Details for: IKZF5

Gene ID: 64376

Symbol: IKZF5

Ensembl ID: ENSG00000095574

Description: IKAROS family zinc finger 5

Associated with

  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein domain specific binding
    (GO:0019904)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 2969535074

Symbol: IKZF5_HUMAN

Name: Zinc finger protein Pegasus

UniProtKB Accession Codes:

Q9H5V7 B3KVH7 D3DRE7 Q9H2T0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10978333

Title: Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.

PubMed ID: 10978333

DOI: 10.1074/jbc.m005457200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31217188

Title: Germline mutations in the transcription factor IKZF5 cause thrombocytopenia.

PubMed ID: 31217188

DOI: 10.1182/blood.2019000782

PubMed ID: 32419556

Title: Highly impaired platelet ultrastructure in two families with novel IKZF5 variants.

PubMed ID: 32419556

DOI: 10.1080/09537104.2020.1764921

Sequence Information:

  • Length: 419
  • Mass: 46510
  • Checksum: 71845E9DE10BB2E8
  • Sequence:
    • MGEKKPEPLD FVKDFQEYLT QQTHHVNMIS GSVSGDKEAE ALQGAGTDGD QNGLDHPSVE 
VSLDENSGML VDGFERTFDG KLKCRYCNYA SKGTARLIEH IRIHTGEKPH RCHLCPFASA 
YERHLEAHMR SHTGEKPYKC ELCSFRCSDR SNLSHHRRRK HKMVPIKGTR SSLSSKKMWG 
VLQKKTSNLG YSRRALINLS PPSMVVQKPD YLNDFTHEIP NIQTDSYESM AKTTPTGGLP 
RDPQELMVDN PLNQLSTLAG QLSSLPPENQ NPASPDVVPC PDEKPFMIQQ PSTQAVVSAV 
SASIPQSSSP TSPEPRPSHS QRNYSPVAGP SSEPSAHTST PSIGNSQPST PAPALPVQDP 
QLLHHCQHCD MYFADNILYT IHMGCHGYEN PFQCNICGCK CKNKYDFACH FARGQHNQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.