Details for: BDKRB2

Gene ID: 624

Symbol: BDKRB2

Ensembl ID: ENSG00000168398

Description: bradykinin receptor B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 16.6059
    Cell Significance Index: -7.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.7249
    Cell Significance Index: -8.3300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 4.6308
    Cell Significance Index: 74.4600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8123
    Cell Significance Index: 19.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7342
    Cell Significance Index: 139.7200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.6802
    Cell Significance Index: 10.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5000
    Cell Significance Index: 25.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4225
    Cell Significance Index: 12.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3506
    Cell Significance Index: 316.5900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3393
    Cell Significance Index: 3.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3139
    Cell Significance Index: 6.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2699
    Cell Significance Index: 4.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2166
    Cell Significance Index: 21.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2142
    Cell Significance Index: 12.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2107
    Cell Significance Index: 22.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2047
    Cell Significance Index: 33.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1961
    Cell Significance Index: 2.0300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1949
    Cell Significance Index: 1.4000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1841
    Cell Significance Index: 2.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1679
    Cell Significance Index: 7.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1555
    Cell Significance Index: 28.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1454
    Cell Significance Index: 4.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1408
    Cell Significance Index: 2.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1326
    Cell Significance Index: 9.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1190
    Cell Significance Index: 4.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1004
    Cell Significance Index: 5.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0915
    Cell Significance Index: 1.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0692
    Cell Significance Index: 13.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0603
    Cell Significance Index: 7.4200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0603
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0567
    Cell Significance Index: 6.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0554
    Cell Significance Index: 19.8600
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 0.0484
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0260
    Cell Significance Index: 4.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0218
    Cell Significance Index: 15.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0102
    Cell Significance Index: 0.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0028
    Cell Significance Index: 0.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0022
    Cell Significance Index: -1.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0025
    Cell Significance Index: -0.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0030
    Cell Significance Index: -1.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0126
    Cell Significance Index: -5.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0139
    Cell Significance Index: -2.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0176
    Cell Significance Index: -1.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0178
    Cell Significance Index: -0.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0217
    Cell Significance Index: -1.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0248
    Cell Significance Index: -0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0320
    Cell Significance Index: -9.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0388
    Cell Significance Index: -4.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0398
    Cell Significance Index: -4.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0419
    Cell Significance Index: -8.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0509
    Cell Significance Index: -5.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0588
    Cell Significance Index: -1.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0681
    Cell Significance Index: -8.8000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0768
    Cell Significance Index: -0.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0826
    Cell Significance Index: -2.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0841
    Cell Significance Index: -9.9200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0892
    Cell Significance Index: -0.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0943
    Cell Significance Index: -7.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1008
    Cell Significance Index: -3.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1014
    Cell Significance Index: -8.0300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1021
    Cell Significance Index: -0.9200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1028
    Cell Significance Index: -4.4700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1033
    Cell Significance Index: -1.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1082
    Cell Significance Index: -8.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1245
    Cell Significance Index: -4.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1346
    Cell Significance Index: -8.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1433
    Cell Significance Index: -2.1600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1437
    Cell Significance Index: -1.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1457
    Cell Significance Index: -3.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1531
    Cell Significance Index: -7.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1556
    Cell Significance Index: -8.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1619
    Cell Significance Index: -7.6100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1772
    Cell Significance Index: -4.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1773
    Cell Significance Index: -9.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1804
    Cell Significance Index: -7.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1894
    Cell Significance Index: -3.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1989
    Cell Significance Index: -7.3000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2022
    Cell Significance Index: -4.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2099
    Cell Significance Index: -7.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2129
    Cell Significance Index: -6.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2163
    Cell Significance Index: -6.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2172
    Cell Significance Index: -3.1100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2191
    Cell Significance Index: -3.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2609
    Cell Significance Index: -6.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2742
    Cell Significance Index: -9.5300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2754
    Cell Significance Index: -6.8700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2813
    Cell Significance Index: -2.5900
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.2910
    Cell Significance Index: -3.0800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2919
    Cell Significance Index: -4.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2925
    Cell Significance Index: -7.8300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3037
    Cell Significance Index: -4.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3084
    Cell Significance Index: -8.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3116
    Cell Significance Index: -7.9400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3136
    Cell Significance Index: -5.3600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3148
    Cell Significance Index: -4.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3198
    Cell Significance Index: -9.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3204
    Cell Significance Index: -6.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: The B2 receptor is a type II transmembrane receptor, consisting of seven transmembrane alpha-helices and an intracellular C-terminal tail. The extracellular N-terminal domain contains the binding site for bradykinin. 2. **Expression**: The B2 receptor is widely expressed in various cell types, including cardiac endothelial cells, renal alpha-intercalated cells, and GABAergic interneurons in the cerebral cortex. 3. **Function**: The B2 receptor is a Gq-protein coupled receptor, which activates phospholipase C (PLC) upon ligand binding. This activation leads to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG), resulting in increased intracellular calcium levels and smooth muscle contraction. 4. **Signaling pathways**: The B2 receptor is involved in various signaling pathways, including the regulation of vascular permeability, vasoconstriction, and vasodilation. It also plays a role in the inflammatory response and innate immunity. **Pathways and Functions** 1. **Vascular regulation**: The B2 receptor is involved in the regulation of vascular tone, with bradykinin-induced activation leading to vasodilation and decreased blood pressure. 2. **Inflammation**: Bradykinin binding to the B2 receptor activates immune cells, such as neutrophils and macrophages, leading to the production of pro-inflammatory cytokines and chemokines. 3. **Smooth muscle contraction**: The B2 receptor is involved in the contraction of smooth muscle cells, particularly in the cardiovascular system. 4. **Cell proliferation and apoptosis**: The B2 receptor has been shown to regulate cell proliferation and apoptosis in various cell types, including cancer cells. 5. **Neurotransmission**: The B2 receptor is involved in the regulation of neurotransmitter release, particularly in the cerebral cortex. **Clinical Significance** 1. **Hypertension**: The B2 receptor plays a role in the regulation of blood pressure, and its dysregulation has been implicated in hypertension. 2. **Cardiovascular disease**: Bradykinin-induced activation of the B2 receptor has been shown to contribute to the development of cardiovascular disease, including heart failure and atherosclerosis. 3. **Inflammatory disorders**: The B2 receptor is involved in the regulation of inflammation, and its dysregulation has been implicated in various inflammatory disorders, including arthritis and asthma. 4. **Neurological disorders**: The B2 receptor has been implicated in the regulation of neurotransmitter release and synaptic plasticity, and its dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 5. **Cancer**: The B2 receptor has been shown to regulate cell proliferation and apoptosis in cancer cells, and its dysregulation has been implicated in various types of cancer. In conclusion, the BDKRB2 gene encodes for the bradykinin receptor B2, a G-protein coupled receptor involved in various physiological and pathological processes. Its dysregulation has been implicated in various diseases, including hypertension, cardiovascular disease, inflammatory disorders, neurological disorders, and cancer. Further research is needed to fully understand the role of the B2 receptor in human health and disease.

Genular Protein ID: 1199126099

Symbol: BKRB2_HUMAN

Name: B2 bradykinin receptor

UniProtKB Accession Codes:

P30411

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 11 EMDB 3 Ensembl 3 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1314587

Title: Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor.

PubMed ID: 1314587

DOI: 10.1016/0006-291x(92)91187-u

PubMed ID: 7916737

Title: Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14.

PubMed ID: 7916737

DOI: 10.1006/geno.1993.1084

PubMed ID: 8394991

Title: Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity.

PubMed ID: 8394991

PubMed ID: 1329734

Title: Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene.

PubMed ID: 1329734

DOI: 10.1016/0006-291x(92)90445-q

PubMed ID: 7835885

Title: Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor.

PubMed ID: 7835885

DOI: 10.1006/geno.1994.1512

PubMed ID: 7779090

Title: Identification of polymorphic sites of the human bradykinin B2 receptor gene.

PubMed ID: 7779090

DOI: 10.1006/bbrc.1995.1801

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8652530

Title: Structure of the bradykinin B2 receptors' amino terminus.

PubMed ID: 8652530

DOI: 10.1021/bi9601060

PubMed ID: 18672896

Title: Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.

PubMed ID: 18672896

DOI: 10.1021/bi8003846

PubMed ID: 11517230

Title: Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

PubMed ID: 11517230

DOI: 10.1074/jbc.m107024200

Sequence Information:

  • Length: 391
  • Mass: 44461
  • Checksum: 066940ED3D18BB66
  • Sequence:
    • MFSPWKISMF LSVREDSVPT TASFSADMLN VTLQGPTLNG TFAQSKCPQV EWLGWLNTIQ 
PPFLWVLFVL ATLENIFVLS VFCLHKSSCT VAEIYLGNLA AADLILACGL PFWAITISNN 
FDWLFGETLC RVVNAIISMN LYSSICFLML VSIDRYLALV KTMSMGRMRG VRWAKLYSLV 
IWGCTLLLSS PMLVFRTMKE YSDEGHNVTA CVISYPSLIW EVFTNMLLNV VGFLLPLSVI 
TFCTMQIMQV LRNNEMQKFK EIQTERRATV LVLVVLLLFI ICWLPFQIST FLDTLHRLGI 
LSSCQDERII DVITQIASFM AYSNSCLNPL VYVIVGKRFR KKSWEVYQGV CQKGGCRSEP 
IQMENSMGTL RTSISVERQI HKLQDWAGSR Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.