Details for: SMOC2

Gene ID: 64094

Symbol: SMOC2

Ensembl ID: ENSG00000112562

Description: SPARC related modular calcium binding 2

Associated with

  • Basement membrane
    (GO:0005604)
  • Calcium ion binding
    (GO:0005509)
  • Cell periphery
    (GO:0071944)
  • Extracellular matrix binding
    (GO:0050840)
  • Extracellular matrix organization
    (GO:0030198)
  • Extracellular space
    (GO:0005615)
  • Heparin binding
    (GO:0008201)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of dna biosynthetic process
    (GO:2000573)
  • Positive regulation of endothelial cell chemotaxis
    (GO:2001028)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of fibroblast growth factor receptor signaling pathway
    (GO:0045743)
  • Positive regulation of mitotic cell cycle
    (GO:0045931)
  • Positive regulation of vascular endothelial growth factor signaling pathway
    (GO:1900748)
  • Positive regulation of vascular wound healing
    (GO:0035470)
  • Protein binding
    (GO:0005515)

Other Information

Genular Protein ID: 3198118001

Symbol: SMOC2_HUMAN

Name: SPARC-related modular calcium-binding protein 2

UniProtKB Accession Codes:

Q9H3U7 B3KPS7 Q4G169 Q5TAT7 Q5TAT8 Q86VV9 Q96SF3 Q9H1L3 Q9H1L4 Q9H3U0 Q9H4F7 Q9HCV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMART 2 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12031507

Title: Identification of a novel smooth muscle associated protein, smap2, upregulated during neointima formation in a rat carotid endarterectomy model.

PubMed ID: 12031507

DOI: 10.1016/s0167-4781(02)00345-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12741954

Title: Characterization of SMOC-2, a modular extracellular calcium-binding protein.

PubMed ID: 12741954

DOI: 10.1042/bj20030532

PubMed ID: 16774925

Title: The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity.

PubMed ID: 16774925

DOI: 10.1074/jbc.m513463200

PubMed ID: 22152679

Title: Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects.

PubMed ID: 22152679

DOI: 10.1016/j.ajhg.2011.11.002

Sequence Information:

  • Length: 446
  • Mass: 49674
  • Checksum: CF0D92A71C9E1006
  • Sequence:
    • MLLPQLCWLP LLAGLLPPVP AQKFSALTFL RVDQDKDKDC SLDCAGSPQK PLCASDGRTF 
LSRCEFQRAK CKDPQLEIAY RGNCKDVSRC VAERKYTQEQ ARKEFQQVFI PECNDDGTYS 
QVQCHSYTGY CWCVTPNGRP ISGTAVAHKT PRCPGSVNEK LPQREGTGKT DDAAAPALET 
QPQGDEEDIA SRYPTLWTEQ VKSRQNKTNK NSVSSCDQEH QSALEEAKQP KNDNVVIPEC 
AHGGLYKPVQ CHPSTGYCWC VLVDTGRPIP GTSTRYEQPK CDNTARAHPA KARDLYKGRQ 
LQGCPGAKKH EFLTSVLDAL STDMVHAASD PSSSSGRLSE PDPSHTLEER VVHWYFKLLD 
KNSSGDIGKK EIKPFKRFLR KKSKPKKCVK KFVEYCDVNN DKSISVQELM GCLGVAKEDG 
KADTKKRHTP RGHAESTSNR QPRKQG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.