Details for: BLM
Associated with
Other Information
Genular Protein ID: 1285275157
Symbol: BLM_HUMAN
Name: Bloom syndrome protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7585968
Title: The Bloom's syndrome gene product is homologous to RecQ helicases.
PubMed ID: 7585968
PubMed ID: 9388193
Title: The Bloom's syndrome gene product is a 3'-5' DNA helicase.
PubMed ID: 9388193
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9388480
Title: BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal.
PubMed ID: 9388480
PubMed ID: 10783165
Title: BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
PubMed ID: 10783165
PubMed ID: 15257300
Title: BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks.
PubMed ID: 15257300
PubMed ID: 12019152
Title: The BLM helicase is necessary for normal DNA double-strand break repair.
PubMed ID: 12019152
PubMed ID: 15775963
Title: BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.
PubMed ID: 15775963
PubMed ID: 16595695
Title: A double Holliday junction dissolvasome comprising BLM, topoisomerase III alpha, and BLAP75.
PubMed ID: 16595695
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17961633
Title: Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.
PubMed ID: 17961633
PubMed ID: 18923082
Title: RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
PubMed ID: 18923082
DOI: 10.1101/gad.1708608
PubMed ID: 18923083
Title: BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.
PubMed ID: 18923083
DOI: 10.1101/gad.1725108
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21325134
Title: BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
PubMed ID: 21325134
DOI: 10.1101/gad.2003811
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23509288
Title: Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.
PubMed ID: 23509288
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 32690953
Title: Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.
PubMed ID: 32690953
PubMed ID: 34606619
Title: USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM.
PubMed ID: 34606619
DOI: 10.1093/nar/gkab842
PubMed ID: 20639533
Title: Structure and function of the regulatory HRDC domain from human Bloom syndrome protein.
PubMed ID: 20639533
DOI: 10.1093/nar/gkq586
PubMed ID: 24257077
Title: Structure of the RecQ C-terminal domain of human Bloom syndrome protein.
PubMed ID: 24257077
DOI: 10.1038/srep03294
PubMed ID: 24816114
Title: Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.
PubMed ID: 24816114
PubMed ID: 24435566
Title: Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein.
PubMed ID: 24435566
PubMed ID: 25901030
Title: Crystal structure of the Bloom's syndrome heli case indicates a role for the HRDC domain in conformational changes.
PubMed ID: 25901030
DOI: 10.1093/nar/gkv373
PubMed ID: 28228481
Title: A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.
PubMed ID: 28228481
PubMed ID: 9285778
Title: Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.
PubMed ID: 9285778
DOI: 10.1093/hmg/6.9.1427
PubMed ID: 10862105
Title: Identification of a novel BLM missense mutation (2706T>C) in a Moroccan patient with Bloom's syndrome.
PubMed ID: 10862105
DOI: 10.1002/1098-1004(200006)15:6<584::aid-humu28>3.0.co;2-i
Sequence Information:
- Length: 1417
- Mass: 159000
- Checksum: 423DF5F381194E11
- Sequence:
MAAVPQNNLQ EQLERHSART LNNKLSLSKP KFSGFTFKKK TSSDNNVSVT NVSVAKTPVL RNKDVNVTED FSFSEPLPNT TNQQRVKDFF KNAPAGQETQ RGGSKSLLPD FLQTPKEVVC TTQNTPTVKK SRDTALKKLE FSSSPDSLST INDWDDMDDF DTSETSKSFV TPPQSHFVRV STAQKSKKGK RNFFKAQLYT TNTVKTDLPP PSSESEQIDL TEEQKDDSEW LSSDVICIDD GPIAEVHINE DAQESDSLKT HLEDERDNSE KKKNLEEAEL HSTEKVPCIE FDDDDYDTDF VPPSPEEIIS ASSSSSKCLS TLKDLDTSDR KEDVLSTSKD LLSKPEKMSM QELNPETSTD CDARQISLQQ QLIHVMEHIC KLIDTIPDDK LKLLDCGNEL LQQRNIRRKL LTEVDFNKSD ASLLGSLWRY RPDSLDGPME GDSCPTGNSM KELNFSHLPS NSVSPGDCLL TTTLGKTGFS ATRKNLFERP LFNTHLQKSF VSSNWAETPR LGKKNESSYF PGNVLTSTAV KDQNKHTASI NDLERETQPS YDIDNFDIDD FDDDDDWEDI MHNLAASKSS TAAYQPIKEG RPIKSVSERL SSAKTDCLPV SSTAQNINFS ESIQNYTDKS AQNLASRNLK HERFQSLSFP HTKEMMKIFH KKFGLHNFRT NQLEAINAAL LGEDCFILMP TGGGKSLCYQ LPACVSPGVT VVISPLRSLI VDQVQKLTSL DIPATYLTGD KTDSEATNIY LQLSKKDPII KLLYVTPEKI CASNRLISTL ENLYERKLLA RFVIDEAHCV SQWGHDFRQD YKRMNMLRQK FPSVPVMALT ATANPRVQKD ILTQLKILRP QVFSMSFNRH NLKYYVLPKK PKKVAFDCLE WIRKHHPYDS GIIYCLSRRE CDTMADTLQR DGLAALAYHA GLSDSARDEV QQKWINQDGC QVICATIAFG MGIDKPDVRF VIHASLPKSV EGYYQESGRA GRDGEISHCL LFYTYHDVTR LKRLIMMEKD GNHHTRETHF NNLYSMVHYC ENITECRRIQ LLAYFGENGF NPDFCKKHPD VSCDNCCKTK DYKTRDVTDD VKSIVRFVQE HSSSQGMRNI KHVGPSGRFT MNMLVDIFLG SKSAKIQSGI FGKGSAYSRH NAERLFKKLI LDKILDEDLY INANDQAIAY VMLGNKAQTV LNGNLKVDFM ETENSSSVKK QKALVAKVSQ REEMVKKCLG ELTEVCKSLG KVFGVHYFNI FNTVTLKKLA ESLSSDPEVL LQIDGVTEDK LEKYGAEVIS VLQKYSEWTS PAEDSSPGIS LSSSRGPGRS AAEELDEEIP VSSHYFASKT RNERKRKKMP ASQRSKRRKT ASSGSKAKGG SATCRKISSK TKSSSIIGSS SASHTSQATS GANSKLGIMA PPKPINRPFL KPSYAFS
Genular Protein ID: 690498366
Symbol: B7ZKN7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 1042
- Mass: 117063
- Checksum: A309494729FFE9D8
- Sequence:
MEHICKLIDT IPDDKLKLLD CGNELLQQRN IRRKLLTEVD FNKSDASLLG SLWRYRPDSL DGPMEGDSCP TGNSMKELNF SHLPSNSVSP GDCLLTTTLG KTGFSATRKN LFERPLFNTH LQKSFVSSNW AETPRLGKKN ESSYFPGNVL TSTAVKDQNK HTASINDLER ETQPSYDIDN FDIDDFDDDD DWEDIMHNLA ASKSSTAAYQ PIKEGRPIKS VSERLSSAKT DCLPVSSTAQ NINFSESIQN YTDKSAQNLA SRNLKHERFQ SLSFPHTKEM MKIFHKKFGL HNFRTNQLEA INAALLGEDC FILMPTGGGK SLCYQLPACV SPGVTVVISP LRSLIVDQVQ KLTSLDIPAT YLTGDKTDSE ATNIYLQLSK KDPIIKLLYV TPEKICASNR LISTLENLYE RKLLARFVID EAHCVSQWGH DFRQDYKRMN MLRQKFPSVP VMALTATANP RVQKDILTQL KILRPQVFSM SFNRHNLKYY VLPKKPKKVA FDCLEWIRKH HPYDSGIIYC LSRRECDTMA DTLQRDGLAA LAYHAGLSDS ARDEVQQKWI NQDGCQVICA TIAFGMGIDK PDVRFVIHAS LPKSVEGYYQ ESGRAGRDGE ISHCLLFYTY HDVTRLKRLI MMEKDGNHHT RETHFNNLYS MVHYCENITE CRRIQLLAYF GENGFNPDFC KKHPDVSCDN CCKTKDYKTR DVTDDVKSIV RFVQEHSSSQ GMRNIKHVGP SGRFTMNMLV DIFLGSKSAK IQSGIFGKGS AYSRHNAERL FKKLILDKIL DEDLYINAND QAIAYVMLGN KAQTVLNDNL KVDFMETENS SSVKKQKALV AKVSQREEMV KKCLGELTEV CKSLGKVFGV HYFNIFNTVT LKKLAESLSS DPEVLLQIDG VTEDKLEKYG AEVISVLQKY SEWTSPAEDS SPGISLSSSR GPGRSAAEEL DEEIPVSSHY FASKTRNERK RKKMPASQRS KRRKTASSGS KAKGGSATCR KISSKTKSSS IIGSSSASHT SQATSGANSK LGIMAPPKPI NRPFLKPSYA FS
Genular Protein ID: 524980488
Symbol: H0YNU5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
Sequence Information:
- Length: 1286
- Mass: 144472
- Checksum: ECFA21B0D535FA58
- Sequence:
MAAVPQNNLQ EQLERHSART LNNKLSLSKP KFSGFTFKKK TSSDNNVSVT NVSVAKTPVL RNKDVNVTED FSFSEPLPNT TNQQRVKDFF KNAPAGQETQ RGGSKSLLPD FLQTPKEVVC TTQNTPTVKK SRDTALKKLE FSSSPDSLST INDWDDMDDF DTSETSKSFV TPPQSHFVRV STAQKSKKGK RNFFKAQLYT TNTVKTDLPP PSSESEQIDL TEEQKDDSEW LSSDVICIDD GPIAEVHINE DAQESDSLKT HLEDERDNSE KKKNLEEAEL HSTEKVPCIE FDDDDYDTDF VPPSPEEIIS ASSSSSKCLS TLKDLDTSDR KEDVLSTSKD LLSKPEKMSM QELNPETSTD CDARQISLQQ QLIHVMEHIC KLIDTIPDDK LKLLDCGNEL LQQRNIRRKL LTEVDFNKSD ASLLGSLWRY RPDSLDGPME GDSCPTGNSM KELNFSHLPS NSVSPGDCLL TTTLGKTGFS ATRKNLFERP LFNTHLQKSF VSSNWAETPR LGKKNESSYF PGNVLTSTAV KDQNKHTASI NDLERETQPS YDIDNFDIDD FDDDDDWEDI MHNLAASKSS TAAYQPIKEG RPIKSVSERL SSAKTDCLPV SSTAQNINFS ESIQNYTDKS AQNLASRNLK HERFQSLSFP HTKEMMKIFH KKFGLHNFRT NQLEAINAAL LGEDCFILMP TGGGKSLCYQ LPACVSPGVT VVISPLRSLI VDQVQKLTSL DIPATYLTGD KTDSEATNIY LQLSKKDPII KLLYVTPEKI CASNRLISTL ENLYERKLLA RFVIDEAHCV SQWGHDFRQD YKRMNMLRQK FPSVPVMALT ATANPRVQKD ILTQLKILRP QVFSMSFNRH NLKYYVLPKK PKKVAFDCLE WIRKHHPYDS GIIYCLSRRE CDTMADTLQR DGLAALAYHA GLSDSARDEV QQKWINQDGC QVICATIAFG MGIDKPDVRF VIHASLPKSV EGYYQESGRA GRDGEISHCL LFYTYHDVTR LKRLIMMEKD GNHHTRETHF NNLYSMVHYC ENITECRRIQ LLAYFGENGF NPDFCKKHPD VSCDNCCKTK DYKTRDVTDD VKSIVRFVQE HSSSQGMRNI KHVGPSGRFT MNMLVDIFLE SLSSDPEVLL QIDGVTEDKL EKYGAEVISV LQKYSEWTSP AEDSSPGISL SSSRGPGRSA AEELDEEIPV SSHYFASKTR NERKRKKMPA SQRSKRRKTA SSGSKAKGGS ATCRKISSKT KSSSIIGSSS ASHTSQATSG ANSKLGIMAP PKPINRPFLK PSYAFS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.