BCAN | ENSG00000132692 | NCBI 63827

Details for: BCAN

Gene ID: 63827

Symbol: BCAN

Ensembl ID: ENSG00000132692

Description: brevican

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-HSA-1971475)
Chondroitin sulfate/dermatan sulfate metabolism
(R-HSA-1793185)
Chondroitin sulfate biosynthesis
(R-HSA-2022870)
Cs/ds degradation
(R-HSA-2024101)
Defective b3galt6 causes edsp2 and semdjl1
(R-HSA-4420332)
Defective b3gat3 causes jdssdhd
(R-HSA-3560801)
Defective b4galt7 causes eds, progeroid type
(R-HSA-3560783)
Defective chst3 causes sedcjd
(R-HSA-3595172)
Defective chst14 causes eds, musculocontractural type
(R-HSA-3595174)
Defective chsy1 causes tpbs
(R-HSA-3595177)
Degradation of the extracellular matrix
(R-HSA-1474228)
Dermatan sulfate biosynthesis
(R-HSA-2022923)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Ecm proteoglycans
(R-HSA-3000178)
Extracellular matrix organization
(R-HSA-1474244)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Carbohydrate binding
(GO:0030246)
Cell adhesion
(GO:0007155)
Central nervous system development
(GO:0007417)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glial cell differentiation
(GO:0010001)
Glutamatergic synapse
(GO:0098978)
Golgi lumen
(GO:0005796)
Hippocampus development
(GO:0021766)
Hyaluronic acid binding
(GO:0005540)
Lysosomal lumen
(GO:0043202)
Perineuronal net
(GO:0072534)
Positive regulation of neuroblast proliferation
(GO:0002052)
Protein binding
(GO:0005515)
Side of membrane
(GO:0098552)
Skeletal system development
(GO:0001501)
Synapse
(GO:0045202)
Synapse maturation
(GO:0060074)

Other Information

Proteins

Brevican core protein

Genular Protein ID: 1261288002

Symbol: PGCB_HUMAN

Name: Brevican core protein

UniProtKB Accession Codes:

Q96GW7 D3DVC2 Q5SZ10 Q5T3I5 Q8TBB9 Q9HBK1 Q9HBK4

Database IDs:

Citations:

PubMed ID: 11054543

Title: cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma.

PubMed ID: 11054543

DOI: 10.1016/s0378-1119(00)00362-0

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 29777959

Title: Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.

PubMed ID: 29777959

DOI: 10.1016/j.actbio.2018.05.023

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

Sequence Information:

Length: 911
Mass: 99118
Checksum: 5268E796FA3938D2
Sequence:

MAQLFLPLLA ALVLAQAPAA LADVLEGDSS EDRAFRVRIA GDAPLQGVLG GALTIPCHVH 
YLRPPPSRRA VLGSPRVKWT FLSRGREAEV LVARGVRVKV NEAYRFRVAL PAYPASLTDV 
SLALSELRPN DSGIYRCEVQ HGIDDSSDAV EVKVKGVVFL YREGSARYAF SFSGAQEACA 
RIGAHIATPE QLYAAYLGGY EQCDAGWLSD QTVRYPIQTP REACYGDMDG FPGVRNYGVV 
DPDDLYDVYC YAEDLNGELF LGDPPEKLTL EEARAYCQER GAEIATTGQL YAAWDGGLDH 
CSPGWLADGS VRYPIVTPSQ RCGGGLPGVK TLFLFPNQTG FPNKHSRFNV YCFRDSAQPS 
AIPEASNPAS NPASDGLEAI VTVTETLEEL QLPQEATESE SRGAIYSIPI MEDGGGGSST 
PEDPAEAPRT LLEFETQSMV PPTGFSEEEG KALEEEEKYE DEEEKEEEEE EEEVEDEALW 
AWPSELSSPG PEASLPTEPA AQEESLSQAP ARAVLQPGAS PLPDGESEAS RPPRVHGPPT 
ETLPTPRERN LASPSPSTLV EAREVGEATG GPELSGVPRG ESEETGSSEG APSLLPATRA 
PEGTRELEAP SEDNSGRTAP AGTSVQAQPV LPTDSASRGG VAVVPASGDC VPSPCHNGGT 
CLEEEEGVRC LCLPGYGGDL CDVGLRFCNP GWDAFQGACY KHFSTRRSWE EAETQCRMYG 
AHLASISTPE EQDFINNRYR EYQWIGLNDR TIEGDFLWSD GVPLLYENWN PGQPDSYFLS 
GENCVVMVWH DQGQWSDVPC NYHLSYTCKM GLVSCGPPPE LPLAQVFGRP RLRYEVDTVL 
RYRCREGLAQ RNLPLIRCQE NGRWEAPQIS CVPRRPARAL HPEEDPEGRQ GRLLGRWKAL 
LIPPSSPMPG P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BCAN

Associated with

Other Information

cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. PubMed ID: 11054543

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Enrichment of glycopeptides for glycan structure and attachment site identification. PubMed ID: 19838169

Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans. PubMed ID: 25326458

Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix. PubMed ID: 29777959

Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics. PubMed ID: 37453717