Details for: BID

Gene ID: 637

Symbol: BID

Ensembl ID: ENSG00000015475

Description: BH3 interacting domain death agonist

Associated with

  • Activation, myristolyation of bid and translocation to mitochondria
    (R-HSA-75108)
  • Activation, translocation and oligomerization of bax
    (R-HSA-114294)
  • Activation and oligomerization of bak protein
    (R-HSA-111452)
  • Activation of bad and translocation to mitochondria
    (R-HSA-111447)
  • Activation of bh3-only proteins
    (R-HSA-114452)
  • Apoptosis
    (R-HSA-109581)
  • Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
    (R-HSA-111453)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Intrinsic pathway for apoptosis
    (R-HSA-109606)
  • Programmed cell death
    (R-HSA-5357801)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Tp53 regulates transcription of cell death genes
    (R-HSA-5633008)
  • Tp53 regulates transcription of genes involved in cytochrome c release
    (R-HSA-6803204)
  • Transcriptional regulation by tp53
    (R-HSA-3700989)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Apoptotic mitochondrial changes
    (GO:0008637)
  • Cytosol
    (GO:0005829)
  • Death receptor binding
    (GO:0005123)
  • Establishment of protein localization to membrane
    (GO:0090150)
  • Extrinsic apoptotic signaling pathway via death domain receptors
    (GO:0008625)
  • Hepatocyte apoptotic process
    (GO:0097284)
  • Membrane
    (GO:0016020)
  • Mitochondrial atp synthesis coupled electron transport
    (GO:0042775)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrial outer membrane permeabilization
    (GO:0097345)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
    (GO:1902230)
  • Neuron apoptotic process
    (GO:0051402)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of fibroblast apoptotic process
    (GO:2000271)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of mitochondrial membrane potential
    (GO:0010918)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein binding
    (GO:0005515)
  • Protein targeting to mitochondrion
    (GO:0006626)
  • Regulation of epithelial cell proliferation
    (GO:0050678)
  • Regulation of g1/s transition of mitotic cell cycle
    (GO:2000045)
  • Regulation of t cell proliferation
    (GO:0042129)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Signal transduction in response to dna damage
    (GO:0042770)
  • Supramolecular fiber organization
    (GO:0097435)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 1583757468

Symbol: BID_HUMAN

Name: BH3-interacting domain death agonist

UniProtKB Accession Codes:

P55957 Q549M7 Q71T04 Q7Z4M9 Q8IY86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 11 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 16 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8918887

Title: BID: a novel BH3 domain-only death agonist.

PubMed ID: 8918887

DOI: 10.1101/gad.10.22.2859

PubMed ID: 9721221

Title: The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6.

PubMed ID: 9721221

DOI: 10.1006/geno.1998.5392

PubMed ID: 14583606

Title: Three novel Bid proteins generated by alternative splicing of the human Bid gene.

PubMed ID: 14583606

DOI: 10.1074/jbc.m309769200

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15661737

Title: Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak.

PubMed ID: 15661737

DOI: 10.1074/jbc.m411902200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 20392206

Title: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid.

PubMed ID: 20392206

DOI: 10.1111/j.1742-4658.2010.07562.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29531808

Title: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetero-oligomerization through interaction with Bid in human colon cancer.

PubMed ID: 29531808

DOI: 10.1038/s41420-017-0006-5

PubMed ID: 33106313

Title: Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.

PubMed ID: 33106313

DOI: 10.1074/jbc.ra120.013023

PubMed ID: 32029622

Title: An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.

PubMed ID: 32029622

DOI: 10.1126/science.aay0542

PubMed ID: 10089877

Title: Solution structure of BID, an intracellular amplifier of apoptotic signaling.

PubMed ID: 10089877

DOI: 10.1016/s0092-8674(00)80572-3

Sequence Information:

  • Length: 195
  • Mass: 21995
  • Checksum: B17A07334C1AFBEF
  • Sequence:
    • MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD 
GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE 
EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ 
NLRTYVRSLA RNGMD

Genular Protein ID: 2661786990

Symbol: B3KT21_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KT21

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 6 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 7 SMR 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 241
  • Mass: 26809
  • Checksum: 4BCE1D7C769F8527
  • Sequence:
    • MCSGAGVMMA RWAARGRAGW RSTVRILSPL GHCEPGVSRS CRAAQAMDCE VNNGSSLRDE 
CITNLLVFGF LQSCSDSSFR RELDALGHEL PVLAPQWEGY DELQTDGNRS SHSRLGRIEA 
DSESQEDIIR NIARHLAQVG DSMDRSIPPG LVNGLALQLR NTSRSEEDRN RDLATALEQL 
LQAYPRDMEK EKTMLVLALL LAKKVASHTP SLLRDVFHTT VNFINQNLRT YVRSLARNGM 
D

Genular Protein ID: 2855580393

Symbol: B2ZP79_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2ZP79

Database IDs:

ARBA 4 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 PharmGKB 1 RefSeq 4 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 99
  • Mass: 11263
  • Checksum: 482F50C9C7DF86B0
  • Sequence:
    • MDRSIPPGLV NGLALQLRNT SRSEEDRNRD LATALEQLLQ AYPRDMEKEK TMLVLALLLA 
KKVASHTPSL LRDVFHTTVN FINQNLRTYV RSLARNGMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.