HHIP | ENSG00000164161 | NCBI 64399

Details for: HHIP

Gene ID: 64399

Symbol: HHIP

Ensembl ID: ENSG00000164161

Description: hedgehog interacting protein

Associated with

Gli proteins bind promoters of hh responsive genes to promote transcription
(R-HSA-5635851)
Hedgehog 'on' state
(R-HSA-5632684)
Ligand-receptor interactions
(R-HSA-5632681)
Signaling by hedgehog
(R-HSA-5358351)
Cell surface
(GO:0009986)
Ciliary membrane
(GO:0060170)
Cytoplasm
(GO:0005737)
Dorsal/ventral pattern formation
(GO:0009953)
Epithelial tube branching involved in lung morphogenesis
(GO:0060441)
Extracellular region
(GO:0005576)
Hedgehog family protein binding
(GO:0097108)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of signal transduction
(GO:0009968)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Neuroblast proliferation
(GO:0007405)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of fibroblast growth factor receptor signaling pathway
(GO:0040036)
Signal transduction
(GO:0007165)
Skeletal system morphogenesis
(GO:0048705)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Hedgehog-interacting protein

Genular Protein ID: 294286751

Symbol: HHIP_HUMAN

Name: Hedgehog-interacting protein

UniProtKB Accession Codes:

Q96QV1 Q6PK09 Q8NCI7 Q9BXK3 Q9H1J4 Q9H7E7

Database IDs:

Citations:

PubMed ID: 11435703

Title: The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3.

PubMed ID: 11435703

DOI: 10.1159/000056918

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11472839

Title: Comparative biological responses to human Sonic, Indian, and Desert hedgehog.

PubMed ID: 11472839

DOI: 10.1016/s0925-4773(01)00427-0

PubMed ID: 18391950

Title: Identification of ten loci associated with height highlights new biological pathways in human growth.

PubMed ID: 18391950

DOI: 10.1038/ng.125

PubMed ID: 19561609

Title: The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

PubMed ID: 19561609

DOI: 10.1038/nsmb.1632

PubMed ID: 19561611

Title: Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

PubMed ID: 19561611

DOI: 10.1038/nsmb.1607

Sequence Information:

Length: 700
Mass: 78851
Checksum: CC1CB3435E29303A
Sequence:

MLKMLSFKLL LLAVALGFFE GDAKFGERNE GSGARRRRCL NGNPPKRLKR RDRRMMSQLE 
LLSGGEMLCG GFYPRLSCCL RSDSPGLGRL ENKIFSVTNN TECGKLLEEI KCALCSPHSQ 
SLFHSPEREV LERDLVLPLL CKDYCKEFFY TCRGHIPGFL QTTADEFCFY YARKDGGLCF 
PDFPRKQVRG PASNYLDQME EYDKVEEISR KHKHNCFCIQ EVVSGLRQPV GALHSGDGSQ 
RLFILEKEGY VKILTPEGEI FKEPYLDIHK LVQSGIKGGD ERGLLSLAFH PNYKKNGKLY 
VSYTTNQERW AIGPHDHILR VVEYTVSRKN PHQVDLRTAR VFLEVAELHR KHLGGQLLFG 
PDGFLYIILG DGMITLDDME EMDGLSDFTG SVLRLDVDTD MCNVPYSIPR SNPHFNSTNQ 
PPEVFAHGLH DPGRCAVDRH PTDININLTI LCSDSNGKNR SSARILQIIK GKDYESEPSL 
LEFKPFSNGP LVGGFVYRGC QSERLYGSYV FGDRNGNFLT LQQSPVTKQW QEKPLCLGTS 
GSCRGYFSGH ILGFGEDELG EVYILSSSKS MTQTHNGKLY KIVDPKRPLM PEECRATVQP 
AQTLTSECSR LCRNGYCTPT GKCCCSPGWE GDFCRTAKCE PACRHGGVCV RPNKCLCKKG 
YLGPQCEQVD RNIRRVTRAG ILDQIIDMTS YLLDLTSYIV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HHIP

Associated with

Other Information

The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21--&gt;q31.3. PubMed ID: 11435703

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Comparative biological responses to human Sonic, Indian, and Desert hedgehog. PubMed ID: 11472839

Identification of ten loci associated with height highlights new biological pathways in human growth. PubMed ID: 18391950

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. PubMed ID: 19561609

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP. PubMed ID: 19561611