Details for: BDKRB1

Gene ID: 623

Symbol: BDKRB1

Ensembl ID: ENSG00000100739

Description: bradykinin receptor B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 11.9675
    Cell Significance Index: -4.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.8961
    Cell Significance Index: 83.0200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.7350
    Cell Significance Index: 5.1600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.5907
    Cell Significance Index: 25.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2955
    Cell Significance Index: 79.4300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.1791
    Cell Significance Index: 13.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6302
    Cell Significance Index: 15.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4589
    Cell Significance Index: 8.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3564
    Cell Significance Index: 67.8300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3028
    Cell Significance Index: 4.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2234
    Cell Significance Index: 22.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2060
    Cell Significance Index: 185.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1111
    Cell Significance Index: 18.0700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0822
    Cell Significance Index: 0.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0799
    Cell Significance Index: 8.6900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0797
    Cell Significance Index: 1.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0453
    Cell Significance Index: 2.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0327
    Cell Significance Index: 2.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0180
    Cell Significance Index: 0.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0155
    Cell Significance Index: 0.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0044
    Cell Significance Index: 1.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0026
    Cell Significance Index: -0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0028
    Cell Significance Index: -2.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0052
    Cell Significance Index: -0.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0055
    Cell Significance Index: -3.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0082
    Cell Significance Index: -0.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0084
    Cell Significance Index: -5.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0090
    Cell Significance Index: -0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0109
    Cell Significance Index: -2.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0116
    Cell Significance Index: -2.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0124
    Cell Significance Index: -4.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0125
    Cell Significance Index: -1.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0136
    Cell Significance Index: -1.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0153
    Cell Significance Index: -1.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0188
    Cell Significance Index: -5.4200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0221
    Cell Significance Index: -0.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0237
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0239
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0258
    Cell Significance Index: -4.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0268
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0270
    Cell Significance Index: -5.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0353
    Cell Significance Index: -4.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0365
    Cell Significance Index: -5.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0365
    Cell Significance Index: -4.7100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0386
    Cell Significance Index: -0.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0390
    Cell Significance Index: -2.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0461
    Cell Significance Index: -2.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0619
    Cell Significance Index: -4.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0634
    Cell Significance Index: -0.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0645
    Cell Significance Index: -4.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0710
    Cell Significance Index: -1.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0787
    Cell Significance Index: -6.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0792
    Cell Significance Index: -1.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0815
    Cell Significance Index: -2.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0832
    Cell Significance Index: -3.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0846
    Cell Significance Index: -5.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0899
    Cell Significance Index: -1.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0900
    Cell Significance Index: -2.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0902
    Cell Significance Index: -2.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0911
    Cell Significance Index: -5.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0932
    Cell Significance Index: -3.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0947
    Cell Significance Index: -4.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1048
    Cell Significance Index: -5.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1095
    Cell Significance Index: -6.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1099
    Cell Significance Index: -5.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1116
    Cell Significance Index: -3.9100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1119
    Cell Significance Index: -1.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1161
    Cell Significance Index: -3.1000
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1231
    Cell Significance Index: -1.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1320
    Cell Significance Index: -5.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1366
    Cell Significance Index: -2.8600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1381
    Cell Significance Index: -3.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1395
    Cell Significance Index: -2.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1578
    Cell Significance Index: -3.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1580
    Cell Significance Index: -5.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1582
    Cell Significance Index: -5.9900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1597
    Cell Significance Index: -1.7500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1618
    Cell Significance Index: -2.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1622
    Cell Significance Index: -5.3100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1700
    Cell Significance Index: -1.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1706
    Cell Significance Index: -5.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1739
    Cell Significance Index: -2.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1788
    Cell Significance Index: -2.5600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1788
    Cell Significance Index: -2.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1858
    Cell Significance Index: -2.0200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1879
    Cell Significance Index: -3.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1913
    Cell Significance Index: -5.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1966
    Cell Significance Index: -5.6100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1990
    Cell Significance Index: -4.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1997
    Cell Significance Index: -5.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2003
    Cell Significance Index: -5.0000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2011
    Cell Significance Index: -2.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor structure:** BDKRB1 is a GPCR that belongs to the class A/1 rhodopsin-like receptors. It is characterized by a unique structure that includes seven transmembrane domains and an intracellular domain that interacts with G proteins. 2. **Activation by bradykinin:** BDKRB1 is activated by bradykinin, a peptide that is released in response to inflammation and tissue damage. The activation of BDKRB1 triggers a signaling cascade that leads to the regulation of various cellular processes. 3. **Expression in different tissues:** BDKRB1 is expressed in various tissues, including the colon, mammary gland, and small intestine, where it is involved in the regulation of inflammation, cell growth, and calcium ion concentration. 4. **Signaling pathways:** BDKRB1 activates various signaling pathways, including Gα(i) and Gα(q) signaling events, which lead to the regulation of cell migration, inflammation, and blood pressure. **Pathways and Functions:** 1. **Inflammatory response:** BDKRB1 plays a crucial role in the regulation of the inflammatory response by activating signaling pathways that lead to the production of pro-inflammatory cytokines and chemokines. 2. **Cell migration:** BDKRB1 is involved in the regulation of cell migration by activating signaling pathways that lead to the activation of integrins and the regulation of cytoskeletal dynamics. 3. **Blood pressure regulation:** BDKRB1 is involved in the regulation of blood pressure by activating signaling pathways that lead to the relaxation of smooth muscle cells and the dilation of blood vessels. 4. **Cell growth and differentiation:** BDKRB1 is involved in the regulation of cell growth and differentiation by activating signaling pathways that lead to the activation of transcription factors and the regulation of gene expression. 5. **Calcium ion concentration:** BDKRB1 is involved in the regulation of calcium ion concentration by activating signaling pathways that lead to the release of sequestered calcium ions into the cytosol. **Clinical Significance:** 1. **Inflammatory disorders:** BDKRB1 has been implicated in the pathogenesis of various inflammatory disorders, including arthritis, asthma, and allergies. 2. **Cardiovascular disease:** BDKRB1 has been implicated in the regulation of blood pressure and the development of cardiovascular disease. 3. **Cancer:** BDKRB1 has been implicated in the regulation of cell growth and differentiation, and its dysregulation has been associated with the development of cancer. 4. **Neurological disorders:** BDKRB1 has been implicated in the regulation of neuronal function and the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the BDKRB1 gene plays a crucial role in the regulation of various physiological and pathological processes, including inflammation, cell migration, and blood pressure regulation. Its dysregulation has been implicated in the development of various diseases, including inflammatory disorders, cardiovascular disease, cancer, and neurological disorders. Further research is needed to fully understand the complexities of BDKRB1 and its role in human disease.

Genular Protein ID: 3829210543

Symbol: BKRB1_HUMAN

Name: B1 bradykinin receptor

UniProtKB Accession Codes:

P46663 A8K7F5 Q546S7 Q8N0Y8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8063797

Title: Expression cloning of a human B1 bradykinin receptor.

PubMed ID: 8063797

DOI: 10.1016/s0021-9258(17)31844-6

PubMed ID: 8651911

Title: Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions.

PubMed ID: 8651911

DOI: 10.1006/bbrc.1996.0810

PubMed ID: 8660997

Title: Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1).

PubMed ID: 8660997

DOI: 10.1006/geno.1996.0213

PubMed ID: 10422787

Title: Molecular characterisation of cloned bradykinin B1 receptors from rat and human.

PubMed ID: 10422787

DOI: 10.1016/s0014-2999(99)00315-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 353
  • Mass: 40495
  • Checksum: B62B0690A7593077
  • Sequence:
    • MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF GLLGNLFVLL 
VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ FNWPFGALLC RVINGVIKAN 
LFISIFLVVA ISQDRYRVLV HPMASRRQQR RRQARVTCVL IWVVGGLLSI PTFLLRSIQA 
VPDLNITACI LLLPHEAWHF ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC 
GGRKDSKTTA LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF 
AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF WRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.