Details for: BICD1

Gene ID: 636

Symbol: BICD1

Ensembl ID: ENSG00000151746

Description: BICD cargo adaptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 422.4173
    Cell Significance Index: -65.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 253.5647
    Cell Significance Index: -64.3200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 165.2152
    Cell Significance Index: -68.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 134.8802
    Cell Significance Index: -63.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 118.3487
    Cell Significance Index: -48.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.5583
    Cell Significance Index: -66.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.7074
    Cell Significance Index: -60.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.2064
    Cell Significance Index: -55.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.7991
    Cell Significance Index: -66.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.6585
    Cell Significance Index: -34.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 7.6089
    Cell Significance Index: 130.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.2789
    Cell Significance Index: 102.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.8614
    Cell Significance Index: 1385.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.5948
    Cell Significance Index: 201.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.8973
    Cell Significance Index: 178.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7927
    Cell Significance Index: 560.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.4069
    Cell Significance Index: 1664.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.2918
    Cell Significance Index: 65.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.2295
    Cell Significance Index: 149.9100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.1761
    Cell Significance Index: 30.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1578
    Cell Significance Index: 428.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.1008
    Cell Significance Index: 46.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4153
    Cell Significance Index: 36.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2017
    Cell Significance Index: 92.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.1336
    Cell Significance Index: 1541.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0242
    Cell Significance Index: 194.9200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.8870
    Cell Significance Index: 9.2400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.8791
    Cell Significance Index: 11.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7376
    Cell Significance Index: 27.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7157
    Cell Significance Index: 390.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7117
    Cell Significance Index: 82.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6875
    Cell Significance Index: 30.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5452
    Cell Significance Index: 839.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4248
    Cell Significance Index: 42.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3840
    Cell Significance Index: 346.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3613
    Cell Significance Index: 666.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2527
    Cell Significance Index: 34.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2114
    Cell Significance Index: 34.3900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2009
    Cell Significance Index: 2.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1603
    Cell Significance Index: 301.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1496
    Cell Significance Index: 4.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1457
    Cell Significance Index: 17.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1417
    Cell Significance Index: 90.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1400
    Cell Significance Index: 3.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1059
    Cell Significance Index: 0.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0771
    Cell Significance Index: 35.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0092
    Cell Significance Index: -1.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0176
    Cell Significance Index: -1.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0610
    Cell Significance Index: -8.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0621
    Cell Significance Index: -46.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0686
    Cell Significance Index: -50.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0919
    Cell Significance Index: -11.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0931
    Cell Significance Index: -70.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1039
    Cell Significance Index: -58.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1052
    Cell Significance Index: -2.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1064
    Cell Significance Index: -47.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1167
    Cell Significance Index: -72.8800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1443
    Cell Significance Index: -1.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1677
    Cell Significance Index: -7.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1874
    Cell Significance Index: -53.9200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2397
    Cell Significance Index: -4.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2665
    Cell Significance Index: -27.2200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2784
    Cell Significance Index: -5.9500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3093
    Cell Significance Index: -3.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3164
    Cell Significance Index: -54.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3217
    Cell Significance Index: -67.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3219
    Cell Significance Index: -19.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3282
    Cell Significance Index: -7.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3767
    Cell Significance Index: -48.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3818
    Cell Significance Index: -48.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3821
    Cell Significance Index: -26.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3842
    Cell Significance Index: -20.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3900
    Cell Significance Index: -40.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3942
    Cell Significance Index: -13.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4847
    Cell Significance Index: -15.8700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4881
    Cell Significance Index: -9.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5064
    Cell Significance Index: -58.0200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5103
    Cell Significance Index: -6.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5259
    Cell Significance Index: -16.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5411
    Cell Significance Index: -34.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5856
    Cell Significance Index: -11.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6031
    Cell Significance Index: -28.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6612
    Cell Significance Index: -40.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6836
    Cell Significance Index: -35.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6876
    Cell Significance Index: -18.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6891
    Cell Significance Index: -54.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7000
    Cell Significance Index: -10.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7150
    Cell Significance Index: -53.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7209
    Cell Significance Index: -15.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7245
    Cell Significance Index: -45.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7590
    Cell Significance Index: -24.3100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7785
    Cell Significance Index: -13.4600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7959
    Cell Significance Index: -11.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7968
    Cell Significance Index: -56.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9088
    Cell Significance Index: -47.2100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.9505
    Cell Significance Index: -12.6800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.9670
    Cell Significance Index: -7.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.0017
    Cell Significance Index: -12.6400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.0127
    Cell Significance Index: -21.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0163
    Cell Significance Index: -35.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BICD1 is a 76-kDa protein that belongs to the bicaudal D (BICD) family of proteins. It contains three PDZ domains, which are essential for its function as a cargo adaptor. BICD1 interacts with various proteins, including dynactin, dynein, and microtubule-associated proteins, to regulate microtubule dynamics and vesicle trafficking. Its ability to bind to microtubules and regulate their organization has been shown to be crucial for maintaining cellular morphology and function. BICD1 is also a positive regulator of protein localization to centrosomes and the Golgi apparatus. It binds to specific motifs on target proteins, facilitating their transport to these organelles. Furthermore, BICD1 has been shown to interact with G-protein coupled receptors (GPCRs) and regulate their signaling pathways. **Pathways and Functions** BICD1 is involved in several cellular pathways, including: 1. **Microtubule organization and dynamics**: BICD1 regulates microtubule organization by interacting with microtubule-associated proteins and regulating their dynamics. 2. **Vesicle-mediated transport**: BICD1 is a cargo adaptor that regulates the transport of vesicles containing specific proteins to the Golgi apparatus and other organelles. 3. **Protein localization**: BICD1 regulates the localization of proteins to specific organelles, such as the centrosome and Golgi apparatus. 4. **GPCR signaling**: BICD1 interacts with GPCRs and regulates their signaling pathways. 5. **Stress granule assembly**: BICD1 is involved in the assembly of stress granules, which are involved in the regulation of mRNA translation. **Clinical Significance** Dysregulation of BICD1 has been implicated in several neurological disorders, including: 1. **Neurodegenerative diseases**: BICD1 has been shown to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Psychiatric conditions**: BICD1 has been implicated in the pathogenesis of psychiatric conditions, such as schizophrenia and bipolar disorder. 3. **Neurodevelopmental disorders**: BICD1 has been shown to be involved in the regulation of neuronal development and function, and its dysregulation has been implicated in neurodevelopmental disorders, such as autism spectrum disorder. In summary, BICD1 is a multifunctional protein that plays a crucial role in various cellular processes, including microtubule organization, vesicle-mediated transport, protein localization, and GPCR signaling. Its dysregulation has been implicated in several neurological disorders, highlighting the importance of this protein in maintaining cellular homeostasis and function.

Genular Protein ID: 1913779515

Symbol: BICD1_HUMAN

Name: Protein bicaudal D homolog 1

UniProtKB Accession Codes:

Q96G01 A8K2C3 F8W113 O43892 O43893

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 3 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9367685

Title: A human homologue (BICD1) of the Drosophila bicaudal-D gene.

PubMed ID: 9367685

DOI: 10.1006/geno.1997.4971

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12447383

Title: Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex.

PubMed ID: 12447383

DOI: 10.1038/ncb891

PubMed ID: 17707369

Title: A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells.

PubMed ID: 17707369

DOI: 10.1016/j.yexcr.2007.05.032

PubMed ID: 20089649

Title: Bicaudal D1-dependent trafficking of human cytomegalovirus tegument protein pp150 in virus-infected cells.

PubMed ID: 20089649

DOI: 10.1128/jvi.01776-09

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 975
  • Mass: 110750
  • Checksum: CCF0FB12013AA294
  • Sequence:
    • MAAEEVLQTV DHYKTEIERL TKELTETTHE KIQAAEYGLV VLEEKLTLKQ QYDELEAEYD 
SLKQELEQLK EAFGQSFSIH RKVAEDGETR EETLLQESAS KEAYYLGKIL EMQNELKQSR 
AVVTNVQAEN ERLTAVVQDL KENNEMVELQ RIRMKDEIRE YKFREARLLQ DYTELEEENI 
TLQKLVSTLK QNQVEYEGLK HEIKRFEEET VLLNSQLEDA IRLKEIAEHQ LEEALETLKN 
EREQKNNLRK ELSQYISLND NHISISVDGL KFAEDGSEPN NDDKMNGHIH GPLVKLNGDY 
RTPTLRKGES LNPVSDLFSE LNISEIQKLK QQLMQVEREK AILLANLQES QTQLEHTKGA 
LTEQHERVHR LTEHVNAMRG LQSSKELKAE LDGEKGRDSG EEAHDYEVDI NGLEILECKY 
RVAVTEVIDL KAEIKALKEK YNKSVENYTD EKAKYESKIQ MYDEQVTSLE KTTKESGEKM 
AHMEKELQKM TSIANENHST LNTAQDELVT FSEELAQLYH HVCLCNNETP NRVMLDYYRQ 
SRVTRSGSLK GPDDPRGLLS PRLARRGVSS PVETRTSSEP VAKESTEASK EPSPTKTPTI 
SPVITAPPSS PVLDTSDIRK EPMNIYNLNA IIRDQIKHLQ KAVDRSLQLS RQRAAARELA 
PMIDKDKEAL MEEILKLKSL LSTKREQIAT LRAVLKANKQ TAEVALANLK NKYENEKAMV 
TETMTKLRNE LKALKEDAAT FSSLRAMFAT RCDEYVTQLD EMQRQLAAAE DEKKTLNTLL 
RMAIQQKLAL TQRLEDLEFD HEQSRRSKGK LGKSKIGSPK VSGEASVTVP TIDTYLLHSQ 
GPQTPNIRVS SGTQRKRQFS PSLCDQSRPR TSGASYLQNL LRVPPDPTST ESFLLKGPPS 
MSEFIQGHRL SKEKRLTVAP PDCQQPAASV PPQCSQLAGR QDCPTVSPDT ALPEEQPHSS 
SQCAPLHCLS KPPHP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.