Details for: NOD2
Associated with
Other Information
Genular Protein ID: 421911463
Symbol: NOD2_HUMAN
Name: Inflammatory bowel disease protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11087742
Title: Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.
PubMed ID: 11087742
PubMed ID: 11385576
Title: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.
PubMed ID: 11385576
DOI: 10.1038/35079107
PubMed ID: 20698950
Title: NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner.
PubMed ID: 20698950
PubMed ID: 14570728
Title: Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.
PubMed ID: 14570728
PubMed ID: 12514169
Title: Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.
PubMed ID: 12514169
PubMed ID: 12527755
Title: Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.
PubMed ID: 12527755
PubMed ID: 12871942
Title: Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.
PubMed ID: 12871942
PubMed ID: 12626759
Title: Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.
PubMed ID: 12626759
PubMed ID: 15044951
Title: Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.
PubMed ID: 15044951
PubMed ID: 15998797
Title: Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition.
PubMed ID: 15998797
PubMed ID: 16203728
Title: A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling.
PubMed ID: 16203728
PubMed ID: 17355968
Title: The NOD2-RICK complex signals from the plasma membrane.
PubMed ID: 17355968
PubMed ID: 18511561
Title: A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.
PubMed ID: 18511561
PubMed ID: 19592251
Title: ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.
PubMed ID: 19592251
PubMed ID: 19701189
Title: Activation of innate immune antiviral responses by Nod2.
PubMed ID: 19701189
DOI: 10.1038/ni.1782
PubMed ID: 20637199
Title: ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis.
PubMed ID: 20637199
PubMed ID: 21887730
Title: Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.
PubMed ID: 21887730
DOI: 10.1002/ibd.21851
PubMed ID: 22857257
Title: The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment.
PubMed ID: 22857257
DOI: 10.1021/ja303883c
PubMed ID: 22700971
Title: The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process.
PubMed ID: 22700971
PubMed ID: 23019338
Title: Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components.
PubMed ID: 23019338
PubMed ID: 22829933
Title: TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.
PubMed ID: 22829933
PubMed ID: 23376921
Title: TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3.
PubMed ID: 23376921
DOI: 10.1038/emboj.2013.8
PubMed ID: 23711367
Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.
PubMed ID: 23711367
PubMed ID: 23806334
Title: OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.
PubMed ID: 23806334
PubMed ID: 23322906
Title: A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-kappaB signaling pathways.
PubMed ID: 23322906
PubMed ID: 24960071
Title: Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.
PubMed ID: 24960071
PubMed ID: 25093298
Title: Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators.
PubMed ID: 25093298
PubMed ID: 24790089
Title: The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.
PubMed ID: 24790089
PubMed ID: 25891078
Title: IRGM governs the core autophagy machinery to conduct antimicrobial defense.
PubMed ID: 25891078
PubMed ID: 26369908
Title: Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2.
PubMed ID: 26369908
PubMed ID: 27007849
Title: NOD1 and NOD2 signalling links ER stress with inflammation.
PubMed ID: 27007849
DOI: 10.1038/nature17631
PubMed ID: 27283905
Title: Crystal structure of NOD2 and its implications in human disease.
PubMed ID: 27283905
DOI: 10.1038/ncomms11813
PubMed ID: 27812135
Title: Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.
PubMed ID: 27812135
PubMed ID: 27748583
Title: Molecular recognition of muramyl dipeptide occurs in the leucine-rich repeat domain of Nod2.
PubMed ID: 27748583
PubMed ID: 23300079
Title: Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2.
PubMed ID: 23300079
PubMed ID: 28436939
Title: An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.
PubMed ID: 28436939
DOI: 10.1172/jci86282
PubMed ID: 30279485
Title: RIP2 filament formation is required for NOD2 dependent NF-kappaB signalling.
PubMed ID: 30279485
PubMed ID: 30478312
Title: Structural basis of RIP2 activation and signaling.
PubMed ID: 30478312
PubMed ID: 30559449
Title: Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens.
PubMed ID: 30559449
PubMed ID: 31649195
Title: Palmitoylation of NOD1 and NOD2 is required for bacterial sensing.
PubMed ID: 31649195
PubMed ID: 33942347
Title: Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate.
PubMed ID: 33942347
PubMed ID: 34293401
Title: S-palmitoylation of NOD2 controls its localization to the plasma membrane.
PubMed ID: 34293401
PubMed ID: 35066577
Title: Palmitoylation restricts SQSTM1/p62-mediated autophagic degradation of NOD2 to modulate inflammation.
PubMed ID: 35066577
PubMed ID: 36221902
Title: Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection.
PubMed ID: 36221902
PubMed ID: 36002575
Title: Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
PubMed ID: 36002575
PubMed ID: 11385577
Title: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.
PubMed ID: 11385577
DOI: 10.1038/35079114
PubMed ID: 11528384
PubMed ID: 15024686
Title: Crohn disease: frequency and nature of CARD15 mutations in Ashkenazi and Sephardi/Oriental Jewish families.
PubMed ID: 15024686
DOI: 10.1086/382226
PubMed ID: 15198989
Title: Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations.
PubMed ID: 15198989
DOI: 10.1093/hmg/ddh182
PubMed ID: 15459013
Title: Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome.
PubMed ID: 15459013
PubMed ID: 15812565
PubMed ID: 16485124
Title: Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease.
PubMed ID: 16485124
PubMed ID: 19479837
Title: NOD2-associated pediatric granulomatous arthritis, an expanding phenotype: study of an international registry and a national cohort in Spain.
PubMed ID: 19479837
DOI: 10.1002/art.24533
PubMed ID: 19116920
Title: Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis.
PubMed ID: 19116920
DOI: 10.1002/art.24134
PubMed ID: 19359344
Title: Cardiac infiltration in early-onset sarcoidosis associated with a novel heterozygous mutation, G481D, in CARD15.
PubMed ID: 19359344
PubMed ID: 19169908
Title: A novel mutation in the NOD2 gene associated with Blau syndrome: a Norwegian family with four affected members.
PubMed ID: 19169908
PubMed ID: 20199415
Title: Sporadic Blau syndrome with onset of widespread granulomatous dermatitis in the newborn period.
PubMed ID: 20199415
PubMed ID: 21914217
Title: A new category of autoinflammatory disease associated with NOD2 gene mutations.
PubMed ID: 21914217
DOI: 10.1186/ar3462
PubMed ID: 25692065
PubMed ID: 25724124
Title: Somatic NOD2 mosaicism in Blau syndrome.
PubMed ID: 25724124
PubMed ID: 26070941
Title: NOD2-associated autoinflammatory disease: a large cohort study.
PubMed ID: 26070941
PubMed ID: 34251956
Title: A novel pathogenic NOD2 variant in a mother and daughter with Blau syndrome.
PubMed ID: 34251956
Sequence Information:
- Length: 1040
- Mass: 115283
- Checksum: 0037592D96D7DDFF
- Sequence:
MGEEGGSASH DEEERASVLL GHSPGCEMCS QEAFQAQRSQ LVELLVSGSL EGFESVLDWL LSWEVLSWED YEGFHLLGQP LSHLARRLLD TVWNKGTWAC QKLIAAAQEA QADSQSPKLH GCWDPHSLHP ARDLQSHRPA IVRRLHSHVE NMLDLAWERG FVSQYECDEI RLPIFTPSQR ARRLLDLATV KANGLAAFLL QHVQELPVPL ALPLEAATCK KYMAKLRTTV SAQSRFLSTY DGAETLCLED IYTENVLEVW ADVGMAGPPQ KSPATLGLEE LFSTPGHLND DADTVLVVGE AGSGKSTLLQ RLHLLWAAGQ DFQEFLFVFP FSCRQLQCMA KPLSVRTLLF EHCCWPDVGQ EDIFQLLLDH PDRVLLTFDG FDEFKFRFTD RERHCSPTDP TSVQTLLFNL LQGNLLKNAR KVVTSRPAAV SAFLRKYIRT EFNLKGFSEQ GIELYLRKRH HEPGVADRLI RLLQETSALH GLCHLPVFSW MVSKCHQELL LQEGGSPKTT TDMYLLILQH FLLHATPPDS ASQGLGPSLL RGRLPTLLHL GRLALWGLGM CCYVFSAQQL QAAQVSPDDI SLGFLVRAKG VVPGSTAPLE FLHITFQCFF AAFYLALSAD VPPALLRHLF NCGRPGNSPM ARLLPTMCIQ ASEGKDSSVA ALLQKAEPHN LQITAAFLAG LLSREHWGLL AECQTSEKAL LRRQACARWC LARSLRKHFH SIPPAAPGEA KSVHAMPGFI WLIRSLYEMQ EERLARKAAR GLNVGHLKLT FCSVGPTECA ALAFVLQHLR RPVALQLDYN SVGDIGVEQL LPCLGVCKAL YLRDNNISDR GICKLIECAL HCEQLQKLAL FNNKLTDGCA HSMAKLLACR QNFLALRLGN NYITAAGAQV LAEGLRGNTS LQFLGFWGNR VGDEGAQALA EALGDHQSLR WLSLVGNNIG SVGAQALALM LAKNVMLEEL CLEENHLQDE GVCSLAEGLK KNSSLKILKL SNNCITYLGA EALLQALERN DTILEVWLRG NTFSLEEVDK LGCRDTRLLL
Genular Protein ID: 1327207586
Symbol: A0A286YF65_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
Sequence Information:
- Length: 793
- Mass: 88448
- Checksum: E3D34A4652F34C44
- Sequence:
MCSQEAFQAQ RSQLVELLVS GSLEGFESVL DWLLSWEVLS WEDYEGFHLL GQPLSHLARR LLDTVWNKGT WACQKLIAAA QEAQADSQSP KLHGCWDPHS LHPARDLQSH RPAIVRRLHS HVENMLDLAW ERGFVSQYEC DEIRLPIFTP SQRARRLLDL ATVKANGLAA FLLQHVQELP VPLALPLEAA TCKKYMAKLR TTVSAQSRFL STYDGAETLC LEDIYTENVL EVWADVGMAG PPQKSPATLG LEELFSTPGH LNDDADTVLV VGEAGSGKST LLQRLHLLWA AGQDFQEFLF VFPFSCRQLQ CMAKPLSVRT LLFEHCCWPD VGQEDIFQLL LDHPDRVLLT FDGFDEFKFR FTDRERHCSP TDPTSVQTLL FNLLQGNLLK NARKVVTSRP AAVSAFLRKY IRTEFNLKGF SEQGIELYLR KRHHEPGVAD RLIRLLQETS ALHGLCHLPV FSWMVSKCHQ ELLLQEGGSP KTTTDMYLLI LQHFLLHATP PDSASQGLGP SLLRGRLPTL LHLGRLALWG LGMCCYVFSA QQLQAAQVSP DDISLGFLVR AKGVVPGSTA PLEFLHITFQ CFFAAFYLAL SADVPPALLR HLFNCGRPGN SPMARLLPTM CIQASEGKDS SVAALLQKAE PHNLQITAAF LAGLLSREHW GLLAECQTSE KALLRRQACA RWCLARSLRK HFHSIPPAAP GEAKSVHAMP GFIWLIRSLY EMQEERLARK AARGLNVGHL KLTFCSVGPT ECAALAFVLQ HLRRPVALQL DYNSVGDIGV EQLLPCLGVC KAL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.