ELMO2 | ENSG00000062598 | NCBI 63916

Details for: ELMO2

Gene ID: 63916

Symbol: ELMO2

Ensembl ID: ENSG00000062598

Description: engulfment and cell motility 2

Associated with

Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-HSA-8849471)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin filament organization
(GO:0007015)
Apoptotic process
(GO:0006915)
Cell chemotaxis
(GO:0060326)
Cell motility
(GO:0048870)
Cytosol
(GO:0005829)
Membrane
(GO:0016020)
Phagocytosis
(GO:0006909)
Protein binding
(GO:0005515)
Receptor tyrosine kinase binding
(GO:0030971)
Sh3 domain binding
(GO:0017124)

Other Information

Proteins

Engulfment and cell motility protein 2

Genular Protein ID: 2838986904

Symbol: ELMO2_HUMAN

Name: Engulfment and cell motility protein 2

UniProtKB Accession Codes:

Q96JJ3 E1P5T3 Q5JVZ6 Q7Z5G9 Q96CJ2 Q96ME5 Q96PA9 Q9H938 Q9H9L5 Q9HAH0 Q9NQQ6

Database IDs:

Citations:

PubMed ID: 11595183

Title: CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.

PubMed ID: 11595183

DOI: 10.1016/s0092-8674(01)00520-7

PubMed ID: 11703939

Title: The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.

PubMed ID: 11703939

DOI: 10.1016/s1534-5807(01)00058-2

PubMed ID: 11347906

Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11347906

DOI: 10.1093/dnares/8.2.85

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20679435

Title: Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.

PubMed ID: 20679435

DOI: 10.1083/jcb.201005141

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24567399

Title: G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates.

PubMed ID: 24567399

DOI: 10.1073/pnas.1313886111

PubMed ID: 27476657

Title: Loss-of-function mutations in ELMO2 cause intraosseous vascular malformation by impeding RAC1 signaling.

PubMed ID: 27476657

DOI: 10.1016/j.ajhg.2016.06.008

Sequence Information:

Length: 720
Mass: 82615
Checksum: A67377E3B26F2937
Sequence:

MPPPSDIVKV AIEWPGANAQ LLEIDQKRPL ASIIKEVCDG WSLPNPEYYT LRYADGPQLY 
ITEQTRSDIK NGTILQLAIS PSRAARQLME RTQSSNMETR LDAMKELAKL SADVTFATEF 
INMDGIIVLT RLVESGTKLL SHYSEMLAFT LTAFLELMDH GIVSWDMVSI TFIKQIAGYV 
SQPMVDVSIL QRSLAILESM VLNSQSLYQK IAEEITVGQL ISHLQVSNQE IQTYAIALIN 
ALFLKAPEDK RQDMANAFAQ KHLRSIILNH VIRGNRPIKT EMAHQLYVLQ VLTFNLLEER 
MMTKMDPNDQ AQRDIIFELR RIAFDAESDP SNAPGSGTEK RKAMYTKDYK MLGFTNHINP 
AMDFTQTPPG MLALDNMLYL AKVHQDTYIR IVLENSSRED KHECPFGRSA IELTKMLCEI 
LQVGELPNEG RNDYHPMFFT HDRAFEELFG ICIQLLNKTW KEMRATAEDF NKVMQVVREQ 
ITRALPSKPN SLDQFKSKLR SLSYSEILRL RQSERMSQDD FQSPPIVELR EKIQPEILEL 
IKQQRLNRLC EGSSFRKIGN RRRQERFWYC RLALNHKVLH YGDLDDNPQG EVTFESLQEK 
IPVADIKAIV TGKDCPHMKE KSALKQNKEV LELAFSILYD PDETLNFIAP NKYEYCIWID 
GLSALLGKDM SSELTKSDLD TLLSMEMKLR LLDLENIQIP EAPPPIPKEP SSYDFVYHYG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ELMO2

Associated with

Other Information

CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. PubMed ID: 11595183

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. PubMed ID: 11703939

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 11347906

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. PubMed ID: 20679435

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. PubMed ID: 24567399

Loss-of-function mutations in ELMO2 cause intraosseous vascular malformation by impeding RAC1 signaling. PubMed ID: 27476657