Dlg2 | ENSRNOG00000022635 | NCBI 64053

Details for: Dlg2

Gene ID: 64053

Symbol: Dlg2

Ensembl ID: ENSRNOG00000022635

Description: discs large MAGUK scaffold protein 2

Associated with

Activation of nmda receptors and postsynaptic events
(R-RNO-442755)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Neurexins and neuroligins
(R-RNO-6794361)
Neuronal system
(R-RNO-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-RNO-112314)
Protein-protein interactions at synapses
(R-RNO-6794362)
Raf/map kinase cascade
(R-RNO-5673001)
Signal transduction
(R-RNO-162582)
Transmission across chemical synapses
(R-RNO-112315)
Unblocking of nmda receptors, glutamate binding and activation
(R-RNO-438066)
Anterograde axonal protein transport
(GO:0099641)
Axon cytoplasm
(GO:1904115)
Axon initial segment
(GO:0043194)
Basolateral plasma membrane
(GO:0016323)
Cell-cell adhesion
(GO:0098609)
Cell junction
(GO:0030054)
Cellular response to potassium ion
(GO:0035865)
Chemical synaptic transmission
(GO:0007268)
Clustering of voltage-gated potassium channels
(GO:0045163)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Embryo development
(GO:0009790)
Establishment or maintenance of epithelial cell apical/basal polarity
(GO:0045197)
Glutamatergic synapse
(GO:0098978)
Juxtaparanode region of axon
(GO:0044224)
Kinase binding
(GO:0019900)
Maintenance of postsynaptic density structure
(GO:0099562)
Membrane
(GO:0016020)
Neuromuscular junction
(GO:0031594)
Neuronal cell body
(GO:0043025)
Neuronal ion channel clustering
(GO:0045161)
Neuron projection
(GO:0043005)
Neurotransmitter receptor localization to postsynaptic specialization membrane
(GO:0099645)
Nucleus
(GO:0005634)
Pdz domain binding
(GO:0030165)
Perikaryon
(GO:0043204)
Plasma membrane
(GO:0005886)
Postsynapse organization
(GO:0099173)
Postsynaptic density
(GO:0014069)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic membrane
(GO:0045211)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein phosphatase binding
(GO:0019903)
Receptor clustering
(GO:0043113)
Receptor localization to synapse
(GO:0097120)
Retrograde axonal protein transport
(GO:0099642)
Sensory perception of pain
(GO:0019233)
Structural constituent of postsynaptic density
(GO:0098919)
Synaptic vesicle membrane
(GO:0030672)
Voltage-gated potassium channel complex
(GO:0008076)

Other Information

Proteins

Disks large homolog 2

Genular Protein ID: 2983194638

Symbol: DLG2_RAT

Name: Disks large homolog 2

UniProtKB Accession Codes:

Q63622 P70548 Q62939

Database IDs:

Citations:

PubMed ID: 8755482

Title: Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins.

PubMed ID: 8755482

DOI: 10.1016/s0896-6273(00)80284-6

PubMed ID: 8625413

Title: Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.

PubMed ID: 8625413

DOI: 10.1016/s0092-8674(00)81053-3

PubMed ID: 15304517

Title: An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1.

PubMed ID: 15304517

DOI: 10.1074/jbc.m407575200

PubMed ID: 8922396

Title: Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein.

PubMed ID: 8922396

DOI: 10.1523/jneurosci.16-23-07407.1996

PubMed ID: 10779526

Title: Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs.

PubMed ID: 10779526

DOI: 10.1074/jbc.m909919199

PubMed ID: 11095503

Title: Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains.

PubMed ID: 11095503

DOI: 10.1097/00001756-200011090-00016

PubMed ID: 11997254

Title: Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses.

PubMed ID: 11997254

DOI: 10.1152/ajpcell.00615.2001

PubMed ID: 16630835

Title: SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.

PubMed ID: 16630835

DOI: 10.1016/j.neuron.2006.04.005

PubMed ID: 19118189

Title: Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.

PubMed ID: 19118189

DOI: 10.1523/jneurosci.3112-08.2008

PubMed ID: 20089912

Title: ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.

PubMed ID: 20089912

DOI: 10.1523/jneurosci.4661-09.2010

PubMed ID: 21119615

Title: DGKiota regulates presynaptic release during mGluR-dependent LTD.

PubMed ID: 21119615

DOI: 10.1038/emboj.2010.286

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 852
Mass: 94934
Checksum: F8D414A8B9CF5B09
Sequence:

MFFACYCALR TNVKKYRYQD EDGPHDHSLP RLTHEVRGPE LVHVSEKNLS QIENVHGYVL 
QSHISPLKAS PAPIIVNTDT LDTIPYVNGT EIEYEFEEIT LERGNSGLGF SIAGGTDNPH 
IGDDPGIFIT KIIPGGAAAE DGRLRVNDCI LRVNEVDVSE VSHSKAVEAL KEAGSIVRLY 
VRRRRPILET VVEIKLFKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIDG GAAQKDGRLQ 
VGDRLLMVNN YSLEEVTHEE AVAILKNTSD VVYLKVGKPT TIYMTDPYGP PDITHSYSPP 
MENHLLSGNN GTLEYKTSLP PISPGRYSPI PKHMLVEDDY TRPPEPVYST VNKLCDKPAS 
PRHYSPVECD KSFLLSTPYP HYHLGLLPDS DMTSHSQHST ATRQPSVTLQ RAISLEGEPR 
KVVLHKGSTG LGFNIVGGED GEGIFVSFIL AGGPADLSGE LQRGDQILSV NGIDLRGASH 
EQAAAALKGA GQTVTIIAQY QPEDYARFEA KIHDLREQMM NHSMSSGSGS LRTNQKRSLY 
VRAMFDYDKS KDSGLPSQGL SFKYGDILHV INASDDEWWQ ARRVILDGDS EEMGVIPSKR 
RVERKERARL KTVKFNAKPG VIDSKGDIPG LGDDGYGTKT LRGQEDLILS YEPVTRQEIN 
YTRPVIILGP MKDRINDDLI SEFPDKFGSC VPHTTRPKRD YEVDGRDYHF VISREQMEKD 
IQEHKFIEAG QYNDNLYGTS VQSVRFVAER GKHCILDVSG NAIKRLQVAQ LYPIAIFIKP 
KSLEPLMEMN KRLTEEQAKK TYDRAIKLEQ EFGEYFTAIV QGDTLEDIYN QCKLVIEEQS 
GPFIWIPSKE KL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dlg2

Associated with

Other Information

Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. PubMed ID: 8755482

Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. PubMed ID: 8625413

An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1. PubMed ID: 15304517

Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein. PubMed ID: 8922396

Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs. PubMed ID: 10779526

Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains. PubMed ID: 11095503

Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. PubMed ID: 11997254

SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses. PubMed ID: 16630835

Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. PubMed ID: 19118189

ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. PubMed ID: 20089912

DGKiota regulates presynaptic release during mGluR-dependent LTD. PubMed ID: 21119615

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903