Details for: CFB

Gene ID: 629

Symbol: CFB

Ensembl ID: ENSG00000243649

Description: complement factor B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 30.7563
    Cell Significance Index: -12.6700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.7290
    Cell Significance Index: 45.9000
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 2.2970
    Cell Significance Index: 16.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.9614
    Cell Significance Index: 28.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4094
    Cell Significance Index: 40.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3749
    Cell Significance Index: 82.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.3422
    Cell Significance Index: 31.0100
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 1.2722
    Cell Significance Index: 8.5000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.1583
    Cell Significance Index: 12.6700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0206
    Cell Significance Index: 15.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6347
    Cell Significance Index: 7.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5508
    Cell Significance Index: 59.9200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.5080
    Cell Significance Index: 1.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3543
    Cell Significance Index: 24.5100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3499
    Cell Significance Index: 3.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2820
    Cell Significance Index: 6.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2739
    Cell Significance Index: 14.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2384
    Cell Significance Index: 6.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1694
    Cell Significance Index: 4.6100
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1524
    Cell Significance Index: 1.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1413
    Cell Significance Index: 127.5500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1349
    Cell Significance Index: 0.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1269
    Cell Significance Index: 79.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1256
    Cell Significance Index: 9.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1180
    Cell Significance Index: 14.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1064
    Cell Significance Index: 20.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0824
    Cell Significance Index: 14.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0824
    Cell Significance Index: 2.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0765
    Cell Significance Index: 3.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0743
    Cell Significance Index: 12.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0596
    Cell Significance Index: 9.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0439
    Cell Significance Index: 1.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0372
    Cell Significance Index: 1.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0276
    Cell Significance Index: 1.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0105
    Cell Significance Index: 1.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0032
    Cell Significance Index: 1.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0028
    Cell Significance Index: 0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0028
    Cell Significance Index: -0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0061
    Cell Significance Index: -0.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0064
    Cell Significance Index: -3.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0097
    Cell Significance Index: -0.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0108
    Cell Significance Index: -8.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0108
    Cell Significance Index: -16.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0130
    Cell Significance Index: -8.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0133
    Cell Significance Index: -1.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0133
    Cell Significance Index: -18.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0143
    Cell Significance Index: -8.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0146
    Cell Significance Index: -1.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0166
    Cell Significance Index: -12.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0182
    Cell Significance Index: -2.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0190
    Cell Significance Index: -6.8100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0304
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0308
    Cell Significance Index: -6.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0317
    Cell Significance Index: -14.3800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0389
    Cell Significance Index: -0.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0457
    Cell Significance Index: -9.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0502
    Cell Significance Index: -3.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0628
    Cell Significance Index: -8.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0654
    Cell Significance Index: -7.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0702
    Cell Significance Index: -10.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0709
    Cell Significance Index: -1.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0744
    Cell Significance Index: -7.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0748
    Cell Significance Index: -3.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0829
    Cell Significance Index: -5.8700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0966
    Cell Significance Index: -0.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0968
    Cell Significance Index: -1.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1012
    Cell Significance Index: -4.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1152
    Cell Significance Index: -3.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1312
    Cell Significance Index: -13.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1334
    Cell Significance Index: -2.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1406
    Cell Significance Index: -8.8600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1412
    Cell Significance Index: -2.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1492
    Cell Significance Index: -17.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1547
    Cell Significance Index: -12.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1604
    Cell Significance Index: -1.6600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1715
    Cell Significance Index: -3.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1928
    Cell Significance Index: -2.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1951
    Cell Significance Index: -14.9700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2395
    Cell Significance Index: -2.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2454
    Cell Significance Index: -13.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2480
    Cell Significance Index: -5.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2618
    Cell Significance Index: -6.9900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2841
    Cell Significance Index: -1.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2974
    Cell Significance Index: -8.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3023
    Cell Significance Index: -15.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3037
    Cell Significance Index: -11.1500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3039
    Cell Significance Index: -2.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3063
    Cell Significance Index: -10.7300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3198
    Cell Significance Index: -3.3100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3363
    Cell Significance Index: -3.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3517
    Cell Significance Index: -5.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3549
    Cell Significance Index: -11.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3551
    Cell Significance Index: -11.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3557
    Cell Significance Index: -9.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3563
    Cell Significance Index: -15.7600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3741
    Cell Significance Index: -4.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CFB is a 113-kDa protein that belongs to the complement factor family. It is a serine-type endopeptidase, which means it catalyzes the cleavage of peptide bonds in proteins. CFB is unique in its ability to bind to C3b, a product of the classical and lectin pathways, and facilitate the amplification of the alternative complement pathway. This binding event triggers a cascade of reactions that ultimately leads to the cleavage of C3 and the production of C3b, which can then bind to CFB and amplify the reaction. **Pathways and Functions** CFB is involved in the following pathways: 1. **Activation of C3 and C5**: CFB is required for the activation of C3 and C5, which are key components of the complement cascade. The activation of C3 and C5 leads to the production of C3b and C5b, respectively, which can then bind to CFB and amplify the reaction. 2. **Alternative Complement Activation**: CFB is a key component of the alternative complement pathway, which is responsible for the clearance of pathogens and the elimination of apoptotic cells. 3. **Blood Microparticle**: CFB is also involved in the formation of blood microparticles, which are small vesicles that can be released from platelets and other cells. These microparticles can play a role in the regulation of immune responses. 4. **Complement Activation**: CFB is involved in the regulation of complement activation, including the activation of C3 and C5, and the amplification of the alternative complement pathway. **Clinical Significance** Dysregulation of the complement cascade, including the alternative complement pathway, has been implicated in various diseases, including: 1. **Autoimmune Disorders**: Dysregulation of the complement cascade has been linked to autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Infectious Diseases**: The alternative complement pathway is involved in the clearance of pathogens, including bacteria and viruses. Dysregulation of this pathway can lead to increased susceptibility to infection. 3. **Neurological Disorders**: The complement cascade, including the alternative complement pathway, has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and multiple sclerosis. 4. **Cancer**: The complement cascade, including the alternative complement pathway, has been implicated in the regulation of cancer progression and metastasis. In summary, CFB is a crucial component of the innate immune system, playing a pivotal role in the regulation of the complement cascade. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 2397268688

Symbol: CFAB_HUMAN

Name: Complement factor B

UniProtKB Accession Codes:

P00751 B0QZQ6 O15006 Q29944 Q53F89 Q5JP67 Q5ST50 Q96HX6 Q9BTF5 Q9BX92

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 2 EMBL 23 EMDB 4 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PIR 1 PIRSF 2 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2249879

Title: Molecular characterization of human complement factor B subtypes.

PubMed ID: 2249879

DOI: 10.1007/bf00211644

PubMed ID: 8181962

Title: Human factor B. Complete cDNA sequence of the BF*S allele.

PubMed ID: 8181962

DOI: 10.1016/0198-8859(94)90100-7

PubMed ID: 8225386

Title: Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase.

PubMed ID: 8225386

DOI: 10.1016/s0171-2985(11)80231-7

PubMed ID: 8247029

Title: Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression.

PubMed ID: 8247029

DOI: 10.1016/0161-5890(93)90450-p

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6546754

Title: Complete primary structure for the zymogen of human complement factor B.

PubMed ID: 6546754

DOI: 10.1016/s0021-9258(17)43108-5

PubMed ID: 6342610

Title: Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment.

PubMed ID: 6342610

DOI: 10.1042/bj2090061

PubMed ID: 6308626

Title: Molecular cloning and characterization of the gene coding for human complement protein factor B.

PubMed ID: 6308626

DOI: 10.1073/pnas.80.14.4464

PubMed ID: 6957884

Title: Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product.

PubMed ID: 6957884

DOI: 10.1073/pnas.79.18.5661

PubMed ID: 6323161

Title: Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen.

PubMed ID: 6323161

DOI: 10.1002/j.1460-2075.1984.tb01776.x

PubMed ID: 3643061

Title: Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements.

PubMed ID: 3643061

DOI: 10.1016/0092-8674(87)90436-3

PubMed ID: 2006911

Title: The principal site of glycation of human complement factor B.

PubMed ID: 2006911

DOI: 10.1042/bj2740473

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24152280

Title: Deficiency in complement factor B.

PubMed ID: 24152280

DOI: 10.1056/nejmc1306326

PubMed ID: 10637221

Title: New structural motifs on the chymotrypsin fold and their potential roles in complement factor B.

PubMed ID: 10637221

DOI: 10.1093/emboj/19.2.164

PubMed ID: 17310251

Title: Factor B structure provides insights into activation of the central protease of the complement system.

PubMed ID: 17310251

DOI: 10.1038/nsmb1210

PubMed ID: 19574954

Title: Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex.

PubMed ID: 19574954

DOI: 10.1038/emboj.2009.184

PubMed ID: 28264884

Title: Functional and structural insight into properdin control of complement alternative pathway amplification.

PubMed ID: 28264884

DOI: 10.15252/embj.201696173

PubMed ID: 31507604

Title: Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.

PubMed ID: 31507604

DOI: 10.3389/fimmu.2019.02007

PubMed ID: 16518403

Title: Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration.

PubMed ID: 16518403

DOI: 10.1038/ng1750

PubMed ID: 17182750

Title: Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.

PubMed ID: 17182750

DOI: 10.1073/pnas.0603420103

PubMed ID: 20513133

Title: Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.

PubMed ID: 20513133

DOI: 10.1002/humu.21256

Sequence Information:

  • Length: 764
  • Mass: 85533
  • Checksum: 8BB6C101CC6AC200
  • Sequence:
    • MGSNLSPQLC LMPFILGLLS GGVTTTPWSL ARPQGSCSLE GVEIKGGSFR LLQEGQALEY 
VCPSGFYPYP VQTRTCRSTG SWSTLKTQDQ KTVRKAECRA IHCPRPHDFE NGEYWPRSPY 
YNVSDEISFH CYDGYTLRGS ANRTCQVNGR WSGQTAICDN GAGYCSNPGI PIGTRKVGSQ 
YRLEDSVTYH CSRGLTLRGS QRRTCQEGGS WSGTEPSCQD SFMYDTPQEV AEAFLSSLTE 
TIEGVDAEDG HGPGEQQKRK IVLDPSGSMN IYLVLDGSDS IGASNFTGAK KCLVNLIEKV 
ASYGVKPRYG LVTYATYPKI WVKVSEADSS NADWVTKQLN EINYEDHKLK SGTNTKKALQ 
AVYSMMSWPD DVPPEGWNRT RHVIILMTDG LHNMGGDPIT VIDEIRDLLY IGKDRKNPRE 
DYLDVYVFGV GPLVNQVNIN ALASKKDNEQ HVFKVKDMEN LEDVFYQMID ESQSLSLCGM 
VWEHRKGTDY HKQPWQAKIS VIRPSKGHES CMGAVVSEYF VLTAAHCFTV DDKEHSIKVS 
VGGEKRDLEI EVVLFHPNYN INGKKEAGIP EFYDYDVALI KLKNKLKYGQ TIRPICLPCT 
EGTTRALRLP PTTTCQQQKE ELLPAQDIKA LFVSEEEKKL TRKEVYIKNG DKKGSCERDA 
QYAPGYDKVK DISEVVTPRF LCTGGVSPYA DPNTCRGDSG GPLIVHKRSR FIQVGVISWG 
VVDVCKNQKR QKQVPAHARD FHINLFQVLP WLKEKLQDED LGFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.