Pde10a | ENSRNOG00000011310 | NCBI 63885

Details for: Pde10a

Gene ID: 63885

Symbol: Pde10a

Ensembl ID: ENSRNOG00000011310

Description: phosphodiesterase 10A

Associated with

Cgmp effects
(R-RNO-418457)
G alpha (s) signalling events
(R-RNO-418555)
Gpcr downstream signalling
(R-RNO-388396)
Hemostasis
(R-RNO-109582)
Nitric oxide stimulates guanylate cyclase
(R-RNO-392154)
Platelet homeostasis
(R-RNO-418346)
Signaling by gpcr
(R-RNO-372790)
3',5'-cyclic-amp phosphodiesterase activity
(GO:0004115)
3',5'-cyclic-gmp phosphodiesterase activity
(GO:0047555)
3',5'-cyclic-nucleotide phosphodiesterase activity
(GO:0004114)
Camp-mediated signaling
(GO:0019933)
Camp binding
(GO:0030552)
Camp catabolic process
(GO:0006198)
Cgmp-stimulated cyclic-nucleotide phosphodiesterase activity
(GO:0004118)
Cgmp binding
(GO:0030553)
Cgmp catabolic process
(GO:0046069)
Cyclic-nucleotide phosphodiesterase activity
(GO:0004112)
Cytosol
(GO:0005829)
Metal ion binding
(GO:0046872)
Negative regulation of camp-mediated signaling
(GO:0043951)
Negative regulation of cgmp-mediated signaling
(GO:0010754)
Neuronal cell body
(GO:0043025)
Perikaryon
(GO:0043204)
Regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0106070)
Regulation of protein kinase a signaling
(GO:0010738)
Signal transduction
(GO:0007165)

Other Information

Proteins

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Genular Protein ID: 3399526415

Symbol: PDE10_RAT

Name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

UniProtKB Accession Codes:

Q9QYJ6 Q6S9E6 Q6S9E7 Q6S9E8 Q6S9E9 Q9QYJ5

Database IDs:

Citations:

PubMed ID: 10583409

Title: Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10A.

PubMed ID: 10583409

DOI: 10.1046/j.1432-1327.1999.00963.x

PubMed ID: 14752115

Title: Differential amplification of intron-containing transcripts reveals long term potentiation-associated up-regulation of specific Pde10A phosphodiesterase splice variants.

PubMed ID: 14752115

DOI: 10.1074/jbc.m312500200

PubMed ID: 17228859

Title: Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors.

PubMed ID: 17228859

DOI: 10.1021/jm060653b

Sequence Information:

Length: 794
Mass: 90161
Checksum: A36C4678B385846E
Sequence:

MEDGPSNNAS CFRRLTECFL SPSLTDEKVK AYLSLHPQVL DEFVSESVSA ETVEKWLKRK 
NNKAEDEPSP KEVSRYQDTN MQGVVYELNS YIEQRLDTGG DNHLLLYELS SIIRIATKAD 
GFALYFLGEC NNSLCVFTPP GMKEGQPRLI PAGPITQGTT ISAYVAKSRK TLLVEDILGD 
ERFPRGTGLE SGTRIQSVLC LPIVTAIGDL IGILELYRHW GKEAFCLSHQ EVATANLAWA 
SVAIHQVQVC RGLAKQTELN DFLLDVSKTY FDNIVAIDSL LEHIMIYAKN LVNADRCALF 
QVDHKNKELY SDLFDIGEEK EGKPVFKKTK EIRFSIEKGI AGQVARTGEV LNIPDAYADP 
RFNREVDLYT GYTTRNILCM PIVSRGSVIG VVQMVNKISG SAFSKTDENN FKMFAVFCAL 
ALHCANMYHR IRHSECIYRV TMEKLSYHSI CTSEEWQGLM HFNLPARICR DIELFHFDIG 
PFENMWPGIF VYMIHRSCGT SCFELEKLCR FIMSVKKNYR RVPYHNWKHA VTVAHCMYAI 
LQNNNGLFTD LERKGLLIAC LCHDLDHRGF SNSYLQKFDH PLAALYSTST MEQHHFSQTV 
SILQLEGHNI FSTLSSSEYE QVLEIIRKAI IATDLALYFG NRKQLEEMYQ TGSLNLHNQS 
HRDRVIGLMM TACDLCSVTK LWPVTKLTAN DIYAEFWAEG DEMKKLGIQP IPMMDRDKRD 
EVPQGQLGFY NAVAIPCYTT LTQILPPTEP LLKACRDNLN QWEKVIRGEE TAMWISGPAT 
SKSTSEKPTR KVDD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.