BDNF | ENSG00000176697 | NCBI 627

Details for: BDNF

Gene ID: 627

Symbol: BDNF

Ensembl ID: ENSG00000176697

Description: brain derived neurotrophic factor

Associated with

Activated ntrk2 signals through cdk5
(R-HSA-9032845)
Activated ntrk2 signals through frs2 and frs3
(R-HSA-9028731)
Activated ntrk2 signals through fyn
(R-HSA-9032500)
Activated ntrk2 signals through pi3k
(R-HSA-9028335)
Activated ntrk2 signals through plcg1
(R-HSA-9026527)
Activated ntrk2 signals through ras
(R-HSA-9026519)
Bdnf activates ntrk2 (trkb) signaling
(R-HSA-9024909)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intracellular signaling by second messengers
(R-HSA-9006925)
Loss of function of mecp2 in rett syndrome
(R-HSA-9005891)
Loss of mecp2 binding ability to 5mc-dna
(R-HSA-9022538)
Mecp2 regulates transcription of neuronal ligands
(R-HSA-9022702)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Npas4 regulates expression of target genes
(R-HSA-9768919)
Ntrk2 activates rac1
(R-HSA-9032759)
Pervasive developmental disorders
(R-HSA-9005895)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by npas4
(R-HSA-9634815)
Axon
(GO:0030424)
Axon guidance
(GO:0007411)
Brain-derived neurotrophic factor receptor signaling pathway
(GO:0031547)
Cell surface receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Collateral sprouting
(GO:0048668)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of myotube differentiation
(GO:0010832)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nerve development
(GO:0021675)
Nerve growth factor receptor binding
(GO:0005163)
Nerve growth factor signaling pathway
(GO:0038180)
Nervous system development
(GO:0007399)
Neuron projection morphogenesis
(GO:0048812)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of brain-derived neurotrophic factor receptor signaling pathway
(GO:0031550)
Positive regulation of collateral sprouting
(GO:0048672)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of receptor binding
(GO:1900122)
Positive regulation of synapse assembly
(GO:0051965)
Protein binding
(GO:0005515)
Regulation of protein localization to cell surface
(GO:2000008)
Synapse assembly
(GO:0007416)
Synaptic vesicle
(GO:0008021)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 29.3719
Cell Significance Index: -7.4500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.9978
Cell Significance Index: 201.5700
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.0496
Cell Significance Index: 15.7200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.8782
Cell Significance Index: 25.0600
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.8385
Cell Significance Index: 20.4600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6860
Cell Significance Index: 130.5500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6198
Cell Significance Index: 47.5700
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.4771
Cell Significance Index: 6.3700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4363
Cell Significance Index: 43.1600
Cell Name: theca cell (CL0000503)
Fold Change: 0.3881
Cell Significance Index: 2.2800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3732
Cell Significance Index: 336.9700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.3402
Cell Significance Index: 7.1200
Cell Name: myometrial cell (CL0002366)
Fold Change: 0.3378
Cell Significance Index: 3.8900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3306
Cell Significance Index: 150.0600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2942
Cell Significance Index: 59.0200
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.2591
Cell Significance Index: 1.7200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2280
Cell Significance Index: 37.0800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2263
Cell Significance Index: 4.8200
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.2114
Cell Significance Index: 1.7500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2092
Cell Significance Index: 22.7500
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.1574
Cell Significance Index: 1.6400
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.1466
Cell Significance Index: 1.1300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1224
Cell Significance Index: 24.2900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1206
Cell Significance Index: 7.2400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1096
Cell Significance Index: 59.8300
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.0954
Cell Significance Index: 0.8400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0928
Cell Significance Index: 1.5900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0912
Cell Significance Index: 6.3100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0827
Cell Significance Index: 36.5600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0816
Cell Significance Index: 56.4100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0678
Cell Significance Index: 3.5600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0527
Cell Significance Index: 2.3900
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.0305
Cell Significance Index: 0.2900
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.0264
Cell Significance Index: 0.3200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0201
Cell Significance Index: 0.5800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0168
Cell Significance Index: 10.6800
Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: 0.0118
Cell Significance Index: 0.0800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0108
Cell Significance Index: 0.3800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0092
Cell Significance Index: 0.2000
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0057
Cell Significance Index: 10.4900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0055
Cell Significance Index: 8.4800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0047
Cell Significance Index: 8.9400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0033
Cell Significance Index: 0.4800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0028
Cell Significance Index: 0.0700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0000
Cell Significance Index: 0.0200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0078
Cell Significance Index: -2.8200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0099
Cell Significance Index: -7.2800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0107
Cell Significance Index: -8.1300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0108
Cell Significance Index: -7.9700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0140
Cell Significance Index: -7.9200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0163
Cell Significance Index: -1.0000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0166
Cell Significance Index: -0.2500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0199
Cell Significance Index: -5.7400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0219
Cell Significance Index: -0.4600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0251
Cell Significance Index: -4.5300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0365
Cell Significance Index: -1.1700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0371
Cell Significance Index: -3.7900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0374
Cell Significance Index: -5.1400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0391
Cell Significance Index: -4.0800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0397
Cell Significance Index: -8.3700
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0433
Cell Significance Index: -0.5400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0437
Cell Significance Index: -5.3700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0437
Cell Significance Index: -7.4700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0477
Cell Significance Index: -1.2200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0484
Cell Significance Index: -5.6400
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0530
Cell Significance Index: -0.6800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0632
Cell Significance Index: -8.1600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0637
Cell Significance Index: -1.7800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0674
Cell Significance Index: -7.7200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0684
Cell Significance Index: -4.3100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0704
Cell Significance Index: -4.5400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0708
Cell Significance Index: -8.3500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0777
Cell Significance Index: -1.0600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0871
Cell Significance Index: -2.1100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0873
Cell Significance Index: -4.9000
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0935
Cell Significance Index: -1.1800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1047
Cell Significance Index: -4.8800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1093
Cell Significance Index: -6.7200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1108
Cell Significance Index: -2.9700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1119
Cell Significance Index: -5.8300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1134
Cell Significance Index: -8.4500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1184
Cell Significance Index: -5.1500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1205
Cell Significance Index: -2.5800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1219
Cell Significance Index: -6.3300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1303
Cell Significance Index: -2.1800
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1356
Cell Significance Index: -2.9700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1372
Cell Significance Index: -1.9700
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.1442
Cell Significance Index: -0.6900
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1450
Cell Significance Index: -2.3900
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.1463
Cell Significance Index: -1.9500
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1463
Cell Significance Index: -2.1600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1480
Cell Significance Index: -2.2300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1572
Cell Significance Index: -7.3900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1592
Cell Significance Index: -7.0400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1598
Cell Significance Index: -5.8700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1631
Cell Significance Index: -4.2900
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1631
Cell Significance Index: -5.1600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1658
Cell Significance Index: -5.8100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1674
Cell Significance Index: -4.4700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1677
Cell Significance Index: -5.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** BDNF is a member of the neurotrophin family, which includes Nerve Growth Factor (NGF), Neurotrophin-3 (NT-3), and Neurotrophin-4/5 (NT-4/5). BDNF is produced by various cell types, including neurons, astrocytes, and microglia, and is secreted into the extracellular space. BDNF binds to its receptor, TrkB, which is a member of the receptor tyrosine kinase family. The binding of BDNF to TrkB triggers a signaling cascade that involves the activation of various downstream pathways, including the PI3K/Akt and MAPK/ERK pathways. **Pathways and Functions** BDNF signaling pathways are complex and involve multiple downstream effectors. Some of the key pathways and functions of BDNF include: * **Synaptic Plasticity**: BDNF promotes synaptic plasticity, the ability of synapses to change and adapt in response to experience and learning. * **Neuronal Survival**: BDNF protects neurons from apoptosis (programmed cell death) and promotes neuronal survival. * **Differentiation**: BDNF regulates the differentiation of neurons and neural stem cells. * **Growth and Development**: BDNF promotes the growth and development of neurons and neural circuits. * **Neurotransmission**: BDNF regulates the release and uptake of neurotransmitters, such as glutamate and GABA. **Clinical Significance** Dysregulation of BDNF signaling has been implicated in various neurological disorders, including: * **Depression**: BDNF levels are reduced in individuals with depression, and BDNF agonists have been shown to improve depressive symptoms. * **Anxiety**: BDNF levels are also reduced in individuals with anxiety disorders, and BDNF agonists have been shown to reduce anxiety-like behavior. * **Neurodegenerative Diseases**: BDNF signaling is reduced in neurodegenerative diseases such as Alzheimer's and Parkinson's, and BDNF agonists have been shown to slow disease progression. * **Pervasive Developmental Disorders**: BDNF levels are reduced in individuals with pervasive developmental disorders, such as autism spectrum disorder, and BDNF agonists have been shown to improve social and cognitive function. In conclusion, BDNF is a critical protein that plays a key role in the development, maintenance, and function of the nervous system. Dysregulation of BDNF signaling has been implicated in various neurological disorders, and BDNF agonists have shown promise as therapeutic agents for the treatment of these conditions. Further research is needed to fully understand the mechanisms of BDNF signaling and the therapeutic potential of BDNF agonists.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Brain-derived neurotrophic factor

Genular Protein ID: 3624270972

Symbol: BDNF_HUMAN

Name: Brain-derived neurotrophic factor

UniProtKB Accession Codes:

P23560 A7LA85 A7LA92 D3DQZ2 Q598Q1 Q6DN19 Q6YNR2 Q6YNR3 Q9BYY7 Q9UC24

Database IDs:

Citations:

PubMed ID: 2236018

Title: Molecular cloning of a human gene that is a member of the nerve growth factor family.

PubMed ID: 2236018

DOI: 10.1073/pnas.87.20.8060

PubMed ID: 1889806

Title: Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.

PubMed ID: 1889806

DOI: 10.1016/0888-7543(91)90436-i

PubMed ID: 1339267

Title: Characterization of the 5'-flanking region of the human brain-derived neurotrophic factor gene.

PubMed ID: 1339267

DOI: 10.1016/s0006-291x(05)80148-2

PubMed ID: 15666411

Title: Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease.

PubMed ID: 15666411

DOI: 10.1002/ajmg.b.30109

PubMed ID: 17629449

Title: Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters.

PubMed ID: 17629449

DOI: 10.1016/j.ygeno.2007.05.004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2025430

Title: Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.

PubMed ID: 2025430

DOI: 10.1016/0896-6273(91)90180-8

PubMed ID: 8527932

Title: Purification and identification of brain-derived neurotrophic factor from human serum.

PubMed ID: 8527932

DOI: 10.1006/prep.1995.1062

PubMed ID: 11214319

Title: Molecular phylogenetics and the origins of placental mammals.

PubMed ID: 11214319

DOI: 10.1038/35054550

PubMed ID: 11152678

Title: Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor.

PubMed ID: 11152678

DOI: 10.1074/jbc.m008104200

PubMed ID: 19467646

Title: Identification of pro- and mature brain-derived neurotrophic factor in human saliva.

PubMed ID: 19467646

DOI: 10.1016/j.archoralbio.2009.04.005

PubMed ID: 24908487

Title: SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

PubMed ID: 24908487

DOI: 10.1016/j.neuron.2014.04.022

PubMed ID: 7703225

Title: Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.

PubMed ID: 7703225

DOI: 10.1021/bi00013a001

PubMed ID: 10631974

Title: The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.

PubMed ID: 10631974

DOI: 10.1110/ps.8.12.2589

PubMed ID: 15115760

Title: Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations.

PubMed ID: 15115760

DOI: 10.1093/hmg/ddh137

PubMed ID: 18753648

Title: Brain-derived neurotrophic factor and obesity in the WAGR syndrome.

PubMed ID: 18753648

DOI: 10.1056/nejmoa0801119

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 11840487

Title: Idiopathic congenital central hypoventilation syndrome: evaluation of brain-derived neurotrophic factor genomic DNA sequence variation.

PubMed ID: 11840487

DOI: 10.1002/ajmg.10133

PubMed ID: 12836135

Title: Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder.

PubMed ID: 12836135

DOI: 10.1086/377003

PubMed ID: 12553913

Title: The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.

PubMed ID: 12553913

DOI: 10.1016/s0092-8674(03)00035-7

PubMed ID: 14566559

Title: Molecular analysis of congenital central hypoventilation syndrome.

PubMed ID: 14566559

DOI: 10.1007/s00439-003-1036-z

PubMed ID: 12888803

Title: Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type.

PubMed ID: 12888803

DOI: 10.1038/sj.mp.4001281

PubMed ID: 28397838

Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PubMed ID: 28397838

DOI: 10.1038/mp.2017.60

PubMed ID: 29909994

Title: The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.

PubMed ID: 29909994

DOI: 10.1016/j.neuron.2018.05.024

Sequence Information:

Length: 247
Mass: 27818
Checksum: 0A60488254722A99
Sequence:

MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK AGSRGLTSLA 
DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA 
NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY 
FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT 
LTIKRGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BDNF

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a human gene that is a member of the nerve growth factor family. PubMed ID: 2236018

Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. PubMed ID: 1889806

Characterization of the 5'-flanking region of the human brain-derived neurotrophic factor gene. PubMed ID: 1339267

Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. PubMed ID: 15666411

Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. PubMed ID: 17629449

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. PubMed ID: 2025430

Purification and identification of brain-derived neurotrophic factor from human serum. PubMed ID: 8527932

Molecular phylogenetics and the origins of placental mammals. PubMed ID: 11214319

Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. PubMed ID: 11152678

Identification of pro- and mature brain-derived neurotrophic factor in human saliva. PubMed ID: 19467646

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. PubMed ID: 24908487

Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer. PubMed ID: 7703225

The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site. PubMed ID: 10631974

Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. PubMed ID: 15115760

Brain-derived neurotrophic factor and obesity in the WAGR syndrome. PubMed ID: 18753648

Characterization of single-nucleotide polymorphisms in coding regions of human genes. PubMed ID: 10391209

Idiopathic congenital central hypoventilation syndrome: evaluation of brain-derived neurotrophic factor genomic DNA sequence variation. PubMed ID: 11840487

Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. PubMed ID: 12836135

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. PubMed ID: 12553913

Molecular analysis of congenital central hypoventilation syndrome. PubMed ID: 14566559

Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. PubMed ID: 12888803

Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families. PubMed ID: 28397838

The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. PubMed ID: 29909994