CARD9 | ENSG00000187796 | NCBI 64170

Details for: CARD9

Gene ID: 64170

Symbol: CARD9

Ensembl ID: ENSG00000187796

Description: caspase recruitment domain family member 9

Associated with

C-type lectin receptors (clrs)
(R-HSA-5621481)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Antifungal innate immune response
(GO:0061760)
Card domain binding
(GO:0050700)
Cbm complex
(GO:0032449)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to gram-positive bacterium
(GO:0050830)
Defense response to virus
(GO:0051607)
Host-mediated regulation of intestinal microbiota composition
(GO:0048874)
Immunoglobulin mediated immune response
(GO:0016064)
Jnk cascade
(GO:0007254)
Metal ion binding
(GO:0046872)
Neutrophil mediated immunity
(GO:0002446)
Plasma membrane
(GO:0005886)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of cytokine production involved in inflammatory response
(GO:1900017)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of granulocyte macrophage colony-stimulating factor production
(GO:0032725)
Positive regulation of innate immune response
(GO:0045089)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of macrophage cytokine production
(GO:0060907)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of stress-activated mapk cascade
(GO:0032874)
Positive regulation of t-helper 17 type immune response
(GO:2000318)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein homooligomerization
(GO:0051260)
Protein self-association
(GO:0043621)
Regulation of apoptotic process
(GO:0042981)
Regulation of interleukin-2 production
(GO:0032663)
Response to aldosterone
(GO:1904044)
Response to exogenous dsrna
(GO:0043330)
Response to muramyl dipeptide
(GO:0032495)
Response to peptidoglycan
(GO:0032494)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

CARD9_HUMAN

Genular Protein ID: 2734543800

Symbol: CARD9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H257 Q5SXM5 Q5SXM6 Q9H854

Database IDs:

Citations:

PubMed ID: 11053425

Title: CARD9 is a novel caspase recruitment domain-containing protein that interacts with Bcl10/CLAP and activates NF-kappa B.

PubMed ID: 11053425

DOI: 10.1074/jbc.c000726200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19864672

Title: A homozygous CARD9 mutation in a family with susceptibility to fungal infections.

PubMed ID: 19864672

DOI: 10.1056/nejmoa0810719

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24960071

Title: Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.

PubMed ID: 24960071

DOI: 10.1016/j.febslet.2014.06.035

PubMed ID: 26488816

Title: Ubiquitin ligase TRIM62 regulates CARD9-mediated anti-fungal immunity and intestinal inflammation.

PubMed ID: 26488816

DOI: 10.1016/j.immuni.2015.10.005

PubMed ID: 26440558

Title: CARD9 mutation linked to Corynespora cassiicola infection in a Chinese patient.

PubMed ID: 26440558

DOI: 10.1111/bjd.14082

PubMed ID: 28984994

Title: Novel bi-allelic splice mutations in CARD9 causing adult-onset Candida endophthalmitis.

PubMed ID: 28984994

DOI: 10.1111/myc.12701

PubMed ID: 33093067

Title: USP15 deubiquitinates CARD9 to downregulate C-type lectin receptor-mediated signaling.

PubMed ID: 33093067

DOI: 10.4049/immunohorizons.2000036

PubMed ID: 30206119

Title: Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.

PubMed ID: 30206119

DOI: 10.1074/jbc.ra118.004821

PubMed ID: 31296852

Title: Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.

PubMed ID: 31296852

DOI: 10.1038/s41467-019-10953-z

PubMed ID: 23335372

Title: Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency.

PubMed ID: 23335372

DOI: 10.1182/blood-2012-08-450551

PubMed ID: 24131138

Title: Deep dermatophytosis and inherited CARD9 deficiency.

PubMed ID: 24131138

DOI: 10.1056/nejmoa1208487

PubMed ID: 24704721

Title: CARD9 deficiency and spontaneous central nervous system candidiasis: complete clinical remission with GM-CSF therapy.

PubMed ID: 24704721

DOI: 10.1093/cid/ciu215

PubMed ID: 24231284

Title: CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies.

PubMed ID: 24231284

DOI: 10.1016/j.jaci.2013.09.033

PubMed ID: 25372963

Title: Posaconazole treatment of extensive skin and nail dermatophytosis due to autosomal recessive deficiency of CARD9.

PubMed ID: 25372963

DOI: 10.1001/jamadermatol.2014.2154

PubMed ID: 25702837

Title: Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species-induced meningoencephalitis, colitis, or both.

PubMed ID: 25702837

DOI: 10.1016/j.jaci.2014.12.1930

PubMed ID: 26044242

Title: A homozygous CARD9 mutation in a Brazilian patient with deep dermatophytosis.

PubMed ID: 26044242

DOI: 10.1007/s10875-015-0170-4

PubMed ID: 25057046

Title: Inherited CARD9 deficiency in 2 unrelated patients with invasive Exophiala infection.

PubMed ID: 25057046

DOI: 10.1093/infdis/jiu412

PubMed ID: 25933095

Title: Chronic candida albicans meningitis in a 4-year-old girl with a homozygous mutation in the CARD9 gene (Q295X).

PubMed ID: 25933095

DOI: 10.1097/inf.0000000000000736

PubMed ID: 26679537

Title: CARD9-dependent neutrophil recruitment protects against fungal invasion of the central nervous system.

PubMed ID: 26679537

DOI: 10.1371/journal.ppat.1005293

PubMed ID: 26961233

Title: Chronic and invasive fungal infections in a family with CARD9 deficiency.

PubMed ID: 26961233

DOI: 10.1007/s10875-016-0255-8

PubMed ID: 26941346

Title: Endogenous Candida endophthalmitis and osteomyelitis associated with CARD9 deficiency.

PubMed ID: 26941346

DOI: 10.1136/bcr-2015-214117

PubMed ID: 26521038

Title: Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians.

PubMed ID: 26521038

DOI: 10.1016/j.jaci.2015.09.016

PubMed ID: 27777981

Title: Extrapulmonary Aspergillus infection in patients with CARD9 deficiency.

PubMed ID: 27777981

DOI: 10.1172/jci.insight.89890

PubMed ID: 26658378

Title: Successful granulocyte colony-stimulating factor treatment of relapsing candida albicans meningoencephalitis caused by CARD9 deficiency.

PubMed ID: 26658378

DOI: 10.1097/inf.0000000000001028

PubMed ID: 28391957

Title: Dermatophytic disease with deficit in CARD9: A new case with a brain impairment.

PubMed ID: 28391957

DOI: 10.1016/j.mycmed.2017.01.001

PubMed ID: 29307770

Title: A young girl with severe cerebral fungal infection due to card 9 deficiency.

PubMed ID: 29307770

DOI: 10.1016/j.clim.2018.01.002

PubMed ID: 29080677

Title: Impaired specific antifungal immunity in CARD9-deficient patients with phaeohyphomycosis.

PubMed ID: 29080677

DOI: 10.1016/j.jid.2017.10.009

PubMed ID: 31469433

Title: Novel CARD9 mutation in a patient with chronic invasive dermatophyte infection (tinea profunda).

PubMed ID: 31469433

DOI: 10.1111/cup.13574

PubMed ID: 33548172

Title: Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies.

PubMed ID: 33548172

DOI: 10.1016/j.cell.2021.01.016

PubMed ID: 33558980

Title: Inherited CARD9 deficiency in a child with invasive disease due to Exophiala dermatitidis and two older but asymptomatic siblings.

PubMed ID: 33558980

DOI: 10.1007/s10875-021-00988-7

Sequence Information:

Length: 536
Mass: 62241
Checksum: 6EB18353112F2BAC
Sequence:

MSDYENDDEC WSVLEGFRVT LTSVIDPSRI TPYLRQCKVL NPDDEEQVLS DPNLVIRKRK 
VGVLLDILQR TGHKGYVAFL ESLELYYPQL YKKVTGKEPA RVFSMIIDAS GESGLTQLLM 
TEVMKLQKKV QDLTALLSSK DDFIKELRVK DSLLRKHQER VQRLKEECEA GSRELKRCKE 
ENYDLAMRLA HQSEEKGAAL MRNRDLQLEI DQLKHSLMKA EDDCKVERKH TLKLRHAMEQ 
RPSQELLWEL QQEKALLQAR VQELEASVQE GKLDRSSPYI QVLEEDWRQA LRDHQEQANT 
IFSLRKDLRQ GEARRLRCME EKEMFELQCL ALRKDSKMYK DRIEAILLQM EEVAIERDQA 
IATREELHAQ HARGLQEKDA LRKQVRELGE KADELQLQVF QCEAQLLAVE GRLRRQQLET 
LVLSSDLEDG SPRRSQELSL PQDLEDTQLS DKGCLAGGGS PKQPFAALHQ EQVLRNPHDA 
GLSSGEPPEK ERRRLKESFE NYRRKRALRK MQKGWRQGEE DRENTTGSDN TDTEGS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CARD9

Associated with

Other Information

CARD9 is a novel caspase recruitment domain-containing protein that interacts with Bcl10/CLAP and activates NF-kappa B. PubMed ID: 11053425

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A homozygous CARD9 mutation in a family with susceptibility to fungal infections. PubMed ID: 19864672

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain. PubMed ID: 24960071

Ubiquitin ligase TRIM62 regulates CARD9-mediated anti-fungal immunity and intestinal inflammation. PubMed ID: 26488816

CARD9 mutation linked to Corynespora cassiicola infection in a Chinese patient. PubMed ID: 26440558

Novel bi-allelic splice mutations in CARD9 causing adult-onset Candida endophthalmitis. PubMed ID: 28984994

USP15 deubiquitinates CARD9 to downregulate C-type lectin receptor-mediated signaling. PubMed ID: 33093067

Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9. PubMed ID: 30206119

Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation. PubMed ID: 31296852

Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. PubMed ID: 23335372

Deep dermatophytosis and inherited CARD9 deficiency. PubMed ID: 24131138

CARD9 deficiency and spontaneous central nervous system candidiasis: complete clinical remission with GM-CSF therapy. PubMed ID: 24704721

CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies. PubMed ID: 24231284

Posaconazole treatment of extensive skin and nail dermatophytosis due to autosomal recessive deficiency of CARD9. PubMed ID: 25372963

Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species-induced meningoencephalitis, colitis, or both. PubMed ID: 25702837

A homozygous CARD9 mutation in a Brazilian patient with deep dermatophytosis. PubMed ID: 26044242

Inherited CARD9 deficiency in 2 unrelated patients with invasive Exophiala infection. PubMed ID: 25057046

Chronic candida albicans meningitis in a 4-year-old girl with a homozygous mutation in the CARD9 gene (Q295X). PubMed ID: 25933095

CARD9-dependent neutrophil recruitment protects against fungal invasion of the central nervous system. PubMed ID: 26679537

Chronic and invasive fungal infections in a family with CARD9 deficiency. PubMed ID: 26961233

Endogenous Candida endophthalmitis and osteomyelitis associated with CARD9 deficiency. PubMed ID: 26941346

Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians. PubMed ID: 26521038

Extrapulmonary Aspergillus infection in patients with CARD9 deficiency. PubMed ID: 27777981

Successful granulocyte colony-stimulating factor treatment of relapsing candida albicans meningoencephalitis caused by CARD9 deficiency. PubMed ID: 26658378

Dermatophytic disease with deficit in CARD9: A new case with a brain impairment. PubMed ID: 28391957

A young girl with severe cerebral fungal infection due to card 9 deficiency. PubMed ID: 29307770

Impaired specific antifungal immunity in CARD9-deficient patients with phaeohyphomycosis. PubMed ID: 29080677

Novel CARD9 mutation in a patient with chronic invasive dermatophyte infection (tinea profunda). PubMed ID: 31469433

Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies. PubMed ID: 33548172

Inherited CARD9 deficiency in a child with invasive disease due to Exophiala dermatitidis and two older but asymptomatic siblings. PubMed ID: 33558980