Sirt2 | ENSMUSG00000015149 | NCBI 64383

Details for: Sirt2

Gene ID: 64383

Symbol: Sirt2

Ensembl ID: ENSMUSG00000015149

Description: sirtuin 2

Associated with

Cell cycle, mitotic
(R-MMU-69278)
Initiation of nuclear envelope (ne) reformation
(R-MMU-2995383)
Mitotic anaphase
(R-MMU-68882)
Mitotic metaphase and anaphase
(R-MMU-2555396)
M phase
(R-MMU-68886)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Autophagy
(GO:0006914)
Beta-tubulin binding
(GO:0048487)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Cellular lipid catabolic process
(GO:0044242)
Cellular response to caloric restriction
(GO:0061433)
Cellular response to epinephrine stimulus
(GO:0071872)
Cellular response to hypoxia
(GO:0071456)
Cellular response to oxidative stress
(GO:0034599)
Centriole
(GO:0005814)
Centrosome
(GO:0005813)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Chromosome
(GO:0005694)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dna-binding transcription factor binding
(GO:0140297)
Epigenetic regulation of gene expression
(GO:0040029)
Heterochromatin
(GO:0000792)
Histone acetyltransferase binding
(GO:0035035)
Histone deacetylase activity
(GO:0004407)
Histone deacetylase binding
(GO:0042826)
Meiotic cell cycle
(GO:0051321)
Metal ion binding
(GO:0046872)
Microtubule
(GO:0005874)
Mitochondrion
(GO:0005739)
Myelination in peripheral nervous system
(GO:0022011)
Nad+ binding
(GO:0070403)
Nad-dependent histone deacetylase activity
(GO:0017136)
Nad-dependent histone h4k16 deacetylase activity
(GO:0046970)
Nad-dependent protein deacetylase activity
(GO:0034979)
Nad-dependent protein demyristoylase activity
(GO:0140773)
Nad-dependent protein depalmitoylase activity
(GO:0140774)
Nad binding
(GO:0051287)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of nlrp3 inflammasome complex assembly
(GO:1900226)
Negative regulation of oligodendrocyte differentiation
(GO:0048715)
Negative regulation of oligodendrocyte progenitor proliferation
(GO:0070446)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of reactive oxygen species metabolic process
(GO:2000378)
Negative regulation of striated muscle tissue development
(GO:0045843)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Nlrp3 inflammasome complex assembly
(GO:0044546)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Peptidyl-lysine deacetylation
(GO:0034983)
Positive regulation of attachment of spindle microtubules to kinetochore
(GO:0051987)
Positive regulation of cell division
(GO:0051781)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of execution phase of apoptosis
(GO:1900119)
Positive regulation of fatty acid biosynthetic process
(GO:0045723)
Positive regulation of meiotic nuclear division
(GO:0045836)
Positive regulation of oocyte maturation
(GO:1900195)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein deacetylation
(GO:0006476)
Protein lysine deacetylase activity
(GO:0033558)
Regulation of cell cycle
(GO:0051726)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of myelination
(GO:0031641)
Regulation of postsynaptic neurotransmitter receptor internalization
(GO:0099149)
Spindle
(GO:0005819)
Transcription factor binding
(GO:0008134)
Transferase activity
(GO:0016740)
Tubulin deacetylase activity
(GO:0042903)
Tubulin deacetylation
(GO:0090042)
Ubiquitin binding
(GO:0043130)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

NAD-dependent protein deacetylase sirtuin-2

Genular Protein ID: 347272540

Symbol: SIR2_MOUSE

Name: NAD-dependent protein deacetylase sirtuin-2

UniProtKB Accession Codes:

Q8VDQ8 E9PXF5 Q9CXS5 Q9EQ18 Q9ERJ9 U5TP50

Database IDs:

Citations:

PubMed ID: 11056054

Title: Cloning and characterization of two mouse genes with homology to the yeast sir2 gene.

PubMed ID: 11056054

DOI: 10.1006/geno.2000.6360

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 24177535

Title: Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform.

PubMed ID: 24177535

DOI: 10.1016/j.jmb.2013.10.027

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 17521387

Title: SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction.

PubMed ID: 17521387

DOI: 10.1111/j.1474-9726.2007.00304.x

PubMed ID: 17681146

Title: SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.

PubMed ID: 17681146

DOI: 10.1016/j.cmet.2007.07.003

PubMed ID: 17634366

Title: Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.

PubMed ID: 17634366

DOI: 10.1523/jneurosci.1254-07.2007

PubMed ID: 16933150

Title: Microtubule deacetylases, SirT2 and HDAC6, in the nervous system.

PubMed ID: 16933150

DOI: 10.1007/s11064-006-9127-6

PubMed ID: 17574768

Title: Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation.

PubMed ID: 17574768

DOI: 10.1016/j.neuroscience.2007.04.059

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18332217

Title: The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility.

PubMed ID: 18332217

DOI: 10.1083/jcb.200707126

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19037106

Title: SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma.

PubMed ID: 19037106

DOI: 10.1091/mbc.e08-06-0647

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22014574

Title: SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.

PubMed ID: 22014574

DOI: 10.1016/j.ccr.2011.09.004

PubMed ID: 21791548

Title: The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.

PubMed ID: 21791548

DOI: 10.1093/hmg/ddr326

PubMed ID: 21949390

Title: Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.

PubMed ID: 21949390

DOI: 10.1073/pnas.1104969108

PubMed ID: 21841822

Title: Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.

PubMed ID: 21841822

DOI: 10.1038/onc.2011.347

PubMed ID: 22943040

Title: SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis.

PubMed ID: 22943040

PubMed ID: 23468428

Title: The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation.

PubMed ID: 23468428

DOI: 10.1101/gad.211342.112

PubMed ID: 24460154

Title: Localization of sirtuins in the mouse inner ear.

PubMed ID: 24460154

DOI: 10.3109/00016489.2013.861928

PubMed ID: 24334550

Title: Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis.

PubMed ID: 24334550

DOI: 10.1096/fj.13-244111

Sequence Information:

Length: 389
Mass: 43256
Checksum: 15F96635445A1BC0
Sequence:

MAEPDPSDPL ETQAGKVQEA QDSDSDTEGG ATGGEAEMDF LRNLFTQTLG LGSQKERLLD 
ELTLEGVTRY MQSERCRKVI CLVGAGISTS AGIPDFRSPS TGLYANLEKY HLPYPEAIFE 
ISYFKKHPEP FFALAKELYP GQFKPTICHY FIRLLKEKGL LLRCYTQNID TLERVAGLEP 
QDLVEAHGTF YTSHCVNTSC RKEYTMGWMK EKIFSEATPR CEQCQSVVKP DIVFFGENLP 
SRFFSCMQSD FSKVDLLIIM GTSLQVQPFA SLISKAPLAT PRLLINKEKT GQTDPFLGMM 
MGLGGGMDFD SKKAYRDVAW LGDCDQGCLA LADLLGWKKE LEDLVRREHA NIDAQSGSQA 
PNPSTTISPG KSPPPAKEAA RTKEKEEQQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sirt2

Associated with

Other Information

Cloning and characterization of two mouse genes with homology to the yeast sir2 gene. PubMed ID: 11056054

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform. PubMed ID: 24177535

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. PubMed ID: 17521387

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. PubMed ID: 17681146

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. PubMed ID: 17634366

Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. PubMed ID: 16933150

Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation. PubMed ID: 17574768

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. PubMed ID: 18332217

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. PubMed ID: 19037106

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. PubMed ID: 22014574

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS. PubMed ID: 21791548

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. PubMed ID: 21949390

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. PubMed ID: 21841822

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis. PubMed ID: 22943040

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. PubMed ID: 23468428

Localization of sirtuins in the mouse inner ear. PubMed ID: 24460154

Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis. PubMed ID: 24334550