Sirt3 | ENSMUSG00000025486 | NCBI 64384

Details for: Sirt3

Gene ID: 64384

Symbol: Sirt3

Ensembl ID: ENSMUSG00000025486

Description: sirtuin 3

Associated with

Foxo-mediated transcription
(R-MMU-9614085)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Mitochondrial biogenesis
(R-MMU-1592230)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Regulation of foxo transcriptional activity by acetylation
(R-MMU-9617629)
Rna polymerase ii transcription
(R-MMU-73857)
Transcriptional activation of mitochondrial biogenesis
(R-MMU-2151201)
Aerobic respiration
(GO:0009060)
Enzyme binding
(GO:0019899)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Nad+ binding
(GO:0070403)
Nad-dependent histone deacetylase activity
(GO:0017136)
Nad-dependent protein deacetylase activity
(GO:0034979)
Nad binding
(GO:0051287)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of peptidyl-lysine acetylation
(GO:2000757)
Negative regulation of reactive oxygen species metabolic process
(GO:2000378)
Nucleus
(GO:0005634)
Peptidyl-lysine deacetylation
(GO:0034983)
Positive regulation of catalase activity
(GO:1902553)
Positive regulation of ceramide biosynthetic process
(GO:2000304)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of mitochondrial transcription
(GO:1903109)
Positive regulation of superoxide dismutase activity
(GO:1901671)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein deacetylation
(GO:0006476)
Protein lysine deacetylase activity
(GO:0033558)
Sequence-specific dna binding
(GO:0043565)
Transferase activity
(GO:0016740)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

NAD-dependent protein deacetylase sirtuin-3
Q4FJK3_MOUSE

Genular Protein ID: 2075434646

Symbol: SIR3_MOUSE

Name: NAD-dependent protein deacetylase sirtuin-3

UniProtKB Accession Codes:

Q8R104 B9W0A9 C6ZII7 Q9EPA8

Database IDs:

Citations:

PubMed ID: 11056054

Title: Cloning and characterization of two mouse genes with homology to the yeast sir2 gene.

PubMed ID: 11056054

DOI: 10.1006/geno.2000.6360

PubMed ID: 19333382

Title: A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein.

PubMed ID: 19333382

DOI: 10.1371/journal.pone.0004986

PubMed ID: 19241369

Title: Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.

PubMed ID: 19241369

DOI: 10.1002/pro.50

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16790548

Title: Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.

PubMed ID: 16790548

DOI: 10.1073/pnas.0604392103

PubMed ID: 17923681

Title: Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

PubMed ID: 17923681

DOI: 10.1128/mcb.01636-07

PubMed ID: 18794531

Title: A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.

PubMed ID: 18794531

DOI: 10.1073/pnas.0803790105

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21172655

Title: Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

PubMed ID: 21172655

DOI: 10.1016/j.molcel.2010.12.013

PubMed ID: 21858060

Title: Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.

PubMed ID: 21858060

DOI: 10.1371/journal.pone.0023295

PubMed ID: 23283301

Title: A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

PubMed ID: 23283301

DOI: 10.1007/s00018-012-1244-6

PubMed ID: 23835326

Title: Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation.

PubMed ID: 23835326

DOI: 10.2337/db12-1650

PubMed ID: 23438705

Title: Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.

PubMed ID: 23438705

DOI: 10.1016/j.mito.2013.02.002

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24252090

Title: SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient and exercise-induced stress.

PubMed ID: 24252090

DOI: 10.1089/ars.2013.5420

PubMed ID: 26620563

Title: SIRT3 deacetylates ceramide synthases: Implications for mitochondrial dysfunction and brain injury.

PubMed ID: 26620563

DOI: 10.1074/jbc.m115.668228

PubMed ID: 36804859

Title: Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis.

PubMed ID: 36804859

DOI: 10.1097/hep.0000000000000314

Sequence Information:

Length: 334
Mass: 36615
Checksum: D8C936A83C4A8AF7
Sequence:

MALDPLGAVV LQSIMALSGR LALAALRLWG PGGGRRPISL CVGASGGFGG GGSSEKKFSL 
QDVAELLRTR ACSRVVVMVG AGISTPSGIP DFRSPGSGLY SNLQQYDIPY PEAIFELGFF 
FHNPKPFFML AKELYPGHYR PNVTHYFLRL LHDKELLLRL YTQNIDGLER ASGIPASKLV 
EAHGTFVTAT CTVCRRSFPG EDIWADVMAD RVPRCPVCTG VVKPDIVFFG EQLPARFLLH 
MADFALADLL LILGTSLEVE PFASLSEAVQ KSVPRLLINR DLVGPFVLSP RRKDVVQLGD 
VVHGVERLVD LLGWTQELLD LMQRERGKLD GQDR

Genular Protein ID: 267661155

Symbol: Q4FJK3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q4FJK3

Database IDs:

Sequence Information:

Length: 257
Mass: 28822
Checksum: F756041FBC9B985E
Sequence:

MVGAGISTPS GIPDFRSPGS GLYSNLQQYD IPYPEAIFEL GFFFHNPKPF FMLAKELYPG 
HYRPNVTHYF LRLLHDKELL LRLYTQNIDG LERASGIPAS KLVEAHGTFV TATCTVCRRS 
FPGEDIWADV MADRVPRCPV CTGVVKPDIV FFGEQLPARF LLHMADFALA DLLLILGTSL 
EVEPFASLSE AVQKSVPRLL INRDLVGPFV LSPRRKDVVQ LGDVVHGVER LVDLLGWTQE 
LLDLMQRERG KLDGQDR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sirt3

Associated with

Other Information

Cloning and characterization of two mouse genes with homology to the yeast sir2 gene. PubMed ID: 11056054

A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein. PubMed ID: 19333382

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. PubMed ID: 19241369

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. PubMed ID: 16790548

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. PubMed ID: 17923681

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. PubMed ID: 18794531

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. PubMed ID: 21172655

Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PubMed ID: 21858060

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. PubMed ID: 23283301

Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. PubMed ID: 23835326

Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. PubMed ID: 23438705

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient and exercise-induced stress. PubMed ID: 24252090

SIRT3 deacetylates ceramide synthases: Implications for mitochondrial dysfunction and brain injury. PubMed ID: 26620563

Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis. PubMed ID: 36804859