Mre11 | ENSRNOG00000009506 | NCBI 64046

Details for: Mre11

Gene ID: 64046

Symbol: Mre11

Ensembl ID: ENSRNOG00000009506

Description: MRE11 homolog, double strand break repair nuclease

Associated with

Cell cycle
(R-RNO-1640170)
Cell cycle checkpoints
(R-RNO-69620)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular senescence
(R-RNO-2559583)
Cytosolic sensors of pathogen-associated dna
(R-RNO-1834949)
Dna damage/telomere stress induced senescence
(R-RNO-2559586)
Dna double-strand break repair
(R-RNO-5693532)
Dna double strand break response
(R-RNO-5693606)
Dna repair
(R-RNO-73894)
G2/m checkpoints
(R-RNO-69481)
G2/m dna damage checkpoint
(R-RNO-69473)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Hdr through homologous recombination (hrr)
(R-RNO-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-RNO-5693567)
Hdr through mmej (alt-nhej)
(R-RNO-5685939)
Hdr through single strand annealing (ssa)
(R-RNO-5685938)
Homologous dna pairing and strand exchange
(R-RNO-5693579)
Homology directed repair
(R-RNO-5693538)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Nonhomologous end-joining (nhej)
(R-RNO-5693571)
Presynaptic phase of homologous dna pairing and strand exchange
(R-RNO-5693616)
Processing of dna double-strand break ends
(R-RNO-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-RNO-5693565)
Regulation of tp53 activity
(R-RNO-5633007)
Regulation of tp53 activity through phosphorylation
(R-RNO-6804756)
Resolution of d-loop structures
(R-RNO-5693537)
Resolution of d-loop structures through holliday junction intermediates
(R-RNO-5693568)
Rna polymerase ii transcription
(R-RNO-73857)
Sensing of dna double strand breaks
(R-RNO-5693548)
Transcriptional regulation by tp53
(R-RNO-3700989)
3'-5'-dna exonuclease activity
(GO:0008296)
3'-5' exonuclease activity
(GO:0008408)
5'-3' exonuclease activity
(GO:0008409)
Brca1-c complex
(GO:0070533)
Cell population proliferation
(GO:0008283)
Chromatin
(GO:0000785)
Chromosome, telomeric region
(GO:0000781)
Chromosome organization
(GO:0051276)
Condensed nuclear chromosome
(GO:0000794)
Cytoplasm
(GO:0005737)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna duplex unwinding
(GO:0032508)
Dna endonuclease activity
(GO:0004520)
Dna helicase activity
(GO:0003678)
Dna strand resection involved in replication fork processing
(GO:0110025)
Double-strand break repair
(GO:0006302)
Double-strand break repair via homologous recombination
(GO:0000724)
Double-strand break repair via nonhomologous end joining
(GO:0006303)
Heart development
(GO:0007507)
Homologous chromosome pairing at meiosis
(GO:0007129)
Identical protein binding
(GO:0042802)
Manganese ion binding
(GO:0030145)
Meiotic cell cycle
(GO:0051321)
Meiotic dna double-strand break formation
(GO:0042138)
Mitochondrial double-strand break repair via homologous recombination
(GO:0097552)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Mitotic intra-s dna damage checkpoint signaling
(GO:0031573)
Mre11 complex
(GO:0030870)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of viral entry into host cell
(GO:0046597)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Pml body
(GO:0016605)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of telomere maintenance
(GO:0032206)
Protein binding
(GO:0005515)
Replication fork
(GO:0005657)
Single-stranded dna endodeoxyribonuclease activity
(GO:0000014)
Sister chromatid cohesion
(GO:0007062)
Site of double-strand break
(GO:0035861)
Telomere maintenance
(GO:0000723)
Telomeric 3' overhang formation
(GO:0031860)

Other Information

Proteins

Double-strand break repair protein MRE11
A0A8I6A2X5_RAT

Genular Protein ID: 2395023298

Symbol: MRE11_RAT

Name: Double-strand break repair protein MRE11

UniProtKB Accession Codes:

Q9JIM0

Database IDs:

Citations:

PubMed ID: 10908350

Title: The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes.

PubMed ID: 10908350

DOI: 10.1093/nar/28.15.2882

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 706
Mass: 80122
Checksum: 0183A41BC015FDA0
Sequence:

MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD 
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEIISDQSVN FGFSKFPWVN YRDGNLNISI 
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG 
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL 
VIWGHEHECK IGPTRNEQQL FYVSQPGSSV VTALSPGETV KKHVGLLRVK GRKMNMQKLP 
LRTVRQFFME DVVLANHPSL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPEK 
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGKLIIK 
PASEGTTLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE 
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSENAASA 
FSADDLSFDI TEQTADDSDD SQSAVPSRGR GRGRGRRGGR GQSTAPRGGS QRGRDTGLGI 
STRGRSSKAT ASTSRNMSII DAFRSTRQQP SRNVATKNYS ETIEVDESDD DDSFPTSSRA 
DQRWSGTAPS KRMSQSQTAK GVDFESDEDD DDDPFMSGSC PRRNRR

Genular Protein ID: 2542914774

Symbol: A0A8I6A2X5_RAT

Name: N/A

UniProtKB Accession Codes:

A0A8I6A2X5

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 706
Mass: 80064
Checksum: F7DF06A12615E6FA
Sequence:

MSPADPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD 
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEIISDQSVN FGFSKFPWVN YQDGNLNISI 
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG 
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL 
VIWGHEHECK IGPTRNEQQL FYVSQPGSSV VTALSPGETV KKHVGLLRVK GRKMNMQKLP 
LRTVRQFFME DVVLANHPSL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPEK 
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGKLIIK 
PASEGTTLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE 
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSENAASA 
FSADDLSFDI TEQTADDSDD SQSAVPSRGR GRGRGRRGGR GQSTAPRGGS QRGRDTGLGI 
STRGRSSKAT ASTSRNMSII DAFRSTRQQP SRNVATKNYS ETIEVDESDD DDSFPTSSRA 
DQRWSGTAPS KRMSQSQTAK GVDFESDEDD DDDPFMSGSC PRRNRR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.