Details for: RRAGC

Gene ID: 64121

Symbol: RRAGC

Ensembl ID: ENSG00000116954

Description: Ras related GTP binding C

Associated with

Other Information

Genular Protein ID: 1198563758

Symbol: RRAGC_HUMAN

Name: Ras-related GTP-binding protein C

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11145883

Title: Adenovirus immunoregulatory genes and their cellular targets.

PubMed ID: 11145883

DOI: 10.1006/viro.2000.0738

PubMed ID: 11073942

Title: Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.

PubMed ID: 11073942

DOI: 10.1074/jbc.m004389200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14660641

Title: A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.

PubMed ID: 14660641

DOI: 10.1074/jbc.m305935200

PubMed ID: 18497260

Title: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

PubMed ID: 18497260

DOI: 10.1126/science.1157535

PubMed ID: 20381137

Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

PubMed ID: 20381137

DOI: 10.1016/j.cell.2010.02.024

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22575674

Title: SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.

PubMed ID: 22575674

DOI: 10.1016/j.molcel.2012.04.007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24095279

Title: The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

PubMed ID: 24095279

DOI: 10.1016/j.molcel.2013.09.016

PubMed ID: 25259925

Title: Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

PubMed ID: 25259925

DOI: 10.1016/j.cell.2014.08.038

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25561175

Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

PubMed ID: 25561175

DOI: 10.1038/nature14107

PubMed ID: 25567906

Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

PubMed ID: 25567906

DOI: 10.1126/science.1257132

PubMed ID: 32612235

Title: A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome.

PubMed ID: 32612235

DOI: 10.1038/s41586-020-2444-0

PubMed ID: 28935770

Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

PubMed ID: 28935770

DOI: 10.1126/science.aao1583

PubMed ID: 29590090

Title: Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.

PubMed ID: 29590090

DOI: 10.1038/nature26158

PubMed ID: 31704029

Title: Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.

PubMed ID: 31704029

DOI: 10.1016/j.cell.2019.10.036

PubMed ID: 31601764

Title: Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

PubMed ID: 31601764

DOI: 10.1126/science.aax3939

PubMed ID: 31601708

Title: Structural basis for the docking of mTORC1 on the lysosomal surface.

PubMed ID: 31601708

DOI: 10.1126/science.aay0166

PubMed ID: 31672913

Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.

PubMed ID: 31672913

DOI: 10.1126/science.aax0364

PubMed ID: 32868926

Title: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.

PubMed ID: 32868926

DOI: 10.1038/s41594-020-0490-9

PubMed ID: 35338845

Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.

PubMed ID: 35338845

DOI: 10.1016/j.molcel.2022.03.002

PubMed ID: 36103527

Title: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.

PubMed ID: 36103527

DOI: 10.1126/sciadv.add2926

PubMed ID: 36697823

Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.

PubMed ID: 36697823

DOI: 10.1038/s41586-022-05652-7

PubMed ID: 27234373

Title: De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy.

PubMed ID: 27234373

DOI: 10.1007/s00439-016-1685-3

PubMed ID: 26691987

Title: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.

PubMed ID: 26691987

DOI: 10.1038/ng.3473

Sequence Information:

  • Length: 399
  • Mass: 44224
  • Checksum: 35B3171253CC69CF
  • Sequence:
  • MSLQYGAEET PLAGSYGAAD SFPKDFGYGV EEEEEEAAAA GGGVGAGAGG GCGPGGADSS 
    KPRILLMGLR RSGKSSIQKV VFHKMSPNET LFLESTNKIY KDDISNSSFV NFQIWDFPGQ 
    MDFFDPTFDY EMIFRGTGAL IYVIDAQDDY MEALTRLHIT VSKAYKVNPD MNFEVFIHKV 
    DGLSDDHKIE TQRDIHQRAN DDLADAGLEK LHLSFYLTSI YDHSIFEAFS KVVQKLIPQL 
    PTLENLLNIF ISNSGIEKAF LFDVVSKIYI ATDSSPVDMQ SYELCCDMID VVIDVSCIYG 
    LKEDGSGSAY DKESMAIIKL NNTTVLYLKE VTKFLALVCI LREESFERKG LIDYNFHCFR 
    KAIHEVFEVG VTSHRSCGHQ TSASSLKALT HNGTPRNAI

Genular Protein ID: 3838474104

Symbol: B4DQG4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 365
  • Mass: 40230
  • Checksum: 95347C6682134322
  • Sequence:
  • MSLQYGAEET PLAGSYGAAD SFPKDFGCGV EEEEEEAAAA GGGVGAGAGG GCGPGGADSS 
    KPRILLMGLR RSGKSSIQKI WDFPGQMDFF DPTFDYEMIF RGTGALIYVI DAQDDYMEAL 
    TRLHITVSRA YKVNPDMNFE VFIHKVDGLS DDHKIETQRD IHQRANDDLA DAGLEKLHLS 
    FYLTSIYDHS IFEAFSKVVQ KLIPQLPTLE NLLNIFISNS GIEKAFLFDV VSKIYIATDS 
    SPVDMQSYEL CCDMIDVVID VSCIYGLKED GSGSAYDKES MAIIKLNNTT VLYLKEVTKF 
    LALVCILREE SFERKGLIDY NFHCFRKAIH EVFEVGVTSH RSCGHQTSAS SLKALTHNGT 
    PRNAI

Genular Protein ID: 3118679225

Symbol: B4DQ03_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 279
  • Mass: 31695
  • Checksum: 04F214082A679573
  • Sequence:
  • MDFFDPTFDY EMIFRGTGAL IYVIDAQDDY MEALTRLHIT VSKAYKVNPD MNFEVFIHKV 
    DGLSDDHKIE TQRDIHQRAN DDLADAGLEK LHLSFYLTSI YDHSIFEAFS KVVQKLIPQL 
    PTLENLLNIF ISNSGIEKAF LFDVVSKIYI ATDSSPVDMQ SYELCCDMID VVIDVSCIYG 
    LKEDGSGSAY DKESMAIIKL NNTTVLYLKE VTKFLALVCI LREESFERKG LIDYNFHCFR 
    KAIHEVFEVG VTSHRSCGHQ TSASSLKALT HNGTPRNVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.