Details for: BGLAP

Gene ID: 632

Symbol: BGLAP

Ensembl ID: ENSG00000242252

Description: bone gamma-carboxyglutamate protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.8054
    Cell Significance Index: -4.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.8741
    Cell Significance Index: -4.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.5102
    Cell Significance Index: -4.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.3292
    Cell Significance Index: 74.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.1100
    Cell Significance Index: -4.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8018
    Cell Significance Index: 102.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5305
    Cell Significance Index: 100.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4442
    Cell Significance Index: 26.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2896
    Cell Significance Index: 18.2500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2887
    Cell Significance Index: 4.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2679
    Cell Significance Index: 7.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2467
    Cell Significance Index: 26.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1857
    Cell Significance Index: 18.3700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.1741
    Cell Significance Index: 1.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1467
    Cell Significance Index: 132.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1455
    Cell Significance Index: 3.9600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1402
    Cell Significance Index: 2.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1192
    Cell Significance Index: 8.2400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1160
    Cell Significance Index: 1.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1101
    Cell Significance Index: 17.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0699
    Cell Significance Index: 3.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0437
    Cell Significance Index: 8.7600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0431
    Cell Significance Index: 0.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0308
    Cell Significance Index: 3.7900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0270
    Cell Significance Index: 0.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0227
    Cell Significance Index: 8.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0218
    Cell Significance Index: 0.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0180
    Cell Significance Index: 0.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0160
    Cell Significance Index: 1.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0102
    Cell Significance Index: 0.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0100
    Cell Significance Index: 0.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0079
    Cell Significance Index: 1.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0028
    Cell Significance Index: 0.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0025
    Cell Significance Index: 0.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0023
    Cell Significance Index: -0.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0038
    Cell Significance Index: -1.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0039
    Cell Significance Index: -2.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0050
    Cell Significance Index: -3.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0050
    Cell Significance Index: -3.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0052
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0089
    Cell Significance Index: -5.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0113
    Cell Significance Index: -0.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0131
    Cell Significance Index: -0.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0133
    Cell Significance Index: -0.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0155
    Cell Significance Index: -4.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0160
    Cell Significance Index: -0.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0169
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0192
    Cell Significance Index: -3.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0195
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0224
    Cell Significance Index: -4.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0230
    Cell Significance Index: -3.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0254
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0256
    Cell Significance Index: -2.9300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0260
    Cell Significance Index: -0.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0274
    Cell Significance Index: -2.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0307
    Cell Significance Index: -3.1400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0318
    Cell Significance Index: -0.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0376
    Cell Significance Index: -4.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0390
    Cell Significance Index: -0.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0412
    Cell Significance Index: -2.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0415
    Cell Significance Index: -3.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0489
    Cell Significance Index: -2.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0506
    Cell Significance Index: -1.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0514
    Cell Significance Index: -4.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0534
    Cell Significance Index: -3.7800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0560
    Cell Significance Index: -1.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0589
    Cell Significance Index: -0.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0657
    Cell Significance Index: -3.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0663
    Cell Significance Index: -3.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0723
    Cell Significance Index: -1.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0743
    Cell Significance Index: -1.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0875
    Cell Significance Index: -3.8700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0906
    Cell Significance Index: -3.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0909
    Cell Significance Index: -3.1600
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: -0.0917
    Cell Significance Index: -0.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0979
    Cell Significance Index: -3.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0996
    Cell Significance Index: -3.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1053
    Cell Significance Index: -2.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1060
    Cell Significance Index: -3.4700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1068
    Cell Significance Index: -1.7600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1091
    Cell Significance Index: -2.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1193
    Cell Significance Index: -3.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1213
    Cell Significance Index: -3.2500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1240
    Cell Significance Index: -1.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1294
    Cell Significance Index: -1.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1299
    Cell Significance Index: -3.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1346
    Cell Significance Index: -4.9400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1400
    Cell Significance Index: -2.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1407
    Cell Significance Index: -3.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1415
    Cell Significance Index: -2.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1459
    Cell Significance Index: -3.5000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1468
    Cell Significance Index: -1.9800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1476
    Cell Significance Index: -3.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1502
    Cell Significance Index: -4.4100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.1507
    Cell Significance Index: -0.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1509
    Cell Significance Index: -3.0300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1522
    Cell Significance Index: -0.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1527
    Cell Significance Index: -3.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1528
    Cell Significance Index: -2.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Gamma-carboxylation**: The BGLAP gene is involved in the gamma-carboxylation process, which is a critical post-translational modification that activates certain proteins involved in bone metabolism. 2. **Bone development and mineralization**: Osteocalcin plays a key role in regulating bone development, mineralization, and density, making it an essential component of bone health. 3. **Cellular expression**: The BGLAP gene is expressed in various tissues, including bone, brain, and intestinal epithelium, highlighting its importance in maintaining tissue homeostasis. 4. **Disease associations**: Dysregulation of the BGLAP gene has been linked to several diseases, including osteoporosis, diabetes, and cognitive disorders. **Pathways and Functions** 1. **Bone development and mineralization**: Osteocalcin regulates the expression of genes involved in bone development and mineralization, including Runx2, a transcription factor essential for osteoblast differentiation. 2. **Cellular response to growth factors**: The BGLAP gene is involved in the regulation of cellular responses to growth factors, such as insulin and vitamin D, which are essential for maintaining tissue homeostasis. 3. **Gamma-carboxylation**: Osteocalcin is involved in the gamma-carboxylation process, which activates certain proteins involved in bone metabolism. 4. **Protein binding**: The BGLAP gene encodes for a protein that binds to hydroxyapatite, a key component of bone matrix, highlighting its importance in regulating bone mineralization. **Clinical Significance** 1. **Osteoporosis**: Dysregulation of the BGLAP gene has been linked to osteoporosis, a condition characterized by reduced bone density and increased risk of fractures. 2. **Diabetes**: Osteocalcin has been shown to regulate glucose homeostasis, and dysregulation of the BGLAP gene has been linked to diabetes. 3. **Cognitive disorders**: The BGLAP gene is involved in regulating cognitive functions, and dysregulation of the gene has been linked to cognitive disorders, such as Alzheimer's disease. 4. **Bone resorption**: Osteocalcin regulates the expression of genes involved in bone resorption, making it an essential component of bone health. In conclusion, the BGLAP gene plays a crucial role in regulating bone development, mineralization, and overall skeletal health. Its dysregulation has been linked to several diseases, including osteoporosis, diabetes, and cognitive disorders, highlighting the importance of maintaining the balance of osteocalcin expression in maintaining tissue homeostasis.

Genular Protein ID: 2974643023

Symbol: OSTCN_HUMAN

Name: Osteocalcin

UniProtKB Accession Codes:

P02818 Q5TCK6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 8 Ensembl 1 GO 50 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 3019668

Title: Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones.

PubMed ID: 3019668

DOI: 10.1002/j.1460-2075.1986.tb04440.x

PubMed ID: 2336375

Title: The cDNA and derived amino acid sequences of human and bovine bone Gla protein.

PubMed ID: 2336375

DOI: 10.1093/nar/18.7.1909

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6967872

Title: Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue.

PubMed ID: 6967872

DOI: 10.1016/s0021-9258(18)43554-5

Sequence Information:

  • Length: 100
  • Mass: 10963
  • Checksum: 4DF2A0A80849CB71
  • Sequence:
    • MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR RYLYQWLGAP 
VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.