Details for: BHMT

Gene ID: 635

Symbol: BHMT

Ensembl ID: ENSG00000145692

Description: betaine--homocysteine S-methyltransferase

Associated with

Other Information

Genular Protein ID: 3674512377

Symbol: BHMT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q93088 Q9UNI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 10 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniPathway 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8798461

Title: Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase.

PubMed ID: 8798461

DOI: 10.1074/jbc.271.37.22831

PubMed ID: 10075673

Title: Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene.

PubMed ID: 10075673

DOI: 10.1074/jbc.274.12.7816

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9281325

Title: Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene.

PubMed ID: 9281325

DOI: 10.1006/abbi.1997.0246

PubMed ID: 9681996

Title: Human betaine-homocysteine methyltransferase is a zinc metalloenzyme.

PubMed ID: 9681996

DOI: 10.1006/abbi.1998.0757

PubMed ID: 10529246

Title: Recombinant human liver betaine-homocysteine S-methyltransferase: identification of three cysteine residues critical for zinc binding.

PubMed ID: 10529246

DOI: 10.1021/bi991003v

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12220488

Title: Betaine-homocysteine methyltransferase: zinc in a distorted barrel.

PubMed ID: 12220488

DOI: 10.1016/s0969-2126(02)00796-7

PubMed ID: 12818402

Title: Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease.

PubMed ID: 12818402

DOI: 10.1016/s0021-9150(03)00010-8

Sequence Information:

  • Length: 406
  • Mass: 44998
  • Checksum: 557855B8CEDD0D54
  • Sequence:
    • MPPVGGKKAK KGILERLNAG EIVIGDGGFV FALEKRGYVK AGPWTPEAAV EHPEAVRQLH 
REFLRAGSNV MQTFTFYASE DKLENRGNYV LEKISGQEVN EAACDIARQV ADEGDALVAG 
GVSQTPSYLS CKSETEVKKV FLQQLEVFMK KNVDFLIAEY FEHVEEAVWA VETLIASGKP 
VAATMCIGPE GDLHGVPPGE CAVRLVKAGA SIIGVNCHFD PTISLKTVKL MKEGLEAARL 
KAHLMSQPLA YHTPDCNKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC 
GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWVRARARKE YWENLRIASG 
RPYNPSMSKP DGWGVTKGTA ELMQQKEATT EQQLKELFEK QKFKSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.