Details for: BLM

Gene ID: 641

Symbol: BLM

Ensembl ID: ENSG00000197299

Description: BLM RecQ like helicase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.17
    Marker Score: 6564
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169359
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.45
    Marker Score: 903
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.39
    Marker Score: 3166
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.33
    Marker Score: 2317
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.28
    Marker Score: 2430
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2444
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18302
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71793
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48018
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Marker Score: 19648
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.97
    Marker Score: 314
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.95
    Marker Score: 8333
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.95
    Marker Score: 2572
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.93
    Marker Score: 296
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.93
    Marker Score: 332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.91
    Marker Score: 408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5139
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9
    Marker Score: 606
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 358
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.88
    Marker Score: 1094
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.8
    Marker Score: 1873
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1240
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.73
    Marker Score: 349
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3065
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 658
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.72
    Marker Score: 537
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.7
    Marker Score: 925
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.67
    Marker Score: 810
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.67
    Marker Score: 24563
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.66
    Marker Score: 1971
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.66
    Marker Score: 307
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.62
    Marker Score: 620
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.6
    Marker Score: 858
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.59
    Marker Score: 333
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.59
    Marker Score: 186
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.58
    Marker Score: 2072
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.57
    Marker Score: 538
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.54
    Marker Score: 672
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 341
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 138
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.51
    Marker Score: 250
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 301
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.5
    Marker Score: 399
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.49
    Marker Score: 238
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.48
    Marker Score: 242
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.48
    Marker Score: 348
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.45
    Marker Score: 10094
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.45
    Marker Score: 199
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.43
    Marker Score: 464
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.41
    Marker Score: 359.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.41
    Marker Score: 2636
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.41
    Marker Score: 115
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 393
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4
    Marker Score: 167
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 101
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.36
    Marker Score: 162
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.36
    Marker Score: 375
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.35
    Marker Score: 97
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.35
    Marker Score: 554
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.34
    Marker Score: 1383
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.33
    Marker Score: 98
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.32
    Marker Score: 536
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.31
    Marker Score: 297
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.31
    Marker Score: 341
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.3
    Marker Score: 188
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.29
    Marker Score: 142
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.29
    Marker Score: 327
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.29
    Marker Score: 144
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.29
    Marker Score: 409
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.29
    Marker Score: 117
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.29
    Marker Score: 1104
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.28
    Marker Score: 201
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.28
    Marker Score: 67
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 177
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.28
    Marker Score: 95
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.27
    Marker Score: 124
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.27
    Marker Score: 176
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.27
    Marker Score: 154
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.27
    Marker Score: 67
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.27
    Marker Score: 93
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.27
    Marker Score: 3095
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.27
    Marker Score: 345
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.27
    Marker Score: 131
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.26
    Marker Score: 76
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.26
    Marker Score: 227
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.26
    Marker Score: 96
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.26
    Marker Score: 292

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Other Information

**Key characteristics:** - The BLM gene is located on chromosome 15q23.1. - It is a large gene with a complex structure that includes multiple exons and intronic regions. - The protein encoded by BLM is a helicase that is responsible for breaking DNA double-strand breaks (DSBs). - BLM is a key enzyme in the DNA repair process, and its deficiency can lead to genomic instability and cancer. **Pathways and functions:** - BLM is involved in the cell cycle checkpoints of the G1 and G2 phases, where it monitors the integrity of DNA and prevents cell cycle progression in the presence of DNA damage. - It also plays a role in DNA repair pathways by facilitating the repair of DSBs through the homologous directed repair (HDR) mechanism. - BLM is also involved in meiosis and meiotic recombination, where it is responsible for the repair of DNA damage that occurs during chromosome pairing and synapsis. - Additionally, BLM is involved in the metabolism of proteins, as it is a key enzyme in the ubiquitination and degradation of damaged proteins. **Clinical significance:** - Mutations in the BLM gene have been linked to several human diseases, including Bloom syndrome, which is characterized by a high risk of cancer and developmental abnormalities. - Studies of BLM mutations have also been linked to other genetic disorders, such as breast cancer, colon cancer, and leukemia. - The development of therapeutic agents targeting BLM has emerged as a promising approach for the treatment of human cancers.

Genular Protein ID: 1285275157

Symbol: BLM_HUMAN

Name: Bloom syndrome protein

UniProtKB Accession Codes:

P54132 Q52M96

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 ELM 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 63 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 15 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 17 RefSeq 4 Rhea 1 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7585968

Title: The Bloom's syndrome gene product is homologous to RecQ helicases.

PubMed ID: 7585968

DOI: 10.1016/0092-8674(95)90105-1

PubMed ID: 9388193

Title: The Bloom's syndrome gene product is a 3'-5' DNA helicase.

PubMed ID: 9388193

DOI: 10.1074/jbc.272.49.30611

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9388480

Title: BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal.

PubMed ID: 9388480

DOI: 10.1006/bbrc.1997.7648

PubMed ID: 10783165

Title: BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

PubMed ID: 10783165

PubMed ID: 15257300

Title: BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks.

PubMed ID: 15257300

DOI: 10.1038/sj.emboj.7600277

PubMed ID: 12019152

Title: The BLM helicase is necessary for normal DNA double-strand break repair.

PubMed ID: 12019152

PubMed ID: 15775963

Title: BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.

PubMed ID: 15775963

DOI: 10.1038/sj.emboj.7600622

PubMed ID: 16595695

Title: A double Holliday junction dissolvasome comprising BLM, topoisomerase III alpha, and BLAP75.

PubMed ID: 16595695

DOI: 10.1074/jbc.c600051200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17961633

Title: Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.

PubMed ID: 17961633

DOI: 10.1016/j.mad.2007.09.001

PubMed ID: 18923082

Title: RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.

PubMed ID: 18923082

DOI: 10.1101/gad.1708608

PubMed ID: 18923083

Title: BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.

PubMed ID: 18923083

DOI: 10.1101/gad.1725108

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21325134

Title: BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.

PubMed ID: 21325134

DOI: 10.1101/gad.2003811

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23509288

Title: Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.

PubMed ID: 23509288

DOI: 10.1073/pnas.1220921110

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32690953

Title: Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.

PubMed ID: 32690953

DOI: 10.1038/s41564-020-0753-6

PubMed ID: 34606619

Title: USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM.

PubMed ID: 34606619

DOI: 10.1093/nar/gkab842

PubMed ID: 20639533

Title: Structure and function of the regulatory HRDC domain from human Bloom syndrome protein.

PubMed ID: 20639533

DOI: 10.1093/nar/gkq586

PubMed ID: 24257077

Title: Structure of the RecQ C-terminal domain of human Bloom syndrome protein.

PubMed ID: 24257077

DOI: 10.1038/srep03294

PubMed ID: 24816114

Title: Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.

PubMed ID: 24816114

DOI: 10.1107/s139900471400501x

PubMed ID: 24435566

Title: Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein.

PubMed ID: 24435566

DOI: 10.1007/s10858-014-9812-8

PubMed ID: 25901030

Title: Crystal structure of the Bloom's syndrome heli case indicates a role for the HRDC domain in conformational changes.

PubMed ID: 25901030

DOI: 10.1093/nar/gkv373

PubMed ID: 28228481

Title: A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.

PubMed ID: 28228481

DOI: 10.1074/jbc.m116.761510

PubMed ID: 9285778

Title: Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.

PubMed ID: 9285778

DOI: 10.1093/hmg/6.9.1427

PubMed ID: 10862105

Title: Identification of a novel BLM missense mutation (2706T>C) in a Moroccan patient with Bloom's syndrome.

PubMed ID: 10862105

DOI: 10.1002/1098-1004(200006)15:6<584::aid-humu28>3.0.co;2-i

Sequence Information:

  • Length: 1417
  • Mass: 159000
  • Checksum: 423DF5F381194E11
  • Sequence:
    • MAAVPQNNLQ EQLERHSART LNNKLSLSKP KFSGFTFKKK TSSDNNVSVT NVSVAKTPVL 
RNKDVNVTED FSFSEPLPNT TNQQRVKDFF KNAPAGQETQ RGGSKSLLPD FLQTPKEVVC 
TTQNTPTVKK SRDTALKKLE FSSSPDSLST INDWDDMDDF DTSETSKSFV TPPQSHFVRV 
STAQKSKKGK RNFFKAQLYT TNTVKTDLPP PSSESEQIDL TEEQKDDSEW LSSDVICIDD 
GPIAEVHINE DAQESDSLKT HLEDERDNSE KKKNLEEAEL HSTEKVPCIE FDDDDYDTDF 
VPPSPEEIIS ASSSSSKCLS TLKDLDTSDR KEDVLSTSKD LLSKPEKMSM QELNPETSTD 
CDARQISLQQ QLIHVMEHIC KLIDTIPDDK LKLLDCGNEL LQQRNIRRKL LTEVDFNKSD 
ASLLGSLWRY RPDSLDGPME GDSCPTGNSM KELNFSHLPS NSVSPGDCLL TTTLGKTGFS 
ATRKNLFERP LFNTHLQKSF VSSNWAETPR LGKKNESSYF PGNVLTSTAV KDQNKHTASI 
NDLERETQPS YDIDNFDIDD FDDDDDWEDI MHNLAASKSS TAAYQPIKEG RPIKSVSERL 
SSAKTDCLPV SSTAQNINFS ESIQNYTDKS AQNLASRNLK HERFQSLSFP HTKEMMKIFH 
KKFGLHNFRT NQLEAINAAL LGEDCFILMP TGGGKSLCYQ LPACVSPGVT VVISPLRSLI 
VDQVQKLTSL DIPATYLTGD KTDSEATNIY LQLSKKDPII KLLYVTPEKI CASNRLISTL 
ENLYERKLLA RFVIDEAHCV SQWGHDFRQD YKRMNMLRQK FPSVPVMALT ATANPRVQKD 
ILTQLKILRP QVFSMSFNRH NLKYYVLPKK PKKVAFDCLE WIRKHHPYDS GIIYCLSRRE 
CDTMADTLQR DGLAALAYHA GLSDSARDEV QQKWINQDGC QVICATIAFG MGIDKPDVRF 
VIHASLPKSV EGYYQESGRA GRDGEISHCL LFYTYHDVTR LKRLIMMEKD GNHHTRETHF 
NNLYSMVHYC ENITECRRIQ LLAYFGENGF NPDFCKKHPD VSCDNCCKTK DYKTRDVTDD 
VKSIVRFVQE HSSSQGMRNI KHVGPSGRFT MNMLVDIFLG SKSAKIQSGI FGKGSAYSRH 
NAERLFKKLI LDKILDEDLY INANDQAIAY VMLGNKAQTV LNGNLKVDFM ETENSSSVKK 
QKALVAKVSQ REEMVKKCLG ELTEVCKSLG KVFGVHYFNI FNTVTLKKLA ESLSSDPEVL 
LQIDGVTEDK LEKYGAEVIS VLQKYSEWTS PAEDSSPGIS LSSSRGPGRS AAEELDEEIP 
VSSHYFASKT RNERKRKKMP ASQRSKRRKT ASSGSKAKGG SATCRKISSK TKSSSIIGSS 
SASHTSQATS GANSKLGIMA PPKPINRPFL KPSYAFS

Genular Protein ID: 690498366

Symbol: B7ZKN7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZKN7

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 9 Gene3D 3 GenomeRNAi 1 InterPro 15 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 7 RefSeq 1 Rhea 1 SAM 1 SMART 4 SMR 1 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1042
  • Mass: 117063
  • Checksum: A309494729FFE9D8
  • Sequence:
    • MEHICKLIDT IPDDKLKLLD CGNELLQQRN IRRKLLTEVD FNKSDASLLG SLWRYRPDSL 
DGPMEGDSCP TGNSMKELNF SHLPSNSVSP GDCLLTTTLG KTGFSATRKN LFERPLFNTH 
LQKSFVSSNW AETPRLGKKN ESSYFPGNVL TSTAVKDQNK HTASINDLER ETQPSYDIDN 
FDIDDFDDDD DWEDIMHNLA ASKSSTAAYQ PIKEGRPIKS VSERLSSAKT DCLPVSSTAQ 
NINFSESIQN YTDKSAQNLA SRNLKHERFQ SLSFPHTKEM MKIFHKKFGL HNFRTNQLEA 
INAALLGEDC FILMPTGGGK SLCYQLPACV SPGVTVVISP LRSLIVDQVQ KLTSLDIPAT 
YLTGDKTDSE ATNIYLQLSK KDPIIKLLYV TPEKICASNR LISTLENLYE RKLLARFVID 
EAHCVSQWGH DFRQDYKRMN MLRQKFPSVP VMALTATANP RVQKDILTQL KILRPQVFSM 
SFNRHNLKYY VLPKKPKKVA FDCLEWIRKH HPYDSGIIYC LSRRECDTMA DTLQRDGLAA 
LAYHAGLSDS ARDEVQQKWI NQDGCQVICA TIAFGMGIDK PDVRFVIHAS LPKSVEGYYQ 
ESGRAGRDGE ISHCLLFYTY HDVTRLKRLI MMEKDGNHHT RETHFNNLYS MVHYCENITE 
CRRIQLLAYF GENGFNPDFC KKHPDVSCDN CCKTKDYKTR DVTDDVKSIV RFVQEHSSSQ 
GMRNIKHVGP SGRFTMNMLV DIFLGSKSAK IQSGIFGKGS AYSRHNAERL FKKLILDKIL 
DEDLYINAND QAIAYVMLGN KAQTVLNDNL KVDFMETENS SSVKKQKALV AKVSQREEMV 
KKCLGELTEV CKSLGKVFGV HYFNIFNTVT LKKLAESLSS DPEVLLQIDG VTEDKLEKYG 
AEVISVLQKY SEWTSPAEDS SPGISLSSSR GPGRSAAEEL DEEIPVSSHY FASKTRNERK 
RKKMPASQRS KRRKTASSGS KAKGGSATCR KISSKTKSSS IIGSSSASHT SQATSGANSK 
LGIMAPPKPI NRPFLKPSYA FS

Genular Protein ID: 524980488

Symbol: H0YNU5_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YNU5

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 3 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 11 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1286
  • Mass: 144472
  • Checksum: ECFA21B0D535FA58
  • Sequence:
    • MAAVPQNNLQ EQLERHSART LNNKLSLSKP KFSGFTFKKK TSSDNNVSVT NVSVAKTPVL 
RNKDVNVTED FSFSEPLPNT TNQQRVKDFF KNAPAGQETQ RGGSKSLLPD FLQTPKEVVC 
TTQNTPTVKK SRDTALKKLE FSSSPDSLST INDWDDMDDF DTSETSKSFV TPPQSHFVRV 
STAQKSKKGK RNFFKAQLYT TNTVKTDLPP PSSESEQIDL TEEQKDDSEW LSSDVICIDD 
GPIAEVHINE DAQESDSLKT HLEDERDNSE KKKNLEEAEL HSTEKVPCIE FDDDDYDTDF 
VPPSPEEIIS ASSSSSKCLS TLKDLDTSDR KEDVLSTSKD LLSKPEKMSM QELNPETSTD 
CDARQISLQQ QLIHVMEHIC KLIDTIPDDK LKLLDCGNEL LQQRNIRRKL LTEVDFNKSD 
ASLLGSLWRY RPDSLDGPME GDSCPTGNSM KELNFSHLPS NSVSPGDCLL TTTLGKTGFS 
ATRKNLFERP LFNTHLQKSF VSSNWAETPR LGKKNESSYF PGNVLTSTAV KDQNKHTASI 
NDLERETQPS YDIDNFDIDD FDDDDDWEDI MHNLAASKSS TAAYQPIKEG RPIKSVSERL 
SSAKTDCLPV SSTAQNINFS ESIQNYTDKS AQNLASRNLK HERFQSLSFP HTKEMMKIFH 
KKFGLHNFRT NQLEAINAAL LGEDCFILMP TGGGKSLCYQ LPACVSPGVT VVISPLRSLI 
VDQVQKLTSL DIPATYLTGD KTDSEATNIY LQLSKKDPII KLLYVTPEKI CASNRLISTL 
ENLYERKLLA RFVIDEAHCV SQWGHDFRQD YKRMNMLRQK FPSVPVMALT ATANPRVQKD 
ILTQLKILRP QVFSMSFNRH NLKYYVLPKK PKKVAFDCLE WIRKHHPYDS GIIYCLSRRE 
CDTMADTLQR DGLAALAYHA GLSDSARDEV QQKWINQDGC QVICATIAFG MGIDKPDVRF 
VIHASLPKSV EGYYQESGRA GRDGEISHCL LFYTYHDVTR LKRLIMMEKD GNHHTRETHF 
NNLYSMVHYC ENITECRRIQ LLAYFGENGF NPDFCKKHPD VSCDNCCKTK DYKTRDVTDD 
VKSIVRFVQE HSSSQGMRNI KHVGPSGRFT MNMLVDIFLE SLSSDPEVLL QIDGVTEDKL 
EKYGAEVISV LQKYSEWTSP AEDSSPGISL SSSRGPGRSA AEELDEEIPV SSHYFASKTR 
NERKRKKMPA SQRSKRRKTA SSGSKAKGGS ATCRKISSKT KSSSIIGSSS ASHTSQATSG 
ANSKLGIMAP PKPINRPFLK PSYAFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.