Casp8 | ENSRNOG00000012331 | NCBI 64044

Details for: Casp8

Gene ID: 64044

Symbol: Casp8

Ensembl ID: ENSRNOG00000012331

Description: caspase 8

Associated with

Activation, myristolyation of bid and translocation to mitochondria
(R-RNO-75108)
Apoptosis
(R-RNO-109581)
Apoptotic cleavage of cellular proteins
(R-RNO-111465)
Apoptotic execution phase
(R-RNO-75153)
C-type lectin receptors (clrs)
(R-RNO-5621481)
Casp8 activity is inhibited
(R-RNO-5218900)
Caspase-mediated cleavage of cytoskeletal proteins
(R-RNO-264870)
Caspase activation via death receptors in the presence of ligand
(R-RNO-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-RNO-5357769)
Clec7a (dectin-1) signaling
(R-RNO-5607764)
Clec7a/inflammasome pathway
(R-RNO-5660668)
Cytokine signaling in immune system
(R-RNO-1280215)
Death receptor signaling
(R-RNO-73887)
Dimerization of procaspase-8
(R-RNO-69416)
Fasl/ cd95l signaling
(R-RNO-75157)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Interleukin-1 family signaling
(R-RNO-446652)
Interleukin-1 signaling
(R-RNO-9020702)
Intrinsic pathway for apoptosis
(R-RNO-109606)
Myd88 cascade initiated on plasma membrane
(R-RNO-975871)
Myd88 dependent cascade initiated on endosome
(R-RNO-975155)
Myd88-independent tlr4 cascade
(R-RNO-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-RNO-166058)
Nod1/2 signaling pathway
(R-RNO-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-RNO-168643)
Programmed cell death
(R-RNO-5357801)
Regulated necrosis
(R-RNO-5218859)
Regulation by c-flip
(R-RNO-3371378)
Regulation of necroptotic cell death
(R-RNO-5675482)
Regulation of nf-kappa b signaling
(R-RNO-9758274)
Regulation of tnfr1 signaling
(R-RNO-5357905)
Ripk1-mediated regulated necrosis
(R-RNO-5213460)
Signaling by interleukins
(R-RNO-449147)
Signal transduction
(R-RNO-162582)
Tak1-dependent ikk and nf-kappa-b activation
(R-RNO-445989)
Tnf signaling
(R-RNO-75893)
Toll-like receptor cascades
(R-RNO-168898)
Toll like receptor 2 (tlr2) cascade
(R-RNO-181438)
Toll like receptor 3 (tlr3) cascade
(R-RNO-168164)
Toll like receptor 4 (tlr4) cascade
(R-RNO-166016)
Toll like receptor 5 (tlr5) cascade
(R-RNO-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-RNO-168181)
Toll like receptor 9 (tlr9) cascade
(R-RNO-168138)
Toll like receptor 10 (tlr10) cascade
(R-RNO-168142)
Toll like receptor tlr1:tlr2 cascade
(R-RNO-168179)
Toll like receptor tlr6:tlr2 cascade
(R-RNO-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-RNO-975138)
Trail signaling
(R-RNO-75158)
Trif(ticam1)-mediated tlr4 signaling
(R-RNO-937061)
Trif-mediated programmed cell death
(R-RNO-2562578)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type endopeptidase activity involved in apoptotic process
(GO:0097153)
Cysteine-type endopeptidase activity involved in apoptotic signaling pathway
(GO:0097199)
Death effector domain binding
(GO:0035877)
Death receptor binding
(GO:0005123)
Endopeptidase activity
(GO:0004175)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Heart development
(GO:0007507)
Identical protein binding
(GO:0042802)
Macrophage differentiation
(GO:0030225)
Necroptotic process
(GO:0070266)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of necroptotic process
(GO:0060546)
Neural tube formation
(GO:0001841)
Peptidase activity
(GO:0008233)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of proteolysis
(GO:0045862)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein maturation
(GO:0051604)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Pyroptosis
(GO:0070269)
Regulation of cytokine production
(GO:0001817)
Regulation of innate immune response
(GO:0045088)
Regulation of thymocyte apoptotic process
(GO:0070243)
Response to auditory stimulus
(GO:0010996)
Response to cobalt ion
(GO:0032025)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to lipopolysaccharide
(GO:0032496)
Response to tumor necrosis factor
(GO:0034612)
Scaffold protein binding
(GO:0097110)
Trail-activated apoptotic signaling pathway
(GO:0036462)
Tumor necrosis factor receptor binding
(GO:0005164)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

CASP8_RAT

Genular Protein ID: 3021221329

Symbol: CASP8_RAT

Name: N/A

UniProtKB Accession Codes:

Q9JHX4

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 10197541

Title: Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

PubMed ID: 10197541

DOI: 10.1016/s0896-6273(00)80716-3

PubMed ID: 15383280

Title: Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.

PubMed ID: 15383280

DOI: 10.1016/j.molcel.2004.08.020

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 482
Mass: 55339
Checksum: 82B4A29330C53264
Sequence:

MDFHSCLYDI AERLGNEELA ALKFLCLDHI PQKKQESIND VLVLFQRLQE EGMLEEDNLS 
FLKELLFHIS RRDLLSRVLK SSPEEMVREL QVLGKAQVSA YRVMLFKLSE DMDKEDLKSF 
KFLLITEIPK CKLQDNSSLL DIFVEMEKRT ILAENNLVTL KSICFRVNRS LLGRIDDYER 
SSTERRMSTE GGEELPVSVL DEVTIKMQDM WDSPGEQESE SLNSDNVYQM KSKPRGYCLI 
FNNNNFSKAR EDIPKLSNMR DRKGTNYDEE ALSKTFKELH FEIVSFSDCT ASQIHEVLVS 
YQSKDHKGKD CFICCILSHG DKGIVYGTDG KEASIYELTS YFTGSKCPSL AGKPKIFFIQ 
ACQGNNFQKA VPVPDETGLE QEHVLEEDSS SYKNYIPDEA DFLLGMATVK NCVSYRDPTR 
GTWYIQSLCQ SLRERCPRGE DILSILTGVN YDVSNKDNPR NMGKQMPQPI FTLRKKLFFP 
PN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Casp8

Associated with

Other Information

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Caspase-8 is required for cell death induced by expanded polyglutamine repeats. PubMed ID: 10197541

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. PubMed ID: 15383280

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Database document:

PubMed ID: 15057822

PubMed ID: 10197541

PubMed ID: 15383280

PubMed ID: 22673903