Details for: IFIH1
Associated with
Other Information
Genular Protein ID: 1885550912
Symbol: IFIH1_HUMAN
Name: Clinically amyopathic dermatomyositis autoantigen 140 kDa
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11805321
Title: mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.
PubMed ID: 11805321
PubMed ID: 14645903
Title: A novel cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication.
PubMed ID: 14645903
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12015121
Title: Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation.
PubMed ID: 12015121
PubMed ID: 15563593
Title: The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter.
PubMed ID: 15563593
PubMed ID: 16127453
Title: IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
PubMed ID: 16127453
DOI: 10.1038/ni1243
PubMed ID: 16177806
Title: Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
PubMed ID: 16177806
DOI: 10.1038/nature04193
PubMed ID: 17460044
Title: Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.
PubMed ID: 17460044
PubMed ID: 17600090
Title: Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.
PubMed ID: 17600090
PubMed ID: 17709747
Title: The Atg5-Atg12 conjugate associates with innate antiviral immune responses.
PubMed ID: 17709747
PubMed ID: 19565506
Title: RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
PubMed ID: 19565506
DOI: 10.1002/art.24621
PubMed ID: 19211564
Title: Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
PubMed ID: 19211564
PubMed ID: 19656871
Title: Activation of MDA5 requires higher-order RNA structures generated during virus infection.
PubMed ID: 19656871
DOI: 10.1128/jvi.00770-09
PubMed ID: 19881509
Title: PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.
PubMed ID: 19881509
DOI: 10.1038/ni.1815
PubMed ID: 20434986
Title: NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
PubMed ID: 20434986
PubMed ID: 20368735
Title: The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.
PubMed ID: 20368735
DOI: 10.1038/cr.2010.41
PubMed ID: 20127681
Title: DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.
PubMed ID: 20127681
PubMed ID: 20015976
Title: The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.
PubMed ID: 20015976
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21616437
Title: Immune signaling by RIG-I-like receptors.
PubMed ID: 21616437
PubMed ID: 21884169
Title: RIG-I-like receptors: cytoplasmic sensors for non-self RNA.
PubMed ID: 21884169
PubMed ID: 21742966
Title: Innate immune responses in human monocyte-derived dendritic cells are highly dependent on the size and the 5' phosphorylation of RNA molecules.
PubMed ID: 21742966
PubMed ID: 20950133
Title: Retinoic acid-inducible gene-I-like receptors.
PubMed ID: 20950133
PubMed ID: 21791617
Title: DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.
PubMed ID: 21791617
DOI: 10.1128/mcb.01368-10
PubMed ID: 21156324
Title: MDA5 is SUMOylated by PIAS2? in the upregulation of type I interferon signaling.
PubMed ID: 21156324
PubMed ID: 21245900
Title: 2 methylate or not 2 methylate: viral evasion of the type I interferon response.
PubMed ID: 21245900
DOI: 10.1038/ni0211-114
PubMed ID: 21217758
Title: Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.
PubMed ID: 21217758
DOI: 10.1038/ni.1979
PubMed ID: 22160685
Title: Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition.
PubMed ID: 22160685
PubMed ID: 22301138
Title: Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.
PubMed ID: 22301138
DOI: 10.1128/jvi.06713-11
PubMed ID: 23711367
Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.
PubMed ID: 23711367
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24390337
Title: Enterovirus 2Apro targets MDA5 and MAVS in infected cells.
PubMed ID: 24390337
DOI: 10.1128/jvi.02712-13
PubMed ID: 25865883
Title: RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.
PubMed ID: 25865883
PubMed ID: 25228397
Title: ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses.
PubMed ID: 25228397
DOI: 10.1159/000365971
PubMed ID: 27312109
Title: RNF123 has an E3 ligase-independent function in RIG-I-like receptor-mediated antiviral signaling.
PubMed ID: 27312109
PubMed ID: 28424289
Title: Disruption of MDA5-Mediated Innate Immune Responses by the 3C Proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68.
PubMed ID: 28424289
DOI: 10.1128/jvi.00546-17
PubMed ID: 29117565
Title: The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I.
PubMed ID: 29117565
PubMed ID: 28594402
Title: ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65.
PubMed ID: 28594402
PubMed ID: 30312637
Title: Encephalomyocarditis virus 2C protein antagonizes interferon-beta signaling pathway through interaction with MDA5.
PubMed ID: 30312637
PubMed ID: 30193849
Title: The zinc-finger protein ZCCHC3 binds RNA and facilitates viral RNA sensing and activation of the RIG-I-like receptors.
PubMed ID: 30193849
PubMed ID: 32169843
Title: NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS.
PubMed ID: 32169843
PubMed ID: 33440148
Title: MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.
PubMed ID: 33440148
PubMed ID: 33514628
Title: SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.
PubMed ID: 33514628
DOI: 10.1128/jvi.02415-20
PubMed ID: 33727702
Title: ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
PubMed ID: 33727702
PubMed ID: 19531363
Title: Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5.
PubMed ID: 19531363
PubMed ID: 19380577
Title: Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors.
PubMed ID: 19380577
PubMed ID: 16699517
Title: A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.
PubMed ID: 16699517
DOI: 10.1038/ng1800
PubMed ID: 24995871
Title: Aicardi-Goutieres syndrome is caused by IFIH1 mutations.
PubMed ID: 24995871
PubMed ID: 24686847
Title: Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling.
PubMed ID: 24686847
DOI: 10.1038/ng.2933
PubMed ID: 25620204
Title: A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome.
PubMed ID: 25620204
PubMed ID: 28606988
Title: Recurrent rhinovirus infections in a child with inherited MDA5 deficiency.
PubMed ID: 28606988
DOI: 10.1084/jem.20161759
PubMed ID: 29018476
Title: Recurrent and prolonged infections in a child with a homozygous IFIH1 nonsense mutation.
PubMed ID: 29018476
Sequence Information:
- Length: 1025
- Mass: 116689
- Checksum: 789CFB4824B92DC9
- Sequence:
MSNGYSTDEN FRYLISCFRA RVKMYIQVEP VLDYLTFLPA EVKEQIQRTV ATSGNMQAVE LLLSTLEKGV WHLGWTREFV EALRRTGSPL AARYMNPELT DLPSPSFENA HDEYLQLLNL LQPTLVDKLL VRDVLDKCME EELLTIEDRN RIAAAENNGN ESGVRELLKR IVQKENWFSA FLNVLRQTGN NELVQELTGS DCSESNAEIE NLSQVDGPQV EEQLLSTTVQ PNLEKEVWGM ENNSSESSFA DSSVVSESDT SLAEGSVSCL DESLGHNSNM GSDSGTMGSD SDEENVAARA SPEPELQLRP YQMEVAQPAL EGKNIIICLP TGSGKTRVAV YIAKDHLDKK KKASEPGKVI VLVNKVLLVE QLFRKEFQPF LKKWYRVIGL SGDTQLKISF PEVVKSCDII ISTAQILENS LLNLENGEDA GVQLSDFSLI IIDECHHTNK EAVYNNIMRH YLMQKLKNNR LKKENKPVIP LPQILGLTAS PGVGGATKQA KAEEHILKLC ANLDAFTIKT VKENLDQLKN QIQEPCKKFA IADATREDPF KEKLLEIMTR IQTYCQMSPM SDFGTQPYEQ WAIQMEKKAA KEGNRKERVC AEHLRKYNEA LQINDTIRMI DAYTHLETFY NEEKDKKFAV IEDDSDEGGD DEYCDGDEDE DDLKKPLKLD ETDRFLMTLF FENNKMLKRL AENPEYENEK LTKLRNTIME QYTRTEESAR GIIFTKTRQS AYALSQWITE NEKFAEVGVK AHHLIGAGHS SEFKPMTQNE QKEVISKFRT GKINLLIATT VAEEGLDIKE CNIVIRYGLV TNEIAMVQAR GRARADESTY VLVAHSGSGV IEHETVNDFR EKMMYKAIHC VQNMKPEEYA HKILELQMQS IMEKKMKTKR NIAKHYKNNP SLITFLCKNC SVLACSGEDI HVIEKMHHVN MTPEFKELYI VRENKALQKK CADYQINGEI ICKCGQAWGT MMVHKGLDLP CLKIRNFVVV FKNNSTKKQY KKWVELPITF PNLDYSECCL FSDED
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.