Rad50 | ENSRNOG00000033065 | NCBI 64012

Details for: Rad50

Gene ID: 64012

Symbol: Rad50

Ensembl ID: ENSRNOG00000033065

Description: RAD50 double strand break repair protein

Associated with

Cell cycle
(R-RNO-1640170)
Cell cycle checkpoints
(R-RNO-69620)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular senescence
(R-RNO-2559583)
Dna damage/telomere stress induced senescence
(R-RNO-2559586)
Dna double-strand break repair
(R-RNO-5693532)
Dna double strand break response
(R-RNO-5693606)
G2/m checkpoints
(R-RNO-69481)
G2/m dna damage checkpoint
(R-RNO-69473)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Hdr through homologous recombination (hrr)
(R-RNO-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-RNO-5693567)
Hdr through mmej (alt-nhej)
(R-RNO-5685939)
Hdr through single strand annealing (ssa)
(R-RNO-5685938)
Homologous dna pairing and strand exchange
(R-RNO-5693579)
Homology directed repair
(R-RNO-5693538)
Nonhomologous end-joining (nhej)
(R-RNO-5693571)
Presynaptic phase of homologous dna pairing and strand exchange
(R-RNO-5693616)
Processing of dna double-strand break ends
(R-RNO-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-RNO-5693565)
Regulation of tp53 activity
(R-RNO-5633007)
Regulation of tp53 activity through phosphorylation
(R-RNO-6804756)
Resolution of d-loop structures
(R-RNO-5693537)
Resolution of d-loop structures through holliday junction intermediates
(R-RNO-5693568)
Rna polymerase ii transcription
(R-RNO-73857)
Sensing of dna double strand breaks
(R-RNO-5693548)
Transcriptional regulation by tp53
(R-RNO-3700989)
3'-5' exonuclease activity
(GO:0008408)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Brca1-c complex
(GO:0070533)
Chromatin
(GO:0000785)
Chromosome, telomeric region
(GO:0000781)
Chromosome organization
(GO:0051276)
Chromosome organization involved in meiotic cell cycle
(GO:0070192)
Condensed nuclear chromosome
(GO:0000794)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna duplex unwinding
(GO:0032508)
Dna helicase activity
(GO:0003678)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Double-strand break repair
(GO:0006302)
Double-stranded dna binding
(GO:0003690)
Double-stranded telomeric dna binding
(GO:0003691)
G-quadruplex dna binding
(GO:0051880)
Heart development
(GO:0007507)
Identical protein binding
(GO:0042802)
Inclusion body
(GO:0016234)
Meiotic cell cycle
(GO:0051321)
Metal ion binding
(GO:0046872)
Mre11 complex
(GO:0030870)
Negative regulation of telomere capping
(GO:1904354)
Negative regulation of viral entry into host cell
(GO:0046597)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of telomere maintenance
(GO:0032206)
Pronucleus
(GO:0045120)
Protein-containing complex binding
(GO:0044877)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Reciprocal meiotic recombination
(GO:0007131)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of mitotic recombination
(GO:0000019)
Response to human chorionic gonadotropin
(GO:0044752)
Single-stranded dna endodeoxyribonuclease activity
(GO:0000014)
Single-stranded telomeric dna binding
(GO:0043047)
Site of double-strand break
(GO:0035861)
Telomere maintenance
(GO:0000723)
Telomere maintenance via recombination
(GO:0000722)
Telomere maintenance via telomerase
(GO:0007004)
Telomeric 3' overhang formation
(GO:0031860)

Other Information

Proteins

DNA repair protein RAD50

Genular Protein ID: 2015537884

Symbol: RAD50_RAT

Name: DNA repair protein RAD50

UniProtKB Accession Codes:

Q9JIL8

Database IDs:

Citations:

PubMed ID: 10908350

Title: The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes.

PubMed ID: 10908350

DOI: 10.1093/nar/28.15.2882

Sequence Information:

Length: 1312
Mass: 153784
Checksum: F13C041BD2C05932
Sequence:

MSRIEKMSTL GVRSFGIEDK DKQIISFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG 
TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GEMVLVQRSM LCSQKSKKTE FKTLEGVITR 
IKHGEKVSLS SKCAEIDREM ISCLGVSKSV LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF 
SATRYIKALD TLRQVRQTQG QKVKECQTEL KYLRQNKEKA CEIRDQITSK EAQLASSREI 
VKAYENELEP LKNRLKEIEH NLSKIMRLDN EIKALDSRKK QMEKDNSELE QKMEKVFQGT 
DEQLNDLYHN HQRTVREKER RLVDCQRELE KLSKEARLLN QERAELLVEQ GRLQLQADRH 
QEHIRARDSL IQSLAAHLEL DGFERGPFSE RQIKNFHELV RERQEREAKT ASQLLSDLTD 
KEALKQRQMD EMRDKKSGLG RMIELKTEIL TKKQTELRNV RNELQQLEGS SDRILELDQE 
LTKAERELSK AEKNSSIETL KAEILNLQSE KADLDRNLRK LDQEMEQLNH HTTTRTQMEM 
LTKDKTDKDE QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HSKSKEINQT RDRLAKLNKE 
LASAEQNKNH INNELKKKEE QLSSYEDKLF DVCGSQDFES DLDRLKEDIE KSSKQRAMLA 
GATAVYSQFI TQLTDENQSC CPGCQRVFQT EAELQEVISD LQSKLRLAPD KLKSTESELK 
KKERRRDEML GLVPMRQSII DLKEKEIPEL RNRLQSVNRD IQRLKNDIEE QETLLGTVMP 
EEESAKVCLT DVTIMERFQM ELKDVERKIA QQAAKLQGVD LDRTVQQVNQ EKQEKQHKLD 
TVSSKIELNR KLIQDQQEQI QHLKSKTNEL KSEKLQIATN LQRRQQMEEQ TVELSTEVQS 
LNREIKDAKE QINPLEIALE KLQQEKEELI HRKNTSNKMA QDKINDIKEK VKNIHGYMKD 
IENYIQDGKD DYKKQKETEL NEVVIQLNEC DKHKEKINKE MGTMRQDIDT KKIQERWLQD 
NLTLRKRREE LKEVEEERKQ HLKEMGQMQV LQMKNEHQKL EENIDTIKRN HSLALGRQKG 
YEEEILHFKK ELREPQFRDA EEKYREMMIV MRTTELVNKD LDIYYKTLDH AIMKFHSMKM 
EEINKIIRDL WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVVMLK GDTALDMRGR 
CSAGQKVLAS LIIRLALAET FCLNCGILAL DEPTTNLDRE NIESLAHALV EIIKSRSQQR 
NFQLLVITHD EDFVELLGRS EYVEKFYRVK KNIDQCSEIV KSSINSLGSY VH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rad50

Associated with

Other Information

The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes. PubMed ID: 10908350

Database document:

PubMed ID: 10908350