BDNF | ENSG00000176697 | NCBI 627

Details for: BDNF

Gene ID: 627

Symbol: BDNF

Ensembl ID: ENSG00000176697

Description: brain derived neurotrophic factor

Associated with

Activated ntrk2 signals through cdk5
(R-HSA-9032845)
Activated ntrk2 signals through frs2 and frs3
(R-HSA-9028731)
Activated ntrk2 signals through fyn
(R-HSA-9032500)
Activated ntrk2 signals through pi3k
(R-HSA-9028335)
Activated ntrk2 signals through plcg1
(R-HSA-9026527)
Activated ntrk2 signals through ras
(R-HSA-9026519)
Bdnf activates ntrk2 (trkb) signaling
(R-HSA-9024909)
Disease
(R-HSA-1643685)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Loss of function of mecp2 in rett syndrome
(R-HSA-9005891)
Loss of mecp2 binding ability to 5mc-dna
(R-HSA-9022538)
Mecp2 regulates transcription of neuronal ligands
(R-HSA-9022702)
Npas4 regulates expression of target genes
(R-HSA-9768919)
Ntrk2 activates rac1
(R-HSA-9032759)
Pervasive developmental disorders
(R-HSA-9005895)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by npas4
(R-HSA-9634815)
Axon
(GO:0030424)
Axon guidance
(GO:0007411)
Brain-derived neurotrophic factor receptor signaling pathway
(GO:0031547)
Collateral sprouting
(GO:0048668)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Memory
(GO:0007613)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of myotube differentiation
(GO:0010832)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nerve development
(GO:0021675)
Nerve growth factor receptor binding
(GO:0005163)
Nerve growth factor signaling pathway
(GO:0038180)
Nervous system development
(GO:0007399)
Neuron projection morphogenesis
(GO:0048812)
Perinuclear region of cytoplasm
(GO:0048471)
Peripheral nervous system development
(GO:0007422)
Positive regulation of brain-derived neurotrophic factor receptor signaling pathway
(GO:0031550)
Positive regulation of collateral sprouting
(GO:0048672)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of receptor binding
(GO:1900122)
Positive regulation of synapse assembly
(GO:0051965)
Protein binding
(GO:0005515)
Regulation of neuron differentiation
(GO:0045664)
Regulation of protein localization to cell surface
(GO:2000008)
Synapse assembly
(GO:0007416)
Synaptic vesicle
(GO:0008021)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Brain-derived neurotrophic factor

Genular Protein ID: 3624270972

Symbol: BDNF_HUMAN

Name: Brain-derived neurotrophic factor

UniProtKB Accession Codes:

P23560 A7LA85 A7LA92 D3DQZ2 Q598Q1 Q6DN19 Q6YNR2 Q6YNR3 Q9BYY7 Q9UC24

Database IDs:

Citations:

PubMed ID: 2236018

Title: Molecular cloning of a human gene that is a member of the nerve growth factor family.

PubMed ID: 2236018

DOI: 10.1073/pnas.87.20.8060

PubMed ID: 1889806

Title: Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.

PubMed ID: 1889806

DOI: 10.1016/0888-7543(91)90436-i

PubMed ID: 1339267

Title: Characterization of the 5'-flanking region of the human brain-derived neurotrophic factor gene.

PubMed ID: 1339267

DOI: 10.1016/s0006-291x(05)80148-2

PubMed ID: 15666411

Title: Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease.

PubMed ID: 15666411

DOI: 10.1002/ajmg.b.30109

PubMed ID: 17629449

Title: Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters.

PubMed ID: 17629449

DOI: 10.1016/j.ygeno.2007.05.004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2025430

Title: Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.

PubMed ID: 2025430

DOI: 10.1016/0896-6273(91)90180-8

PubMed ID: 8527932

Title: Purification and identification of brain-derived neurotrophic factor from human serum.

PubMed ID: 8527932

DOI: 10.1006/prep.1995.1062

PubMed ID: 11214319

Title: Molecular phylogenetics and the origins of placental mammals.

PubMed ID: 11214319

DOI: 10.1038/35054550

PubMed ID: 11152678

Title: Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor.

PubMed ID: 11152678

DOI: 10.1074/jbc.m008104200

PubMed ID: 19467646

Title: Identification of pro- and mature brain-derived neurotrophic factor in human saliva.

PubMed ID: 19467646

DOI: 10.1016/j.archoralbio.2009.04.005

PubMed ID: 24908487

Title: SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

PubMed ID: 24908487

DOI: 10.1016/j.neuron.2014.04.022

PubMed ID: 7703225

Title: Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.

PubMed ID: 7703225

DOI: 10.1021/bi00013a001

PubMed ID: 10631974

Title: The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.

PubMed ID: 10631974

DOI: 10.1110/ps.8.12.2589

PubMed ID: 15115760

Title: Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations.

PubMed ID: 15115760

DOI: 10.1093/hmg/ddh137

PubMed ID: 18753648

Title: Brain-derived neurotrophic factor and obesity in the WAGR syndrome.

PubMed ID: 18753648

DOI: 10.1056/nejmoa0801119

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 11840487

Title: Idiopathic congenital central hypoventilation syndrome: evaluation of brain-derived neurotrophic factor genomic DNA sequence variation.

PubMed ID: 11840487

DOI: 10.1002/ajmg.10133

PubMed ID: 12836135

Title: Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder.

PubMed ID: 12836135

DOI: 10.1086/377003

PubMed ID: 12553913

Title: The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.

PubMed ID: 12553913

DOI: 10.1016/s0092-8674(03)00035-7

PubMed ID: 14566559

Title: Molecular analysis of congenital central hypoventilation syndrome.

PubMed ID: 14566559

DOI: 10.1007/s00439-003-1036-z

PubMed ID: 12888803

Title: Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type.

PubMed ID: 12888803

DOI: 10.1038/sj.mp.4001281

PubMed ID: 28397838

Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PubMed ID: 28397838

DOI: 10.1038/mp.2017.60

PubMed ID: 29909994

Title: The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.

PubMed ID: 29909994

DOI: 10.1016/j.neuron.2018.05.024

Sequence Information:

Length: 247
Mass: 27818
Checksum: 0A60488254722A99
Sequence:

MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK AGSRGLTSLA 
DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA 
NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY 
FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT 
LTIKRGR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BDNF

Associated with

Other Information

Molecular cloning of a human gene that is a member of the nerve growth factor family. PubMed ID: 2236018

Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. PubMed ID: 1889806

Characterization of the 5'-flanking region of the human brain-derived neurotrophic factor gene. PubMed ID: 1339267

Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. PubMed ID: 15666411

Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. PubMed ID: 17629449

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. PubMed ID: 2025430

Purification and identification of brain-derived neurotrophic factor from human serum. PubMed ID: 8527932

Molecular phylogenetics and the origins of placental mammals. PubMed ID: 11214319

Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. PubMed ID: 11152678

Identification of pro- and mature brain-derived neurotrophic factor in human saliva. PubMed ID: 19467646

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. PubMed ID: 24908487

Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer. PubMed ID: 7703225

The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site. PubMed ID: 10631974

Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. PubMed ID: 15115760

Brain-derived neurotrophic factor and obesity in the WAGR syndrome. PubMed ID: 18753648

Characterization of single-nucleotide polymorphisms in coding regions of human genes. PubMed ID: 10391209

Idiopathic congenital central hypoventilation syndrome: evaluation of brain-derived neurotrophic factor genomic DNA sequence variation. PubMed ID: 11840487

Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. PubMed ID: 12836135

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. PubMed ID: 12553913

Molecular analysis of congenital central hypoventilation syndrome. PubMed ID: 14566559

Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. PubMed ID: 12888803

Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families. PubMed ID: 28397838

The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. PubMed ID: 29909994