Details for: RRAGC
Associated with
Other Information
Genular Protein ID: 1198563758
Symbol: RRAGC_HUMAN
Name: Ras-related GTP-binding protein C
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11145883
Title: Adenovirus immunoregulatory genes and their cellular targets.
PubMed ID: 11145883
PubMed ID: 11073942
Title: Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.
PubMed ID: 11073942
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14660641
Title: A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.
PubMed ID: 14660641
PubMed ID: 18497260
Title: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
PubMed ID: 18497260
PubMed ID: 20381137
Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
PubMed ID: 20381137
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22575674
Title: SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.
PubMed ID: 22575674
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24095279
Title: The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
PubMed ID: 24095279
PubMed ID: 25259925
Title: Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
PubMed ID: 25259925
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25561175
Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
PubMed ID: 25561175
DOI: 10.1038/nature14107
PubMed ID: 25567906
Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
PubMed ID: 25567906
PubMed ID: 32612235
Title: A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome.
PubMed ID: 32612235
PubMed ID: 28935770
Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
PubMed ID: 28935770
PubMed ID: 29590090
Title: Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
PubMed ID: 29590090
DOI: 10.1038/nature26158
PubMed ID: 31704029
Title: Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.
PubMed ID: 31704029
PubMed ID: 31601764
Title: Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
PubMed ID: 31601764
PubMed ID: 31601708
Title: Structural basis for the docking of mTORC1 on the lysosomal surface.
PubMed ID: 31601708
PubMed ID: 31672913
Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
PubMed ID: 31672913
PubMed ID: 32868926
Title: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.
PubMed ID: 32868926
PubMed ID: 35338845
Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
PubMed ID: 35338845
PubMed ID: 36103527
Title: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.
PubMed ID: 36103527
PubMed ID: 36697823
Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
PubMed ID: 36697823
PubMed ID: 27234373
Title: De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy.
PubMed ID: 27234373
PubMed ID: 26691987
Title: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
PubMed ID: 26691987
DOI: 10.1038/ng.3473
Sequence Information:
- Length: 399
- Mass: 44224
- Checksum: 35B3171253CC69CF
- Sequence:
MSLQYGAEET PLAGSYGAAD SFPKDFGYGV EEEEEEAAAA GGGVGAGAGG GCGPGGADSS KPRILLMGLR RSGKSSIQKV VFHKMSPNET LFLESTNKIY KDDISNSSFV NFQIWDFPGQ MDFFDPTFDY EMIFRGTGAL IYVIDAQDDY MEALTRLHIT VSKAYKVNPD MNFEVFIHKV DGLSDDHKIE TQRDIHQRAN DDLADAGLEK LHLSFYLTSI YDHSIFEAFS KVVQKLIPQL PTLENLLNIF ISNSGIEKAF LFDVVSKIYI ATDSSPVDMQ SYELCCDMID VVIDVSCIYG LKEDGSGSAY DKESMAIIKL NNTTVLYLKE VTKFLALVCI LREESFERKG LIDYNFHCFR KAIHEVFEVG VTSHRSCGHQ TSASSLKALT HNGTPRNAI
Genular Protein ID: 3838474104
Symbol: B4DQG4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 365
- Mass: 40230
- Checksum: 95347C6682134322
- Sequence:
MSLQYGAEET PLAGSYGAAD SFPKDFGCGV EEEEEEAAAA GGGVGAGAGG GCGPGGADSS KPRILLMGLR RSGKSSIQKI WDFPGQMDFF DPTFDYEMIF RGTGALIYVI DAQDDYMEAL TRLHITVSRA YKVNPDMNFE VFIHKVDGLS DDHKIETQRD IHQRANDDLA DAGLEKLHLS FYLTSIYDHS IFEAFSKVVQ KLIPQLPTLE NLLNIFISNS GIEKAFLFDV VSKIYIATDS SPVDMQSYEL CCDMIDVVID VSCIYGLKED GSGSAYDKES MAIIKLNNTT VLYLKEVTKF LALVCILREE SFERKGLIDY NFHCFRKAIH EVFEVGVTSH RSCGHQTSAS SLKALTHNGT PRNAI
Genular Protein ID: 3118679225
Symbol: B4DQ03_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 279
- Mass: 31695
- Checksum: 04F214082A679573
- Sequence:
MDFFDPTFDY EMIFRGTGAL IYVIDAQDDY MEALTRLHIT VSKAYKVNPD MNFEVFIHKV DGLSDDHKIE TQRDIHQRAN DDLADAGLEK LHLSFYLTSI YDHSIFEAFS KVVQKLIPQL PTLENLLNIF ISNSGIEKAF LFDVVSKIYI ATDSSPVDMQ SYELCCDMID VVIDVSCIYG LKEDGSGSAY DKESMAIIKL NNTTVLYLKE VTKFLALVCI LREESFERKG LIDYNFHCFR KAIHEVFEVG VTSHRSCGHQ TSASSLKALT HNGTPRNVI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.