SLC39A8 | ENSG00000138821 | NCBI 64116

Details for: SLC39A8

Gene ID: 64116

Symbol: SLC39A8

Ensembl ID: ENSG00000138821

Description: solute carrier family 39 member 8

Associated with

Metal ion slc transporters
(R-HSA-425410)
Slc-mediated transmembrane transport
(R-HSA-425407)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-HSA-425366)
Transport of small molecules
(R-HSA-382551)
Zinc influx into cells by the slc39 gene family
(R-HSA-442380)
Zinc transporters
(R-HSA-435354)
Apical plasma membrane
(GO:0016324)
Arginine metabolic process
(GO:0006525)
Basolateral plasma membrane
(GO:0016323)
Bicarbonate transport
(GO:0015701)
Cadmium ion transmembrane transport
(GO:0070574)
Cartilage homeostasis
(GO:1990079)
Cellular detoxification of cadmium ion
(GO:0098849)
Cobalt ion transport
(GO:0006824)
Dna-templated transcription
(GO:0006351)
Extracellular matrix organization
(GO:0030198)
Intracellular manganese ion homeostasis
(GO:0030026)
Intracellular zinc ion homeostasis
(GO:0006882)
Iron ion import across plasma membrane
(GO:0098711)
Leukocyte adhesion to arterial endothelial cell
(GO:0061757)
Lysosomal membrane
(GO:0005765)
Manganese ion transmembrane transport
(GO:0071421)
Mercury ion transport
(GO:0015694)
Mitochondrial manganese ion transmembrane transport
(GO:1990540)
Monoatomic cation:bicarbonate symporter activity
(GO:0140410)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of inflammatory response
(GO:0050728)
Organelle membrane
(GO:0031090)
Plasma membrane
(GO:0005886)
Plasma membrane selenite transport
(GO:0097080)
Protein n-linked glycosylation
(GO:0006487)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of membrane potential
(GO:0042391)
Zinc:bicarbonate symporter activity
(GO:0140412)
Zinc ion import across plasma membrane
(GO:0071578)
Zinc ion transmembrane transport
(GO:0071577)
Zinc ion transmembrane transporter activity
(GO:0005385)
Zinc ion transport
(GO:0006829)

Other Information

Proteins

LIV-1 subfamily of ZIP zinc transporter 6

Genular Protein ID: 3050333212

Symbol: S39A8_HUMAN

Name: LIV-1 subfamily of ZIP zinc transporter 6

UniProtKB Accession Codes:

Q9C0K1 B4E2H3 Q96SM9 Q9BVC0 Q9NSA4

Database IDs:

Citations:

PubMed ID: 12504855

Title: Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures.

PubMed ID: 12504855

DOI: 10.1006/geno.2002.7000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18390834

Title: The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia.

PubMed ID: 18390834

DOI: 10.1152/ajplung.00057.2008

PubMed ID: 19401385

Title: Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells.

PubMed ID: 19401385

DOI: 10.1189/jlb.1208759

PubMed ID: 22898811

Title: ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading.

PubMed ID: 22898811

DOI: 10.1074/jbc.m112.367284

PubMed ID: 23403290

Title: ZIP8 regulates host defense through zinc-mediated inhibition of NF-kappaB.

PubMed ID: 23403290

DOI: 10.1016/j.celrep.2013.01.009

PubMed ID: 27166256

Title: Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake.

PubMed ID: 27166256

DOI: 10.18632/oncotarget.9205

PubMed ID: 28481222

Title: Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity.

PubMed ID: 28481222

DOI: 10.1172/jci90896

PubMed ID: 29337306

Title: Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.

PubMed ID: 29337306

DOI: 10.1172/jci96993

PubMed ID: 29927450

Title: Role of ZIP8 in regulating cell morphology and NF-kappaB/Snail2 signaling.

PubMed ID: 29927450

DOI: 10.1039/c8mt00079d

PubMed ID: 28056086

Title: Zinc Modulates Endotoxin-Induced Human Macrophage Inflammation through ZIP8 Induction and C/EBPbeta Inhibition.

PubMed ID: 28056086

DOI: 10.1371/journal.pone.0169531

PubMed ID: 31699897

Title: The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels.

PubMed ID: 31699897

DOI: 10.1074/jbc.ra119.009371

PubMed ID: 26637978

Title: Autosomal-recessive intellectual disability with cerebellar atrophy syndrome caused by mutation of the manganese and zinc transporter gene SLC39A8.

PubMed ID: 26637978

DOI: 10.1016/j.ajhg.2015.11.002

PubMed ID: 26637979

Title: SLC39A8 deficiency: a disorder of manganese transport and glycosylation.

PubMed ID: 26637979

DOI: 10.1016/j.ajhg.2015.11.003

PubMed ID: 27466201

Title: A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity.

PubMed ID: 27466201

DOI: 10.1093/hmg/ddw236

PubMed ID: 27995398

Title: A SLC39A8 variant causes manganese deficiency, and glycosylation and mitochondrial disorders.

PubMed ID: 27995398

DOI: 10.1007/s10545-016-0010-6

PubMed ID: 29453449

Title: Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders.

PubMed ID: 29453449

DOI: 10.1038/s41598-018-21464-0

Sequence Information:

Length: 460
Mass: 49631
Checksum: E5C03F4576E11E2F
Sequence:

MAPGRAVAGL LLLAAAGLGG VAEGPGLAFS EDVLSVFGAN LSLSAAQLQH LLEQMGAASR 
VGVPEPGQLH FNQCLTAEEI FSLHGFSNAT QITSSKFSVI CPAVLQQLNF HPCEDRPKHK 
TRPSHSEVWG YGFLSVTIIN LASLLGLILT PLIKKSYFPK ILTFFVGLAI GTLFSNAIFQ 
LIPEAFGFDP KVDSYVEKAV AVFGGFYLLF FFERMLKMLL KTYGQNGHTH FGNDNFGPQE 
KTHQPKALPA INGVTCYANP AVTEANGHIH FDNVSVVSLQ DGKKEPSSCT CLKGPKLSEI 
GTIAWMITLC DALHNFIDGL AIGASCTLSL LQGLSTSIAI LCEEFPHELG DFVILLNAGM 
STRQALLFNF LSACSCYVGL AFGILVGNNF APNIIFALAG GMFLYISLAD MFPEMNDMLR 
EKVTGRKTDF TFFMIQNAGM LTGFTAILLI TLYAGEIELE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SLC39A8

Associated with

Other Information

Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures. PubMed ID: 12504855

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Large-scale cDNA transfection screening for genes related to cancer development and progression. PubMed ID: 15498874

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia. PubMed ID: 18390834

Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells. PubMed ID: 19401385

ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading. PubMed ID: 22898811

ZIP8 regulates host defense through zinc-mediated inhibition of NF-kappaB. PubMed ID: 23403290

Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake. PubMed ID: 27166256

Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity. PubMed ID: 28481222

Zinc transporter Slc39a8 is essential for cardiac ventricular compaction. PubMed ID: 29337306

Role of ZIP8 in regulating cell morphology and NF-kappaB/Snail2 signaling. PubMed ID: 29927450

Zinc Modulates Endotoxin-Induced Human Macrophage Inflammation through ZIP8 Induction and C/EBPbeta Inhibition. PubMed ID: 28056086

The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels. PubMed ID: 31699897

Autosomal-recessive intellectual disability with cerebellar atrophy syndrome caused by mutation of the manganese and zinc transporter gene SLC39A8. PubMed ID: 26637978

SLC39A8 deficiency: a disorder of manganese transport and glycosylation. PubMed ID: 26637979

A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity. PubMed ID: 27466201

A SLC39A8 variant causes manganese deficiency, and glycosylation and mitochondrial disorders. PubMed ID: 27995398

Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders. PubMed ID: 29453449