Details for: PIEZO2

Gene ID: 63895

Symbol: PIEZO2

Ensembl ID: ENSG00000154864

Description: piezo type mechanosensitive ion channel component 2

Associated with

  • Cellular response to mechanical stimulus
    (GO:0071260)
  • Detection of mechanical stimulus
    (GO:0050982)
  • Detection of mechanical stimulus involved in sensory perception
    (GO:0050974)
  • Mechanosensitive monoatomic ion channel activity
    (GO:0008381)
  • Monoatomic cation channel activity
    (GO:0005261)
  • Monoatomic cation transmembrane transport
    (GO:0098655)
  • Monoatomic cation transport
    (GO:0006812)
  • Plasma membrane
    (GO:0005886)
  • Regulation of membrane potential
    (GO:0042391)
  • Response to mechanical stimulus
    (GO:0009612)

Other Information

Genular Protein ID: 741580999

Symbol: PIEZ2_HUMAN

Name: Piezo-type mechanosensitive ion channel component 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 27607563

Title: Loss of the proprioception and touch sensation channel PIEZO2 in siblings with a progressive form of contractures.

PubMed ID: 27607563

DOI: 10.1111/cge.12850

PubMed ID: 27653382

Title: The Role of PIEZO2 in Human Mechanosensation.

PubMed ID: 27653382

DOI: 10.1056/nejmoa1602812

PubMed ID: 23487782

Title: Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of distal arthrogryposis.

PubMed ID: 23487782

DOI: 10.1073/pnas.1221400110

PubMed ID: 24726473

Title: Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5.

PubMed ID: 24726473

DOI: 10.1016/j.ajhg.2014.03.015

Sequence Information:

  • Length: 2752
  • Mass: 318064
  • Checksum: AD11A1FCEB6D0079
  • Sequence:
  • MASEVVCGLI FRLLLPICLA VACAFRYNGL SFVYLIYLLL IPLFSEPTKT TMQGHTGRLL 
    KSLCFISLSF LLLHIIFHIT LVSLEAQHRI APGYNCSTWE KTFRQIGFES LKGADAGNGI 
    RVFVPDIGMF IASLTIWLLC RNIVQKPVTD EAAQSNPEFE NEELAEGEKI DSEEALIYEE 
    DFNGGDGVEG ELEESTKLKM FRRLASVASK LKEFIGNMIT TAGKVVVTIL LGSSGMMLPS 
    LTSSVYFFVF LGLCTWWSWC RTFDPLLFSC LCVLLAIFTA GHLIGLYLYQ FQFFQEAVPP 
    NDYYARLFGI KSVIQTDCSS TWKIIVNPDL SWYHHANPIL LLVMYYTLAT LIRIWLQEPL 
    VQDEGTKEED KALACSPIQI TAGRRRSLWY ATHYPTDERK LLSMTQDDYK PSDGLLVTVN 
    GNPVDYHTIH PSLPMENGPG KADLYSTPQY RWEPSDESSE KREEEEEEKE EFEEERSREE 
    KRSIKVHAMV SVFQFIMKQS YICALIAMMA WSITYHSWLT FVLLIWSCTL WMIRNRRKYA 
    MISSPFMVVY GNLLLILQYI WSFELPEIKK VPGFLEKKEP GELASKILFT ITFWLLLRQH 
    LTEQKALQEK EALLSEVKIG SQENEEKDEE LQDIQVEGEP KEEEEEEAKE EKQERKKVEQ 
    EEAEEEDEQD IMKVLGNLVV AMFIKYWIYV CGGMFFFVSF EGKIVMYKII YMVLFLFCVA 
    LYQVHYEWWR KILKYFWMSV VIYTMLVLIF IYTYQFENFP GLWQNMTGLK KEKLEDLGLK 
    QFTVAELFTR IFIPTSFLLV CILHLHYFHD RFLELTDLKS IPSKEDNTIY RLAHPEGSLP 
    DLTMMHLTAS LEKPEVRKLA EPGEEKLEGY SEKAQKGDLG KDSEESEEDG EEEEESEEEE 
    ETSDLRNKWH LVIDRLTVLF LKFLEYFHKL QVFMWWILEL HIIKIVSSYI IWVSVKEVSL 
    FNYVFLISWA FALPYAKLRR LASSVCTVWT CVIIVCKMLY QLQTIKPENF SVNCSLPNEN 
    QTNIPFNELN KSLLYSAPID PTEWVGLRKS SPLLVYLRNN LLMLAILAFE VTIYRHQEYY 
    RGRNNLTAPV SRTIFHDITR LHLDDGLINC AKYFINYFFY KFGLETCFLM SVNVIGQRMD 
    FYAMIHACWL IAVLYRRRRK AIAEIWPKYC CFLACIITFQ YFICIGIPPA PCRDYPWRFK 
    GASFNDNIIK WLYFPDFIVR PNPVFLVYDF MLLLCASLQR QIFEDENKAA VRIMAGDNVE 
    ICMNLDAASF SQHNPVPDFI HCRSYLDMSK VIIFSYLFWF VLTIIFITGT TRISIFCMGY 
    LVACFYFLLF GGDLLLKPIK SILRYWDWLI AYNVFVITMK NILSIGACGY IGTLVHNSCW 
    LIQAFSLACT VKGYQMPAAN SPCTLPSGEA GIIWDSICFA FLLLQRRVFM SYYFLHVVAD 
    IKASQILASR GAELFQATIV KAVKARIEEE KKSMDQLKRQ MDRIKARQQK YKKGKERMLS 
    LTQEPGEGQD MQKLSEEDDE READKQKAKG KKKQWWRPWV DHASMVRSGD YYLFETDSEE 
    EEEEELKKED EEPPRRSAFQ FVYQAWITDP KTALRQRHKE KKRSAREERK RRRKGSKEGP 
    VEWEDREDEP IKKKSDGPDN IIKRIFNILK FTWVLFLATV DSFTTWLNSI SREHIDISTV 
    LRIERCMLTR EIKKGNVPTR ESIHMYYQNH IMNLSRESGL DTIDEHPGAA SGAQTAHRMD 
    SLDSHDSISS EPTQCTMLYS RQGTTETIEE VEAEQEEEAG STAPEPREAK EYEATGYDVG 
    AMGAEEASLT PEEELTQFST LDGDVEAPPS YSKAVSFEHL SFGSQDDSAG KNRMAVSPDD 
    SRTDKLGSSI LPPLTHELTA SELLLKKMFH DDELEESEKF YVGQPRFLLL FYAMYNTLVA 
    RSEMVCYFVI ILNHMVSASM ITLLLPILIF LWAMLSVPRP SRRFWMMAIV YTEVAIVVKY 
    FFQFGFFPWN KNVEVNKDKP YHPPNIIGVE KKEGYVLYDL IQLLALFFHR SILKCHGLWD 
    EDDMTESGMA REESDDELSL GHGRRDSSDS LKSINLAASV ESVHVTFPEQ QTAVRRKRSG 
    SSSEPSQRSS FSSNRSQRGS TSTRNSSQKG SSVLSIKQKG KRELYMEKLQ EHLIKAKAFT 
    IKKTLEIYVP IKQFFYNLIH PEYSAVTDVY VLMFLADTVD FIIIVFGFWA FGKHSAAADI 
    TSSLSEDQVP GPFLVMVLIQ FGTMVVDRAL YLRKTVLGKV IFQVILVFGI HFWMFFILPG 
    VTERKFSQNL VAQLWYFVKC VYFGLSAYQI RCGYPTRVLG NFLTKSYNYV NLFLFQGFRL 
    VPFLTELRAV MDWVWTDTTL SLSSWICVED IYAHIFILKC WRESEKRYPQ PRGQKKKKVV 
    KYGMGGMIIV LLICIVWFPL LFMSLIKSVA GVINQPLDVS VTITLGGYQP IFTMSAQQSQ 
    LKVMDQQSFN KFIQAFSRDT GAMQFLENYE KEDITVAELE GNSNSLWTIS PPSKQKMIHE 
    LLDPNSSFSV VFSWSIQRNL SLGAKSEIAT DKLSFPLKNI TRKNIAKMIA GNSTESSKTP 
    VTIEKIYPYY VKAPSDSNSK PIKQLLSENN FMDITIILSR DNTTKYNSEW WVLNLTGNRI 
    YNPNSQALEL VVFNDKVSPP SLGFLAGYGI MGLYASVVLV IGKFVREFFS GISHSIMFEE 
    LPNVDRILKL CTDIFLVRET GELELEEDLY AKLIFLYRSP ETMIKWTREK TN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.