Details for: BLMH

Gene ID: 642

Symbol: BLMH

Ensembl ID: ENSG00000108578

Description: bleomycin hydrolase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 137.8377
    Cell Significance Index: -21.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.6146
    Cell Significance Index: -17.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 63.0663
    Cell Significance Index: -25.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.1263
    Cell Significance Index: -24.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.8637
    Cell Significance Index: -21.0700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.7797
    Cell Significance Index: -24.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.4354
    Cell Significance Index: -21.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.8896
    Cell Significance Index: -23.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9138
    Cell Significance Index: -21.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0364
    Cell Significance Index: -23.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0832
    Cell Significance Index: -11.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5689
    Cell Significance Index: 155.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8984
    Cell Significance Index: 46.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8372
    Cell Significance Index: 50.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8227
    Cell Significance Index: 133.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7589
    Cell Significance Index: 20.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7276
    Cell Significance Index: 7.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6939
    Cell Significance Index: 139.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6803
    Cell Significance Index: 135.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6753
    Cell Significance Index: 43.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6153
    Cell Significance Index: 21.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5628
    Cell Significance Index: 11.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4327
    Cell Significance Index: 390.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4165
    Cell Significance Index: 149.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3560
    Cell Significance Index: 9.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3504
    Cell Significance Index: 40.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3438
    Cell Significance Index: 47.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3221
    Cell Significance Index: 37.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3159
    Cell Significance Index: 60.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3106
    Cell Significance Index: 2.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2991
    Cell Significance Index: 206.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2853
    Cell Significance Index: 16.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2594
    Cell Significance Index: 31.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2434
    Cell Significance Index: 107.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2420
    Cell Significance Index: 132.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2186
    Cell Significance Index: 15.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1878
    Cell Significance Index: 19.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1801
    Cell Significance Index: 32.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1199
    Cell Significance Index: 8.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1036
    Cell Significance Index: 2.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0984
    Cell Significance Index: 2.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0686
    Cell Significance Index: 3.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0644
    Cell Significance Index: 1.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0610
    Cell Significance Index: 7.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0592
    Cell Significance Index: 4.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0493
    Cell Significance Index: 3.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0375
    Cell Significance Index: 1.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0342
    Cell Significance Index: 0.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0313
    Cell Significance Index: 1.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0186
    Cell Significance Index: 3.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0176
    Cell Significance Index: 0.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0120
    Cell Significance Index: 22.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0105
    Cell Significance Index: 0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0089
    Cell Significance Index: 5.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0071
    Cell Significance Index: 0.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0053
    Cell Significance Index: -8.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0097
    Cell Significance Index: -1.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0119
    Cell Significance Index: -5.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0129
    Cell Significance Index: -17.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0148
    Cell Significance Index: -0.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0167
    Cell Significance Index: -0.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0171
    Cell Significance Index: -12.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0195
    Cell Significance Index: -14.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0231
    Cell Significance Index: -17.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0310
    Cell Significance Index: -1.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0332
    Cell Significance Index: -1.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0355
    Cell Significance Index: -20.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0365
    Cell Significance Index: -5.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0449
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0452
    Cell Significance Index: -28.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0638
    Cell Significance Index: -1.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0714
    Cell Significance Index: -20.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0728
    Cell Significance Index: -3.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1177
    Cell Significance Index: -6.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1305
    Cell Significance Index: -27.4900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1318
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1365
    Cell Significance Index: -15.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1895
    Cell Significance Index: -4.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1993
    Cell Significance Index: -14.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2149
    Cell Significance Index: -22.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2280
    Cell Significance Index: -2.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2509
    Cell Significance Index: -6.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2523
    Cell Significance Index: -19.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2710
    Cell Significance Index: -5.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2731
    Cell Significance Index: -1.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2962
    Cell Significance Index: -18.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3166
    Cell Significance Index: -4.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3329
    Cell Significance Index: -7.1200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.3509
    Cell Significance Index: -2.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3599
    Cell Significance Index: -7.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3945
    Cell Significance Index: -6.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4064
    Cell Significance Index: -11.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4347
    Cell Significance Index: -12.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4543
    Cell Significance Index: -10.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4598
    Cell Significance Index: -13.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4606
    Cell Significance Index: -14.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4664
    Cell Significance Index: -15.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4758
    Cell Significance Index: -24.0400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4820
    Cell Significance Index: -7.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BLMH is a cysteine-type aminopeptidase enzyme that exhibits a wide range of cellular distributions, including the cytosol, nucleus, and extracellular exosome. Its expression is significantly observed in various cell types, such as pulmonary interstitial fibroblasts, male germ cells, proerythroblasts, epithelial cells of the nephron, and mesenchymal cells. Notably, BLMH is also expressed in the placental villous trophoblast and fraction A pre-pro B cell, suggesting its involvement in fetal development and immune system maturation. **Pathways and Functions:** BLMH is involved in several critical pathways, including: 1. **Antigen processing and presentation:** BLMH participates in the degradation of proteins, facilitating the presentation of antigens to the immune system via Class I MHC molecules. 2. **Aminopeptidase activity:** BLMH hydrolyzes amino acids, playing a role in protein degradation and the regulation of various cellular processes. 3. **Homocysteine catabolic process:** BLMH is involved in the metabolic breakdown of homocysteine, a toxic amino acid that can cause oxidative stress and cellular damage. 4. **Proteolysis:** BLMH contributes to the degradation of proteins, modulating cellular homeostasis and immune response. **Clinical Significance:** BLMH's involvement in various cellular processes and pathways makes it a promising candidate for therapeutic intervention in several clinical contexts, including: 1. **Immunological disorders:** BLMH's role in antigen processing and presentation suggests its potential involvement in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** BLMH's expression in various cancer cell types implies its potential as a biomarker or therapeutic target for cancer treatment. 3. **Neurological disorders:** BLMH's presence in the brain and its involvement in proteolysis suggest its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 4. **Fetal development:** BLMH's expression in placental villous trophoblasts highlights its importance in fetal development and immune system maturation. In conclusion, Bleomycin Hydrolase (BLMH) is a multifunctional enzyme that plays a critical role in immune system regulation, cellular homeostasis, and response to toxic substances. Further research is necessary to fully elucidate the functional significance of BLMH and its potential therapeutic applications in various clinical contexts.

Genular Protein ID: 3882483353

Symbol: BLMH_HUMAN

Name: Bleomycin hydrolase

UniProtKB Accession Codes:

Q13867 B2R796 Q53F86 Q9UER9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8620487

Title: Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.

PubMed ID: 8620487

PubMed ID: 8639621

Title: Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization.

PubMed ID: 8639621

DOI: 10.1021/bi960092y

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31875550

Title: Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.

PubMed ID: 31875550

DOI: 10.1016/j.celrep.2019.11.108

PubMed ID: 10404591

Title: Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.

PubMed ID: 10404591

DOI: 10.1016/s0969-2126(99)80083-5

Sequence Information:

  • Length: 455
  • Mass: 52562
  • Checksum: 577E86241EB0D460
  • Sequence:
    • MSSSGLNSEK VAALIQKLNS DPQFVLAQNV GTTHDLLDIC LKRATVQRAQ HVFQHAVPQE 
GKPITNQKSS GRCWIFSCLN VMRLPFMKKL NIEEFEFSQS YLFFWDKVER CYFFLSAFVD 
TAQRKEPEDG RLVQFLLMNP ANDGGQWDML VNIVEKYGVI PKKCFPESYT TEATRRMNDI 
LNHKMREFCI RLRNLVHSGA TKGEISATQD VMMEEIFRVV CICLGNPPET FTWEYRDKDK 
NYQKIGPITP LEFYREHVKP LFNMEDKICL VNDPRPQHKY NKLYTVEYLS NMVGGRKTLY 
NNQPIDFLKK MVAASIKDGE AVWFGCDVGK HFNSKLGLSD MNLYDHELVF GVSLKNMNKA 
ERLTFGESLM THAMTFTAVS EKDDQDGAFT KWRVENSWGE DHGHKGYLCM TDEWFSEYVY 
EVVVDRKHVP EEVLAVLEQE PIILPAWDPM GALAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.