Details for: CXCR5

Gene ID: 643

Symbol: CXCR5

Ensembl ID: ENSG00000160683

Description: C-X-C motif chemokine receptor 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.58
    Marker Score: 16548.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.59
    Marker Score: 4397
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 3.21
    Marker Score: 10297
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.5
    Marker Score: 7163
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.16
    Marker Score: 6161
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.09
    Marker Score: 2105
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1994
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.77
    Marker Score: 3080
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.48
    Marker Score: 731
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.44
    Marker Score: 331
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.41
    Marker Score: 2953
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.4
    Marker Score: 2901
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.19
    Marker Score: 626
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4814
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.11
    Marker Score: 3282
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.99
    Marker Score: 595
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.96
    Marker Score: 706
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.95
    Marker Score: 578
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.95
    Marker Score: 225
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14636
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5324
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.93
    Marker Score: 704
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.93
    Marker Score: 915
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.92
    Marker Score: 822
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.84
    Marker Score: 299
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.84
    Marker Score: 200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.82
    Marker Score: 5460
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.82
    Marker Score: 884
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1183.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 289
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.58
    Marker Score: 449
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.58
    Marker Score: 542.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 360
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.54
    Marker Score: 122
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.48
    Marker Score: 1209
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.47
    Marker Score: 250
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.47
    Marker Score: 314
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.47
    Marker Score: 443
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.45
    Marker Score: 324
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.43
    Marker Score: 118
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.42
    Marker Score: 245
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.4
    Marker Score: 945
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 167
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.38
    Marker Score: 114
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.37
    Marker Score: 305
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.31
    Marker Score: 381
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 77
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 297
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 164
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.26
    Marker Score: 114.5
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.24
    Marker Score: 66
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.23
    Marker Score: 116
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.23
    Marker Score: 180
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.2
    Marker Score: 71
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.18
    Marker Score: 108
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.18
    Marker Score: 2112
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.18
    Marker Score: 77
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.17
    Marker Score: 62
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.17
    Marker Score: 475
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.16
    Marker Score: 83
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 331
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.16
    Marker Score: 176
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.15
    Marker Score: 151
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.14
    Marker Score: 92

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Other Information

**Key characteristics:** - Type: Protein - Ensembl ID: ENSG00000160683 - Protein length: 117 amino acids - Subcellular localization: Cell membrane **Pathways and functions:** - B cell activation: CXCR5 is expressed on B cells, where it is important for the activation of B cells. - C-c chemokine binding: CXCR5 binds to the C-c chemokine receptor CXCR2, which is expressed on activated B cells and dendritic cells. This binding activates the CXCR5/CXCR2 complex, which leads to the activation of the B cell. - C-c chemokine receptor activity: CXCR5 is also expressed on endothelial cells in the eye, where it plays a role in the recruitment of immune cells to the retina. - C-x-c chemokine receptor activity: CXCR5 is also expressed on macrophages, where it plays a role in the recruitment of monocytes to sites of inflammation. **Clinical significance:** - Mutations in the CXCR5 gene have been linked to several human diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. - CXCR5 is a potential therapeutic target for these diseases, as blocking CXCR5 signaling has been shown to be effective in inhibiting inflammation. **Additional notes:** - CXCR5 is a member of the chemokine receptor family, which is a large family of cell surface receptors that are expressed on a variety of immune cells. - CXCR5 is a highly conserved protein, with a similar sequence found in mammals, birds, and reptiles. - CXCR5 is a relatively new receptor, with the gene first identified in humans in 1998.

Genular Protein ID: 2217373645

Symbol: CXCR5_HUMAN

Name: C-X-C chemokine receptor type 5

UniProtKB Accession Codes:

P32302 Q14811

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1425907

Title: Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma.

PubMed ID: 1425907

DOI: 10.1002/eji.1830221107

PubMed ID: 7639692

Title: Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation.

PubMed ID: 7639692

DOI: 10.1042/bj3090773

PubMed ID: 9463416

Title: B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.

PubMed ID: 9463416

DOI: 10.1084/jem.187.4.655

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 372
  • Mass: 41955
  • Checksum: 6DF84C839492ACCF
  • Sequence:
    • MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL 
IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF 
LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RRLLSIHITC GTIWLVGFLL 
ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG 
VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL 
PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPSWRRSSL 
SESENATSLT TF

Genular Protein ID: 2114230487

Symbol: Q2YD84_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2YD84

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 6 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 372
  • Mass: 41925
  • Checksum: 6DF856595492ACCF
  • Sequence:
    • MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL 
IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF 
LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RRLLSIHITC GTIWLVGFLL 
ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG 
VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL 
PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPGWRRSSL 
SESENATSLT TF

Genular Protein ID: 909230357

Symbol: A8K647_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K647

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 6 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 372
  • Mass: 41912
  • Checksum: E339A53C757B1B70
  • Sequence:
    • MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL 
IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF 
LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RLLLSIHITC GTIWLVGFLL 
ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG 
VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL 
PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPSWRRSSL 
SESENATSLT TF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.