Details for: PRDM1
Gene ID: 639
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PRDM1
Ensembl ID: ENSG00000057657
Description: PR/SET domain 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 33.01rCSI 31.83%PRS 44.95
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CSI 29.15rCSI 38.21%PRS 83.63
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CSI 20.01rCSI 26.22%PRS 67.93
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CSI 17.69rCSI 13.92%PRS 61.16
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CSI 13.87rCSI 16.61%PRS 72.7
-
CSI 13.5rCSI 20.62%PRS 55.09
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CSI 12.61rCSI 40.89%PRS 55.96
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CSI 12.28rCSI 34.55%PRS 52.17
-
CSI 11.87rCSI 9.23%PRS 72.24
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CSI 11.53rCSI 8.63%PRS 69.69
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CSI 9.67rCSI 9.9%PRS 70.85
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CSI 8.96rCSI 23.64%PRS 62.96
-
CSI 8.19rCSI 7.56%PRS 55.59
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CSI 7.71rCSI 14.55%PRS 64.84
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CSI 7.67rCSI 10.85%PRS 61.03
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CSI 7.56rCSI 17.16%PRS 59.57
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CSI 7.26rCSI 8.17%PRS 70.93
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CSI 6.7rCSI 29.48%PRS 46.06
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CSI 6.63rCSI 8.48%PRS 79.71
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CSI 6.61rCSI 9.09%PRS 74.6
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CSI 6.24rCSI 7.31%PRS 70.7
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CSI 6.17rCSI 28.5%PRS 74.66
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CSI 6.13rCSI 7.62%PRS 35.32
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CSI 5.47rCSI 6.34%PRS 68.95
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CSI 4.86rCSI 9.69%PRS 72.69
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CSI 4.71rCSI 11.17%PRS 59.2
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CSI 4.45rCSI 3.1%PRS 68.7
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CSI 4.26rCSI 7.38%PRS 44.61
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CSI 4.16rCSI 10.75%PRS 81.93
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CSI 4rCSI 3.02%PRS 68.08
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CSI 3.96rCSI 4.13%PRS 79.19
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CSI 3.9rCSI 8.1%PRS 51.68
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CSI 3.71rCSI 2.47%PRS 76.73
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CSI 3.24rCSI 6.17%PRS 70.23
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CSI 3.1rCSI 2.22%PRS 68.37
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CSI 2.95rCSI 2.24%PRS 67.06
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CSI 2.94rCSI 3.52%PRS 74.42
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CSI 2.9rCSI 3.64%PRS 67.22
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CSI 2.88rCSI 6.35%PRS 58.27
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CSI 2.88rCSI 2.66%PRS 74.53
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CSI 2.79rCSI 7.27%PRS 53.64
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CSI 2.73rCSI 2.68%PRS 78.01
-
CSI 2.65rCSI 1.84%PRS 64.77
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CSI 2.64rCSI 1.56%PRS 71.22
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CSI 2.58rCSI 5.78%PRS 72.87
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CSI 2.57rCSI 2.52%PRS 70.26
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CSI 2.56rCSI 2.33%PRS 68.71
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CSI 2.54rCSI 3.96%PRS 79.85
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CSI 2.39rCSI 3.27%PRS 60
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CSI 2.38rCSI 4.51%PRS 85.18
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CSI 2.01rCSI 3.2%PRS 58.24
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CSI 1.95rCSI 1.59%PRS 54.79
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CSI 1.94rCSI 4.33%PRS 61.81
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CSI 1.93rCSI 2.48%PRS 38.17
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CSI 1.91rCSI 2%PRS 51.18
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CSI 1.88rCSI 2.27%PRS 62.84
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CSI 1.88rCSI 12.89%PRS 69.48
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CSI 1.87rCSI 2.82%PRS 57.53
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CSI 1.86rCSI 1.48%PRS 76.51
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CSI 1.84rCSI 6.64%PRS 74.22
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CSI 1.75rCSI 1.3%PRS 72.21
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CSI 1.74rCSI 23.8%PRS 84.1
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CSI 1.69rCSI 9.84%PRS 64.34
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CSI 1.66rCSI 2.84%PRS 79.3
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CSI 1.62rCSI 2.48%PRS 62.75
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CSI 1.59rCSI 4.56%PRS 73.78
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CSI 1.56rCSI 2.51%PRS 44.4
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CSI 1.4rCSI 1.91%PRS 80.07
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CSI 1.35rCSI 1.96%PRS 70.48
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CSI 1.32rCSI 0.89%PRS 66.79
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CSI 1.31rCSI 3.55%PRS 85.79
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CSI 1.3rCSI 1.36%PRS 53.08
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CSI 1.3rCSI 3.13%PRS 87.86
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CSI 1.21rCSI 1.47%PRS 44.59
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CSI 1.21rCSI 2.07%PRS 73.6
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CSI 1.18rCSI 1.08%PRS 62.78
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CSI 1.15rCSI 1.34%PRS 63.3
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CSI 1.15rCSI 7.58%PRS 79.3
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CSI 1.1rCSI 1.68%PRS 71.17
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CSI 0.88rCSI 1.82%PRS 57.66
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CSI 0.88rCSI 3.7%PRS 70.63
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CSI 0.85rCSI 6.24%PRS 74.35
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CSI 0.74rCSI 3.3%PRS 89.36
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CSI 0.68rCSI 0.84%PRS 56.51
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CSI 0.67rCSI 3.01%PRS 87.8
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CSI 0.55rCSI 1.83%PRS 40.65
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CSI 0.53rCSI 2.6%PRS 65.83
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CSI 0.49rCSI 1.75%PRS 64.98
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CSI 0.49rCSI 0.95%PRS 81.8
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CSI 0.48rCSI 2.39%PRS 66.79
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CSI 0.31rCSI 7.31%PRS 75.91
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CSI 0.29rCSI 2.9%PRS 75.4
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CSI 0.19rCSI 1.06%PRS 64.94
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4161602001
Symbol: PRDM1_HUMAN
Name: PR domain zinc finger protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1851123
Title: Identification and characterization of a novel repressor of beta-interferon gene expression.
PubMed ID: 1851123
DOI: 10.1101/gad.5.5.868
PubMed ID: 12626569
Title: Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines.
PubMed ID: 12626569
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21421998
PubMed ID: 22555612
Title: SUMOylation of Blimp-1 is critical for plasma cell differentiation.
PubMed ID: 22555612
PubMed ID: 24613396
Title: DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.
PubMed ID: 24613396
PubMed ID: 24968003
Title: BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans.
PubMed ID: 24968003
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 32417234
Title: LDB1 and the SWI/SNF complex participate in both transcriptional activation and repression by Caenorhabditis elegans BLIMP1/PRDM1.
PubMed ID: 32417234
PubMed ID: 28842558
Title: HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.
PubMed ID: 28842558
Sequence Information:
- Length: 825
- Mass: 91771
- Checksum: 07B389BACCD6172F
- Sequence:
MLDICLEKRV GTTLAAPKCN SSTVRFQGLA EGTKGTMKMD MEDADMTLWT EAEFEEKCTY IVNDHPWDSG ADGGTSVQAE ASLPRNLLFK YATNSEEVIG VMSKEYIPKG TRFGPLIGEI YTNDTVPKNA NRKYFWRIYS RGELHHFIDG FNEEKSNWMR YVNPAHSPRE QNLAACQNGM NIYFYTIKPI PANQELLVWY CRDFAERLHY PYPGELTMMN LTQTQSSLKQ PSTEKNELCP KNVPKREYSV KEILKLDSNP SKGKDLYRSN ISPLTSEKDL DDFRRRGSPE MPFYPRVVYP IRAPLPEDFL KASLAYGIER PTYITRSPIP SSTTPSPSAR SSPDQSLKSS SPHSSPGNTV SPVGPGSQEH RDSYAYLNAS YGTEGLGSYP GYAPLPHLPP AFIPSYNAHY PKFLLPPYGM NCNGLSAVSS MNGINNFGLF PRLCPVYSNL LGGGSLPHPM LNPTSLPSSL PSDGARRLLQ PEHPREVLVP APHSAFSFTG AAASMKDKAC SPTSGSPTAG TAATAEHVVQ PKATSAAMAA PSSDEAMNLI KNKRNMTGYK TLPYPLKKQN GKIKYECNVC AKTFGQLSNL KVHLRVHSGE RPFKCQTCNK GFTQLAHLQK HYLVHTGEKP HECQVCHKRF SSTSNLKTHL RLHSGEKPYQ CKVCPAKFTQ FVHLKLHKRL HTRERPHKCS QCHKNYIHLC SLKVHLKGNC AAAPAPGLPL EDLTRINEEI EKFDISDNAD RLEDVEDDIS VISVVEKEIL AVVRKEKEET GLKVSLQRNM GNGLLSSGCS LYESSDLPLM KLPPSNPLPL VPVKVKQETV EPMDP
Genular Protein ID: 3231884389
Symbol: Q5T4E8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 789
- Mass: 87991
- Checksum: 6A1FEBEAD309BC7D
- Sequence:
MKMDMEDADM TLWTEAEFEE KCTYIVNDHP WDSGADGGTS VQAEASLPRN LLFKYATNSE EVIGVMSKEY IPKGTRFGPL IGEIYTNDTV PKNANRKYFW RIYSRGELHH FIDGFNEEKS NWMRYVNPAH SPREQNLAAC QNGMNIYFYT IKPIPANQEL LVWYCRDFAE RLHYPYPGEL TMMNLTQTQS SLKQPSTEKN ELCPKNVPKR EYSVKEILKL DSNPSKGKDL YRSNISPLTS EKDLDDFRRR GSPEMPFYPR VVYPIRAPLP EDFLKASLAY GIERPTYITR SPIPSSTTPS PSARSSPDQS LKSSSPHSSP GNTVSPVGPG SQEHRDSYAY LNASYGTEGL GSYPGYAPLP HLPPAFIPSY NAHYPKFLLP PYGMNCNGLS AVSSMNGINN FGLFPRLCPV YSNLLGGGSL PHPMLNPTSL PSSLPSDGAR RLLQPEHPRE VLVPAPHSAF SFTGAAASMK DKACSPTSGS PTAGTAATAE HVVQPKATSA AMAAPSSDEA MNLIKNKRNM TGYKTLPYPL KKQNGKIKYE CNVCAKTFGQ LSNLKVHLRV HSGERPFKCQ TCNKGFTQLA HLQKHYLVHT GEKPHECQVC HKRFSSTSNL KTHLRLHSGE KPYQCKVCPA KFTQFVHLKL HKRLHTRERP HKCSQCHKNY IHLCSLKVHL KGNCAAAPAP GLPLEDLTRI NEEIEKFDIS DNADRLEDVE DDISVISVVE KEILAVVRKE KEETGLKVSL QRNMGNGLLS SGCSLYESSD LPLMKLPPSN PLPLVPVKVK QETVEPMDP
Genular Protein ID: 1467833650
Symbol: B4DW27_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 629
- Mass: 70046
- Checksum: 17E63BE19CC57AE7
- Sequence:
MEKIYSRGEL HHFIDGFNEE KSNWMRYVNP AHSPREQNLA ACQNGMNIYF YTIKPIPANQ ELLVWYCRDF AERLHYPYPG ELTMMNLTQT QSSLKQPSTE KNELCPKNVP KREYSVKEIL KLDSNPSKGK DLYRSNISPL TSEKDLDDFR RRGSPEMPFY PRVVYPIRAP LPEDFLKASL AYGIERPTYI TRSPIPSSTT PSPSARSSPD QSLKSSSPHS SPGNTVSPVG PGSQEHRDSY AYLNASYGTE GLGSYPGYAP LPHLPPAFIP SYNAHYPKFL LPPYGMNCNG LSAVSSMNGI NNFGLFPRLC PVYSNLLGGG SLPHPMLNPT SLPSSLPSDG ARRLLQPEHP REVLVPAPHS AFSFTGAAAS MKDKACSPTS GSPTAGTAAT AEHVVQPKAT SAAMAAPSSD EAMNLIKNKR NMTGYKTLPY PLKKQNGKIK YECNVCAKTF GQLSNLKVHL RVHSGERPFK CQTCNKGFTQ LAHLQKHYLV HTGEKPHECQ VCHKRFSSTS NLKTHLRLHS GEKPYQCKVC PAKFTQFVHL KLHKRLHTRE RPHKCSQCHK NYIHLCSLKV HLKGNCAAAP APGLPLEDLT RINEEIEKFD ISDNADRLED VEDDISVISV VEKEILAVV
Genular Protein ID: 3327863494
Symbol: A0A3B3IU23_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
Sequence Information:
- Length: 839
- Mass: 93296
- Checksum: 8802B62F65B12C0A
- Sequence:
MTPGILGHWT VCPEHFSAMR GKARDCSEAA PKCNSSTVRF QGLAEGTKGT MKMDMEDADM TLWTEAEFEE KCTYIVNDHP WDSGADGGTS VQAEASLPRN LLFKYATNSE EVIGVMSKEY IPKGTRFGPL IGEIYTNDTV PKNANRKYFW RIYSRGELHH FIDGFNEEKS NWMRYVNPAH SPREQNLAAC QNGMNIYFYT IKPIPANQEL LVWYCRDFAE RLHYPYPGEL TMMNLTQTQS SLKQPSTEKN ELCPKNVPKR EYSVKEILKL DSNPSKGKDL YRSNISPLTS EKDLDDFRRR GSPEMPFYPR VVYPIRAPLP EDFLKASLAY GIERPTYITR SPIPSSTTPS PSARSSPDQS LKSSSPHSSP GNTVSPVGPG SQEHRDSYAY LNASYGTEGL GSYPGYAPLP HLPPAFIPSY NAHYPKFLLP PYGMNCNGLS AVSSMNGINN FGLFPRLCPV YSNLLGGGSL PHPMLNPTSL PSSLPSDGAR RLLQPEHPRE VLVPAPHSAF SFTGAAASMK DKACSPTSGS PTAGTAATAE HVVQPKATSA AMAAPSSDEA MNLIKNKRNM TGYKTLPYPL KKQNGKIKYE CNVCAKTFGQ LSNLKVHLRV HSGERPFKCQ TCNKGFTQLA HLQKHYLVHT GEKPHECQVC HKRFSSTSNL KTHLRLHSGE KPYQCKVCPA KFTQFVHLKL HKRLHTRERP HKCSQCHKNY IHLCSLKVHL KGNCAAAPAP GLPLEDLTRI NEEIEKFDIS DNADRLEDVE DDISVISVVE KEILAVVRKE KEETGLKVSL QRNMGNGLLS SGCSLYESSD LPLMKLPPSN PLPLVPVKVK QETVEPMDP