Details for: CEACAM1

Gene ID: 634

Symbol: CEACAM1

Ensembl ID: ENSG00000079385

Description: CEA cell adhesion molecule 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.1398
    Cell Significance Index: -9.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.4829
    Cell Significance Index: -9.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.7294
    Cell Significance Index: -9.5300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 7.0563
    Cell Significance Index: 43.5400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 5.4809
    Cell Significance Index: 48.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.5262
    Cell Significance Index: 48.1100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 3.1447
    Cell Significance Index: 11.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0983
    Cell Significance Index: -8.3000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 2.6103
    Cell Significance Index: 32.8700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.5409
    Cell Significance Index: 15.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.5400
    Cell Significance Index: 38.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5085
    Cell Significance Index: -5.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4151
    Cell Significance Index: -9.5300
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.3133
    Cell Significance Index: 23.9600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.1375
    Cell Significance Index: 22.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0388
    Cell Significance Index: 387.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9556
    Cell Significance Index: 88.6400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.5672
    Cell Significance Index: 1.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5225
    Cell Significance Index: 79.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0957
    Cell Significance Index: 31.5700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.0220
    Cell Significance Index: 7.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0006
    Cell Significance Index: 903.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9951
    Cell Significance Index: 161.8400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.9159
    Cell Significance Index: 9.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8706
    Cell Significance Index: 14.6700
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.8244
    Cell Significance Index: 8.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7929
    Cell Significance Index: 102.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7875
    Cell Significance Index: 77.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7183
    Cell Significance Index: 33.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6967
    Cell Significance Index: 20.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6707
    Cell Significance Index: 72.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6677
    Cell Significance Index: 132.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5919
    Cell Significance Index: 27.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5445
    Cell Significance Index: 14.5900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5180
    Cell Significance Index: 7.4500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4856
    Cell Significance Index: 7.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4356
    Cell Significance Index: 30.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3878
    Cell Significance Index: 8.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3144
    Cell Significance Index: 7.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2524
    Cell Significance Index: 6.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2254
    Cell Significance Index: 13.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2112
    Cell Significance Index: 15.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1657
    Cell Significance Index: 33.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1363
    Cell Significance Index: 4.7900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1356
    Cell Significance Index: 1.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1104
    Cell Significance Index: 19.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1024
    Cell Significance Index: 29.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0741
    Cell Significance Index: 9.1200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0660
    Cell Significance Index: 1.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0564
    Cell Significance Index: 20.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0544
    Cell Significance Index: 1.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0533
    Cell Significance Index: 2.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0520
    Cell Significance Index: 0.7500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0489
    Cell Significance Index: 0.4700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0472
    Cell Significance Index: 0.5800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0393
    Cell Significance Index: 0.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0342
    Cell Significance Index: 52.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0334
    Cell Significance Index: 0.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0302
    Cell Significance Index: 3.4500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0299
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0258
    Cell Significance Index: 48.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0250
    Cell Significance Index: 46.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0237
    Cell Significance Index: 0.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0197
    Cell Significance Index: 2.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0190
    Cell Significance Index: 0.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0180
    Cell Significance Index: 1.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0088
    Cell Significance Index: 0.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0034
    Cell Significance Index: 0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0025
    Cell Significance Index: 3.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0021
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0025
    Cell Significance Index: -1.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0066
    Cell Significance Index: -2.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0069
    Cell Significance Index: -5.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0076
    Cell Significance Index: -4.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0086
    Cell Significance Index: -5.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0100
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0111
    Cell Significance Index: -1.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0116
    Cell Significance Index: -5.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0118
    Cell Significance Index: -2.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0158
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0180
    Cell Significance Index: -3.7900
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.0181
    Cell Significance Index: -0.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0255
    Cell Significance Index: -3.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0358
    Cell Significance Index: -1.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0398
    Cell Significance Index: -2.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0481
    Cell Significance Index: -1.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0528
    Cell Significance Index: -5.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0552
    Cell Significance Index: -6.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0622
    Cell Significance Index: -7.3400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0747
    Cell Significance Index: -0.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0752
    Cell Significance Index: -1.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0755
    Cell Significance Index: -5.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0791
    Cell Significance Index: -8.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1066
    Cell Significance Index: -6.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1145
    Cell Significance Index: -2.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1227
    Cell Significance Index: -9.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEACAM1 is a member of the immunoglobulin superfamily and is characterized by its ability to bind to other CEACAM1 molecules or to other adhesion molecules, such as integrins and selectins. It is expressed on the surface of various cell types, including epithelial cells, endothelial cells, and immune cells, and is involved in the regulation of cell-cell adhesion, migration, and signaling. **Pathways and Functions:** CEACAM1 is involved in multiple signaling pathways, including: 1. **Cell-cell adhesion:** CEACAM1 mediates homophilic and heterophilic cell-cell adhesion, regulating the interaction between cells and the extracellular matrix. 2. **Immune response:** CEACAM1 is involved in the regulation of immune responses, including the inhibition of cytotoxic T cell degranulation and the modulation of natural killer cell-mediated cytotoxicity. 3. **Cell migration:** CEACAM1 regulates cell migration, including the migration of immune cells, epithelial cells, and endothelial cells. 4. **Tissue homeostasis:** CEACAM1 is involved in the regulation of tissue homeostasis, including the maintenance of epithelial barrier function and the regulation of cell growth and differentiation. **Clinical Significance:** CEACAM1 has been implicated in various diseases, including: 1. **Cancer:** CEACAM1 is overexpressed in several types of cancer, including colorectal, breast, and lung cancer, and is associated with poor prognosis. 2. **Inflammatory diseases:** CEACAM1 is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in diseases such as atherosclerosis and rheumatoid arthritis. 3. **Neurological disorders:** CEACAM1 has been implicated in the regulation of neuroinflammation and is associated with diseases such as multiple sclerosis and Alzheimer's disease. In conclusion, CEACAM1 is a multifunctional adhesion molecule that plays a crucial role in regulating immune response, cell migration, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of CEACAM1 function and its role in human disease. **Protein Structure and Function:** CEACAM1 is a type II transmembrane glycoprotein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains a carbohydrate-binding site, which allows CEACAM1 to bind to other CEACAM1 molecules or to other adhesion molecules. The intracellular domain contains a phosphorylation site, which is involved in the regulation of signaling pathways. **Cellular Expression and Regulation:** CEACAM1 is expressed on the surface of various cell types, including epithelial cells, endothelial cells, and immune cells. Its expression is regulated by a variety of mechanisms, including transcriptional regulation, post-translational modification, and cell-cell interactions. **Evolutionary Conservation:** CEACAM1 is conserved across species, with orthologs found in mammals, birds, and fish. Its conservation suggests that CEACAM1 has evolved to play a crucial role in regulating immune response and cell migration across species. **Future Directions:** Further research into the mechanisms of CEACAM1 function and its role in human disease is necessary to fully understand its clinical significance. This includes the development of novel therapeutic strategies targeting CEACAM1, as well as the investigation of its role in various diseases.

Genular Protein ID: 3782896633

Symbol: CEAM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P13688 A6NE38 A8MY49 O60430 Q069I7 Q13854 Q13857 Q13858 Q13859 Q13860 Q15600 Q15601 Q16170 Q5UB49 Q7KYP5 Q96CA7 Q9UQV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CPTAC 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 31 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 63 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 Pumba 1 RNAct 1 Reactome 4 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2537311

Title: Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family.

PubMed ID: 2537311

DOI: 10.1083/jcb.108.2.267

PubMed ID: 2457922

Title: Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen.

PubMed ID: 2457922

DOI: 10.1073/pnas.85.18.6959

PubMed ID: 2025273

Title: Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library.

PubMed ID: 2025273

DOI: 10.1016/s0006-291x(05)80223-2

PubMed ID: 8423792

Title: Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins.

PubMed ID: 8423792

DOI: 10.1128/mcb.13.2.1273-1282.1993

PubMed ID: 8018919

Title: CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant.

PubMed ID: 8018919

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8055923

Title: Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas.

PubMed ID: 8055923

DOI: 10.1111/j.1432-1033.1994.tb19022.x

PubMed ID: 7628460

Title: Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene.

PubMed ID: 7628460

DOI: 10.1111/j.1432-1033.1995.tb20676.x

PubMed ID: 7478590

Title: Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas.

PubMed ID: 7478590

PubMed ID: 11501563

Title: Redefined nomenclature for members of the carcinoembryonic antigen family.

PubMed ID: 11501563

DOI: 10.1006/excr.1999.4610

PubMed ID: 10436421

Title: Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat.

PubMed ID: 10436421

DOI: 10.1159/000030075

PubMed ID: 11035932

Title: Cell adhesion molecule CEACAM1 associates with paxillin in granulocytes and epithelial and endothelial cells.

PubMed ID: 11035932

DOI: 10.1006/excr.2000.5026

PubMed ID: 11994468

Title: Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes.

PubMed ID: 11994468

DOI: 10.4049/jimmunol.168.10.5139

PubMed ID: 14522961

Title: CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis.

PubMed ID: 14522961

DOI: 10.1074/jbc.m309115200

PubMed ID: 15467833

Title: CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation.

PubMed ID: 15467833

DOI: 10.1172/jci21786

PubMed ID: 16246332

Title: Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils.

PubMed ID: 16246332

DOI: 10.1016/j.febslet.2005.09.089

PubMed ID: 16291724

Title: CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration.

PubMed ID: 16291724

DOI: 10.1242/jcs.02660

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 18424730

Title: Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70.

PubMed ID: 18424730

DOI: 10.4049/jimmunol.180.9.6085

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23696226

Title: CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling.

PubMed ID: 23696226

DOI: 10.1002/eji.201242676

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25363763

Title: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

PubMed ID: 25363763

DOI: 10.1038/nature13848

PubMed ID: 26483485

Title: Diverse oligomeric states of CEACAM IgV domains.

PubMed ID: 26483485

DOI: 10.1073/pnas.1509511112

PubMed ID: 16929097

Title: Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae.

PubMed ID: 16929097

DOI: 10.1107/s0907444906020737

Sequence Information:

  • Length: 526
  • Mass: 57560
  • Checksum: CAD1B2328D069AF8
  • Sequence:
    • MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 
QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 
TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 
NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 
TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST NDTGISIRWF 
FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN PISKNQSDPI MLNVNYNALP 
QENGLSPGAI AGIVIGVVAL VALIAVALAC FLHFGKTGRA SDQRDLTEHK PSVSNHTQDH 
SNDPPNKMNE VTYSTLNFEA QQPTQPTSAS PSLTATEIIY SEVKKQ

Genular Protein ID: 67132752

Symbol: Q3KRG8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q3KRG8

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 493
  • Mass: 53343
  • Checksum: F19711C3783EE455
  • Sequence:
    • GRGDRAAVLE AFLEPKLSST GEDRASRRHH GAPLSPTSQS ACTLAGLLLT ASLLTFWNPP 
TTAQLTTESM PFNVAEGKEV LLLVHNLPQQ LFGYSWYKGE RVDGNRQIVG YAIGTQQATP 
GPANSGRETI YPNASLLIQN VTQNDTGFYT LQVIKSDLVN EEATGQFHVY PELPKPSISS 
NNSNPVEDKD AVAFTCEPET QDTTYLWWIN NQSLPVSPRL QLSNGNRTLT LLSVTRNDTG 
PYECEIQNPV SANRSDPVTL NVTYGPDTPT ISPSDTYYRP GANLSLSCYA ASNPPAQYSW 
LINGTFQQST QELFIPNITV NNSGSYTCHA NNSVTGCNRT TVKTIIVTEL SPVVAKPQIK 
ASKTTVTGDK DSVDLTCSTN DTGISIRWFF KNQSLPSSER MKLSQGNTTL SINPVKREDA 
GTYWCEVFNP ISKNQSDPIM LNVNYNALPQ ENGLSPGAIA GIVIGVVALV ALIAVALACF 
LHFGKTGSSG PLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.