Details for: BGN

Gene ID: 633

Symbol: BGN

Ensembl ID: ENSG00000182492

Description: biglycan

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 110.1941
    Cell Significance Index: -27.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.7561
    Cell Significance Index: -27.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.5375
    Cell Significance Index: -21.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.7915
    Cell Significance Index: -21.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 7.0561
    Cell Significance Index: 90.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8854
    Cell Significance Index: -27.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5511
    Cell Significance Index: -17.0500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.9430
    Cell Significance Index: 29.0400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.0386
    Cell Significance Index: 18.8800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.6726
    Cell Significance Index: 12.3400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.2379
    Cell Significance Index: 13.8500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.1477
    Cell Significance Index: 12.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8548
    Cell Significance Index: 53.1700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.7002
    Cell Significance Index: 9.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.5007
    Cell Significance Index: 26.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4901
    Cell Significance Index: 191.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9631
    Cell Significance Index: 425.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8545
    Cell Significance Index: 117.3500
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.6899
    Cell Significance Index: 5.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6297
    Cell Significance Index: 13.1800
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.4611
    Cell Significance Index: 4.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3524
    Cell Significance Index: 2.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2623
    Cell Significance Index: 52.0500
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.1126
    Cell Significance Index: 0.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0490
    Cell Significance Index: 0.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0187
    Cell Significance Index: 0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0097
    Cell Significance Index: -0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0121
    Cell Significance Index: -22.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0131
    Cell Significance Index: -7.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0178
    Cell Significance Index: -11.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0201
    Cell Significance Index: -37.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0235
    Cell Significance Index: -36.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0272
    Cell Significance Index: -37.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0282
    Cell Significance Index: -20.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0304
    Cell Significance Index: -16.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0305
    Cell Significance Index: -23.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0374
    Cell Significance Index: -23.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0429
    Cell Significance Index: -7.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0565
    Cell Significance Index: -25.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0617
    Cell Significance Index: -13.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0642
    Cell Significance Index: -3.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0716
    Cell Significance Index: -25.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0994
    Cell Significance Index: -17.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0994
    Cell Significance Index: -28.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1227
    Cell Significance Index: -12.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1297
    Cell Significance Index: -14.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1322
    Cell Significance Index: -16.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1333
    Cell Significance Index: -5.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1408
    Cell Significance Index: -28.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1649
    Cell Significance Index: -11.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1777
    Cell Significance Index: -25.8300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1857
    Cell Significance Index: -2.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1862
    Cell Significance Index: -24.0500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1916
    Cell Significance Index: -3.0400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2089
    Cell Significance Index: -5.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2123
    Cell Significance Index: -24.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2252
    Cell Significance Index: -17.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2305
    Cell Significance Index: -26.8600
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2365
    Cell Significance Index: -2.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2692
    Cell Significance Index: -14.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2693
    Cell Significance Index: -28.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3162
    Cell Significance Index: -25.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3236
    Cell Significance Index: -24.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3371
    Cell Significance Index: -8.8700
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.3467
    Cell Significance Index: -2.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3839
    Cell Significance Index: -10.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4112
    Cell Significance Index: -27.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4315
    Cell Significance Index: -20.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4449
    Cell Significance Index: -27.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4878
    Cell Significance Index: -25.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4898
    Cell Significance Index: -30.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5071
    Cell Significance Index: -31.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5231
    Cell Significance Index: -10.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5386
    Cell Significance Index: -25.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5704
    Cell Significance Index: -6.4800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5856
    Cell Significance Index: -9.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6186
    Cell Significance Index: -34.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6256
    Cell Significance Index: -16.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6354
    Cell Significance Index: -22.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6488
    Cell Significance Index: -19.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7021
    Cell Significance Index: -36.4700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7046
    Cell Significance Index: -17.5700
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: -0.7151
    Cell Significance Index: -4.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7362
    Cell Significance Index: -27.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7663
    Cell Significance Index: -19.1400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7740
    Cell Significance Index: -11.1200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8137
    Cell Significance Index: -11.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8152
    Cell Significance Index: -30.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8265
    Cell Significance Index: -28.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.8473
    Cell Significance Index: -6.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8735
    Cell Significance Index: -23.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8923
    Cell Significance Index: -9.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9013
    Cell Significance Index: -29.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9193
    Cell Significance Index: -29.2800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.9327
    Cell Significance Index: -11.3500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.9672
    Cell Significance Index: -9.0800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9716
    Cell Significance Index: -19.7700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9759
    Cell Significance Index: -27.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9860
    Cell Significance Index: -25.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Biglycan is a small leucine-rich proteoglycan with a molecular weight of approximately 30-40 kDa. It is composed of a core protein domain and multiple glycosaminoglycan (GAG) chains. Biglycan has several key characteristics that distinguish it from other proteoglycans: * **Glycosaminoglycan composition**: Biglycan contains a unique GAG composition, consisting of a tetrasaccharide linker sequence, which is essential for its function. * **Collagen binding**: Biglycan binds to collagen type II, a key component of articular cartilage, and modulates its function. * **Growth factor binding**: Biglycan binds to various growth factors, including TGF-β, BMPs, and FGFs, and regulates their activity. * **Antioxidant properties**: Biglycan has antioxidant properties and can neutralize reactive oxygen species (ROS). **Pathways and Functions** Biglycan is involved in various biological pathways, including: * **Articular cartilage development**: Biglycan regulates the development and maintenance of articular cartilage by modulating the activity of growth factors and collagen type II. * **Bone development**: Biglycan is involved in bone development and remodeling, where it regulates the activity of osteoblasts and osteoclasts. * **Extracellular matrix organization**: Biglycan contributes to the organization and structure of the extracellular matrix by binding to collagen and other matrix components. * **Cell signaling**: Biglycan modulates cell signaling pathways, including those involved in inflammation, apoptosis, and cell proliferation. **Clinical Significance** Dysregulation of biglycan expression and function has been implicated in various diseases, including: * **Osteoarthritis**: Abnormal biglycan expression and function have been linked to osteoarthritis, a degenerative joint disease characterized by cartilage loss and bone-on-bone contact. * **Rickets**: Defects in biglycan expression have been associated with rickets, a disorder of bone mineralization caused by vitamin D deficiency. * **Progeroid syndromes**: Mutations in the BGN gene have been linked to progeroid syndromes, a group of rare disorders characterized by premature aging. * **Cancer**: Abnormal biglycan expression has been observed in various types of cancer, including breast, lung, and colon cancer. In conclusion, biglycan is a multifunctional proteoglycan that plays a crucial role in various biological processes, including articular cartilage development, bone development, and extracellular matrix organization. Its dysregulation has been implicated in various diseases, highlighting the importance of biglycan in maintaining tissue homeostasis and overall health.

Genular Protein ID: 2548018623

Symbol: PGS1_HUMAN

Name: Biglycan

UniProtKB Accession Codes:

P21810 D3DWU3 P13247

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 11 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2647739

Title: Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species.

PubMed ID: 2647739

DOI: 10.1016/s0021-9258(18)83781-4

PubMed ID: 1860845

Title: Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization.

PubMed ID: 1860845

DOI: 10.1016/s0021-9258(18)98694-1

PubMed ID: 10854409

Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.

PubMed ID: 10854409

DOI: 10.1101/gr.10.6.758

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2590169

Title: Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II.

PubMed ID: 2590169

DOI: 10.1042/bj2620823

PubMed ID: 3597437

Title: Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone.

PubMed ID: 3597437

DOI: 10.1016/s0021-9258(18)47991-4

PubMed ID: 7881444

Title: Dinucleotide repeat polymorphism at the human biglycan (BGN) locus.

PubMed ID: 7881444

DOI: 10.1093/hmg/3.12.2268

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27236923

Title: BGN mutations in X-linked spondyloepimetaphyseal dysplasia.

PubMed ID: 27236923

DOI: 10.1016/j.ajhg.2016.04.004

PubMed ID: 27632686

Title: Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections.

PubMed ID: 27632686

DOI: 10.1038/gim.2016.126

Sequence Information:

  • Length: 368
  • Mass: 41654
  • Checksum: BF16F304C5CD3B3E
  • Sequence:
    • MWPLWRLVSL LALSQALPFE QRGFWDFTLD DGPFMMNDEE ASGADTSGVL DPDSVTPTYS 
AMCPFGCHCH LRVVQCSDLG LKSVPKEISP DTTLLDLQNN DISELRKDDF KGLQHLYALV 
LVNNKISKIH EKAFSPLRKL QKLYISKNHL VEIPPNLPSS LVELRIHDNR IRKVPKGVFS 
GLRNMNCIEM GGNPLENSGF EPGAFDGLKL NYLRISEAKL TGIPKDLPET LNELHLDHNK 
IQAIELEDLL RYSKLYRLGL GHNQIRMIEN GSLSFLPTLR ELHLDNNKLA RVPSGLPDLK 
LLQVVYLHSN NITKVGVNDF CPMGFGVKRA YYNGISLFNN PVPYWEVQPA TFRCVTDRLA 
IQFGNYKK

Genular Protein ID: 2098812654

Symbol: B4DNL4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNL4

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 3 SUPFAM 1

Sequence Information:

  • Length: 297
  • Mass: 33509
  • Checksum: 504590033068FA4C
  • Sequence:
    • MWPLWRLVSL LALSQALPFE QRGFWDFTLD DGPFMMNDEE ASGADTSGVL DPDSVTPTYS 
AMCPFGCHCH LRVVQCSDLG LKSVPKEISL VELRIHDNRI RKVPKGVFSG LRNMNCIEMG 
GNPLENSGFE PGAFDGLKLN YLRISEAKLT GIPKDLPETL NELHLDHNKI QAIELEDLLR 
YSKLYRLGLG HNQIRMIENG SLSFLPTLRE LHLDNNKLAR VPSGLPDLKL LQVVYLHSNN 
ITKVGVNDFC PMGFGVKRAY YNGISLFNNP VPYWEVQPAT FRCVTDRLAI QFGNYKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.