This reaction is a critical step in the ketone body metabolism pathway, which is essential for energy production in cells. The BDH1 protein is a member of the NAD+-dependent dehydrogenase family, which is characterized by its ability to transfer electrons from NAD+ to an electron acceptor. **Pathways and Functions** BDH1 is involved in several metabolic pathways, including: 1. **Ketone body metabolism**: BDH1 is a key enzyme in the conversion of 3-hydroxybutyrate to acetoacetate, which is a critical step in the ketone body metabolism pathway. 2. **Lipid metabolism**: BDH1 is involved in the breakdown of fatty acids, which is essential for energy production in cells. 3. **Protein synthesis**: BDH1 is required for the synthesis of certain amino acids, such as leucine, which is an important energy source for cells. 4. **Mitochondrial protein degradation**: BDH1 is involved in the regulation of mitochondrial protein degradation, which is essential for maintaining cellular homeostasis. **Clinical Significance** Dysregulation of BDH1 has been implicated in various diseases, including: 1. **Diabetes**: BDH1 is involved in the regulation of glucose metabolism, and its dysregulation can contribute to the development of diabetes. 2. **Neurodegenerative diseases**: BDH1 is involved in the regulation of energy metabolism in neurons, and its dysregulation can contribute to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: BDH1 is involved in the regulation of energy metabolism in cancer cells, and its dysregulation can contribute to the development and progression of cancer. In conclusion, the BDH1 gene plays a crucial role in various metabolic pathways, including ketone body metabolism, lipid metabolism, and protein synthesis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the regulation of BDH1 in maintaining cellular homeostasis. Further research is needed to elucidate the mechanisms by which BDH1 regulates metabolic pathways and its implications for human health.

Genular Protein ID: 2789983625

Symbol: BDH_HUMAN

Name: Short chain dehydrogenase/reductase family 9C member 1

UniProtKB Accession Codes:

Q02338 D3DXC0 Q96ET1 Q9BRZ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1639787

Title: Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart.

PubMed ID: 1639787

DOI: 10.1016/s0021-9258(19)49556-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 343
  • Mass: 38157
  • Checksum: B8AA1148111ACA8F
  • Sequence:
    • MLATRLSRPL SRLPGKTLSA CDRENGARRP LLLGSTSFIP IGRRTYASAA EPVGSKAVLV 
TGCDSGFGFS LAKHLHSKGF LVFAGCLMKD KGHDGVKELD SLNSDRLRTV QLNVCSSEEV 
EKVVEIVRSS LKDPEKGMWG LVNNAGISTF GEVEFTSLET YKQVAEVNLW GTVRMTKSFL 
PLIRRAKGRV VNISSMLGRM ANPARSPYCI TKFGVEAFSD CLRYEMYPLG VKVSVVEPGN 
FIAATSLYSP ESIQAIAKKM WEELPEVVRK DYGKKYFDEK IAKMETYCSS GSTDTSPVID 
AVTHALTATT PYTRYHPMDY YWWLRMQIMT HLPGAISDMI YIR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.