Details for: BDKRB2

Gene ID: 624

Symbol: BDKRB2

Ensembl ID: ENSG00000168398

Description: bradykinin receptor B2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 3.58
    Marker Score: 1390.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 860
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.04
    Marker Score: 1964.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.01
    Marker Score: 532
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.94
    Marker Score: 392
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5305
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.87
    Marker Score: 216
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.86
    Marker Score: 216
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.81
    Marker Score: 843.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.76
    Marker Score: 3299
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.74
    Marker Score: 214.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 669
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1485
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 552
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.71
    Marker Score: 223
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.68
    Marker Score: 4102
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.65
    Marker Score: 433
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10107
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.62
    Marker Score: 894
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.61
    Marker Score: 1632
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.59
    Marker Score: 6680.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.58
    Marker Score: 329
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.57
    Marker Score: 19468
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 377
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.54
    Marker Score: 914
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.53
    Marker Score: 153
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.52
    Marker Score: 133
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 305
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.5
    Marker Score: 248
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.48
    Marker Score: 115
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 189
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 254
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.44
    Marker Score: 109
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.43
    Marker Score: 363
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.43
    Marker Score: 296
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.42
    Marker Score: 95
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.41
    Marker Score: 190
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.4
    Marker Score: 624
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.4
    Marker Score: 3421
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 367.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.37
    Marker Score: 135
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 366
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.36
    Marker Score: 321
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.35
    Marker Score: 430
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.34
    Marker Score: 402
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.34
    Marker Score: 2678
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.34
    Marker Score: 133
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.34
    Marker Score: 286
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.33
    Marker Score: 339
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.33
    Marker Score: 255
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 292
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.32
    Marker Score: 795
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.31
    Marker Score: 1081
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.3
    Marker Score: 2636
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.29
    Marker Score: 270
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.28
    Marker Score: 328
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.27
    Marker Score: 245
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.27
    Marker Score: 116
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.26
    Marker Score: 253
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.26
    Marker Score: 167.5
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.25
    Marker Score: 57
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.25
    Marker Score: 777
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.24
    Marker Score: 336
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.24
    Marker Score: 115
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.24
    Marker Score: 100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.24
    Marker Score: 439.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.23
    Marker Score: 433
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.23
    Marker Score: 59
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.22
    Marker Score: 235
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.22
    Marker Score: 108
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.22
    Marker Score: 615
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.21
    Marker Score: 145
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 123
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 125
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.21
    Marker Score: 441
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.2
    Marker Score: 42

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Other Information

**Key characteristics:** * BDKRB2 is a type a/1 rhodopsin-like receptor. * It is a transmembrane protein that is expressed on the cell surface. * It is a G protein-coupled receptor. * It is significantly expressed in cells that are involved in inflammation and smooth muscle contraction. **Pathways and functions:** * BDKRB2 is a key regulator of inflammation. It is expressed in cells that are activated by inflammatory stimuli, and it is thought to play a role in the regulation of inflammation-related diseases. * It is also involved in smooth muscle contraction. * It is a potential therapeutic target for inflammatory diseases. **Clinical significance:** * BDKRB2 is a potential therapeutic target for inflammatory diseases. * It is expressed in cells that are activated by inflammatory stimuli, and it is thought to play a role in the regulation of inflammation-related diseases. * It is a potential therapeutic target for conditions such as rheumatoid arthritis, asthma, and inflammatory bowel disease.

Genular Protein ID: 1199126099

Symbol: BKRB2_HUMAN

Name: B2 bradykinin receptor

UniProtKB Accession Codes:

P30411

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 11 EMDB 3 Ensembl 3 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1314587

Title: Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor.

PubMed ID: 1314587

DOI: 10.1016/0006-291x(92)91187-u

PubMed ID: 7916737

Title: Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14.

PubMed ID: 7916737

DOI: 10.1006/geno.1993.1084

PubMed ID: 8394991

Title: Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity.

PubMed ID: 8394991

PubMed ID: 1329734

Title: Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene.

PubMed ID: 1329734

DOI: 10.1016/0006-291x(92)90445-q

PubMed ID: 7835885

Title: Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor.

PubMed ID: 7835885

DOI: 10.1006/geno.1994.1512

PubMed ID: 7779090

Title: Identification of polymorphic sites of the human bradykinin B2 receptor gene.

PubMed ID: 7779090

DOI: 10.1006/bbrc.1995.1801

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8652530

Title: Structure of the bradykinin B2 receptors' amino terminus.

PubMed ID: 8652530

DOI: 10.1021/bi9601060

PubMed ID: 18672896

Title: Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.

PubMed ID: 18672896

DOI: 10.1021/bi8003846

PubMed ID: 11517230

Title: Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

PubMed ID: 11517230

DOI: 10.1074/jbc.m107024200

Sequence Information:

  • Length: 391
  • Mass: 44461
  • Checksum: 066940ED3D18BB66
  • Sequence:
    • MFSPWKISMF LSVREDSVPT TASFSADMLN VTLQGPTLNG TFAQSKCPQV EWLGWLNTIQ 
PPFLWVLFVL ATLENIFVLS VFCLHKSSCT VAEIYLGNLA AADLILACGL PFWAITISNN 
FDWLFGETLC RVVNAIISMN LYSSICFLML VSIDRYLALV KTMSMGRMRG VRWAKLYSLV 
IWGCTLLLSS PMLVFRTMKE YSDEGHNVTA CVISYPSLIW EVFTNMLLNV VGFLLPLSVI 
TFCTMQIMQV LRNNEMQKFK EIQTERRATV LVLVVLLLFI ICWLPFQIST FLDTLHRLGI 
LSSCQDERII DVITQIASFM AYSNSCLNPL VYVIVGKRFR KKSWEVYQGV CQKGGCRSEP 
IQMENSMGTL RTSISVERQI HKLQDWAGSR Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.