Details for: BICD1

Gene ID: 636

Symbol: BICD1

Ensembl ID: ENSG00000151746

Description: BICD cargo adaptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 7.48
    Marker Score: 25069
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 6.43
    Marker Score: 33740
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.58
    Marker Score: 154700
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.95
    Marker Score: 29766
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.71
    Marker Score: 1782
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.67
    Marker Score: 19723
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.4
    Marker Score: 4779.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.11
    Marker Score: 14367
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.96
    Marker Score: 978
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.95
    Marker Score: 62991
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.95
    Marker Score: 3570
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.83
    Marker Score: 2133
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.81
    Marker Score: 3775
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.79
    Marker Score: 21372
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.73
    Marker Score: 40835
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.73
    Marker Score: 54282
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.68
    Marker Score: 1569
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.64
    Marker Score: 6064
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.58
    Marker Score: 98096
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.55
    Marker Score: 3172
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.47
    Marker Score: 10255
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.42
    Marker Score: 1595
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.38
    Marker Score: 998
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.35
    Marker Score: 1316
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.32
    Marker Score: 85682
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.31
    Marker Score: 8915
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.24
    Marker Score: 863
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.23
    Marker Score: 1717
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.2
    Marker Score: 3692
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.14
    Marker Score: 20101
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.12
    Marker Score: 6052
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126460
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.02
    Marker Score: 735
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2
    Marker Score: 20666
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.96
    Marker Score: 4695
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18091
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.87
    Marker Score: 16021
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.86
    Marker Score: 2144
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.85
    Marker Score: 7533
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.85
    Marker Score: 1103
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.82
    Marker Score: 3502
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.79
    Marker Score: 490
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.73
    Marker Score: 1497
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.71
    Marker Score: 992
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.67
    Marker Score: 864
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.63
    Marker Score: 6806.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2484
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.56
    Marker Score: 1684
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.56
    Marker Score: 3420
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.54
    Marker Score: 490
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.53
    Marker Score: 483
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.53
    Marker Score: 1715
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.52
    Marker Score: 1314
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.47
    Marker Score: 431
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167833
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.46
    Marker Score: 5650
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.45
    Marker Score: 537
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.44
    Marker Score: 1778
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.37
    Marker Score: 1707
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.37
    Marker Score: 24257
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.31
    Marker Score: 3222
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.22
    Marker Score: 4324
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.21
    Marker Score: 1765
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.2
    Marker Score: 649
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.19
    Marker Score: 864.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.19
    Marker Score: 41134
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.17
    Marker Score: 4887
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.16
    Marker Score: 1108
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.16
    Marker Score: 11631.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.15
    Marker Score: 685.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.15
    Marker Score: 1633
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.15
    Marker Score: 554
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 17940
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.14
    Marker Score: 4749
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.13
    Marker Score: 1974
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.12
    Marker Score: 553
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.1
    Marker Score: 318
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.1
    Marker Score: 344
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.1
    Marker Score: 658
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.09
    Marker Score: 414
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.08
    Marker Score: 2546
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.07
    Marker Score: 1135
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.06
    Marker Score: 341.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2149
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.04
    Marker Score: 926
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.04
    Marker Score: 377
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.03
    Marker Score: 312
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.01
    Marker Score: 1076.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71722
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47949
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.99
    Marker Score: 372
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.97
    Marker Score: 248
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.97
    Marker Score: 1173
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.96
    Marker Score: 486
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.96
    Marker Score: 15449
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.94
    Marker Score: 6122
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443

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Other Information

**Key characteristics:** - BICD1 is a type I transmembrane protein with a predicted molecular weight of approximately 150 kDa. - It contains a conserved cysteine-rich domain that is essential for its function. - It is a transmembrane protein that is localized to the cytoplasmic face of the ER and the cytosolic face of the Golgi apparatus. - It is a scaffolding protein that facilitates the interaction between the ER and the Golgi apparatus. **Pathways and functions:** - BICD1 is involved in the co-ordination of the secretory and lysosomal pathways. - It is a key regulator of the transport of secretory vesicles from the ER to the Golgi apparatus. - It is also involved in the sorting and transport of lysosomal enzymes from the ER to the lysosome. - BICD1 is also involved in the regulation of cytoskeletal dynamics and cell migration. **Clinical significance:** - Mutations in BICD1 have been linked to several human diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. - These diseases are characterized by the accumulation of amyloid plaques and neurofibrillary tangles, which are believed to be caused by defects in protein trafficking. - Therefore, BICD1 is a promising target for the treatment of these diseases. **Additional information:** - BICD1 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. - It is a member of the BICD family of proteins, which are involved in the sorting and transport of proteins between the ER and the Golgi apparatus. - BICD1 is a dynamic and regulated protein that undergoes various conformational changes that are essential for its function.

Genular Protein ID: 1913779515

Symbol: BICD1_HUMAN

Name: Protein bicaudal D homolog 1

UniProtKB Accession Codes:

Q96G01 A8K2C3 F8W113 O43892 O43893

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9367685

Title: A human homologue (BICD1) of the Drosophila bicaudal-D gene.

PubMed ID: 9367685

DOI: 10.1006/geno.1997.4971

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12447383

Title: Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex.

PubMed ID: 12447383

DOI: 10.1038/ncb891

PubMed ID: 17707369

Title: A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells.

PubMed ID: 17707369

DOI: 10.1016/j.yexcr.2007.05.032

PubMed ID: 20089649

Title: Bicaudal D1-dependent trafficking of human cytomegalovirus tegument protein pp150 in virus-infected cells.

PubMed ID: 20089649

DOI: 10.1128/jvi.01776-09

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 975
  • Mass: 110750
  • Checksum: CCF0FB12013AA294
  • Sequence:
    • MAAEEVLQTV DHYKTEIERL TKELTETTHE KIQAAEYGLV VLEEKLTLKQ QYDELEAEYD 
SLKQELEQLK EAFGQSFSIH RKVAEDGETR EETLLQESAS KEAYYLGKIL EMQNELKQSR 
AVVTNVQAEN ERLTAVVQDL KENNEMVELQ RIRMKDEIRE YKFREARLLQ DYTELEEENI 
TLQKLVSTLK QNQVEYEGLK HEIKRFEEET VLLNSQLEDA IRLKEIAEHQ LEEALETLKN 
EREQKNNLRK ELSQYISLND NHISISVDGL KFAEDGSEPN NDDKMNGHIH GPLVKLNGDY 
RTPTLRKGES LNPVSDLFSE LNISEIQKLK QQLMQVEREK AILLANLQES QTQLEHTKGA 
LTEQHERVHR LTEHVNAMRG LQSSKELKAE LDGEKGRDSG EEAHDYEVDI NGLEILECKY 
RVAVTEVIDL KAEIKALKEK YNKSVENYTD EKAKYESKIQ MYDEQVTSLE KTTKESGEKM 
AHMEKELQKM TSIANENHST LNTAQDELVT FSEELAQLYH HVCLCNNETP NRVMLDYYRQ 
SRVTRSGSLK GPDDPRGLLS PRLARRGVSS PVETRTSSEP VAKESTEASK EPSPTKTPTI 
SPVITAPPSS PVLDTSDIRK EPMNIYNLNA IIRDQIKHLQ KAVDRSLQLS RQRAAARELA 
PMIDKDKEAL MEEILKLKSL LSTKREQIAT LRAVLKANKQ TAEVALANLK NKYENEKAMV 
TETMTKLRNE LKALKEDAAT FSSLRAMFAT RCDEYVTQLD EMQRQLAAAE DEKKTLNTLL 
RMAIQQKLAL TQRLEDLEFD HEQSRRSKGK LGKSKIGSPK VSGEASVTVP TIDTYLLHSQ 
GPQTPNIRVS SGTQRKRQFS PSLCDQSRPR TSGASYLQNL LRVPPDPTST ESFLLKGPPS 
MSEFIQGHRL SKEKRLTVAP PDCQQPAASV PPQCSQLAGR QDCPTVSPDT ALPEEQPHSS 
SQCAPLHCLS KPPHP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.