Details for: CXCR5

Gene ID: 643

Symbol: CXCR5

Ensembl ID: ENSG00000160683

Description: C-X-C motif chemokine receptor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centroblast (CL0009112)
    Fold Change: 10.4112
    Cell Significance Index: 24.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 7.2983
    Cell Significance Index: -2.9700
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.7774
    Cell Significance Index: 5.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0081
    Cell Significance Index: 118.8900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9476
    Cell Significance Index: 14.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8315
    Cell Significance Index: 18.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6504
    Cell Significance Index: 20.8300
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.6212
    Cell Significance Index: 1.5300
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.5901
    Cell Significance Index: 2.9600
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.5836
    Cell Significance Index: 2.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.5144
    Cell Significance Index: -1.5800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.5036
    Cell Significance Index: 5.0500
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.2484
    Cell Significance Index: 1.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2092
    Cell Significance Index: 12.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1841
    Cell Significance Index: 35.0400
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.1501
    Cell Significance Index: 1.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.1375
    Cell Significance Index: 8.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1266
    Cell Significance Index: 5.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1183
    Cell Significance Index: 3.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1182
    Cell Significance Index: 7.2700
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.1000
    Cell Significance Index: 0.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0903
    Cell Significance Index: 9.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0896
    Cell Significance Index: 2.1500
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.0861
    Cell Significance Index: 0.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0592
    Cell Significance Index: 0.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0396
    Cell Significance Index: 0.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0351
    Cell Significance Index: 2.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0293
    Cell Significance Index: 0.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0260
    Cell Significance Index: 0.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0159
    Cell Significance Index: 1.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0114
    Cell Significance Index: 1.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0113
    Cell Significance Index: 10.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0084
    Cell Significance Index: 5.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0080
    Cell Significance Index: 1.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0052
    Cell Significance Index: 9.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0051
    Cell Significance Index: 0.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0048
    Cell Significance Index: 0.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0028
    Cell Significance Index: 1.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0027
    Cell Significance Index: 0.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0024
    Cell Significance Index: 0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0009
    Cell Significance Index: 0.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.3200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0005
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0017
    Cell Significance Index: -0.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0019
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0024
    Cell Significance Index: -1.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0025
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0026
    Cell Significance Index: -1.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0029
    Cell Significance Index: -1.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -1.9700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0035
    Cell Significance Index: -0.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0036
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0041
    Cell Significance Index: -1.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0042
    Cell Significance Index: -1.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0045
    Cell Significance Index: -0.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0048
    Cell Significance Index: -0.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0058
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0076
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0083
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0087
    Cell Significance Index: -1.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0115
    Cell Significance Index: -0.8100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0125
    Cell Significance Index: -0.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0154
    Cell Significance Index: -0.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0175
    Cell Significance Index: -1.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0206
    Cell Significance Index: -0.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0221
    Cell Significance Index: -2.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0238
    Cell Significance Index: -1.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0241
    Cell Significance Index: -1.6200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0250
    Cell Significance Index: -0.3200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0263
    Cell Significance Index: -0.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0268
    Cell Significance Index: -1.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0269
    Cell Significance Index: -2.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0299
    Cell Significance Index: -1.2300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0303
    Cell Significance Index: -0.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0317
    Cell Significance Index: -1.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0323
    Cell Significance Index: -1.5200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0342
    Cell Significance Index: -0.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0383
    Cell Significance Index: -2.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0391
    Cell Significance Index: -3.1000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0392
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0397
    Cell Significance Index: -1.0800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0403
    Cell Significance Index: -0.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0457
    Cell Significance Index: -1.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0457
    Cell Significance Index: -2.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0459
    Cell Significance Index: -1.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0460
    Cell Significance Index: -2.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0512
    Cell Significance Index: -1.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0546
    Cell Significance Index: -1.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0553
    Cell Significance Index: -1.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0557
    Cell Significance Index: -2.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0559
    Cell Significance Index: -2.9100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0588
    Cell Significance Index: -0.8600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0612
    Cell Significance Index: -0.8000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0618
    Cell Significance Index: -0.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** CXCR5 is a transmembrane receptor with seven transmembrane domains, characteristic of the G protein-coupled receptor (GPCR) family. 2. **Ligand Binding:** CXCR5 binds to specific chemokines, such as CCL21, which is crucial for its function in immune response and tissue development. 3. **Signaling Pathways:** CXCR5 activates various signaling pathways, including calcium-mediated signaling, G alpha (i) signaling, and phospholipase C (PLC) signaling, which regulate cellular responses such as chemotaxis, proliferation, and differentiation. 4. **Cellular Expression:** CXCR5 is expressed in a diverse range of cell types, including B-1 B cells, blood vessel endothelial cells, and epithelial cells, highlighting its role in multiple physiological and pathological processes. **Pathways and Functions:** 1. **Immune Response:** CXCR5 plays a critical role in the immune response, particularly in the development and homing of B-1 B cells, which are involved in the production of natural antibodies and the defense against pathogens. 2. **Cell Chemotaxis:** CXCR5 mediates chemotaxis, the directed movement of cells in response to chemical gradients, facilitating the recruitment of immune cells to sites of inflammation and tissue injury. 3. **Lymph Node Development:** CXCR5 is essential for the development and organization of lymphoid organs, including lymph nodes, which are critical for immune cell activation and interaction. 4. **Cytokinesis and Cell Proliferation:** CXCR5 regulates cytokinesis and cell proliferation, influencing the development and homeostasis of tissues. **Clinical Significance:** CXCR5's involvement in immune response and tissue development has significant implications for various diseases, including: 1. **Autoimmune Disorders:** Dysregulation of CXCR5 signaling has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where immune cell homing and activation are disrupted. 2. **Cancer:** CXCR5 expression is often upregulated in cancer, including lymphoma and leukemia, where it promotes tumor growth, angiogenesis, and metastasis. 3. **Inflammatory Diseases:** CXCR5 is involved in the pathogenesis of inflammatory diseases, such as atherosclerosis and inflammatory bowel disease, where it regulates immune cell recruitment and tissue damage. 4. **Immunotherapy:** Targeting CXCR5 with specific ligands or antibodies may provide a novel therapeutic strategy for treating autoimmune and inflammatory diseases. In conclusion, CXCR5 is a multifaceted receptor that plays a critical role in immune response, cell chemotaxis, and tissue development. Its dysregulation has significant implications for various diseases, highlighting the need for further research into the mechanisms of CXCR5 signaling and its therapeutic potential.

Genular Protein ID: 2217373645

Symbol: CXCR5_HUMAN

Name: C-X-C chemokine receptor type 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1425907

Title: Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma.

PubMed ID: 1425907

DOI: 10.1002/eji.1830221107

PubMed ID: 7639692

Title: Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation.

PubMed ID: 7639692

DOI: 10.1042/bj3090773

PubMed ID: 9463416

Title: B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.

PubMed ID: 9463416

DOI: 10.1084/jem.187.4.655

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 372
  • Mass: 41955
  • Checksum: 6DF84C839492ACCF
  • Sequence:
  • MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL 
    IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF 
    LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RRLLSIHITC GTIWLVGFLL 
    ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG 
    VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL 
    PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPSWRRSSL 
    SESENATSLT TF

Genular Protein ID: 2114230487

Symbol: Q2YD84_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 372
  • Mass: 41925
  • Checksum: 6DF856595492ACCF
  • Sequence:
  • MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL 
    IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF 
    LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RRLLSIHITC GTIWLVGFLL 
    ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG 
    VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL 
    PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPGWRRSSL 
    SESENATSLT TF

Genular Protein ID: 909230357

Symbol: A8K647_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 372
  • Mass: 41912
  • Checksum: E339A53C757B1B70
  • Sequence:
  • MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL 
    IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF 
    LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RLLLSIHITC GTIWLVGFLL 
    ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG 
    VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL 
    PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPSWRRSSL 
    SESENATSLT TF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.