Details for: BDKRB1

Gene ID: 623

Symbol: BDKRB1

Ensembl ID: ENSG00000100739

Description: bradykinin receptor B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.42
    Marker Score: 48436
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.31
    Marker Score: 1303
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.16
    Marker Score: 2201.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4815
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251809
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 380.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.9
    Marker Score: 414
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.77
    Marker Score: 645
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 358
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.55
    Marker Score: 185
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1107
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.51
    Marker Score: 211
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7815
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.49
    Marker Score: 325
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.48
    Marker Score: 171
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.47
    Marker Score: 4088
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.45
    Marker Score: 762
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.4
    Marker Score: 385
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.39
    Marker Score: 126
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.33
    Marker Score: 83
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 199
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.33
    Marker Score: 83
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.33
    Marker Score: 471
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.3
    Marker Score: 2342
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.29
    Marker Score: 115
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.27
    Marker Score: 125.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.25
    Marker Score: 1087
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.25
    Marker Score: 240
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 117
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.22
    Marker Score: 86
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.2
    Marker Score: 174
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.2
    Marker Score: 114
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 115
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.19
    Marker Score: 224
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.19
    Marker Score: 211
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.17
    Marker Score: 349
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.15
    Marker Score: 94
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.15
    Marker Score: 73
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.15
    Marker Score: 153
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.14
    Marker Score: 71
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.13
    Marker Score: 30
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.13
    Marker Score: 346
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.13
    Marker Score: 373
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.13
    Marker Score: 235
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.13
    Marker Score: 345
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.13
    Marker Score: 49
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.12
    Marker Score: 153
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.12
    Marker Score: 129
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.11
    Marker Score: 114
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.11
    Marker Score: 1010
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.11
    Marker Score: 94
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.1
    Marker Score: 106
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 321
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1
    Marker Score: 89
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.1
    Marker Score: 233
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.1
    Marker Score: 134
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.1
    Marker Score: 150
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.09
    Marker Score: 93
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.09
    Marker Score: 150.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.09
    Marker Score: 139
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.09
    Marker Score: 321

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Other Information

**Key characteristics:** - BDKRB1 is a transmembrane protein that is composed of 14 extracellular domains and 3 intracellular domains. - It is a member of the bradykinin receptor family of G protein-coupled receptors. - BDKRB1 is a type I receptor, which means that it is a receptor that is activated by the binding of a ligand to its extracellular domain. - BDKRB1 is expressed in high levels in epithelial cells, where it is involved in cell migration and adhesion. - It is also expressed in immune cells, where it is involved in inflammation and immune responses. **Pathways and functions:** - BDKRB1 is a key regulator of cell migration. It is expressed in high levels in epithelial cells, where it is involved in the migration of epithelial cells. - When BDKRB1 is activated by a ligand, it translocates to the cell membrane and undergoes a conformational change that allows it to interact with the G protein. - The activation of BDKRB1 by the G protein leads to the activation of downstream signalling pathways, which include the activation of protein kinase c. - Protein kinase c is a key regulator of cell migration, and its activation by BDKRB1 is essential for the migration of epithelial cells. **Clinical significance:** - BDKRB1 is a potential target for the treatment of cancer. When BDKRB1 is overexpressed in cancer cells, it can promote cell migration and invasion. - Blockade of BDKRB1 with antibodies or small molecules can inhibit cancer cell migration and growth. - Targeting BDKRB1 could be a promising strategy for the treatment of cancer.

Genular Protein ID: 3829210543

Symbol: BKRB1_HUMAN

Name: B1 bradykinin receptor

UniProtKB Accession Codes:

P46663 A8K7F5 Q546S7 Q8N0Y8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8063797

Title: Expression cloning of a human B1 bradykinin receptor.

PubMed ID: 8063797

DOI: 10.1016/s0021-9258(17)31844-6

PubMed ID: 8651911

Title: Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions.

PubMed ID: 8651911

DOI: 10.1006/bbrc.1996.0810

PubMed ID: 8660997

Title: Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1).

PubMed ID: 8660997

DOI: 10.1006/geno.1996.0213

PubMed ID: 10422787

Title: Molecular characterisation of cloned bradykinin B1 receptors from rat and human.

PubMed ID: 10422787

DOI: 10.1016/s0014-2999(99)00315-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 353
  • Mass: 40495
  • Checksum: B62B0690A7593077
  • Sequence:
    • MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF GLLGNLFVLL 
VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ FNWPFGALLC RVINGVIKAN 
LFISIFLVVA ISQDRYRVLV HPMASRRQQR RRQARVTCVL IWVVGGLLSI PTFLLRSIQA 
VPDLNITACI LLLPHEAWHF ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC 
GGRKDSKTTA LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF 
AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF WRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.