Details for: BLK

Gene ID: 640

Symbol: BLK

Ensembl ID: ENSG00000136573

Description: BLK proto-oncogene, Src family tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centroblast (CL0009112)
    Fold Change: 17.0163
    Cell Significance Index: 39.7000
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 16.9083
    Cell Significance Index: -2.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.7631
    Cell Significance Index: -2.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.4768
    Cell Significance Index: -3.8500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 3.8939
    Cell Significance Index: 49.2000
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.0098
    Cell Significance Index: 13.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8270
    Cell Significance Index: 182.3900
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.1310
    Cell Significance Index: 12.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.1169
    Cell Significance Index: -2.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7629
    Cell Significance Index: 207.9000
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.4482
    Cell Significance Index: 4.4700
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.6647
    Cell Significance Index: 5.8400
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.6420
    Cell Significance Index: 3.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3391
    Cell Significance Index: 9.0700
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.3299
    Cell Significance Index: 1.6500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.0801
    Cell Significance Index: 0.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0654
    Cell Significance Index: 1.1200
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.0405
    Cell Significance Index: 0.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0389
    Cell Significance Index: 0.9700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0368
    Cell Significance Index: 0.5700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.0103
    Cell Significance Index: 0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0009
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -2.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0016
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -2.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0029
    Cell Significance Index: -1.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0032
    Cell Significance Index: -0.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0040
    Cell Significance Index: -2.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0048
    Cell Significance Index: -2.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0057
    Cell Significance Index: -1.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0061
    Cell Significance Index: -0.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0071
    Cell Significance Index: -3.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0094
    Cell Significance Index: -0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0131
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0151
    Cell Significance Index: -2.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0191
    Cell Significance Index: -2.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0208
    Cell Significance Index: -2.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0224
    Cell Significance Index: -2.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0233
    Cell Significance Index: -2.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0250
    Cell Significance Index: -0.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0255
    Cell Significance Index: -2.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0262
    Cell Significance Index: -2.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0354
    Cell Significance Index: -3.6200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0383
    Cell Significance Index: -0.5600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0410
    Cell Significance Index: -0.4900
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0422
    Cell Significance Index: -0.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0444
    Cell Significance Index: -1.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0452
    Cell Significance Index: -3.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0455
    Cell Significance Index: -1.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0492
    Cell Significance Index: -3.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0493
    Cell Significance Index: -2.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0503
    Cell Significance Index: -2.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0540
    Cell Significance Index: -2.5400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0551
    Cell Significance Index: -0.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0553
    Cell Significance Index: -2.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0554
    Cell Significance Index: -3.1100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0565
    Cell Significance Index: -0.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0588
    Cell Significance Index: -2.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0626
    Cell Significance Index: -2.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0672
    Cell Significance Index: -2.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0686
    Cell Significance Index: -3.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0691
    Cell Significance Index: -2.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0697
    Cell Significance Index: -2.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0720
    Cell Significance Index: -3.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0724
    Cell Significance Index: -1.9400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0742
    Cell Significance Index: -1.0100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0756
    Cell Significance Index: -0.9900
  • Cell Name: lymphocyte of B lineage (CL0000945)
    Fold Change: -0.0767
    Cell Significance Index: -0.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0774
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0778
    Cell Significance Index: -0.9800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0881
    Cell Significance Index: -1.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0888
    Cell Significance Index: -2.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0892
    Cell Significance Index: -2.2300
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0929
    Cell Significance Index: -0.9800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0931
    Cell Significance Index: -1.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0945
    Cell Significance Index: -2.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0946
    Cell Significance Index: -2.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0961
    Cell Significance Index: -1.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0994
    Cell Significance Index: -2.1100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0998
    Cell Significance Index: -1.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1016
    Cell Significance Index: -3.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1031
    Cell Significance Index: -2.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1036
    Cell Significance Index: -3.6400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1062
    Cell Significance Index: -2.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1065
    Cell Significance Index: -2.3000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1065
    Cell Significance Index: -1.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1071
    Cell Significance Index: -3.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1071
    Cell Significance Index: -2.1500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1086
    Cell Significance Index: -1.0400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1099
    Cell Significance Index: -1.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1123
    Cell Significance Index: -2.2200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1132
    Cell Significance Index: -3.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1156
    Cell Significance Index: -2.4700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1160
    Cell Significance Index: -2.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BLK is a non-membrane spanning protein tyrosine kinase that is specifically expressed in B cells. It is a member of the Src family of tyrosine kinases, which are characterized by their ability to phosphorylate tyrosine residues on target proteins. BLK is activated by the BCR, leading to the phosphorylation of downstream targets, including the transcription factor Runx1, which regulates the expression of genes involved in BCR signaling. BLK has also been shown to interact with other signaling molecules, including the adaptor protein Tec, which is involved in the regulation of immune responses. **Pathways and Functions:** BLK is involved in several key signaling pathways, including: 1. **B Cell Receptor Signaling Pathway:** BLK is activated by the BCR, leading to the generation of second messengers, such as calcium and inositol trisphosphate (IP3), which activate downstream signaling pathways. 2. **Cytosol Signaling Pathway:** BLK phosphorylates and activates downstream targets, including the transcription factor Runx1, which regulates the expression of genes involved in BCR signaling. 3. **Innate Immune Response:** BLK has been shown to interact with other signaling molecules, including the adaptor protein Tec, which is involved in the regulation of immune responses. 4. **Gene Expression Regulation:** BLK regulates the expression of genes involved in BCR signaling, including the transcription factor Runx1. **Clinical Significance:** Dysregulation of the BLK gene has been associated with various immune-related disorders, including: 1. **Autoimmune Diseases:** BLK has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where it is thought to contribute to the dysregulation of B cell responses. 2. **Cancer:** BLK has been shown to be overexpressed in certain types of cancer, including lymphomas and leukemias, where it is thought to contribute to the development and progression of these diseases. 3. **Immunodeficiency Disorders:** BLK has been implicated in the pathogenesis of immunodeficiency disorders, such as X-linked lymphoproliferative disease (XLP), where it is thought to contribute to the dysregulation of B cell responses. In conclusion, the BLK proto-oncogene is a crucial player in B cell receptor signaling and immune regulation, and its dysregulation has been associated with various immune-related disorders. Further research is needed to fully understand the role of BLK in the regulation of immune responses and to develop therapeutic strategies to target this gene in the treatment of immune-related diseases.

Genular Protein ID: 580587198

Symbol: BLK_HUMAN

Name: Tyrosine-protein kinase Blk

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7822795

Title: Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.

PubMed ID: 7822795

PubMed ID: 7845672

Title: Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk).

PubMed ID: 7845672

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8083187

Title: The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

PubMed ID: 8083187

DOI: 10.1016/s0021-9258(17)31595-8

PubMed ID: 8756631

Title: In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.

PubMed ID: 8756631

DOI: 10.1128/mcb.16.9.4735

PubMed ID: 10553071

Title: Early B cell factor is an activator of the B lymphoid kinase promoter in early B cell development.

PubMed ID: 10553071

PubMed ID: 12023895

Title: IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts.

PubMed ID: 12023895

DOI: 10.1042/bj20011696

PubMed ID: 19667185

Title: Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.

PubMed ID: 19667185

DOI: 10.1073/pnas.0906474106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 30356214

Title: Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.

PubMed ID: 30356214

DOI: 10.1038/s41586-018-0629-6

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 505
  • Mass: 57706
  • Checksum: B5F739BEF8389176
  • Sequence:
  • MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP PPDEHLDEDK 
    HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL VTGREGYVPS NFVARVESLE 
    MERWFFRSQG RKEAERQLLA PINKAGSFLI RESETNKGAF SLSVKDVTTQ GELIKHYKIR 
    CLDEGGYYIS PRITFPSLQA LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS 
    LRLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 
    AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD 
    LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 
    FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER 
    PTFEFLQSVL EDFYTATERQ YELQP

Genular Protein ID: 1170099362

Symbol: Q05D26_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 599
  • Mass: 67424
  • Checksum: 37DBDC410DB63823
  • Sequence:
  • MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP PPDEHLDEDK 
    HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL VTGREGYVPS NFVARVESLE 
    MERWFFRSQG RKEAERQLLA PINKAGSFLI RESETNKGAF SLSVKDVTTQ GELIKHYKIR 
    CLDEGGYYIS PRITFPSLQA LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS 
    LRLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 
    AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD 
    LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 
    FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER 
    PTFDCTPGRV TRPLCAASFV EGCNSDLARS SGVLSPSKVF RTGKRLSSSK APVLGTPRAG 
    RVPASAPCVD PALPRYRSQT GSRGRQQGQP QPRLRSSTAG LFCNKVTSVR KKKKKKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.