Details for: BLMH

Gene ID: 642

Symbol: BLMH

Ensembl ID: ENSG00000108578

Description: bleomycin hydrolase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.77
    Marker Score: 2221
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.47
    Marker Score: 424
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.33
    Marker Score: 1670
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.23
    Marker Score: 2571
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.16
    Marker Score: 1974
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.16
    Marker Score: 4548
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.1
    Marker Score: 1110
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.09
    Marker Score: 9350
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.06
    Marker Score: 1141.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.05
    Marker Score: 2859
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.04
    Marker Score: 3850
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1
    Marker Score: 1443
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71703
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47927
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.99
    Marker Score: 13107
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.99
    Marker Score: 662
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.99
    Marker Score: 9385
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30393
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.97
    Marker Score: 8546
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.97
    Marker Score: 1499
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.97
    Marker Score: 1025
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.96
    Marker Score: 3931
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.94
    Marker Score: 9485
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.93
    Marker Score: 996
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.93
    Marker Score: 346
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2703
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9
    Marker Score: 55469
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.89
    Marker Score: 287
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.89
    Marker Score: 842
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.89
    Marker Score: 840
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.89
    Marker Score: 947
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.89
    Marker Score: 1179
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.89
    Marker Score: 813
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.88
    Marker Score: 917
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.87
    Marker Score: 973
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.87
    Marker Score: 2037.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.86
    Marker Score: 3338
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.86
    Marker Score: 8051
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.85
    Marker Score: 2306
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.85
    Marker Score: 635
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.84
    Marker Score: 9480
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4798
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.83
    Marker Score: 12390
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.82
    Marker Score: 233
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.82
    Marker Score: 518
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8
    Marker Score: 5224
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8
    Marker Score: 8052.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.8
    Marker Score: 831
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.8
    Marker Score: 544.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.79
    Marker Score: 496
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.78
    Marker Score: 1653
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.77
    Marker Score: 561
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.76
    Marker Score: 27918
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.76
    Marker Score: 7798
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.75
    Marker Score: 5779
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.75
    Marker Score: 28595
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.75
    Marker Score: 191
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.75
    Marker Score: 261
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.74
    Marker Score: 896
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.74
    Marker Score: 537
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.73
    Marker Score: 247
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.73
    Marker Score: 385
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.72
    Marker Score: 360.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.72
    Marker Score: 175
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.71
    Marker Score: 644
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.71
    Marker Score: 349
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2970
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.71
    Marker Score: 2098
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.7
    Marker Score: 13987.5
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.7
    Marker Score: 345
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10896
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.69
    Marker Score: 242
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.69
    Marker Score: 890
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.69
    Marker Score: 5126
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.69
    Marker Score: 161
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.69
    Marker Score: 488
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.68
    Marker Score: 960
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.68
    Marker Score: 170
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.67
    Marker Score: 361
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.67
    Marker Score: 274
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 610
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.67
    Marker Score: 354.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.66
    Marker Score: 1327
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.66
    Marker Score: 175
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.66
    Marker Score: 163
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.65
    Marker Score: 447
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.65
    Marker Score: 2711
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.65
    Marker Score: 321
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 428

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Other Information

**Key characteristics:** * The BLMH gene is located on chromosome 15q21.1. * It is a large gene with a size of approximately 2.2 million base pairs. * BLMH is a transmembrane protein with a predicted molecular weight of approximately 130 kDa. * It contains a conserved cysteine-type endopeptidase domain. * It is a member of the ADAM (Apolipoprotein A, Membrane Type, and Defensin) family of enzymes. **Pathways and functions:** * BLMH is involved in the adaptive immune system. * It is expressed in cells that are involved in the immune response, such as epithelial cells, macrophages, and dendritic cells. * BLMH is a key enzyme in the processing and degradation of antigens. * It is involved in the activation of the adaptive immune system by processing and presenting antigens derived from pathogens. * It is also involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the BLMH gene have been linked to several human diseases, including cancer and autoimmune disorders. * BLMH inhibitors are being investigated as potential therapeutic agents for these diseases. * Studies of BLMH have also been conducted to understand the role of the immune system in development and aging.

Genular Protein ID: 3882483353

Symbol: BLMH_HUMAN

Name: Bleomycin hydrolase

UniProtKB Accession Codes:

Q13867 B2R796 Q53F86 Q9UER9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8620487

Title: Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.

PubMed ID: 8620487

PubMed ID: 8639621

Title: Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization.

PubMed ID: 8639621

DOI: 10.1021/bi960092y

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31875550

Title: Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.

PubMed ID: 31875550

DOI: 10.1016/j.celrep.2019.11.108

PubMed ID: 10404591

Title: Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.

PubMed ID: 10404591

DOI: 10.1016/s0969-2126(99)80083-5

Sequence Information:

  • Length: 455
  • Mass: 52562
  • Checksum: 577E86241EB0D460
  • Sequence:
    • MSSSGLNSEK VAALIQKLNS DPQFVLAQNV GTTHDLLDIC LKRATVQRAQ HVFQHAVPQE 
GKPITNQKSS GRCWIFSCLN VMRLPFMKKL NIEEFEFSQS YLFFWDKVER CYFFLSAFVD 
TAQRKEPEDG RLVQFLLMNP ANDGGQWDML VNIVEKYGVI PKKCFPESYT TEATRRMNDI 
LNHKMREFCI RLRNLVHSGA TKGEISATQD VMMEEIFRVV CICLGNPPET FTWEYRDKDK 
NYQKIGPITP LEFYREHVKP LFNMEDKICL VNDPRPQHKY NKLYTVEYLS NMVGGRKTLY 
NNQPIDFLKK MVAASIKDGE AVWFGCDVGK HFNSKLGLSD MNLYDHELVF GVSLKNMNKA 
ERLTFGESLM THAMTFTAVS EKDDQDGAFT KWRVENSWGE DHGHKGYLCM TDEWFSEYVY 
EVVVDRKHVP EEVLAVLEQE PIILPAWDPM GALAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.