Gene BIK - ENSG00000100290 | NCBI Gene ID: 638

Details for: BIK

Gene ID: 638

Symbol: BIK

Ensembl ID: ENSG00000100290

Description: BCL2 interacting killer

Associated with

Apoptotic mitochondrial changes
(GO:0008637)
Apoptotic process
(GO:0006915)
Bcl-2 family protein complex
(GO:0097136)
Endomembrane system
(GO:0012505)
Male gonad development
(GO:0008584)
Mitochondrial membrane
(GO:0031966)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of release of cytochrome c from mitochondria
(GO:0090200)
Protein binding
(GO:0005515)
Regulation of apoptotic process
(GO:0042981)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.87
Marker Score: 5560
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.65
Marker Score: 1301
Cell Name: club cell (CL0000158)
Fold Change: 1.63
Marker Score: 1902
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.45
Marker Score: 3289
Cell Name: centrocyte (CL0009111)
Fold Change: 1.43
Marker Score: 340
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.43
Marker Score: 869
Cell Name: secretory cell (CL0000151)
Fold Change: 1.38
Marker Score: 2519.5
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.36
Marker Score: 8699
Cell Name: centroblast (CL0009112)
Fold Change: 1.34
Marker Score: 662
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.19
Marker Score: 4606
Cell Name: stem cell (CL0000034)
Fold Change: 1.13
Marker Score: 2675
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.11
Marker Score: 283
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.1
Marker Score: 9574
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.05
Marker Score: 1310
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251779
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71797
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48021
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.99
Marker Score: 575
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 497
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 451
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.94
Marker Score: 841
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.94
Marker Score: 462
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5322
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.91
Marker Score: 2865
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2731
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.89
Marker Score: 1310
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.89
Marker Score: 256
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 317
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.87
Marker Score: 1656
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5275
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.85
Marker Score: 13350
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.82
Marker Score: 261
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.81
Marker Score: 2388
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.79
Marker Score: 371
Cell Name: malignant cell (CL0001064)
Fold Change: 0.79
Marker Score: 10556
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 593
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.77
Marker Score: 1822
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1250
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.77
Marker Score: 850
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.77
Marker Score: 265
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.75
Marker Score: 5586
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 387
Cell Name: plasmablast (CL0000980)
Fold Change: 0.74
Marker Score: 987
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.74
Marker Score: 455
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.74
Marker Score: 627
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.71
Marker Score: 285
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2905.5
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.68
Marker Score: 196
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.66
Marker Score: 632
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.64
Marker Score: 678
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.63
Marker Score: 5455
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.63
Marker Score: 21786
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.62
Marker Score: 320
Cell Name: peptic cell (CL0000155)
Fold Change: 0.61
Marker Score: 257
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.59
Marker Score: 1351
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.59
Marker Score: 393
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.57
Marker Score: 141
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.56
Marker Score: 1365
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 436
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.53
Marker Score: 129
Cell Name: serous secreting cell (CL0000313)
Fold Change: 0.53
Marker Score: 211
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.52
Marker Score: 249
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.51
Marker Score: 3960
Cell Name: brush cell (CL0002204)
Fold Change: 0.5
Marker Score: 453
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.48
Marker Score: 480
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.48
Marker Score: 399.5
Cell Name: oocyte (CL0000023)
Fold Change: 0.48
Marker Score: 118
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.45
Marker Score: 171
Cell Name: germ cell (CL0000586)
Fold Change: 0.45
Marker Score: 791
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.44
Marker Score: 128
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.44
Marker Score: 697
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.43
Marker Score: 152
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.42
Marker Score: 414
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.42
Marker Score: 1140
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.42
Marker Score: 694
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.42
Marker Score: 851
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.41
Marker Score: 728
Cell Name: ionocyte (CL0005006)
Fold Change: 0.41
Marker Score: 124
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4
Marker Score: 256
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.4
Marker Score: 139
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.4
Marker Score: 3354
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.39
Marker Score: 147
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.38
Marker Score: 121
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.38
Marker Score: 251
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.37
Marker Score: 1287
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.36
Marker Score: 1059
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.36
Marker Score: 245
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.35
Marker Score: 233
Cell Name: paneth cell (CL0000510)
Fold Change: 0.35
Marker Score: 245
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.35
Marker Score: 110
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.35
Marker Score: 90
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.33
Marker Score: 184
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.33
Marker Score: 225
Cell Name: basal cell (CL0000646)
Fold Change: 0.33
Marker Score: 429
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.33
Marker Score: 107
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.33
Marker Score: 151
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.33
Marker Score: 325

Hover over a box to see details here...

**Key characteristics**: - BIK is a transmembrane protein with a molecular weight of approximately 110 kDa. - BIK is a cysteine-rich protein that is highly conserved across species. - BIK is a key regulator of apoptosis in both human and mouse cells. - BIK is involved in the regulation of mitochondrial apoptosis, which is a form of apoptosis that is triggered by the mitochondria. **Pathways and functions**: - BIK is involved in the regulation of mitochondrial apoptosis. - BIK binds to the pro-apoptotic protein Bax, which triggers the mitochondrial pathway of apoptosis. - BIK also binds to the pro-apoptotic protein Bad, which inhibits the mitochondrial pathway of apoptosis. - The binding of BIK to Bax and Bad prevents them from interacting with mitochondrial proteins that are required for apoptosis. **Clinical significance**: - Mutations in the BIK gene have been linked to a number of human cancers. - BIK inhibitors are being investigated as a treatment for cancer. - BIK is a promising target for cancer immunotherapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Bcl-2-interacting killer

Genular Protein ID: 2636869855

Symbol: BIK_HUMAN

Name: Bcl-2-interacting killer

UniProtKB Accession Codes:

Q13323 Q16582 Q6FH93

Database IDs:

Citations:

PubMed ID: 7478623

Title: Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

PubMed ID: 7478623

PubMed ID: 8816500

Title: Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K.

PubMed ID: 8816500

DOI: 10.1128/mcb.16.10.5857

PubMed ID: 10500065

Title: Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer.

PubMed ID: 10500065

DOI: 10.1016/s0016-5085(99)70341-0

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8521816

Title: A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

PubMed ID: 8521816

DOI: 10.1002/j.1460-2075.1995.tb00246.x

PubMed ID: 18953687

Title: A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis.

PubMed ID: 18953687

DOI: 10.1007/s00018-008-8452-0

PubMed ID: 23235460

Title: The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.

PubMed ID: 23235460

DOI: 10.1038/cddis.2012.178

PubMed ID: 23563182

Title: Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B.

PubMed ID: 23563182

DOI: 10.1038/onc.2013.99

Sequence Information:

Length: 160
Mass: 18016
Checksum: 89034F4443F5A136
Sequence:

MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC MEGSDALALR 
LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI RDVLRSFMDG FTTLKENIMR 
FWRSPNPGSW VSCEQVLLAL LLLLALLLPL LSGGLHLLLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: BIK

Associated with

Cells (max top 100)

Other Information

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. PubMed ID: 7478623

Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. PubMed ID: 8816500

Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer. PubMed ID: 10500065

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. PubMed ID: 8521816

A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. PubMed ID: 18953687

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist. PubMed ID: 23235460

Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B. PubMed ID: 23563182