Details for: BLK
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: centroblast (CL0009112)
Fold Change: 17.0163
Cell Significance Index: 39.7000 - Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 16.9083
Cell Significance Index: -2.6300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 10.7631
Cell Significance Index: -2.7300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 9.4768
Cell Significance Index: -3.8500 - Cell Name: thymocyte (CL0000893)
Fold Change: 3.8939
Cell Significance Index: 49.2000 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.0098
Cell Significance Index: 13.4600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.8270
Cell Significance Index: 182.3900 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.1310
Cell Significance Index: 12.8700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 2.1169
Cell Significance Index: -2.6100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.7629
Cell Significance Index: 207.9000 - Cell Name: centrocyte (CL0009111)
Fold Change: 1.4482
Cell Significance Index: 4.4700 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.6647
Cell Significance Index: 5.8400 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.6420
Cell Significance Index: 3.2200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3391
Cell Significance Index: 9.0700 - Cell Name: follicular B cell (CL0000843)
Fold Change: 0.3299
Cell Significance Index: 1.6500 - Cell Name: stellate neuron (CL0000122)
Fold Change: 0.0801
Cell Significance Index: 0.9100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0654
Cell Significance Index: 1.1200 - Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.0405
Cell Significance Index: 0.2200 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0389
Cell Significance Index: 0.9700 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0368
Cell Significance Index: 0.5700 - Cell Name: memory B cell (CL0000787)
Fold Change: 0.0103
Cell Significance Index: 0.1100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0009
Cell Significance Index: 0.1800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0004
Cell Significance Index: -0.7700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0007
Cell Significance Index: -0.0100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0013
Cell Significance Index: -2.4300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0013
Cell Significance Index: -2.0700 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0016
Cell Significance Index: -0.2100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0022
Cell Significance Index: -2.9400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0029
Cell Significance Index: -1.0600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0032
Cell Significance Index: -0.6300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0036
Cell Significance Index: -2.7300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0037
Cell Significance Index: -2.7400 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0040
Cell Significance Index: -2.1800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0048
Cell Significance Index: -2.7000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0049
Cell Significance Index: -3.1000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0057
Cell Significance Index: -1.6400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0061
Cell Significance Index: -0.2700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0071
Cell Significance Index: -3.2400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0094
Cell Significance Index: -0.2400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0131
Cell Significance Index: -2.3700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0151
Cell Significance Index: -2.5800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0191
Cell Significance Index: -2.7800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0208
Cell Significance Index: -2.8500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0224
Cell Significance Index: -2.7600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0233
Cell Significance Index: -2.6700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0250
Cell Significance Index: -0.7000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0255
Cell Significance Index: -2.9700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0262
Cell Significance Index: -2.7300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0354
Cell Significance Index: -3.6200 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0383
Cell Significance Index: -0.5600 - Cell Name: B cell (CL0000236)
Fold Change: -0.0410
Cell Significance Index: -0.4900 - Cell Name: mature B cell (CL0000785)
Fold Change: -0.0422
Cell Significance Index: -0.2800 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0444
Cell Significance Index: -1.1100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0452
Cell Significance Index: -3.4700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0455
Cell Significance Index: -1.1700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0492
Cell Significance Index: -3.6700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0493
Cell Significance Index: -2.4900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0503
Cell Significance Index: -2.0600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0540
Cell Significance Index: -2.5400 - Cell Name: naive B cell (CL0000788)
Fold Change: -0.0551
Cell Significance Index: -0.5800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0553
Cell Significance Index: -2.5800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0554
Cell Significance Index: -3.1100 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.0565
Cell Significance Index: -0.9600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0588
Cell Significance Index: -2.0600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0626
Cell Significance Index: -2.7700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0672
Cell Significance Index: -2.2000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0686
Cell Significance Index: -3.5700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0691
Cell Significance Index: -2.0300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0697
Cell Significance Index: -2.2200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0720
Cell Significance Index: -3.7500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0724
Cell Significance Index: -1.9400 - Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0742
Cell Significance Index: -1.0100 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.0756
Cell Significance Index: -0.9900 - Cell Name: lymphocyte of B lineage (CL0000945)
Fold Change: -0.0767
Cell Significance Index: -0.5700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0774
Cell Significance Index: -2.9300 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0778
Cell Significance Index: -0.9800 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0881
Cell Significance Index: -1.1400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0888
Cell Significance Index: -2.1500 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0892
Cell Significance Index: -2.2300 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: -0.0929
Cell Significance Index: -0.9800 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0931
Cell Significance Index: -1.0200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0945
Cell Significance Index: -2.0700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0946
Cell Significance Index: -2.5300 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0961
Cell Significance Index: -1.8800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0994
Cell Significance Index: -2.1100 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.0998
Cell Significance Index: -1.4200 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1016
Cell Significance Index: -3.7300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1031
Cell Significance Index: -2.7100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1036
Cell Significance Index: -3.6400 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.1062
Cell Significance Index: -2.1600 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1065
Cell Significance Index: -2.3000 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1065
Cell Significance Index: -1.3500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1071
Cell Significance Index: -3.7200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1071
Cell Significance Index: -2.1500 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.1086
Cell Significance Index: -1.0400 - Cell Name: immature B cell (CL0000816)
Fold Change: -0.1099
Cell Significance Index: -1.0400 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1123
Cell Significance Index: -2.2200 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1132
Cell Significance Index: -3.5800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1156
Cell Significance Index: -2.4700 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1160
Cell Significance Index: -2.4200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 580587198
Symbol: BLK_HUMAN
Name: Tyrosine-protein kinase Blk
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7822795
Title: Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.
PubMed ID: 7822795
PubMed ID: 7845672
Title: Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk).
PubMed ID: 7845672
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8083187
Title: The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.
PubMed ID: 8083187
PubMed ID: 8756631
Title: In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.
PubMed ID: 8756631
PubMed ID: 10553071
Title: Early B cell factor is an activator of the B lymphoid kinase promoter in early B cell development.
PubMed ID: 10553071
PubMed ID: 12023895
Title: IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts.
PubMed ID: 12023895
DOI: 10.1042/bj20011696
PubMed ID: 19667185
Title: Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.
PubMed ID: 19667185
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 30356214
Title: Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
PubMed ID: 30356214
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 505
- Mass: 57706
- Checksum: B5F739BEF8389176
- Sequence:
MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP PPDEHLDEDK HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL VTGREGYVPS NFVARVESLE MERWFFRSQG RKEAERQLLA PINKAGSFLI RESETNKGAF SLSVKDVTTQ GELIKHYKIR CLDEGGYYIS PRITFPSLQA LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS LRLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER PTFEFLQSVL EDFYTATERQ YELQP
Genular Protein ID: 1170099362
Symbol: Q05D26_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 599
- Mass: 67424
- Checksum: 37DBDC410DB63823
- Sequence:
MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP PPDEHLDEDK HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL VTGREGYVPS NFVARVESLE MERWFFRSQG RKEAERQLLA PINKAGSFLI RESETNKGAF SLSVKDVTTQ GELIKHYKIR CLDEGGYYIS PRITFPSLQA LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS LRLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER PTFDCTPGRV TRPLCAASFV EGCNSDLARS SGVLSPSKVF RTGKRLSSSK APVLGTPRAG RVPASAPCVD PALPRYRSQT GSRGRQQGQP QPRLRSSTAG LFCNKVTSVR KKKKKKKKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.