Details for: BID

Gene ID: 637

Symbol: BID

Ensembl ID: ENSG00000015475

Description: BH3 interacting domain death agonist

Associated with

  • Activation, myristolyation of bid and translocation to mitochondria
    (R-HSA-75108)
  • Activation, translocation and oligomerization of bax
    (R-HSA-114294)
  • Activation and oligomerization of bak protein
    (R-HSA-111452)
  • Activation of bad and translocation to mitochondria
    (R-HSA-111447)
  • Activation of bh3-only proteins
    (R-HSA-114452)
  • Apoptosis
    (R-HSA-109581)
  • Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
    (R-HSA-111453)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Intrinsic pathway for apoptosis
    (R-HSA-109606)
  • Programmed cell death
    (R-HSA-5357801)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Tp53 regulates transcription of cell death genes
    (R-HSA-5633008)
  • Tp53 regulates transcription of genes involved in cytochrome c release
    (R-HSA-6803204)
  • Transcriptional regulation by tp53
    (R-HSA-3700989)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Apoptotic mitochondrial changes
    (GO:0008637)
  • Cytosol
    (GO:0005829)
  • Death receptor binding
    (GO:0005123)
  • Establishment of protein localization to membrane
    (GO:0090150)
  • Extrinsic apoptotic signaling pathway via death domain receptors
    (GO:0008625)
  • Hepatocyte apoptotic process
    (GO:0097284)
  • Membrane
    (GO:0016020)
  • Mitochondrial atp synthesis coupled electron transport
    (GO:0042775)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrial outer membrane permeabilization
    (GO:0097345)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
    (GO:1902230)
  • Neuron apoptotic process
    (GO:0051402)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of fibroblast apoptotic process
    (GO:2000271)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of mitochondrial membrane potential
    (GO:0010918)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein binding
    (GO:0005515)
  • Protein targeting to mitochondrion
    (GO:0006626)
  • Regulation of epithelial cell proliferation
    (GO:0050678)
  • Regulation of g1/s transition of mitotic cell cycle
    (GO:2000045)
  • Regulation of t cell proliferation
    (GO:0042129)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Signal transduction in response to dna damage
    (GO:0042770)
  • Supramolecular fiber organization
    (GO:0097435)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.68
    Marker Score: 3238
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.35
    Marker Score: 4586
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.35
    Marker Score: 5662
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.05
    Marker Score: 836
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.03
    Marker Score: 113384
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.79
    Marker Score: 7318
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.78
    Marker Score: 1401
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.63
    Marker Score: 2399
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.63
    Marker Score: 1695.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.62
    Marker Score: 41425
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.61
    Marker Score: 18716
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.59
    Marker Score: 3962
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.58
    Marker Score: 1592
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.47
    Marker Score: 808
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 166976
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.46
    Marker Score: 725
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.43
    Marker Score: 4232
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.4
    Marker Score: 968
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.39
    Marker Score: 3594
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.37
    Marker Score: 1598
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.33
    Marker Score: 1332
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.32
    Marker Score: 469
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.29
    Marker Score: 634
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.29
    Marker Score: 13055
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.29
    Marker Score: 3141
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.28
    Marker Score: 2335
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.28
    Marker Score: 12027
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.27
    Marker Score: 48185
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.24
    Marker Score: 294
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.23
    Marker Score: 1249
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.2
    Marker Score: 3322
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.19
    Marker Score: 1577
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.18
    Marker Score: 1240
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.17
    Marker Score: 801
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.16
    Marker Score: 305
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.16
    Marker Score: 295
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.15
    Marker Score: 2740
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.14
    Marker Score: 1755
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.13
    Marker Score: 2003
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.12
    Marker Score: 468
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.12
    Marker Score: 9640
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.12
    Marker Score: 435
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.1
    Marker Score: 749
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.09
    Marker Score: 1251.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 693
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.09
    Marker Score: 6630
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.09
    Marker Score: 723
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.08
    Marker Score: 37561
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.08
    Marker Score: 10286
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.07
    Marker Score: 609
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.06
    Marker Score: 15892
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.05
    Marker Score: 2226
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.05
    Marker Score: 361
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.03
    Marker Score: 461
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Marker Score: 34811
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.02
    Marker Score: 2406
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.01
    Marker Score: 2759
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.01
    Marker Score: 949
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71637
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1
    Marker Score: 524
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47863
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30381
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.98
    Marker Score: 596
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.97
    Marker Score: 481
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.97
    Marker Score: 59717
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.97
    Marker Score: 4009.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.96
    Marker Score: 702
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.96
    Marker Score: 470
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.95
    Marker Score: 314
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.95
    Marker Score: 1663
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.95
    Marker Score: 1664
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.94
    Marker Score: 708
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2385
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.94
    Marker Score: 323
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.93
    Marker Score: 1038
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.92
    Marker Score: 321
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.91
    Marker Score: 272
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.91
    Marker Score: 618
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5156
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.9
    Marker Score: 566.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2679
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.89
    Marker Score: 860
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.89
    Marker Score: 287
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.89
    Marker Score: 1158
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.89
    Marker Score: 1618
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.87
    Marker Score: 3368
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.87
    Marker Score: 377
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.87
    Marker Score: 303
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.87
    Marker Score: 928
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.87
    Marker Score: 214
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.86
    Marker Score: 276
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.86
    Marker Score: 3323
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.86
    Marker Score: 491
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.85
    Marker Score: 204
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.85
    Marker Score: 270

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Other Information

**Key characteristics:** - BID is a protein that is involved in the regulation of apoptosis. - It is a BH3-interacting domain (BID) protein, which is a key regulator of apoptosis. - BID is a pro-apoptotic protein that is normally degraded by the proteasome. - Upon activation, BID translocates to the mitochondria, where it triggers the mitochondrial pathway of apoptosis. **Pathways and functions:** - BID is involved in the activation of the mitochondrial pathway of apoptosis. - The mitochondrial pathway is a form of apoptosis that is triggered by the release of cytochrome c from the mitochondria into the cytoplasm. - Cytochrome c triggers the activation of caspase-9, which is a key enzyme in the mitochondrial pathway of apoptosis. **Clinical significance:** - Mutations in the BID gene have been linked to a number of human cancers. - BID is a potential target for cancer therapy. - Small molecule inhibitors of BID have been shown to be effective in inhibiting cancer growth in vitro and in vivo. **Additional notes:** - BID is a highly conserved protein that is found in organisms from yeast to humans. - BID is a multifunctional protein that can also regulate cell cycle progression and proliferation. - BID is a promising target for cancer therapy due to its important role in apoptosis.

Genular Protein ID: 1583757468

Symbol: BID_HUMAN

Name: BH3-interacting domain death agonist

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8918887

Title: BID: a novel BH3 domain-only death agonist.

PubMed ID: 8918887

DOI: 10.1101/gad.10.22.2859

PubMed ID: 9721221

Title: The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6.

PubMed ID: 9721221

DOI: 10.1006/geno.1998.5392

PubMed ID: 14583606

Title: Three novel Bid proteins generated by alternative splicing of the human Bid gene.

PubMed ID: 14583606

DOI: 10.1074/jbc.m309769200

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15661737

Title: Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak.

PubMed ID: 15661737

DOI: 10.1074/jbc.m411902200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 20392206

Title: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid.

PubMed ID: 20392206

DOI: 10.1111/j.1742-4658.2010.07562.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29531808

Title: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetero-oligomerization through interaction with Bid in human colon cancer.

PubMed ID: 29531808

DOI: 10.1038/s41420-017-0006-5

PubMed ID: 33106313

Title: Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.

PubMed ID: 33106313

DOI: 10.1074/jbc.ra120.013023

PubMed ID: 32029622

Title: An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.

PubMed ID: 32029622

DOI: 10.1126/science.aay0542

PubMed ID: 10089877

Title: Solution structure of BID, an intracellular amplifier of apoptotic signaling.

PubMed ID: 10089877

DOI: 10.1016/s0092-8674(00)80572-3

Sequence Information:

  • Length: 195
  • Mass: 21995
  • Checksum: B17A07334C1AFBEF
  • Sequence:
  • MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD 
    GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE 
    EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ 
    NLRTYVRSLA RNGMD

Genular Protein ID: 2661786990

Symbol: B3KT21_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 241
  • Mass: 26809
  • Checksum: 4BCE1D7C769F8527
  • Sequence:
  • MCSGAGVMMA RWAARGRAGW RSTVRILSPL GHCEPGVSRS CRAAQAMDCE VNNGSSLRDE 
    CITNLLVFGF LQSCSDSSFR RELDALGHEL PVLAPQWEGY DELQTDGNRS SHSRLGRIEA 
    DSESQEDIIR NIARHLAQVG DSMDRSIPPG LVNGLALQLR NTSRSEEDRN RDLATALEQL 
    LQAYPRDMEK EKTMLVLALL LAKKVASHTP SLLRDVFHTT VNFINQNLRT YVRSLARNGM 
    D

Genular Protein ID: 2855580393

Symbol: B2ZP79_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 99
  • Mass: 11263
  • Checksum: 482F50C9C7DF86B0
  • Sequence:
  • MDRSIPPGLV NGLALQLRNT SRSEEDRNRD LATALEQLLQ AYPRDMEKEK TMLVLALLLA 
    KKVASHTPSL LRDVFHTTVN FINQNLRTYV RSLARNGMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.