Details for: BID

Gene ID: 637

Symbol: BID

Ensembl ID: ENSG00000015475

Description: BH3 interacting domain death agonist

Associated with

  • Activation, myristolyation of bid and translocation to mitochondria
    (R-HSA-75108)
  • Activation, translocation and oligomerization of bax
    (R-HSA-114294)
  • Activation and oligomerization of bak protein
    (R-HSA-111452)
  • Activation of bad and translocation to mitochondria
    (R-HSA-111447)
  • Activation of bh3-only proteins
    (R-HSA-114452)
  • Apoptosis
    (R-HSA-109581)
  • Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
    (R-HSA-111453)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Intrinsic pathway for apoptosis
    (R-HSA-109606)
  • Programmed cell death
    (R-HSA-5357801)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Tp53 regulates transcription of cell death genes
    (R-HSA-5633008)
  • Tp53 regulates transcription of genes involved in cytochrome c release
    (R-HSA-6803204)
  • Transcriptional regulation by tp53
    (R-HSA-3700989)
  • Apoptotic mitochondrial changes
    (GO:0008637)
  • Cysteine-type endopeptidase regulator activity involved in apoptotic process
    (GO:0043028)
  • Cytosol
    (GO:0005829)
  • Death receptor binding
    (GO:0005123)
  • Establishment of protein localization to membrane
    (GO:0090150)
  • Extrinsic apoptotic signaling pathway via death domain receptors
    (GO:0008625)
  • Hepatocyte apoptotic process
    (GO:0097284)
  • Membrane
    (GO:0016020)
  • Mitochondrial atp synthesis coupled electron transport
    (GO:0042775)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrial outer membrane permeabilization
    (GO:0097345)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
    (GO:1902230)
  • Neuron apoptotic process
    (GO:0051402)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of fibroblast apoptotic process
    (GO:2000271)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of mitochondrial membrane potential
    (GO:0010918)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein binding
    (GO:0005515)
  • Protein targeting to mitochondrion
    (GO:0006626)
  • Regulation of epithelial cell proliferation
    (GO:0050678)
  • Regulation of g1/s transition of mitotic cell cycle
    (GO:2000045)
  • Regulation of t cell proliferation
    (GO:0042129)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Signal transduction in response to dna damage
    (GO:0042770)
  • Supramolecular fiber organization
    (GO:0097435)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 150.6314
    Cell Significance Index: -23.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.0553
    Cell Significance Index: -18.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.1804
    Cell Significance Index: -26.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 63.7017
    Cell Significance Index: -30.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.5055
    Cell Significance Index: -29.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.2484
    Cell Significance Index: -26.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3714
    Cell Significance Index: -26.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.3730
    Cell Significance Index: -22.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0729
    Cell Significance Index: -27.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2865
    Cell Significance Index: -11.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.0090
    Cell Significance Index: 55.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9828
    Cell Significance Index: 1790.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8618
    Cell Significance Index: 96.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7547
    Cell Significance Index: 23.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2564
    Cell Significance Index: 11.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1785
    Cell Significance Index: 76.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1518
    Cell Significance Index: 30.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1431
    Cell Significance Index: 134.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0741
    Cell Significance Index: 138.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9649
    Cell Significance Index: 45.3500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.8842
    Cell Significance Index: 15.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7051
    Cell Significance Index: 385.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6521
    Cell Significance Index: 117.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6402
    Cell Significance Index: 78.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5878
    Cell Significance Index: 117.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5414
    Cell Significance Index: 107.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5162
    Cell Significance Index: 36.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4895
    Cell Significance Index: 216.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4224
    Cell Significance Index: 151.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4180
    Cell Significance Index: 31.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3436
    Cell Significance Index: 9.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3138
    Cell Significance Index: 16.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2499
    Cell Significance Index: 47.5600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2322
    Cell Significance Index: 3.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1820
    Cell Significance Index: 125.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1638
    Cell Significance Index: 4.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1518
    Cell Significance Index: 6.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1099
    Cell Significance Index: 1.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1065
    Cell Significance Index: 10.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0931
    Cell Significance Index: 5.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0891
    Cell Significance Index: 2.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0326
    Cell Significance Index: 4.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0214
    Cell Significance Index: 39.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0144
    Cell Significance Index: 0.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0119
    Cell Significance Index: 0.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0074
    Cell Significance Index: -13.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0154
    Cell Significance Index: -0.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0176
    Cell Significance Index: -23.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0278
    Cell Significance Index: -21.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0333
    Cell Significance Index: -24.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0365
    Cell Significance Index: -23.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0383
    Cell Significance Index: -28.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0490
    Cell Significance Index: -27.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0517
    Cell Significance Index: -32.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0549
    Cell Significance Index: -0.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0565
    Cell Significance Index: -5.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0577
    Cell Significance Index: -26.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0724
    Cell Significance Index: -20.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0749
    Cell Significance Index: -9.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0844
    Cell Significance Index: -14.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0851
    Cell Significance Index: -9.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1077
    Cell Significance Index: -15.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1120
    Cell Significance Index: -2.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1196
    Cell Significance Index: -3.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1219
    Cell Significance Index: -6.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1446
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1496
    Cell Significance Index: -31.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1664
    Cell Significance Index: -4.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1672
    Cell Significance Index: -8.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1710
    Cell Significance Index: -19.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1732
    Cell Significance Index: -11.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1749
    Cell Significance Index: -7.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1867
    Cell Significance Index: -2.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1934
    Cell Significance Index: -5.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2171
    Cell Significance Index: -8.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2494
    Cell Significance Index: -19.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2518
    Cell Significance Index: -2.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2559
    Cell Significance Index: -5.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2665
    Cell Significance Index: -27.7500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2978
    Cell Significance Index: -6.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3117
    Cell Significance Index: -10.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3270
    Cell Significance Index: -20.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3586
    Cell Significance Index: -28.4000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3958
    Cell Significance Index: -2.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4293
    Cell Significance Index: -9.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4486
    Cell Significance Index: -9.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4949
    Cell Significance Index: -31.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5008
    Cell Significance Index: -12.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5061
    Cell Significance Index: -16.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5325
    Cell Significance Index: -10.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5347
    Cell Significance Index: -17.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5812
    Cell Significance Index: -17.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5930
    Cell Significance Index: -20.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5963
    Cell Significance Index: -9.9800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.6003
    Cell Significance Index: -3.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6361
    Cell Significance Index: -16.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6666
    Cell Significance Index: -24.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6753
    Cell Significance Index: -14.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **BH3 domain:** BID contains a BH3 domain, which is a conserved motif that interacts with anti-apoptotic BCL-2 family members, such as BCL-2, BCL-XL, and BCL-W. 2. **Activation:** BID can be activated through various pathways, including the regulation of BAX, BAK, and BAD, and the activation of BH3-only proteins. 3. **Oligomerization:** Activated BID oligomerizes with BAX and BAK, leading to the formation of the BAX/BID and BAK/BID complexes, which are essential for the release of cytochrome c from mitochondria. 4. **Pro-apoptotic function:** Activated BID promotes apoptosis by regulating the release of cytochrome c from mitochondria, leading to the activation of caspases and the execution of cell death. **Pathways and Functions:** 1. **Activation of BAX, BAK, and BAD:** BID can interact with and activate BAX, BAK, and BAD, leading to their oligomerization and the release of cytochrome c from mitochondria. 2. **Regulation of cytochrome c release:** Activated BID promotes the release of cytochrome c from mitochondria, which is a critical step in the intrinsic apoptotic pathway. 3. **Regulation of caspases:** Activated BID can regulate the activation of caspases, including caspase-9 and caspase-3, which are essential for the execution of cell death. 4. **Regulation of mitochondrial membrane potential:** Activated BID can regulate the mitochondrial membrane potential, leading to the depolarization of mitochondria and the activation of the intrinsic apoptotic pathway. 5. **Regulation of protein-containing complex assembly:** Activated BID can regulate the assembly of protein-containing complexes, such as the BAX/BID complex, which is essential for the release of cytochrome c from mitochondria. **Clinical Significance:** 1. **Cancer:** Dysregulation of BID has been implicated in several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative disorders:** BID has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Inflammatory disorders:** BID has been implicated in inflammatory disorders, such as atherosclerosis and rheumatoid arthritis. 4. **Therapeutic targeting:** BID has been identified as a potential therapeutic target for the treatment of cancer and neurodegenerative disorders. In conclusion, BID is a critical regulator of apoptosis and programmed cell death, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the mechanisms of BID and its role in regulating apoptosis and programmed cell death.

Genular Protein ID: 1583757468

Symbol: BID_HUMAN

Name: BH3-interacting domain death agonist

UniProtKB Accession Codes:

P55957 Q549M7 Q71T04 Q7Z4M9 Q8IY86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 11 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8918887

Title: BID: a novel BH3 domain-only death agonist.

PubMed ID: 8918887

DOI: 10.1101/gad.10.22.2859

PubMed ID: 9721221

Title: The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6.

PubMed ID: 9721221

DOI: 10.1006/geno.1998.5392

PubMed ID: 14583606

Title: Three novel Bid proteins generated by alternative splicing of the human Bid gene.

PubMed ID: 14583606

DOI: 10.1074/jbc.m309769200

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15661737

Title: Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak.

PubMed ID: 15661737

DOI: 10.1074/jbc.m411902200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 20392206

Title: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid.

PubMed ID: 20392206

DOI: 10.1111/j.1742-4658.2010.07562.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29531808

Title: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetero-oligomerization through interaction with Bid in human colon cancer.

PubMed ID: 29531808

DOI: 10.1038/s41420-017-0006-5

PubMed ID: 33106313

Title: Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.

PubMed ID: 33106313

DOI: 10.1074/jbc.ra120.013023

PubMed ID: 32029622

Title: An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.

PubMed ID: 32029622

DOI: 10.1126/science.aay0542

PubMed ID: 10089877

Title: Solution structure of BID, an intracellular amplifier of apoptotic signaling.

PubMed ID: 10089877

DOI: 10.1016/s0092-8674(00)80572-3

Sequence Information:

  • Length: 195
  • Mass: 21995
  • Checksum: B17A07334C1AFBEF
  • Sequence:
    • MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD 
GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE 
EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ 
NLRTYVRSLA RNGMD

Genular Protein ID: 2855580393

Symbol: B2ZP79_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2ZP79

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 6 Gene3D 1 HOGENOM 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 PharmGKB 1 RefSeq 4 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 99
  • Mass: 11263
  • Checksum: 482F50C9C7DF86B0
  • Sequence:
    • MDRSIPPGLV NGLALQLRNT SRSEEDRNRD LATALEQLLQ AYPRDMEKEK TMLVLALLLA 
KKVASHTPSL LRDVFHTTVN FINQNLRTYV RSLARNGMD

Genular Protein ID: 2661786990

Symbol: B3KT21_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KT21

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 7 SMR 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 241
  • Mass: 26809
  • Checksum: 4BCE1D7C769F8527
  • Sequence:
    • MCSGAGVMMA RWAARGRAGW RSTVRILSPL GHCEPGVSRS CRAAQAMDCE VNNGSSLRDE 
CITNLLVFGF LQSCSDSSFR RELDALGHEL PVLAPQWEGY DELQTDGNRS SHSRLGRIEA 
DSESQEDIIR NIARHLAQVG DSMDRSIPPG LVNGLALQLR NTSRSEEDRN RDLATALEQL 
LQAYPRDMEK EKTMLVLALL LAKKVASHTP SLLRDVFHTT VNFINQNLRT YVRSLARNGM 
D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.