Details for: BIK

Gene ID: 638

Symbol: BIK

Ensembl ID: ENSG00000100290

Description: BCL2 interacting killer

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.1643
    Cell Significance Index: -8.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.8557
    Cell Significance Index: -8.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.8291
    Cell Significance Index: -8.4200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 6.5408
    Cell Significance Index: 15.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.0977
    Cell Significance Index: 594.0800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.9481
    Cell Significance Index: 48.5800
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.6368
    Cell Significance Index: 8.1300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.3212
    Cell Significance Index: 14.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.2099
    Cell Significance Index: -5.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1667
    Cell Significance Index: -8.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1529
    Cell Significance Index: 253.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8090
    Cell Significance Index: 93.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5098
    Cell Significance Index: 32.7100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4549
    Cell Significance Index: 21.8000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.3762
    Cell Significance Index: 19.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1275
    Cell Significance Index: 84.0300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.0916
    Cell Significance Index: 11.2600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.0301
    Cell Significance Index: 6.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9586
    Cell Significance Index: 66.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8101
    Cell Significance Index: 36.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7488
    Cell Significance Index: 21.5800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.7167
    Cell Significance Index: 7.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5909
    Cell Significance Index: 27.5500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.5662
    Cell Significance Index: 4.6800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4899
    Cell Significance Index: 5.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4770
    Cell Significance Index: 12.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4608
    Cell Significance Index: 14.7600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.3921
    Cell Significance Index: 5.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3889
    Cell Significance Index: 8.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3760
    Cell Significance Index: 205.3400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.3638
    Cell Significance Index: 0.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3202
    Cell Significance Index: 15.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2742
    Cell Significance Index: 35.4300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2554
    Cell Significance Index: 1.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2254
    Cell Significance Index: 36.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2229
    Cell Significance Index: 42.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2209
    Cell Significance Index: 21.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1925
    Cell Significance Index: 6.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1913
    Cell Significance Index: 4.4200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.1677
    Cell Significance Index: 0.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1505
    Cell Significance Index: 29.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1086
    Cell Significance Index: 7.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0986
    Cell Significance Index: 2.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0884
    Cell Significance Index: 15.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0831
    Cell Significance Index: 51.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0802
    Cell Significance Index: 2.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0703
    Cell Significance Index: 1.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0576
    Cell Significance Index: 0.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0552
    Cell Significance Index: 6.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0278
    Cell Significance Index: 12.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0051
    Cell Significance Index: 0.8700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.0036
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0013
    Cell Significance Index: 0.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0044
    Cell Significance Index: -6.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0063
    Cell Significance Index: -1.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0068
    Cell Significance Index: -9.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0089
    Cell Significance Index: -5.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0140
    Cell Significance Index: -2.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0149
    Cell Significance Index: -5.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0193
    Cell Significance Index: -8.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0200
    Cell Significance Index: -0.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0216
    Cell Significance Index: -2.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0242
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0268
    Cell Significance Index: -3.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0272
    Cell Significance Index: -7.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0398
    Cell Significance Index: -4.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0490
    Cell Significance Index: -5.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0497
    Cell Significance Index: -7.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0610
    Cell Significance Index: -1.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0662
    Cell Significance Index: -9.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0665
    Cell Significance Index: -4.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0755
    Cell Significance Index: -3.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0785
    Cell Significance Index: -4.9500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0789
    Cell Significance Index: -3.2300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0835
    Cell Significance Index: -0.7100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0836
    Cell Significance Index: -0.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0836
    Cell Significance Index: -8.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0937
    Cell Significance Index: -0.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0937
    Cell Significance Index: -7.1900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0988
    Cell Significance Index: -1.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0996
    Cell Significance Index: -7.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1023
    Cell Significance Index: -6.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1056
    Cell Significance Index: -2.1900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1058
    Cell Significance Index: -1.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1107
    Cell Significance Index: -0.7500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1117
    Cell Significance Index: -1.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1207
    Cell Significance Index: -4.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1235
    Cell Significance Index: -7.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1332
    Cell Significance Index: -8.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1478
    Cell Significance Index: -4.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1540
    Cell Significance Index: -8.6400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1596
    Cell Significance Index: -2.2400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1607
    Cell Significance Index: -2.2300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1664
    Cell Significance Index: -1.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1731
    Cell Significance Index: -4.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BIK is a pro-apoptotic protein that belongs to the Bcl-2 family. It is characterized by its ability to interact with Bcl-2 and other anti-apoptotic proteins, leading to the activation of pro-apoptotic pathways. BIK is specifically expressed in various cell types, including germinal center B cells, epithelial cells, and club cells, highlighting its importance in different tissues and organs. The protein is also involved in the regulation of mitochondrial membrane permeabilization and the release of cytochrome c, making it a key player in the intrinsic pathway of apoptosis. **Pathways and Functions:** BIK is involved in several key pathways, including: 1. **Apoptotic mitochondrial changes:** BIK interacts with Bcl-2 and other anti-apoptotic proteins to regulate mitochondrial membrane permeabilization and the release of cytochrome c. 2. **Apoptotic process:** BIK plays a critical role in the intrinsic pathway of apoptosis, promoting the activation of caspases and the execution of cell death. 3. **Bcl-2 family protein complex:** BIK interacts with other Bcl-2 family members, including Bcl-2, Bcl-XL, and Bcl-W, to regulate their pro-apoptotic activity. 4. **Endomembrane system:** BIK has been implicated in the regulation of endomembrane system function, particularly in the context of cell development and differentiation. 5. **Male gonad development:** BIK is specifically expressed in male gonads and has been shown to play a role in the regulation of spermatogenesis. **Clinical Significance:** The BIK gene has been implicated in various diseases, including: 1. **Cancer:** BIK has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer, where it promotes tumor progression and resistance to chemotherapy. 2. **Autoimmune diseases:** BIK has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it contributes to the dysregulation of immune responses. 3. **Neurodegenerative diseases:** BIK has been shown to be involved in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it contributes to the regulation of neuronal survival and death. In conclusion, the BIK gene is a critical regulator of apoptosis and has been implicated in various cellular processes, including cell development, differentiation, and response to stress. Its dysregulation has been linked to several diseases, highlighting the importance of BIK in maintaining tissue homeostasis and preventing disease. Further research on the BIK gene is needed to fully understand its mechanisms of action and its role in human disease.

Genular Protein ID: 2636869855

Symbol: BIK_HUMAN

Name: BIP1

UniProtKB Accession Codes:

Q13323 Q16582 Q6FH93

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 15 Ensembl 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7478623

Title: Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

PubMed ID: 7478623

PubMed ID: 8816500

Title: Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K.

PubMed ID: 8816500

DOI: 10.1128/mcb.16.10.5857

PubMed ID: 10500065

Title: Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer.

PubMed ID: 10500065

DOI: 10.1016/s0016-5085(99)70341-0

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8521816

Title: A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

PubMed ID: 8521816

DOI: 10.1002/j.1460-2075.1995.tb00246.x

PubMed ID: 18953687

Title: A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis.

PubMed ID: 18953687

DOI: 10.1007/s00018-008-8452-0

PubMed ID: 23235460

Title: The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.

PubMed ID: 23235460

DOI: 10.1038/cddis.2012.178

PubMed ID: 23563182

Title: Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B.

PubMed ID: 23563182

DOI: 10.1038/onc.2013.99

PubMed ID: 31387940

Title: BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.

PubMed ID: 31387940

DOI: 10.1083/jcb.201901156

Sequence Information:

  • Length: 160
  • Mass: 18016
  • Checksum: 89034F4443F5A136
  • Sequence:
    • MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC MEGSDALALR 
LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI RDVLRSFMDG FTTLKENIMR 
FWRSPNPGSW VSCEQVLLAL LLLLALLLPL LSGGLHLLLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.