Details for: MOAP1

Gene ID: 64112

Symbol: MOAP1

Ensembl ID: ENSG00000165943

Description: modulator of apoptosis 1

Associated with

Other Information

Genular Protein ID: 20417077

Symbol: MOAP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96BY2 B2RDF6 Q9H833 Q9HAS1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11060313

Title: MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains.

PubMed ID: 11060313

DOI: 10.1074/jbc.m008955200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15949439

Title: The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.

PubMed ID: 15949439

DOI: 10.1016/j.molcel.2005.05.010

PubMed ID: 16199525

Title: MAP-1 is a mitochondrial effector of Bax.

PubMed ID: 16199525

DOI: 10.1073/pnas.0503524102

PubMed ID: 19366867

Title: Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner.

PubMed ID: 19366867

DOI: 10.1093/cercor/bhp062

PubMed ID: 19100260

Title: TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process.

PubMed ID: 19100260

DOI: 10.1016/j.yexcr.2008.11.021

PubMed ID: 22529100

Title: The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1.

PubMed ID: 22529100

DOI: 10.1083/jcb.201111141

PubMed ID: 33783314

Title: The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore.

PubMed ID: 33783314

DOI: 10.1080/15548627.2021.1896157

PubMed ID: 33393215

Title: MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.

PubMed ID: 33393215

DOI: 10.15252/embr.202050854

PubMed ID: 34357660

Title: Structural evidence that MOAP1 and PEG10 are derived from retrovirus/retrotransposon Gag proteins.

PubMed ID: 34357660

DOI: 10.1002/prot.26204

Sequence Information:

  • Length: 351
  • Mass: 39513
  • Checksum: 5310142AC02B563C
  • Sequence:
    • MTLRLLEDWC RGMDMNPRKA LLIAGISQSC SVAEIEEALQ AGLAPLGEYR LLGRMFRRDE 
NRKVALVGLT AETSHALVPK EIPGKGGIWR VIFKPPDPDN TFLSRLNEFL AGEGMTVGEL 
SRALGHENGS LDPEQGMIPE MWAPMLAQAL EALQPALQCL KYKKLRVFSG RESPEPGEEE 
FGRWMFHTTQ MIKAWQVPDV EKRRRLLESL RGPALDVIRV LKINNPLITV DECLQALEEV 
FGVTDNPREL QVKYLTTYQK DEEKLSAYVL RLEPLLQKLV QRGAIERDAV NQARLDQVIA 
GAVHKTIRRE LNLPEDGPAP GFLQLLVLIK DYEAAEEEEA LLQAILEGNF T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.