Details for: CFB

Gene ID: 629

Symbol: CFB

Ensembl ID: ENSG00000243649

Description: complement factor B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 7.53
    Marker Score: 21269
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.91
    Marker Score: 679
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.46
    Marker Score: 683
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 860
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.35
    Marker Score: 901
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.3
    Marker Score: 2683
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.28
    Marker Score: 410
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.17
    Marker Score: 264
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.17
    Marker Score: 575
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1
    Marker Score: 37402
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251792
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 786
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.96
    Marker Score: 1487
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5318
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.88
    Marker Score: 279
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 494
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 674
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.72
    Marker Score: 3876
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3019
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.7
    Marker Score: 406
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.7
    Marker Score: 3001
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.68
    Marker Score: 168
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.64
    Marker Score: 438
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.64
    Marker Score: 452
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.64
    Marker Score: 3140.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.63
    Marker Score: 1033
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.56
    Marker Score: 226
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.55
    Marker Score: 4755
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.54
    Marker Score: 148
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 341.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.52
    Marker Score: 537
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.51
    Marker Score: 303
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.5
    Marker Score: 1141
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.49
    Marker Score: 2565
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 469
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.48
    Marker Score: 1244
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.47
    Marker Score: 3037
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 194
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.46
    Marker Score: 132
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.45
    Marker Score: 823
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.45
    Marker Score: 169
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.45
    Marker Score: 2138
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.45
    Marker Score: 477
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.44
    Marker Score: 1041
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.43
    Marker Score: 125
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.43
    Marker Score: 368
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.43
    Marker Score: 283
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.42
    Marker Score: 290
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.42
    Marker Score: 490
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.42
    Marker Score: 3095
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.41
    Marker Score: 784
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.41
    Marker Score: 5537
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.4
    Marker Score: 182
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.39
    Marker Score: 240
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.38
    Marker Score: 159
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.37
    Marker Score: 660
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.37
    Marker Score: 1318
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.37
    Marker Score: 114
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.37
    Marker Score: 209
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 367
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.35
    Marker Score: 131.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.34
    Marker Score: 1328
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.34
    Marker Score: 329
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 194
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.33
    Marker Score: 84
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.32
    Marker Score: 218
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.3
    Marker Score: 207
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.29
    Marker Score: 290
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.28
    Marker Score: 332
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 0.27
    Marker Score: 80
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.27
    Marker Score: 76
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.27
    Marker Score: 269
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.27
    Marker Score: 116
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.27
    Marker Score: 61
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.26
    Marker Score: 649
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.24
    Marker Score: 218
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.24
    Marker Score: 91
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.24
    Marker Score: 83
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.23
    Marker Score: 316
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.23
    Marker Score: 195
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.22
    Marker Score: 703
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.22
    Marker Score: 114
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.22
    Marker Score: 513

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Other Information

**Key characteristics:** * CFB is a glycoprotein with a molecular weight of approximately 160 kDa. * It is produced by a variety of cell types, including immune cells, epithelial cells, and stromal cells. * CFB is a key regulator of the innate immune response by controlling the alternative complement pathway. **Pathways and functions:** * CFB binds to the terminal complement proteins C1q and C1r, which are components of the classical complement pathway. * Upon binding, CFB undergoes a conformational change that exposes a hydrophobic thumb domain. * This conformational change allows CFB to activate C8 and C9, the central enzymes of the alternative complement pathway. * The alternative pathway is a non-classical pathway that is activated by the binding of CFB to C1q and C1r. * CFB also regulates the classical pathway by binding to C3 and preventing its interaction with C1q and C1r. **Clinical significance:** * Mutations in the CFB gene have been linked to human diseases, including recurrent infections, autoimmune disorders, and cancer. * CFB inhibitors are being investigated as potential treatments for these diseases. * CFB is a promising target for the development of novel therapeutic interventions for immune disorders. **Additional information:** * CFB is also known as CFB1. * It is produced by a single gene, CFB. * CFB is expressed in high levels in the plasma membrane of immune cells. * It is a key regulator of inflammation and immune responses.

Genular Protein ID: 2397268688

Symbol: CFAB_HUMAN

Name: Complement factor B

UniProtKB Accession Codes:

P00751 B0QZQ6 O15006 Q29944 Q53F89 Q5JP67 Q5ST50 Q96HX6 Q9BTF5 Q9BX92

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 5 EC 2 EMBL 23 EMDB 3 EPD 1 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 24 PIR 1 PIRSF 2 PRINTS 2 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2249879

Title: Molecular characterization of human complement factor B subtypes.

PubMed ID: 2249879

DOI: 10.1007/bf00211644

PubMed ID: 8181962

Title: Human factor B. Complete cDNA sequence of the BF*S allele.

PubMed ID: 8181962

DOI: 10.1016/0198-8859(94)90100-7

PubMed ID: 8225386

Title: Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase.

PubMed ID: 8225386

DOI: 10.1016/s0171-2985(11)80231-7

PubMed ID: 8247029

Title: Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression.

PubMed ID: 8247029

DOI: 10.1016/0161-5890(93)90450-p

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6546754

Title: Complete primary structure for the zymogen of human complement factor B.

PubMed ID: 6546754

DOI: 10.1016/s0021-9258(17)43108-5

PubMed ID: 6342610

Title: Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment.

PubMed ID: 6342610

DOI: 10.1042/bj2090061

PubMed ID: 6308626

Title: Molecular cloning and characterization of the gene coding for human complement protein factor B.

PubMed ID: 6308626

DOI: 10.1073/pnas.80.14.4464

PubMed ID: 6957884

Title: Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product.

PubMed ID: 6957884

DOI: 10.1073/pnas.79.18.5661

PubMed ID: 6323161

Title: Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen.

PubMed ID: 6323161

DOI: 10.1002/j.1460-2075.1984.tb01776.x

PubMed ID: 3643061

Title: Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements.

PubMed ID: 3643061

DOI: 10.1016/0092-8674(87)90436-3

PubMed ID: 2006911

Title: The principal site of glycation of human complement factor B.

PubMed ID: 2006911

DOI: 10.1042/bj2740473

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24152280

Title: Deficiency in complement factor B.

PubMed ID: 24152280

DOI: 10.1056/nejmc1306326

PubMed ID: 10637221

Title: New structural motifs on the chymotrypsin fold and their potential roles in complement factor B.

PubMed ID: 10637221

DOI: 10.1093/emboj/19.2.164

PubMed ID: 17310251

Title: Factor B structure provides insights into activation of the central protease of the complement system.

PubMed ID: 17310251

DOI: 10.1038/nsmb1210

PubMed ID: 19574954

Title: Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex.

PubMed ID: 19574954

DOI: 10.1038/emboj.2009.184

PubMed ID: 28264884

Title: Functional and structural insight into properdin control of complement alternative pathway amplification.

PubMed ID: 28264884

DOI: 10.15252/embj.201696173

PubMed ID: 31507604

Title: Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.

PubMed ID: 31507604

DOI: 10.3389/fimmu.2019.02007

PubMed ID: 16518403

Title: Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration.

PubMed ID: 16518403

DOI: 10.1038/ng1750

PubMed ID: 17182750

Title: Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.

PubMed ID: 17182750

DOI: 10.1073/pnas.0603420103

PubMed ID: 20513133

Title: Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.

PubMed ID: 20513133

DOI: 10.1002/humu.21256

Sequence Information:

  • Length: 764
  • Mass: 85533
  • Checksum: 8BB6C101CC6AC200
  • Sequence:
    • MGSNLSPQLC LMPFILGLLS GGVTTTPWSL ARPQGSCSLE GVEIKGGSFR LLQEGQALEY 
VCPSGFYPYP VQTRTCRSTG SWSTLKTQDQ KTVRKAECRA IHCPRPHDFE NGEYWPRSPY 
YNVSDEISFH CYDGYTLRGS ANRTCQVNGR WSGQTAICDN GAGYCSNPGI PIGTRKVGSQ 
YRLEDSVTYH CSRGLTLRGS QRRTCQEGGS WSGTEPSCQD SFMYDTPQEV AEAFLSSLTE 
TIEGVDAEDG HGPGEQQKRK IVLDPSGSMN IYLVLDGSDS IGASNFTGAK KCLVNLIEKV 
ASYGVKPRYG LVTYATYPKI WVKVSEADSS NADWVTKQLN EINYEDHKLK SGTNTKKALQ 
AVYSMMSWPD DVPPEGWNRT RHVIILMTDG LHNMGGDPIT VIDEIRDLLY IGKDRKNPRE 
DYLDVYVFGV GPLVNQVNIN ALASKKDNEQ HVFKVKDMEN LEDVFYQMID ESQSLSLCGM 
VWEHRKGTDY HKQPWQAKIS VIRPSKGHES CMGAVVSEYF VLTAAHCFTV DDKEHSIKVS 
VGGEKRDLEI EVVLFHPNYN INGKKEAGIP EFYDYDVALI KLKNKLKYGQ TIRPICLPCT 
EGTTRALRLP PTTTCQQQKE ELLPAQDIKA LFVSEEEKKL TRKEVYIKNG DKKGSCERDA 
QYAPGYDKVK DISEVVTPRF LCTGGVSPYA DPNTCRGDSG GPLIVHKRSR FIQVGVISWG 
VVDVCKNQKR QKQVPAHARD FHINLFQVLP WLKEKLQDED LGFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.