Gene BGN - ENSG00000182492 | NCBI Gene ID: 633

Details for: BGN

Gene ID: 633

Symbol: BGN

Ensembl ID: ENSG00000182492

Description: biglycan

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-HSA-1971475)
Chondroitin sulfate/dermatan sulfate metabolism
(R-HSA-1793185)
Chondroitin sulfate biosynthesis
(R-HSA-2022870)
Cs/ds degradation
(R-HSA-2024101)
Defective b3galt6 causes edsp2 and semdjl1
(R-HSA-4420332)
Defective b3gat3 causes jdssdhd
(R-HSA-3560801)
Defective b4galt7 causes eds, progeroid type
(R-HSA-3560783)
Defective chst3 causes sedcjd
(R-HSA-3595172)
Defective chst14 causes eds, musculocontractural type
(R-HSA-3595174)
Defective chsy1 causes tpbs
(R-HSA-3595177)
Dermatan sulfate biosynthesis
(R-HSA-2022923)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Ecm proteoglycans
(R-HSA-3000178)
Extracellular matrix organization
(R-HSA-1474244)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Articular cartilage development
(GO:0061975)
Biological_process
(GO:0008150)
Bone development
(GO:0060348)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Cytokine binding
(GO:0019955)
Extracellular exosome
(GO:0070062)
Extracellular matrix
(GO:0031012)
Extracellular matrix binding
(GO:0050840)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular matrix structural constituent conferring compression resistance
(GO:0030021)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glycosaminoglycan binding
(GO:0005539)
Golgi lumen
(GO:0005796)
Lysosomal lumen
(GO:0043202)
Protein binding
(GO:0005515)
Sarcolemma
(GO:0042383)
Transport vesicle
(GO:0030133)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.64
Marker Score: 5004
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.43
Marker Score: 2440
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.4
Marker Score: 3243
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.85
Marker Score: 7469
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.54
Marker Score: 1059
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.49
Marker Score: 16182
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.28
Marker Score: 646
Cell Name: supporting cell (CL0000630)
Fold Change: 2.24
Marker Score: 4213.5
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 2.23
Marker Score: 502
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.13
Marker Score: 2450
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.95
Marker Score: 1230
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.91
Marker Score: 1258
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.85
Marker Score: 461
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.84
Marker Score: 461
Cell Name: endocardial cell (CL0002350)
Fold Change: 1.78
Marker Score: 1008
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.76
Marker Score: 1570
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.62
Marker Score: 412
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.59
Marker Score: 54174.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.52
Marker Score: 2348
Cell Name: theca cell (CL0000503)
Fold Change: 1.52
Marker Score: 1086
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.5
Marker Score: 2882
Cell Name: contractile cell (CL0000183)
Fold Change: 1.48
Marker Score: 802
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.48
Marker Score: 383
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168826
Cell Name: keratocyte (CL0002363)
Fold Change: 1.25
Marker Score: 288
Cell Name: pericyte (CL0000669)
Fold Change: 1.23
Marker Score: 716
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.22
Marker Score: 695
Cell Name: inflammatory cell (CL0009002)
Fold Change: 1.2
Marker Score: 515
Cell Name: Unknown (CL0002371)
Fold Change: 1.19
Marker Score: 1269
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.12
Marker Score: 329
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.11
Marker Score: 248
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.11
Marker Score: 402
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.08
Marker Score: 1163
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.08
Marker Score: 365
Cell Name: goblet cell (CL0000160)
Fold Change: 1.05
Marker Score: 6985
Cell Name: fibroblast (CL0000057)
Fold Change: 1.04
Marker Score: 1004
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71791
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48016
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.97
Marker Score: 248
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.94
Marker Score: 802.5
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.93
Marker Score: 263
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.92
Marker Score: 10315.5
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2730
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5149
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.89
Marker Score: 221
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.87
Marker Score: 11516
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5273
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.82
Marker Score: 811
Cell Name: muscle cell (CL0000187)
Fold Change: 0.8
Marker Score: 227
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.8
Marker Score: 365
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 601
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1266
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.77
Marker Score: 291
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.77
Marker Score: 168
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 700
Cell Name: decidual cell (CL2000002)
Fold Change: 0.76
Marker Score: 3298
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 390
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.75
Marker Score: 2050
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.73
Marker Score: 1239.5
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.73
Marker Score: 630
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.71
Marker Score: 1416
Cell Name: precursor cell (CL0011115)
Fold Change: 0.7
Marker Score: 170
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.7
Marker Score: 345
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: osteoblast (CL0000062)
Fold Change: 0.65
Marker Score: 349
Cell Name: kidney cell (CL1000497)
Fold Change: 0.63
Marker Score: 422
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.62
Marker Score: 812
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.61
Marker Score: 754
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.57
Marker Score: 3435
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.57
Marker Score: 272
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.57
Marker Score: 2108
Cell Name: myometrial cell (CL0002366)
Fold Change: 0.56
Marker Score: 162
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.56
Marker Score: 146
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.55
Marker Score: 205
Cell Name: reticular cell (CL0000432)
Fold Change: 0.55
Marker Score: 200.5
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.54
Marker Score: 5430.5
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.52
Marker Score: 167
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.5
Marker Score: 208
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.5
Marker Score: 318
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.47
Marker Score: 114
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.46
Marker Score: 122
Cell Name: neural cell (CL0002319)
Fold Change: 0.45
Marker Score: 218
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.45
Marker Score: 201
Cell Name: podocyte (CL0000653)
Fold Change: 0.44
Marker Score: 164
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.43
Marker Score: 480
Cell Name: myoepithelial cell (CL0000185)
Fold Change: 0.43
Marker Score: 121
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.43
Marker Score: 255
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.42
Marker Score: 98
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.42
Marker Score: 448.5
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.42
Marker Score: 1633
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.4
Marker Score: 358
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.39
Marker Score: 163
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.39
Marker Score: 242
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.38
Marker Score: 358
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.37
Marker Score: 103
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.37
Marker Score: 392.5
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.37
Marker Score: 241

Hover over a box to see details here...

**Key characteristics**: * Biglycan is a type of glycoprotein, which are proteins that are composed of sugar molecules linked together by peptide bonds. * It is a large protein, with a molecular weight of approximately 120 kDa. * Biglycan is expressed in many tissues in the body, including the lungs, kidneys, heart, bones, and skin. * It is involved in a number of important biological processes, including cell migration, cell adhesion, and tissue development. **Pathways and functions**: * Biglycan is a key component of the extracellular matrix, which is a complex network of proteins and polysaccharides that holds cells and tissues together. * It is involved in cell migration, cell adhesion, and tissue development. * It is also involved in a number of other biological processes, including the regulation of cell growth, differentiation, and apoptosis. **Clinical significance**: * Mutations in the BIGLYCAN gene have been linked to a number of human diseases, including: * Dermatan sulfate dysplasia * Ehlers-Danlos syndrome * Marfan syndrome * Osteogenesis imperfecta * Fibrocartilage disorder * These diseases are caused by mutations in genes that are involved in the production or function of biglycan. * Biglycan is a promising target for the treatment of these diseases, as it is a key component of the extracellular matrix that is disrupted in these disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Biglycan
B4DNL4_HUMAN

Genular Protein ID: 2548018623

Symbol: PGS1_HUMAN

Name: Biglycan

UniProtKB Accession Codes:

P21810 D3DWU3 P13247

Database IDs:

Citations:

PubMed ID: 2647739

Title: Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species.

PubMed ID: 2647739

DOI: 10.1016/s0021-9258(18)83781-4

PubMed ID: 1860845

Title: Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization.

PubMed ID: 1860845

DOI: 10.1016/s0021-9258(18)98694-1

PubMed ID: 10854409

Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.

PubMed ID: 10854409

DOI: 10.1101/gr.10.6.758

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2590169

Title: Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II.

PubMed ID: 2590169

DOI: 10.1042/bj2620823

PubMed ID: 3597437

Title: Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone.

PubMed ID: 3597437

DOI: 10.1016/s0021-9258(18)47991-4

PubMed ID: 7881444

Title: Dinucleotide repeat polymorphism at the human biglycan (BGN) locus.

PubMed ID: 7881444

DOI: 10.1093/hmg/3.12.2268

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27236923

Title: BGN mutations in X-linked spondyloepimetaphyseal dysplasia.

PubMed ID: 27236923

DOI: 10.1016/j.ajhg.2016.04.004

PubMed ID: 27632686

Title: Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections.

PubMed ID: 27632686

DOI: 10.1038/gim.2016.126

Sequence Information:

Length: 368
Mass: 41654
Checksum: BF16F304C5CD3B3E
Sequence:

MWPLWRLVSL LALSQALPFE QRGFWDFTLD DGPFMMNDEE ASGADTSGVL DPDSVTPTYS 
AMCPFGCHCH LRVVQCSDLG LKSVPKEISP DTTLLDLQNN DISELRKDDF KGLQHLYALV 
LVNNKISKIH EKAFSPLRKL QKLYISKNHL VEIPPNLPSS LVELRIHDNR IRKVPKGVFS 
GLRNMNCIEM GGNPLENSGF EPGAFDGLKL NYLRISEAKL TGIPKDLPET LNELHLDHNK 
IQAIELEDLL RYSKLYRLGL GHNQIRMIEN GSLSFLPTLR ELHLDNNKLA RVPSGLPDLK 
LLQVVYLHSN NITKVGVNDF CPMGFGVKRA YYNGISLFNN PVPYWEVQPA TFRCVTDRLA 
IQFGNYKK

Genular Protein ID: 2098812654

Symbol: B4DNL4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNL4

Database IDs:

Sequence Information:

Length: 297
Mass: 33509
Checksum: 504590033068FA4C
Sequence:

MWPLWRLVSL LALSQALPFE QRGFWDFTLD DGPFMMNDEE ASGADTSGVL DPDSVTPTYS 
AMCPFGCHCH LRVVQCSDLG LKSVPKEISL VELRIHDNRI RKVPKGVFSG LRNMNCIEMG 
GNPLENSGFE PGAFDGLKLN YLRISEAKLT GIPKDLPETL NELHLDHNKI QAIELEDLLR 
YSKLYRLGLG HNQIRMIENG SLSFLPTLRE LHLDNNKLAR VPSGLPDLKL LQVVYLHSNN 
ITKVGVNDFC PMGFGVKRAY YNGISLFNNP VPYWEVQPAT FRCVTDRLAI QFGNYKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: BGN

Associated with

Cells (max top 100)

Other Information

Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. PubMed ID: 2647739

Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization. PubMed ID: 1860845

Comparative genome sequence analysis of the Bpa/Str region in mouse and man. PubMed ID: 10854409

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II. PubMed ID: 2590169

Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. PubMed ID: 3597437

Dinucleotide repeat polymorphism at the human biglycan (BGN) locus. PubMed ID: 7881444

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer. PubMed ID: 32337544

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

BGN mutations in X-linked spondyloepimetaphyseal dysplasia. PubMed ID: 27236923

Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections. PubMed ID: 27632686