CLSPN | ENSG00000092853 | NCBI 63967

Details for: CLSPN

Gene ID: 63967

Symbol: CLSPN

Ensembl ID: ENSG00000092853

Description: claspin

Associated with

Activation of atr in response to replication stress
(R-HSA-176187)
Apoptosis
(R-HSA-109581)
Apoptotic cleavage of cellular proteins
(R-HSA-111465)
Apoptotic execution phase
(R-HSA-75153)
Cell cycle
(R-HSA-1640170)
Cell cycle checkpoints
(R-HSA-69620)
Deubiquitination
(R-HSA-5688426)
Dna double-strand break repair
(R-HSA-5693532)
G2/m checkpoints
(R-HSA-69481)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Processing of dna double-strand break ends
(R-HSA-5693607)
Programmed cell death
(R-HSA-5357801)
Ub-specific processing proteases
(R-HSA-5689880)
Activation of protein kinase activity
(GO:0032147)
Anaphase-promoting complex binding
(GO:0010997)
Dna damage checkpoint signaling
(GO:0000077)
Dna repair
(GO:0006281)
Dna replication checkpoint signaling
(GO:0000076)
Dna secondary structure binding
(GO:0000217)
Golgi apparatus
(GO:0005794)
Mitotic dna replication checkpoint signaling
(GO:0033314)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Protein binding
(GO:0005515)

Other Information

Proteins

CLSPN_HUMAN

Genular Protein ID: 2093650920

Symbol: CLSPN_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9HAW4 A6NFL4 Q1RMC6 Q2KHM3 Q5VYG0 Q6P6H5 Q8IWI1

Database IDs:

Citations:

PubMed ID: 11090622

Title: Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts.

PubMed ID: 11090622

DOI: 10.1016/s1097-2765(05)00092-4

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12766152

Title: Human claspin is required for replication checkpoint control.

PubMed ID: 12766152

DOI: 10.1074/jbc.m301136200

PubMed ID: 15190204

Title: ATR, claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage.

PubMed ID: 15190204

PubMed ID: 15226314

Title: Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.

PubMed ID: 15226314

DOI: 10.1074/jbc.m405793200

PubMed ID: 15096610

Title: Human claspin works with BRCA1 to both positively and negatively regulate cell proliferation.

PubMed ID: 15096610

DOI: 10.1073/pnas.0401847101

PubMed ID: 15707391

Title: DNA-dependent phosphorylation of Chk1 and claspin in a human cell-free system.

PubMed ID: 15707391

DOI: 10.1042/bj20041966

PubMed ID: 16123041

Title: Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.

PubMed ID: 16123041

DOI: 10.1074/jbc.m506460200

PubMed ID: 16901786

Title: A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.

PubMed ID: 16901786

DOI: 10.1016/j.cell.2006.06.039

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16963448

Title: Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function.

PubMed ID: 16963448

DOI: 10.1074/jbc.m604373200

PubMed ID: 17141802

Title: Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.

PubMed ID: 17141802

DOI: 10.1016/j.jmb.2006.10.097

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18662541

Title: The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

PubMed ID: 18662541

DOI: 10.1016/j.cell.2008.05.043

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21680713

Title: Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.

PubMed ID: 21680713

DOI: 10.1091/mbc.e11-01-0048

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 27401717

Title: Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells.

PubMed ID: 27401717

DOI: 10.1038/ncomms12135

PubMed ID: 35585232

Title: Fast and efficient DNA replication with purified human proteins.

PubMed ID: 35585232

DOI: 10.1038/s41586-022-04759-1

PubMed ID: 34694004

Title: Structure of a human replisome shows the organisation and interactions of a DNA replication machine.

PubMed ID: 34694004

DOI: 10.15252/embj.2021108819

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 1339
Mass: 151094
Checksum: 3F3E392D5915955F
Sequence:

MTGEVGSEVH LEINDPNVIS QEEADSPSDS GQGSYETIGP LSEGDSDEEI FVSKKLKNRK 
VLQDSDSETE DTNASPEKTT YDSAEEENKE NLYAGKNTKI KRIYKTVADS DESYMEKSLY 
QENLEAQVKP CLELSLQSGN STDFTTDRKS SKKHIHDKEG TAGKAKVKSK RRLEKEERKM 
EKIRQLKKKE TKNQEDDVEQ PFNDSGCLLV DKDLFETGLE DENNSPLEDE ESLESIRAAV 
KNKVKKHKKK EPSLESGVHS FEEGSELSKG TTRKERKAAR LSKEALKQLH SETQRLIRES 
ALNLPYHMPE NKTIHDFFKR KPRPTCHGNA MALLKSSKYQ SSHHKEIIDT ANTTEMNSDH 
HSKGSEQTTG AENEVETNAL PVVSKETQII TGSDESCRKD LVKNEELEIQ EKQKQSDIRP 
SPGDSSVLQQ ESNFLGNNHS EECQVGGLVA FEPHALEGEG PQNPEETDEK VEEPEQQNKS 
SAVGPPEKVR RFTLDRLKQL GVDVSIKPRL GADEDSFVIL EPETNRELEA LKQRFWKHAN 
PAAKPRAGQT VNVNVIVKDM GTDGKEELKA DVVPVTLAPK KLDGASHTKP GEKLQVLKAK 
LQEAMKLRRF EERQKRQALF KLDNEDGFEE EEEEEEEMTD ESEEDGEEKV EKEEKEEELE 
EEEEKEEEEE EEGNQETAEF LLSSEEIETK DEKEMDKENN DGSSEIGKAV GFLSVPKSLS 
SDSTLLLFKD SSSKMGYFPT EEKSETDENS GKQPSKLDED DSCSLLTKES SHNSSFELIG 
STIPSYQPCN RQTGRGTSFF PTAGGFRSPS PGLFRASLVS SASKSSGKLS EPSLPIEDSQ 
DLYNASPEPK TLFLGAGDFQ FCLEDDTQSQ LLDADGFLNV RNHRNQYQAL KPRLPLASMD 
ENAMDANMDE LLDLCTGKFT SQAEKHLPRK SDKKENMEEL LNLCSGKFTS QDASTPASSE 
LNKQEKESSM GDPMEEALAL CSGSFPTDKE EEDEEEEFGD FRLVSNDNEF DSDEDEHSDS 
GNDLALEDHE DDDEEELLKR SEKLKRQMRL RKYLEDEAEV SGSDVGSEDE YDGEEIDEYE 
EDVIDEVLPS DEELQSQIKK IHMKTMLDDD KRQLRLYQER YLADGDLHSD GPGRMRKFRW 
KNIDDASQMD LFHRDSDDDQ TEEQLDESEA RWRKERIERE QWLRDMAQQG KITAEEEEEI 
GEDSQFMILA KKVTAKALQK NASRPMVIQE SKSLLRNPFE AIRPGSAQQV KTGSLLNQPK 
AVLQKLAALS DHNPSAPRNS RNFVFHTLSP VKAEAAKESS KSQVKKRGPS FMTSPSPKHL 
KTDDSTSGLT RSIFKYLES

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CLSPN

Associated with

Other Information

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. PubMed ID: 11090622

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human claspin is required for replication checkpoint control. PubMed ID: 12766152

ATR, claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. PubMed ID: 15190204

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. PubMed ID: 15226314

Human claspin works with BRCA1 to both positively and negatively regulate cell proliferation. PubMed ID: 15096610

DNA-dependent phosphorylation of Chk1 and claspin in a human cell-free system. PubMed ID: 15707391

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway. PubMed ID: 16123041

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. PubMed ID: 16901786

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. PubMed ID: 16963448

Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. PubMed ID: 17141802

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. PubMed ID: 18662541

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. PubMed ID: 21680713

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells. PubMed ID: 27401717

Fast and efficient DNA replication with purified human proteins. PubMed ID: 35585232

Structure of a human replisome shows the organisation and interactions of a DNA replication machine. PubMed ID: 34694004

A conserved mechanism for regulating replisome disassembly in eukaryotes. PubMed ID: 34700328

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974