Trpv4 | ENSMUSG00000014158 | NCBI 63873

Details for: Trpv4

Gene ID: 63873

Symbol: Trpv4

Ensembl ID: ENSMUSG00000014158

Description: transient receptor potential cation channel, subfamily V, member 4

Associated with

Ion channel transport
(R-MMU-983712)
Stimuli-sensing channels
(R-MMU-2672351)
Transport of small molecules
(R-MMU-382551)
Trp channels
(R-MMU-3295583)
Actin binding
(GO:0003779)
Actin cytoskeleton organization
(GO:0030036)
Actin filament binding
(GO:0051015)
Actin filament organization
(GO:0007015)
Adherens junction
(GO:0005912)
Alpha-tubulin binding
(GO:0043014)
Atp binding
(GO:0005524)
Beta-tubulin binding
(GO:0048487)
Blood vessel endothelial cell delamination
(GO:0097497)
Calcium channel activity
(GO:0005262)
Calcium ion import
(GO:0070509)
Calcium ion import across plasma membrane
(GO:0098703)
Calcium ion import into cytosol
(GO:1902656)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transport
(GO:0006816)
Calmodulin binding
(GO:0005516)
Cartilage development involved in endochondral bone morphogenesis
(GO:0060351)
Cell-cell junction assembly
(GO:0007043)
Cell surface
(GO:0009986)
Cellular hypotonic response
(GO:0071476)
Cellular hypotonic salinity response
(GO:0071477)
Cellular response to heat
(GO:0034605)
Cellular response to osmotic stress
(GO:0071470)
Cilium
(GO:0005929)
Cortical microtubule organization
(GO:0043622)
Cytoplasmic microtubule
(GO:0005881)
Diet induced thermogenesis
(GO:0002024)
Energy homeostasis
(GO:0097009)
Filopodium
(GO:0030175)
Focal adhesion
(GO:0005925)
Glucose homeostasis
(GO:0042593)
Growth cone
(GO:0030426)
Hyperosmotic salinity response
(GO:0042538)
Hypotonic response
(GO:0006971)
Identical protein binding
(GO:0042802)
Intracellular calcium ion homeostasis
(GO:0006874)
Lamellipodium
(GO:0030027)
Lipid binding
(GO:0008289)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Microtubule binding
(GO:0008017)
Microtubule polymerization
(GO:0046785)
Monoatomic cation channel activity
(GO:0005261)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Multicellular organismal-level water homeostasis
(GO:0050891)
Negative regulation of brown fat cell differentiation
(GO:1903444)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleotide binding
(GO:0000166)
Osmosensor activity
(GO:0005034)
Osmosensory signaling pathway
(GO:0007231)
Plasma membrane
(GO:0005886)
Positive regulation of chemokine (c-c motif) ligand 5 production
(GO:0071651)
Positive regulation of chemokine (c-x-c motif) ligand 1 production
(GO:2000340)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of macrophage inflammatory protein 1 alpha production
(GO:0071642)
Positive regulation of microtubule depolymerization
(GO:0031117)
Positive regulation of monocyte chemotactic protein-1 production
(GO:0071639)
Positive regulation of striated muscle contraction
(GO:0045989)
Positive regulation of vascular permeability
(GO:0043117)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein kinase c binding
(GO:0005080)
Regulation of aerobic respiration
(GO:1903715)
Regulation of p38mapk cascade
(GO:1900744)
Regulation of response to osmotic stress
(GO:0047484)
Response to fatty acid
(GO:0070542)
Response to insulin
(GO:0032868)
Response to lipopolysaccharide
(GO:0032496)
Response to osmotic stress
(GO:0006970)
Sh2 domain binding
(GO:0042169)
Stretch-activated, monoatomic cation-selective, calcium channel activity
(GO:0015275)
Transmembrane transport
(GO:0055085)
Vasopressin secretion
(GO:0030103)

Other Information

Proteins

Transient receptor potential cation channel subfamily V member 4

Genular Protein ID: 3604284257

Symbol: TRPV4_MOUSE

Name: Transient receptor potential cation channel subfamily V member 4

UniProtKB Accession Codes:

Q9EPK8 A0JNY0 Q91XR5 Q9EQZ4 Q9ERZ7 Q9ES76

Database IDs:

Citations:

PubMed ID: 11081638

Title: Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.

PubMed ID: 11081638

DOI: 10.1016/s0092-8674(00)00143-4

PubMed ID: 11094154

Title: Trp12, a novel Trp related protein from kidney.

PubMed ID: 11094154

DOI: 10.1016/s0014-5793(00)02212-2

PubMed ID: 11025659

Title: OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity.

PubMed ID: 11025659

DOI: 10.1038/35036318

PubMed ID: 12692122

Title: Impaired pressure sensation in mice lacking TRPV4.

PubMed ID: 12692122

DOI: 10.1074/jbc.m302561200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12093812

Title: Molecular determinants of permeation through the cation channel TRPV4.

PubMed ID: 12093812

DOI: 10.1074/jbc.m204828200

PubMed ID: 14517216

Title: Microtubule-associated protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4).

PubMed ID: 14517216

DOI: 10.1074/jbc.m308212200

PubMed ID: 12538589

Title: Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.

PubMed ID: 12538589

DOI: 10.1074/jbc.m211061200

PubMed ID: 14691263

Title: Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.

PubMed ID: 14691263

DOI: 10.1073/pnas.0303329101

PubMed ID: 16368742

Title: Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking.

PubMed ID: 16368742

DOI: 10.1152/ajprenal.00245.2005

PubMed ID: 16571723

Title: A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.

PubMed ID: 16571723

DOI: 10.1074/jbc.m600549200

PubMed ID: 16627472

Title: PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.

PubMed ID: 16627472

DOI: 10.1074/jbc.m602452200

PubMed ID: 18174177

Title: Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3.

PubMed ID: 18174177

DOI: 10.1074/jbc.m706386200

PubMed ID: 18695040

Title: TRPP2 and TRPV4 form a polymodal sensory channel complex.

PubMed ID: 18695040

DOI: 10.1083/jcb.200805124

PubMed ID: 19033444

Title: Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli.

PubMed ID: 19033444

DOI: 10.1074/jbc.m805357200

PubMed ID: 20043876

Title: Identification of a protein kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel.

PubMed ID: 20043876

DOI: 10.1016/j.bbrc.2009.12.140

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23021218

Title: TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.

PubMed ID: 23021218

DOI: 10.1016/j.cell.2012.08.034

PubMed ID: 24509911

Title: Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1.

PubMed ID: 24509911

DOI: 10.1096/fj.13-243436

PubMed ID: 20413591

Title: The TRPV4 channel contributes to intercellular junction formation in keratinocytes.

PubMed ID: 20413591

DOI: 10.1074/jbc.m110.103606

Sequence Information:

Length: 871
Mass: 98027
Checksum: 5BAC6E33F89CEA05
Sequence:

MADPGDGPRA APGEVAEPPG DESGTSGGEA FPLSSLANLF EGEEGSSSLS PVDASRPAGP 
GDGRPNLRMK FQGAFRKGVP NPIDLLESTL YESSVVPGPK KAPMDSLFDY GTYRHHPSDN 
KRWRRKVVEK QPQSPKAPAP QPPPILKVFN RPILFDIVSR GSTADLDGLL SFLLTHKKRL 
TDEEFREPST GKTCLPKALL NLSNGRNDTI PVLLDIAERT GNMREFINSP FRDIYYRGQT 
SLHIAIERRC KHYVELLVAQ GADVHAQARG RFFQPKDEGG YFYFGELPLS LAACTNQPHI 
VNYLTENPHK KADMRRQDSR GNTVLHALVA IADNTRENTK FVTKMYDLLL LKCSRLFPDS 
NLETVLNNDG LSPLMMAAKT GKIGVFQHII RREVTDEDTR HLSRKFKDWA YGPVYSSLYD 
LSSLDTCGEE VSVLEILVYN SKIENRHEML AVEPINELLR DKWRKFGAVS FYINVVSYLC 
AMVIFTLTAY YQPLEGTPPY PYRTTVDYLR LAGEVITLFT GVLFFFTSIK DLFTKKCPGV 
NSLFVDGSFQ LLYFIYSVLV VVSAALYLAG IEAYLAVMVF ALVLGWMNAL YFTRGLKLTG 
TYSIMIQKIL FKDLFRFLLV YLLFMIGYAS ALVTLLNPCT NMKVCDEDQS NCTVPTYPAC 
RDSETFSAFL LDLFKLTIGM GDLEMLSSAK YPVVFILLLV TYIILTFVLL LNMLIALMGE 
TVGQVSKESK HIWKLQWATT ILDIERSFPV FLRKAFRSGE MVTVGKSSDG TPDRRWCFRV 
DEVNWSHWNQ NLGIINEDPG KSEIYQYYGF SHTVGRLRRD RWSSVVPRVV ELNKNSSADE 
VVVPLDNLGN PNCDGHQQGY APKWRTDDAP L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Trpv4

Associated with

Other Information

Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. PubMed ID: 11081638

Trp12, a novel Trp related protein from kidney. PubMed ID: 11094154

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. PubMed ID: 11025659

Impaired pressure sensation in mice lacking TRPV4. PubMed ID: 12692122

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular determinants of permeation through the cation channel TRPV4. PubMed ID: 12093812

Microtubule-associated protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). PubMed ID: 14517216

Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. PubMed ID: 12538589

Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. PubMed ID: 14691263

Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking. PubMed ID: 16368742

A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. PubMed ID: 16571723

PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. PubMed ID: 16627472

Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. PubMed ID: 18174177

TRPP2 and TRPV4 form a polymodal sensory channel complex. PubMed ID: 18695040

Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli. PubMed ID: 19033444

Identification of a protein kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel. PubMed ID: 20043876

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. PubMed ID: 23021218

Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. PubMed ID: 24509911

The TRPV4 channel contributes to intercellular junction formation in keratinocytes. PubMed ID: 20413591