BGN | ENSG00000182492 | NCBI 633

Details for: BGN

Gene ID: 633

Symbol: BGN

Ensembl ID: ENSG00000182492

Description: biglycan

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-HSA-1971475)
Chondroitin sulfate/dermatan sulfate metabolism
(R-HSA-1793185)
Chondroitin sulfate biosynthesis
(R-HSA-2022870)
Cs/ds degradation
(R-HSA-2024101)
Defective b3galt6 causes edsp2 and semdjl1
(R-HSA-4420332)
Defective b3gat3 causes jdssdhd
(R-HSA-3560801)
Defective b4galt7 causes eds, progeroid type
(R-HSA-3560783)
Defective chst3 causes sedcjd
(R-HSA-3595172)
Defective chst14 causes eds, musculocontractural type
(R-HSA-3595174)
Defective chsy1 causes tpbs
(R-HSA-3595177)
Dermatan sulfate biosynthesis
(R-HSA-2022923)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Ecm proteoglycans
(R-HSA-3000178)
Extracellular matrix organization
(R-HSA-1474244)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Articular cartilage development
(GO:0061975)
Biological_process
(GO:0008150)
Bone development
(GO:0060348)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Cytokine binding
(GO:0019955)
Extracellular exosome
(GO:0070062)
Extracellular matrix
(GO:0031012)
Extracellular matrix binding
(GO:0050840)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular matrix structural constituent conferring compression resistance
(GO:0030021)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glycosaminoglycan binding
(GO:0005539)
Golgi lumen
(GO:0005796)
Lysosomal lumen
(GO:0043202)
Protein binding
(GO:0005515)
Sarcolemma
(GO:0042383)
Transport vesicle
(GO:0030133)

Other Information

Proteins

Biglycan
B4DNL4_HUMAN

Genular Protein ID: 2548018623

Symbol: PGS1_HUMAN

Name: Biglycan

UniProtKB Accession Codes:

P21810 D3DWU3 P13247

Database IDs:

Citations:

PubMed ID: 2647739

Title: Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species.

PubMed ID: 2647739

DOI: 10.1016/s0021-9258(18)83781-4

PubMed ID: 1860845

Title: Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization.

PubMed ID: 1860845

DOI: 10.1016/s0021-9258(18)98694-1

PubMed ID: 10854409

Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.

PubMed ID: 10854409

DOI: 10.1101/gr.10.6.758

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2590169

Title: Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II.

PubMed ID: 2590169

DOI: 10.1042/bj2620823

PubMed ID: 3597437

Title: Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone.

PubMed ID: 3597437

DOI: 10.1016/s0021-9258(18)47991-4

PubMed ID: 7881444

Title: Dinucleotide repeat polymorphism at the human biglycan (BGN) locus.

PubMed ID: 7881444

DOI: 10.1093/hmg/3.12.2268

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27236923

Title: BGN mutations in X-linked spondyloepimetaphyseal dysplasia.

PubMed ID: 27236923

DOI: 10.1016/j.ajhg.2016.04.004

PubMed ID: 27632686

Title: Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections.

PubMed ID: 27632686

DOI: 10.1038/gim.2016.126

Sequence Information:

Length: 368
Mass: 41654
Checksum: BF16F304C5CD3B3E
Sequence:

MWPLWRLVSL LALSQALPFE QRGFWDFTLD DGPFMMNDEE ASGADTSGVL DPDSVTPTYS 
AMCPFGCHCH LRVVQCSDLG LKSVPKEISP DTTLLDLQNN DISELRKDDF KGLQHLYALV 
LVNNKISKIH EKAFSPLRKL QKLYISKNHL VEIPPNLPSS LVELRIHDNR IRKVPKGVFS 
GLRNMNCIEM GGNPLENSGF EPGAFDGLKL NYLRISEAKL TGIPKDLPET LNELHLDHNK 
IQAIELEDLL RYSKLYRLGL GHNQIRMIEN GSLSFLPTLR ELHLDNNKLA RVPSGLPDLK 
LLQVVYLHSN NITKVGVNDF CPMGFGVKRA YYNGISLFNN PVPYWEVQPA TFRCVTDRLA 
IQFGNYKK

Genular Protein ID: 2098812654

Symbol: B4DNL4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNL4

Database IDs:

Sequence Information:

Length: 297
Mass: 33509
Checksum: 504590033068FA4C
Sequence:

MWPLWRLVSL LALSQALPFE QRGFWDFTLD DGPFMMNDEE ASGADTSGVL DPDSVTPTYS 
AMCPFGCHCH LRVVQCSDLG LKSVPKEISL VELRIHDNRI RKVPKGVFSG LRNMNCIEMG 
GNPLENSGFE PGAFDGLKLN YLRISEAKLT GIPKDLPETL NELHLDHNKI QAIELEDLLR 
YSKLYRLGLG HNQIRMIENG SLSFLPTLRE LHLDNNKLAR VPSGLPDLKL LQVVYLHSNN 
ITKVGVNDFC PMGFGVKRAY YNGISLFNNP VPYWEVQPAT FRCVTDRLAI QFGNYKK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BGN

Associated with

Other Information

Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. PubMed ID: 2647739

Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization. PubMed ID: 1860845

Comparative genome sequence analysis of the Bpa/Str region in mouse and man. PubMed ID: 10854409

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II. PubMed ID: 2590169

Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. PubMed ID: 3597437

Dinucleotide repeat polymorphism at the human biglycan (BGN) locus. PubMed ID: 7881444

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer. PubMed ID: 32337544

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

BGN mutations in X-linked spondyloepimetaphyseal dysplasia. PubMed ID: 27236923

Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections. PubMed ID: 27632686