Details for: BDNF

Gene ID: 627

Symbol: BDNF

Ensembl ID: ENSG00000176697

Description: brain derived neurotrophic factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.03
    Marker Score: 4463
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.02
    Marker Score: 5768
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.96
    Marker Score: 4065
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169250
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.4
    Marker Score: 2343
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.17
    Marker Score: 2224
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 485
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7525
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17108
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 501
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.03
    Marker Score: 656
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.9
    Marker Score: 20153
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1619
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.68
    Marker Score: 2776
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.64
    Marker Score: 773
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.64
    Marker Score: 6591
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.63
    Marker Score: 201
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.6
    Marker Score: 250
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.56
    Marker Score: 1324
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 447
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.53
    Marker Score: 491
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 314
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 214
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.42
    Marker Score: 354
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.38
    Marker Score: 104
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.34
    Marker Score: 154
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.31
    Marker Score: 224
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.3
    Marker Score: 207
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.3
    Marker Score: 95
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.28
    Marker Score: 333
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.27
    Marker Score: 776
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 121
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.27
    Marker Score: 336
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.26
    Marker Score: 114.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.25
    Marker Score: 96
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.25
    Marker Score: 268
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 144
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.25
    Marker Score: 63
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.24
    Marker Score: 14689
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.23
    Marker Score: 203
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.23
    Marker Score: 134
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.23
    Marker Score: 3648
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.21
    Marker Score: 1274
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.21
    Marker Score: 112
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 186
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 136
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.2
    Marker Score: 197
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2
    Marker Score: 65
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.2
    Marker Score: 1902
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.2
    Marker Score: 81
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2
    Marker Score: 6860
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2
    Marker Score: 57
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.19
    Marker Score: 591
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.18
    Marker Score: 530
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.18
    Marker Score: 120
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.18
    Marker Score: 170
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.17
    Marker Score: 69
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.17
    Marker Score: 212
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.17
    Marker Score: 57
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.16
    Marker Score: 247
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.16
    Marker Score: 191
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.16
    Marker Score: 209
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.15
    Marker Score: 63
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.15
    Marker Score: 59

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Other Information

**Key characteristics:** - BDNF is a secreted protein that is produced by neurons and acts on a variety of cell types. - It is a potent neurotrophic factor that is essential for the survival and growth of neurons. - BDNF binds to a number of receptors on neurons, including trk receptors, PI3K receptors, and MAPK receptors. - It is a key regulator of neuronal survival, differentiation, and plasticity. **Pathways and functions:** - BDNF binds to trk receptors on neurons and activates them. - Activated trk receptors phosphorylate a number of downstream proteins, including p73 and MAPK. - These downstream proteins regulate a variety of cellular processes, including cell cycle regulation, apoptosis, and differentiation. - BDNF also binds to PI3K receptors on endothelial cells and activates them. - Activated PI3K signaling leads to the phosphorylation of PDK1 and inhibition of p53, which promotes cell cycle progression. **Clinical significance:** - Mutations in the BDNF gene have been linked to a number of human diseases, including Rett syndrome, autism, and schizophrenia. - BDNF is a promising target for the treatment of these disorders. - Current clinical trials are investigating the use of BDNF replacement therapy to treat these diseases. **Other important points:** - BDNF is a highly conserved protein that is found in all mammals. - It is a key factor in the development of the central nervous system. - It is a major regulator of neuronal survival, growth, and differentiation.

Genular Protein ID: 3624270972

Symbol: BDNF_HUMAN

Name: Brain-derived neurotrophic factor

UniProtKB Accession Codes:

P23560 A7LA85 A7LA92 D3DQZ2 Q598Q1 Q6DN19 Q6YNR2 Q6YNR3 Q9BYY7 Q9UC24

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 46 Ensembl 15 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 10 RefSeq 18 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2236018

Title: Molecular cloning of a human gene that is a member of the nerve growth factor family.

PubMed ID: 2236018

DOI: 10.1073/pnas.87.20.8060

PubMed ID: 1889806

Title: Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.

PubMed ID: 1889806

DOI: 10.1016/0888-7543(91)90436-i

PubMed ID: 1339267

Title: Characterization of the 5'-flanking region of the human brain-derived neurotrophic factor gene.

PubMed ID: 1339267

DOI: 10.1016/s0006-291x(05)80148-2

PubMed ID: 15666411

Title: Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease.

PubMed ID: 15666411

DOI: 10.1002/ajmg.b.30109

PubMed ID: 17629449

Title: Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters.

PubMed ID: 17629449

DOI: 10.1016/j.ygeno.2007.05.004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2025430

Title: Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.

PubMed ID: 2025430

DOI: 10.1016/0896-6273(91)90180-8

PubMed ID: 8527932

Title: Purification and identification of brain-derived neurotrophic factor from human serum.

PubMed ID: 8527932

DOI: 10.1006/prep.1995.1062

PubMed ID: 11214319

Title: Molecular phylogenetics and the origins of placental mammals.

PubMed ID: 11214319

DOI: 10.1038/35054550

PubMed ID: 11152678

Title: Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor.

PubMed ID: 11152678

DOI: 10.1074/jbc.m008104200

PubMed ID: 19467646

Title: Identification of pro- and mature brain-derived neurotrophic factor in human saliva.

PubMed ID: 19467646

DOI: 10.1016/j.archoralbio.2009.04.005

PubMed ID: 24908487

Title: SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

PubMed ID: 24908487

DOI: 10.1016/j.neuron.2014.04.022

PubMed ID: 7703225

Title: Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.

PubMed ID: 7703225

DOI: 10.1021/bi00013a001

PubMed ID: 10631974

Title: The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.

PubMed ID: 10631974

DOI: 10.1110/ps.8.12.2589

PubMed ID: 15115760

Title: Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations.

PubMed ID: 15115760

DOI: 10.1093/hmg/ddh137

PubMed ID: 18753648

Title: Brain-derived neurotrophic factor and obesity in the WAGR syndrome.

PubMed ID: 18753648

DOI: 10.1056/nejmoa0801119

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 11840487

Title: Idiopathic congenital central hypoventilation syndrome: evaluation of brain-derived neurotrophic factor genomic DNA sequence variation.

PubMed ID: 11840487

DOI: 10.1002/ajmg.10133

PubMed ID: 12836135

Title: Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder.

PubMed ID: 12836135

DOI: 10.1086/377003

PubMed ID: 12553913

Title: The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.

PubMed ID: 12553913

DOI: 10.1016/s0092-8674(03)00035-7

PubMed ID: 14566559

Title: Molecular analysis of congenital central hypoventilation syndrome.

PubMed ID: 14566559

DOI: 10.1007/s00439-003-1036-z

PubMed ID: 12888803

Title: Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type.

PubMed ID: 12888803

DOI: 10.1038/sj.mp.4001281

PubMed ID: 28397838

Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PubMed ID: 28397838

DOI: 10.1038/mp.2017.60

PubMed ID: 29909994

Title: The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.

PubMed ID: 29909994

DOI: 10.1016/j.neuron.2018.05.024

Sequence Information:

  • Length: 247
  • Mass: 27818
  • Checksum: 0A60488254722A99
  • Sequence:
    • MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK AGSRGLTSLA 
DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA 
NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY 
FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT 
LTIKRGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.